Michael D Geschwind

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Immunologically mediated dementias
    Michael H Rosenbloom
    UCSF Memory and Aging Center, Box 1207, San Francisco, CA 94143, USA
    Curr Neurol Neurosci Rep 9:359-67. 2009
  2. doi request reprint Seizures and epileptiform activity in the early stages of Alzheimer disease
    Keith A Vossel
    Gladstone Institute of Neurological Disease, San Francisco, California2Memory and Aging Center, Department of Neurology, University of California, San Francisco, California
    JAMA Neurol 70:1158-66. 2013
  3. doi request reprint Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia
    David Y Johnson
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
    JAMA Neurol 70:254-7. 2013
  4. pmc Pathologic evidence that the T188R mutation in PRNP is associated with prion disease
    Maria Carmela Tartaglia
    Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA
    J Neuropathol Exp Neurol 69:1220-7. 2010
  5. pmc Clinical overlap between Jakob-Creutzfeldt disease and Lewy body disease
    Maria Carmela Tartaglia
    Department of Neurology, University of California, San Francisco, California, USA
    Can J Neurol Sci 39:304-10. 2012
  6. pmc Rapidly progressive dementia
    Michael D Geschwind
    Department of Neurology, Memory and Aging Center, University of California, San Francisco Medical Center, San Francisco, CA 94117, USA
    Neurol Clin 25:783-807, vii. 2007
  7. ncbi request reprint Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy
    Adam L Boxer
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Arch Neurol 63:81-6. 2006
  8. ncbi request reprint When sporadic disease is not sporadic: the potential for genetic etiology
    Jill S Goldman
    University of California, Memory and Aging Center, San Francisco 94143 1207, USA
    Arch Neurol 61:213-6. 2004
  9. ncbi request reprint Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease
    Michael D Geschwind
    Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
    Arch Neurol 60:813-6. 2003
  10. ncbi request reprint Sporadic Creutzfeldt-Jakob disease mimicking variant Creutzfeldt-Jakob disease
    Jennifer Martindale
    Department of Neurology, University of California San Francisco, 94143, USA
    Arch Neurol 60:767-70. 2003

