M A Geyer

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Differential movement patterns but not amount of activity in unconditioned motor behavior of Fischer, Lewis, and Sprague-Dawley rats
    M P Paulus
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Physiol Behav 65:601-6. 1998
  2. ncbi request reprint The genetic liability to stress and postweaning isolation have a competitive influence on behavioral organization in rats
    M P Paulus
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Physiol Behav 68:389-94. 2000
  3. ncbi request reprint Schizophrenia subjects show intact success-related neural activation but impaired uncertainty processing during decision-making
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California at San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 28:795-806. 2003
  4. ncbi request reprint Trend detection via temporal difference model predicts inferior prefrontal cortex activation during acquisition of advantageous action selection
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, and Department of Psychiatry, University of California San Diego, and Veterans Affairs San Diego Healthcare System, 92093 0603, USA
    Neuroimage 21:733-43. 2004
  5. ncbi request reprint Ventromedial prefrontal cortex activation is critical for preference judgments
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuroreport 14:1311-5. 2003
  6. ncbi request reprint Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, San Diego, CA 92093 0603, USA
    Neuropsychopharmacology 26:53-63. 2002
  7. ncbi request reprint Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuroimage 19:1439-48. 2003
  8. ncbi request reprint Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients
    W Perry
    Department of Psychiatry, University of California, San Diego, USA
    Arch Gen Psychiatry 56:277-81. 1999
  9. ncbi request reprint Symptom correlates of prepulse inhibition deficits in male schizophrenic patients
    D L Braff
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Am J Psychiatry 156:596-602. 1999
  10. ncbi request reprint Effects of LU-111995 in three models of disrupted prepulse inhibition in rats
    M A Geyer
    Department of Psychiatry, University of California at San Diego, San Diego, California, USA
    J Pharmacol Exp Ther 290:716-24. 1999

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Differential movement patterns but not amount of activity in unconditioned motor behavior of Fischer, Lewis, and Sprague-Dawley rats
    M P Paulus
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Physiol Behav 65:601-6. 1998
    ..Differences in movement patterns across strains may provide an important behavioral variable to further explore the genetic and developmental aspects of behavior...
  2. ncbi request reprint The genetic liability to stress and postweaning isolation have a competitive influence on behavioral organization in rats
    M P Paulus
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Physiol Behav 68:389-94. 2000
    ....
  3. ncbi request reprint Schizophrenia subjects show intact success-related neural activation but impaired uncertainty processing during decision-making
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California at San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 28:795-806. 2003
    ..In contrast, task-related activation in SZS was not modulated by the degree of uncertainty. Thus, SZS failed to utilize the parietal cortex to process decision-making situations with highly uncertain outcomes...
  4. ncbi request reprint Trend detection via temporal difference model predicts inferior prefrontal cortex activation during acquisition of advantageous action selection
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, and Department of Psychiatry, University of California San Diego, and Veterans Affairs San Diego Healthcare System, 92093 0603, USA
    Neuroimage 21:733-43. 2004
    ..These findings are consistent with the hypothesis that the inferior prefrontal cortex computes a trend from previously experienced action-outcome sequences based on a value function derived from the temporal difference model...
  5. ncbi request reprint Ventromedial prefrontal cortex activation is critical for preference judgments
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuroreport 14:1311-5. 2003
    ..These findings are consistent with the role of the ventromedial prefrontal cortex in the representation of complex appetitive states...
  6. ncbi request reprint Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, San Diego, CA 92093 0603, USA
    Neuropsychopharmacology 26:53-63. 2002
    ..These results support the basic hypothesis that stimulant-dependent subjects exhibit fundamental cognitive deficits during decision-making that are consistent with both orbitofrontal and dorsolateral prefrontal dysfunction...
  7. ncbi request reprint Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism
    Martin P Paulus
    Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuroimage 19:1439-48. 2003
    ..These results are consistent with the hypothesis that insula activation serves as a critical neural substrate to instantiate aversive somatic markers that guide risk-taking decision-making behavior...
