Michael Geschwind

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease
    Michael D Geschwind
    Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
    Arch Neurol 60:813-6. 2003
  2. ncbi request reprint Sporadic Creutzfeldt-Jakob disease mimicking variant Creutzfeldt-Jakob disease
    Jennifer Martindale
    Department of Neurology, University of California San Francisco, 94143, USA
    Arch Neurol 60:767-70. 2003
  3. pmc Rapidly progressive dementia
    Michael D Geschwind
    Department of Neurology, Memory and Aging Center, University of California, San Francisco Medical Center, San Francisco, CA 94117, USA
    Neurol Clin 25:783-807, vii. 2007
  4. pmc Rapidly progressive dementia
    Michael D Geschwind
    University of California San Francisco Memory and Aging Center, Department of Neurology, San Francisco, CA 94143 1207, USA
    Ann Neurol 64:97-108. 2008
  5. pmc Immunologically mediated dementias
    Michael H Rosenbloom
    UCSF Memory and Aging Center, Box 1207, San Francisco, CA 94143, USA
    Curr Neurol Neurosci Rep 9:359-67. 2009
  6. ncbi request reprint When sporadic disease is not sporadic: the potential for genetic etiology
    Jill S Goldman
    University of California, Memory and Aging Center, San Francisco 94143 1207, USA
    Arch Neurol 61:213-6. 2004
  7. pmc Pathologic evidence that the T188R mutation in PRNP is associated with prion disease
    Maria Carmela Tartaglia
    Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA
    J Neuropathol Exp Neurol 69:1220-7. 2010
  8. ncbi request reprint Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy
    Adam L Boxer
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Arch Neurol 63:81-6. 2006
  9. pmc A case of enteroviral meningoencephalitis presenting as rapidly progressive dementia
    Victor Valcour
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA94143, USA
    Nat Clin Pract Neurol 4:399-403. 2008
  10. ncbi request reprint Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt-Jakob disease
    Chiung Chih Chang
    University of California San Francisco, Department of Neurology, Memory and Aging Center, Box 1207, San Francisco, CA 94143 1207, USA
    Clin Neurol Neurosurg 109:54-7. 2007

