Felix Geser

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases
    Felix Geser
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, HUP, Maloney 3rd Floor, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    J Neurol 256:1205-14. 2009
  2. pmc Clinical and pathological continuum of multisystem TDP-43 proteinopathies
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 66:180-9. 2009
  3. doi request reprint Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Center, Institute on Aging, Philadelphia, USA
    Arch Neurol 65:636-41. 2008
  4. pmc Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis
    Johannes Brettschneider
    Center for Neurodegenerative Disease Research CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 123:395-407. 2012
  5. pmc Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness
    Felix Geser
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 67:1238-50. 2010
  6. pmc Brain progranulin expression in GRN-associated frontotemporal lobar degeneration
    Alice S Chen-Plotkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Acta Neuropathol 119:111-22. 2010
  7. pmc Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis
    Ryan Vass
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 121:373-80. 2011
  8. ncbi request reprint Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease
    Nicholas J Brandmeir
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Acta Neuropathol 115:123-31. 2008
  9. pmc TDP-43 skeins show properties of amyloid in a subset of ALS cases
    John L Robinson
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, Perelman School of Medicine at the University of Pennsylvania, Maloney Building, 3rd Floor, 36th and Spruce Streets, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 125:121-31. 2013
  10. pmc Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy
    Felix Geser
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 121:509-17. 2011

Collaborators

Detail Information

Publications15

  1. pmc Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases
    Felix Geser
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, HUP, Maloney 3rd Floor, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    J Neurol 256:1205-14. 2009
    ..e., TDP-43 proteinopathy...
  2. pmc Clinical and pathological continuum of multisystem TDP-43 proteinopathies
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 66:180-9. 2009
    ....
  3. doi request reprint Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Center, Institute on Aging, Philadelphia, USA
    Arch Neurol 65:636-41. 2008
    ....
  4. pmc Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis
    Johannes Brettschneider
    Center for Neurodegenerative Disease Research CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 123:395-407. 2012
    ..In contrast, AD pathology in ALS is primarily related to increasing age and associated with a poorer performance on the MMSE...
  5. pmc Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness
    Felix Geser
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 67:1238-50. 2010
    ....
  6. pmc Brain progranulin expression in GRN-associated frontotemporal lobar degeneration
    Alice S Chen-Plotkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Acta Neuropathol 119:111-22. 2010
    ....
  7. pmc Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis
    Ryan Vass
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 121:373-80. 2011
    ..These findings implicate the FTLD-TDP risk gene TMEM106B in the development of cognitive impairment in ALS...
  8. ncbi request reprint Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease
    Nicholas J Brandmeir
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Acta Neuropathol 115:123-31. 2008
    ....
  9. pmc TDP-43 skeins show properties of amyloid in a subset of ALS cases
    John L Robinson
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, Perelman School of Medicine at the University of Pennsylvania, Maloney Building, 3rd Floor, 36th and Spruce Streets, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 125:121-31. 2013
    ....
  10. pmc Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy
    Felix Geser
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 121:509-17. 2011
    ....
  11. pmc Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old
    John L Robinson
    Center for Neurodegenerative Disease Research, Institute on Ageing, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain 134:3708-15. 2011
    ....
  12. pmc Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
    Andrew C Elden
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 466:1069-75. 2010
    ..Furthermore, these findings indicate that the TDP-43-ATXN2 interaction may be a promising target for therapeutic intervention in ALS and other TDP-43 proteinopathies...
  13. pmc Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies
    Felix Geser
    The Institute on Aging, Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Pennsylvania 19104 4283, USA
    Neuropathology 30:103-12. 2010
    ..We here review salient findings in the development of a concept of TDP-43 proteinopathy as a novel group of neurodegenerative diseases similar in concept to alpha-synucleinopathies and tauopathies...
  14. pmc Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration
    Alice S Chen-Plotkin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 17:1349-62. 2008
    ..In addition, these data from a large number of human brains provide a valuable resource for future testing of disease hypotheses...
  15. ncbi request reprint Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam
    Felix Geser
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Center, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 4283, USA
    Acta Neuropathol 115:133-45. 2008
    ..Finally, we conclude that the spectrum of TDP-43 proteinopathies should be expanded to include neurodegenerative cognitive and motor diseases, affecting the Chamorro population of Guam...