  8. ncbi request reprint Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients
    W Perry
    Department of Psychiatry, University of California, San Diego, USA
    Arch Gen Psychiatry 56:277-81. 1999
    ..To address this issue, sensorimotor gating and thought disturbance were measured in close temporal proximity, thus strengthening the evidence for the association of these 2 abnormalities in schizophrenic patients...
  9. ncbi request reprint Symptom correlates of prepulse inhibition deficits in male schizophrenic patients
    D L Braff
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Am J Psychiatry 156:596-602. 1999
    ..Prepulse inhibition deficits in schizophrenic patients correlate with core cognitive symptoms, such as thought disorder and distractibility, but their relationship to positive and negative symptoms of schizophrenia is less clear...
  10. ncbi request reprint Effects of LU-111995 in three models of disrupted prepulse inhibition in rats
    M A Geyer
    Department of Psychiatry, University of California at San Diego, San Diego, California, USA
    J Pharmacol Exp Ther 290:716-24. 1999
    ..It remains to be elucidated whether its effects on PPI can be attributed to a blockade of single dopamine and 5-hydroxytryptamine receptor subtypes, especially D(4) and 5-hydroxytryptamine(2A), or a combination of both...
  11. ncbi request reprint Disruption of prepulse inhibition in mice lacking mGluR1
    S A Brody
    Department of Psychiatry and Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Eur J Neurosci 18:3361-6. 2003
    ..Thus, both group I metabotropic glutamate receptors are involved in the regulation of PPI in mice...
  12. ncbi request reprint Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors
    S A Brody
    Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Psychiatry 9:35-41. 2004
    ..The present findings further support the glutamate hypothesis of schizophrenia and identify a functional role for mGluR5 in sensorimotor gating...
  13. ncbi request reprint Latent inhibition in schizophrenia
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 20:91-103. 1996
    ....
  14. ncbi request reprint Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 20:4325-36. 2000
    ..These findings demonstrate robust, innate, neurochemically specific, and apparently heritable phenotypic differences in an animal model of sensorimotor gating deficits in human neuropsychiatric disorders...
  15. pmc Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transl Psychiatry 1:e9. 2011
    ....
  16. ncbi request reprint Strain-specific effects of amphetamine on prepulse inhibition and patterns of locomotor behavior in mice
    R J Ralph
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093-0804, USA
    J Pharmacol Exp Ther 298:148-55. 2001
    ..These findings highlight the importance of selecting appropriate strains of mice for behavioral, pharmacological, and genetic studies...
  17. ncbi request reprint Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach
    C A Ogden
    Laboratory of Neurophenomics, University of California, San Diego, CA, USA
    Mol Psychiatry 9:1007-29. 2004
    ....
  18. ncbi request reprint Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego 92093 0804, USA
    Am J Psychiatry 157:55-9. 2000
    ..Although schizotypal subjects have been shown to have deficits in sensorimotor gating as measured by prepulse inhibition, to the authors' knowledge P50 sensory gating in schizotypal personality disorder has yet to be reported...
  19. ncbi request reprint Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093
    Psychopharmacology (Berl) 101:414-20. 1990
    ....
  20. ncbi request reprint Poor P50 suppression among schizophrenia patients and their first-degree biological relatives
    B A Clementz
    Department of Psychology, University of California, San Diego, La Jolla 92093 0109, USA
    Am J Psychiatry 155:1691-4. 1998
    ..This study's goal was to replicate the finding that family members of schizophrenia patients show poor P50 suppression during a paired-click auditory evoked response paradigm...
  21. ncbi request reprint Aging effects on the startle response and startle plasticity in Fischer F344 rats
    G B Varty
    Department of Psychiatry, University of California San Diego, La Jolla 92093 0804, USA
    Neurobiol Aging 19:243-51. 1998
    ..Finally, there were no effects of age on FPS. In summary, these studies suggest that in Fischer F344 rats, there are age-associated differences in startle reactivity, startle habituation, and PPI, but no aging effect on FPS...
  22. ncbi request reprint Cross-species studies of sensorimotor gating of the startle reflex
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Ann N Y Acad Sci 877:202-16. 1999
    ..In this manner, PPI can be used to probe the sensitivity of DAergic systems, and perhaps other CSPP elements, across normal and neuropsychiatric-disordered populations...