Research Grants

  1. New Clinical Approaches to Creutzfeldt-Jakob Disease
    Michael Geschwind; Fiscal Year: 2007
  2. Early Diagnosis of Human Prion Disease
    Michael Geschwind; Fiscal Year: 2009
  3. Early Diagnosis of Human Prion Disease
    Michael D Geschwind; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease
    Michael D Geschwind
    Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
    Arch Neurol 60:813-6. 2003
    ..Previous studies have suggested that, in the proper clinical context, the 14-3-3 protein in cerebrospinal fluid is a reliable marker for sporadic CJD...
  2. ncbi request reprint Sporadic Creutzfeldt-Jakob disease mimicking variant Creutzfeldt-Jakob disease
    Jennifer Martindale
    Department of Neurology, University of California San Francisco, 94143, USA
    Arch Neurol 60:767-70. 2003
    ..The determination of the form of prion disease and early diagnosis are important for prognostic, public health, and epidemiologic reasons...
  3. pmc Rapidly progressive dementia
    Michael D Geschwind
    Department of Neurology, Memory and Aging Center, University of California, San Francisco Medical Center, San Francisco, CA 94117, USA
    Neurol Clin 25:783-807, vii. 2007
    ..This review discusses a differential diagnostic approach to RPD, emphasizing neurodegenerative, toxic and metabolic, infectious, autoimmune, neoplastic, and other conditions to consider...
  4. pmc Rapidly progressive dementia
    Michael D Geschwind
    University of California San Francisco Memory and Aging Center, Department of Neurology, San Francisco, CA 94143 1207, USA
    Ann Neurol 64:97-108. 2008
    ....
  5. pmc Immunologically mediated dementias
    Michael H Rosenbloom
    UCSF Memory and Aging Center, Box 1207, San Francisco, CA 94143, USA
    Curr Neurol Neurosci Rep 9:359-67. 2009
    ..Diagnostic workup typically reveals evidence of an autoimmune process and, in some cases, cancer. In contrast to the neurodegenerative processes, many of the immunologically mediated dementias respond to immunomodulatory therapy...
  6. ncbi request reprint When sporadic disease is not sporadic: the potential for genetic etiology
    Jill S Goldman
    University of California, Memory and Aging Center, San Francisco 94143 1207, USA
    Arch Neurol 61:213-6. 2004
    ..Approximately 2% of Alzheimer disease cases and 10% to 15% of prion disease cases are due to mutations in autosomal dominant genes. Mutations have been found in patients without family histories of neurological disease...
  7. pmc Pathologic evidence that the T188R mutation in PRNP is associated with prion disease
    Maria Carmela Tartaglia
    Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA
    J Neuropathol Exp Neurol 69:1220-7. 2010
    ....
  8. ncbi request reprint Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy
    Adam L Boxer
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Arch Neurol 63:81-6. 2006
    ..Progressive brain atrophy is associated with the corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP). Regional differences in brain atrophy may reflect the clinical features of disease...
  9. pmc A case of enteroviral meningoencephalitis presenting as rapidly progressive dementia
    Victor Valcour
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA94143, USA
    Nat Clin Pract Neurol 4:399-403. 2008
    ..He had hypophonic speech and had mildly increased axial tone. He scored 5 out of 30 on the Mini Mental State Examination and was admitted for expedited evaluation...
  10. ncbi request reprint Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt-Jakob disease
    Chiung Chih Chang
    University of California San Francisco, Department of Neurology, Memory and Aging Center, Box 1207, San Francisco, CA 94143 1207, USA
    Clin Neurol Neurosurg 109:54-7. 2007
    ..We present a case of anti-glutamic acid decarboxylase antibody (anti-GAD65) positive cerebellar ataxia associated with cognitive complaints and elevated CSF 14-3-3 protein...
  11. ncbi request reprint Autoimmune encephalopathies
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    Neurologist 13:140-7. 2007
    ..This review describes the clinical features of these potentially reversible autoimmune encephalopathies...
  12. ncbi request reprint The diagnostic utility of brain biopsy procedures in patients with rapidly deteriorating neurological conditions or dementia
    S Andrew Josephson
    Department of Neurology, University of California, San Francisco, California, USA
    J Neurosurg 106:72-5. 2007
    ....
  13. pmc Diagnosis of human prion disease
    Jiri G Safar
    Institute for Neurodegenerative Diseases, Memory and Aging Center, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:3501-6. 2005
    ..Moreover, IHC should not be used as the standard against which all other immunodiagnostic techniques are compared because an immunoassay, such as the CDI, is substantially more sensitive...
  14. pmc Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody
    Ramon F Barajas
    Department of Radiology, Neuroradiology Section, University of California, San Francisco, California 94143 1207, USA
    Epilepsia 51:473-7. 2010
    ..Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay...
  15. pmc Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias
    P Vitali
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94143 1207, USA
    Neurology 76:1711-9. 2011
    ..No studies, however, have demonstrated how MRI can distinguish CJD from nonprion causes of rapidly progressive dementia (npRPD). We sought to determine the diagnostic accuracy of MRI for CJD compared to a cohort of npRPD subjects...
  16. pmc Prion proteins in subpopulations of white blood cells from patients with sporadic Creutzfeldt-Jakob disease
    Ed M Choi
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143 0518, USA
    Lab Invest 89:624-35. 2009
    ..If human WBCs harbor prion infectivity in patients with sCJD, then the levels are likely to be low...
  17. pmc AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location
    Meizan Lai
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 65:424-34. 2009
    ..To report the clinical and immunological features of a novel autoantigen related to limbic encephalitis (LE) and the effect of patients' antibodies on neuronal cultures...
  18. pmc Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt disease
    Michael D Geschwind
    Departments of Neurology, University of California, San Francisco, UCSF Memory and Aging Center, Box 1207, SanFrancisco, CA 94143 1207, USA
    Alzheimer Dis Assoc Disord 23:82-87. 2009
    ..77; P=0.0006), followed by reactive astrocytic gliosis (r=0.63, P=0.008). This case provides further evidence that DWI abnormalities correlate well with the clinical features and with PrP(Sc) accumulation and vacuolation...
  19. pmc Neuroimaging in dementia
    Paolo Vitali
    Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, CA 94143, USA
    Semin Neurol 28:467-83. 2008
    ..Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging is clearly an invaluable tool for the clinician in the differential diagnosis...
  20. ncbi request reprint Psychiatric and neuroimaging findings in Creutzfeldt-Jakob disease
    Jennifer L Martindale
    Department of Neurology, University of California, San Francisco, Box 1207, 350 Parnassus 800, 94143, USA
    Curr Psychiatry Rep 5:43-6. 2003
    ..This article discusses how these advances may make neuroimaging the most valuable noninvasive tool for diagnosing CJD, which helps to track the progression of the disease course and provides insight into clinical-anatomic correlations...
  21. pmc Human prions and plasma lipoproteins
    Jiri G Safar
    Institute for Neurodegenerative Diseases, Department of Neurology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:11312-7. 2006
    ..Whether detection of PrP(Sc) in VLDL and LDL particles can be adapted into an antemortem diagnostic test for prions in the blood of humans, livestock, and free-ranging cervids remains to be determined...
  22. ncbi request reprint Human growth hormone-related iatrogenic Creutzfeldt-Jakob disease with abnormal imaging
    Aaron M Lewis
    Department of Neurology, University of California, San Francisco, USA
    Arch Neurol 63:288-90. 2006
    ....
  23. ncbi request reprint Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis
    Geoffrey S Young
    Department of Radiology, University of California, San Francisco, 74143, USA
    AJNR Am J Neuroradiol 26:1551-62. 2005
    ..To our knowledge, no large study has been conducted to determine the sensitivity and specificity of DWI and FLAIR imaging for diagnosing CJD...
  24. pmc Voltage-gated potassium channel autoimmunity mimicking creutzfeldt-jakob disease
    Michael D Geschwind
    Neuroimmunology Laboratory, Hilton 3 78F, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 65:1341-6. 2008
    ..Rapidly progressive dementia has a variety of causes, including Creutzfeldt-Jakob disease (CJD) and neuronal voltage-gated potassium channel (VGKC) autoantibody-associated encephalopathy...
  25. pmc A 54-year-old man with slowness of movement and confusion
    Michael D Geschwind
    Neurology 69:1881-7. 2007
  26. doi request reprint Creutzfeldt-Jakob disease in recipients of corneal transplants
    Ryan A Maddox
    Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Cornea 27:851-4. 2008
    ..We report 4 cases of CJD with a history of corneal transplantation and assess the frequency of coincidental CJD among corneal transplant recipients...

Research Grants4

  1. New Clinical Approaches to Creutzfeldt-Jakob Disease
    Michael Geschwind; Fiscal Year: 2007
    ..Geschwind's training in behavioral neurology and neuroscience, thereby helping him to design and implement future clinical treatment studies for human prion disease and other dementias. ..
  2. Early Diagnosis of Human Prion Disease
    Michael Geschwind; Fiscal Year: 2009
    ..Through earlier diagnosis, patients may be spared unnecessary and time-consuming diagnostic procedures and have better chance of responding to potential treatments, and the risk of transmission can be greatly reduced. ..
  3. Early Diagnosis of Human Prion Disease
    Michael D Geschwind; Fiscal Year: 2010
    ..Through earlier diagnosis, patients may be spared unnecessary and time-consuming diagnostic procedures and have better chance of responding to potential treatments, and the risk of transmission can be greatly reduced. ..