  23. ncbi request reprint Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects
    B A Clementz
    Department of Psychology, University of California, La Jolla, San Diego 92093 0109, USA
    Schizophr Res 30:71-80. 1998
    ..Further work investigating the neuropathological correlates of poor P50 suppression among schizophrenia patients by recording from multiple electrode locations, however, could be helpful...
  24. ncbi request reprint Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists
    R J Ralph
    Departments of Neuroscience and Psychiatry, University of California San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 21:305-13. 2001
    ..Furthermore, D1 receptor activation appears to be the critical substrate for the expression of preservative patterns of motor behavior, whereas both D1 and D2 receptors appear to regulate the amount of motor activity...
  25. ncbi request reprint Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Behav Pharmacol 11:185-204. 2000
    ..Some of these issues--ranging from the cross-species methods for quantifying specific variables to the relevance of genetic drift to animal and human studies of PPI--and their implications for future studies are the focus of this review...
  26. ncbi request reprint Sex differences in sensorimotor gating of the human startle reflex: all smoke?
    N R Swerdlow
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 146:228-32. 1999
    ..A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers...
  27. ncbi request reprint Towards a cross-species pharmacology of sensorimotor gating: effects of amantadine, bromocriptine, pergolide and ropinirole on prepulse inhibition of acoustic startle in rats
    N R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla 92093 0804, USA
    Behav Pharmacol 9:389-96. 1998
    ....
  28. ncbi request reprint Psychopharmacology of prepulse inhibition in mice
    S C Dulawa
    Department of Neuroscience, University of California at San Diego, La Jolla 92093 0804, USA
    Chin J Physiol 39:139-46. 1996
    ..0 mg/kg d-amphetamine produced a large reduction of PPI that approached significance. Our findings suggest that the mouse may provide another model system for the study of sensorimotor gating mechanisms...
  29. ncbi request reprint 5-hydroxytryptamine2A receptor inverse agonists as antipsychotics
    D M Weiner
    ACADIA Pharmaceuticals Inc, San Diego, California 92121, USA
    J Pharmacol Exp Ther 299:268-76. 2001
    ..The behavioral pharmacology of AC-90179 is characteristic of an atypical antipsychotic agent...
  30. ncbi request reprint Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies
    D L Braff
    Department of Psychiatry, UCSD, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 156:234-58. 2001
    ..In humans, PPI occurs in a robust, predictable manner when the prepulse and startling stimuli occur in either the same or different modalities (acoustic, visual, or cutaneous)...
  31. ncbi request reprint Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review
    M A Geyer
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Psychopharmacology (Berl) 156:117-54. 2001
    ..In addition, some developmental manipulations, such as isolation rearing, have provided non-pharmacological animal models of the PPI deficits seen in schizophrenia...
  32. ncbi request reprint Measurement of startle response, prepulse inhibition, and habituation
    M A Geyer
    University of California, San Diego, La Jolla, California, USA
    Curr Protoc Neurosci . 2001
    ....
  33. ncbi request reprint The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice
    R J Ralph
    Department of Neuroscience, University of California at San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 19:4627-33. 1999
    ..Uncovering the neural mechanisms involved in PPI will further our understanding of the substrates of sensorimotor gating and could lead to better therapeutics to treat gating disorders, such as schizophrenia...
  34. pmc Convergent functional genomic studies of omega-3 fatty acids in stress reactivity, bipolar disorder and alcoholism
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transl Psychiatry 1:e4. 2011
    ..In conclusion, our work supports the potential utility of omega-3 fatty acids, specifically DHA, for a spectrum of psychiatric disorders such as stress disorders, bipolar disorder, alcoholism and beyond...
  35. ncbi request reprint 5HT-2 mediation of acute behavioral effects of hallucinogens in rats
    L L Wing
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093
    Psychopharmacology (Berl) 100:417-25. 1990
    ..In contrast, ketanserin had no significant effect on the suppression of activity produced by the 5HT-1A agonist 8-hydroxy-2(di-n-propylamino)tetralin (8OHDPAT).(ABSTRACT TRUNCATED AT 250 WORDS)..
  36. ncbi request reprint Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice
    S A Brody
    Departments of Psychiatry and Neurosciences, University of California San Diego, 9500 Gilman Drive, CA 92093 0804, La Jolla, USA
    Psychopharmacology (Berl) 172:187-95. 2004
    ..Metabotropic glutamate receptor 5 (mGluR5) has been implicated in schizophrenia, in part because mGluR5 knockout (KO) mice exhibit PPI deficits...
  37. ncbi request reprint Information processing deficits of schizophrenia patients: relationship to clinical ratings, gender and medication status
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 28:51-62. 1997
    ..It is possible that VBM and RT share overlapping or interacting neural substrates...
  38. ncbi request reprint Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli
    S C Dulawa
    Department of Neuroscience, University of California at San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 19:9550-6. 1999
    ..Hence, D4R-/- mice exhibit reductions in behavioral responses to novelty, reflecting a decrease in novelty-related exploration...
  39. ncbi request reprint Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges
    N R Swerdlow
    Department of Psychiatry, UCSD Schools of Medicine, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 156:194-215. 2001
    ....
  40. ncbi request reprint Dopamine depletion of the nucleus accumbens reverses isolation-induced deficits in prepulse inhibition in rats
    S B Powell
    Department of Psychiatry, 9500 Gilman Drive, 0804, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroscience 119:233-40. 2003
    ....
  41. ncbi request reprint Tactile prepuff inhibition of startle in children with Tourette's syndrome: in search of an "fMRI-friendly" startle paradigm
    N R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, California 92093-0804, USA
    Biol Psychiatry 50:578-85. 2001
    ..CONCLUSIONS: Sensorimotor gating can be assessed in an "fMRI-friendly" paradigm that detects inhibitory deficits in TS...
  42. ncbi request reprint Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia
    D L Braff
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Schizophr Res 49:171-8. 2001
    ....
  43. doi request reprint Delayed procedural learning in α7-nicotinic acetylcholine receptor knockout mice
    J W Young
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Genes Brain Behav 10:720-33. 2011
    ....
  44. doi request reprint Identification of blood biomarkers for psychosis using convergent functional genomics
    S M Kurian
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Mol Psychiatry 16:37-58. 2011
    ..These results have implications for the development of objective laboratory tests to measure illness severity and response to treatment in devastating disorders such as schizophrenia...
  45. pmc Developing translational animal models for symptoms of schizophrenia or bipolar mania
    M A Geyer
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Neurotox Res 14:71-8. 2008
    ..Another focus includes efforts to develop new human models of psychiatric symptoms that are designed to parallel existing tests used in rodents...
  46. ncbi request reprint Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Biol Psychiatry 45:360-4. 1999
    ..These data support the hypothesis that PPI and habituation are relatively stable neurobiological markers...
  47. ncbi request reprint Mouse genetic models for prepulse inhibition: an early review
    M A Geyer
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Mol Psychiatry 7:1039-53. 2002
    ..The use of mice to study PPI is increasing at a dramatic rate and is helping to increase our understanding of the biological basis for sensorimotor gating...
  48. ncbi request reprint The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity
    S A Henry
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropharmacology 43:1199-209. 2002
    ..The effects of MPEP on the response to PCP may reflect the cooperation and co-localization of NMDA and mGlu5 receptors...
  49. ncbi request reprint Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition
    S C Dulawa
    Department of Neuroscience, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 22:650-9. 2000
    ..Findings suggest that 5-HT(1B) receptor activation decreases PPI and habituation, and 5-HT(1A) receptor activation increases PPI in mice...
  50. ncbi request reprint Impaired postnatal development of hippocampal dentate gyrus in Sp4 null mutant mice
    X Zhou
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Genes Brain Behav 6:269-76. 2007
    ..The abnormality of the molecular layer was indicated by a reduced level of synaptophysin expression in the mutant mice. The Sp4 transcription factor therefore appears to predominantly regulate the development of dentate granule cells...
  51. ncbi request reprint Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization
    X Zhou
    Department of Medicine, Institute of Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Psychiatry 10:393-406. 2005
    ..Our studies thus reveal a novel Sp4 pathway that is essential for hippocampal integrity and modulates behavioral processes relevant to psychiatric disorders...