Collaborators

Detail Information

Publications24

  1. pmc Immunologically mediated dementias
    Michael H Rosenbloom
    UCSF Memory and Aging Center, Box 1207, San Francisco, CA 94143, USA
    Curr Neurol Neurosci Rep 9:359-67. 2009
    ..Diagnostic workup typically reveals evidence of an autoimmune process and, in some cases, cancer. In contrast to the neurodegenerative processes, many of the immunologically mediated dementias respond to immunomodulatory therapy...
  2. doi request reprint Seizures and epileptiform activity in the early stages of Alzheimer disease
    Keith A Vossel
    Gladstone Institute of Neurological Disease, San Francisco, California2Memory and Aging Center, Department of Neurology, University of California, San Francisco, California
    JAMA Neurol 70:1158-66. 2013
    ..We report key features of AD-related seizures and epileptiform activity that are instructive for clinical practice and highlight similarities between AD and transgenic animal models of the disease...
  3. doi request reprint Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia
    David Y Johnson
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
    JAMA Neurol 70:254-7. 2013
    ..To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia...
  4. pmc Pathologic evidence that the T188R mutation in PRNP is associated with prion disease
    Maria Carmela Tartaglia
    Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA
    J Neuropathol Exp Neurol 69:1220-7. 2010
    ....
  5. pmc Clinical overlap between Jakob-Creutzfeldt disease and Lewy body disease
    Maria Carmela Tartaglia
    Department of Neurology, University of California, San Francisco, California, USA
    Can J Neurol Sci 39:304-10. 2012
    ..We delineated the clinical overlap between sCJD and DLB, and assessed the value of magnetic resonance imaging (MRI) to differentiate between them...
  6. pmc Rapidly progressive dementia
    Michael D Geschwind
    Department of Neurology, Memory and Aging Center, University of California, San Francisco Medical Center, San Francisco, CA 94117, USA
    Neurol Clin 25:783-807, vii. 2007
    ..This review discusses a differential diagnostic approach to RPD, emphasizing neurodegenerative, toxic and metabolic, infectious, autoimmune, neoplastic, and other conditions to consider...
  7. ncbi request reprint Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy
    Adam L Boxer
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Arch Neurol 63:81-6. 2006
    ..Progressive brain atrophy is associated with the corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP). Regional differences in brain atrophy may reflect the clinical features of disease...
  8. ncbi request reprint When sporadic disease is not sporadic: the potential for genetic etiology
    Jill S Goldman
    University of California, Memory and Aging Center, San Francisco 94143 1207, USA
    Arch Neurol 61:213-6. 2004
    ..Approximately 2% of Alzheimer disease cases and 10% to 15% of prion disease cases are due to mutations in autosomal dominant genes. Mutations have been found in patients without family histories of neurological disease...
  9. ncbi request reprint Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease
    Michael D Geschwind
    Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
    Arch Neurol 60:813-6. 2003
    ..Previous studies have suggested that, in the proper clinical context, the 14-3-3 protein in cerebrospinal fluid is a reliable marker for sporadic CJD...
  10. ncbi request reprint Sporadic Creutzfeldt-Jakob disease mimicking variant Creutzfeldt-Jakob disease
    Jennifer Martindale
    Department of Neurology, University of California San Francisco, 94143, USA
    Arch Neurol 60:767-70. 2003
    ..The determination of the form of prion disease and early diagnosis are important for prognostic, public health, and epidemiologic reasons...
  11. pmc Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt disease
    Michael D Geschwind
    Departments of Neurology, University of California, San Francisco, UCSF Memory and Aging Center, Box 1207, SanFrancisco, CA 94143 1207, USA
    Alzheimer Dis Assoc Disord 23:82-87. 2009
    ..77; P=0.0006), followed by reactive astrocytic gliosis (r=0.63, P=0.008). This case provides further evidence that DWI abnormalities correlate well with the clinical features and with PrP(Sc) accumulation and vacuolation...
  12. pmc Neuroimaging in dementia
    Paolo Vitali
    Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, CA 94143, USA
    Semin Neurol 28:467-83. 2008
    ..Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging is clearly an invaluable tool for the clinician in the differential diagnosis...
  13. pmc Rapidly progressive dementia
    Michael D Geschwind
    University of California San Francisco Memory and Aging Center, Department of Neurology, San Francisco, CA 94143 1207, USA
    Ann Neurol 64:97-108. 2008
    ....
  14. ncbi request reprint Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt-Jakob disease
    Chiung Chih Chang
    University of California San Francisco, Department of Neurology, Memory and Aging Center, Box 1207, San Francisco, CA 94143 1207, USA
    Clin Neurol Neurosurg 109:54-7. 2007
    ..We present a case of anti-glutamic acid decarboxylase antibody (anti-GAD65) positive cerebellar ataxia associated with cognitive complaints and elevated CSF 14-3-3 protein...
  15. pmc Prion proteins in subpopulations of white blood cells from patients with sporadic Creutzfeldt-Jakob disease
    Ed M Choi
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143 0518, USA
    Lab Invest 89:624-35. 2009
    ..If human WBCs harbor prion infectivity in patients with sCJD, then the levels are likely to be low...
  16. pmc Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody
    Ramon F Barajas
    Department of Radiology, Neuroradiology Section, University of California, San Francisco, California 94143 1207, USA
    Epilepsia 51:473-7. 2010
    ..Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay...
  17. pmc Clinicopathological correlations in corticobasal degeneration
    Suzee E Lee
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 70:327-40. 2011
    ..To characterize cognitive and behavioral features, physical findings, and brain atrophy patterns in pathology-proven corticobasal degeneration (CBD) and corticobasal syndrome (CBS) with known histopathology...
  18. ncbi request reprint The diagnostic utility of brain biopsy procedures in patients with rapidly deteriorating neurological conditions or dementia
    S Andrew Josephson
    Department of Neurology, University of California, San Francisco, California, USA
    J Neurosurg 106:72-5. 2007
    ....
  19. pmc Diagnosis of human prion disease
    Jiri G Safar
    Institute for Neurodegenerative Diseases, Memory and Aging Center, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:3501-6. 2005
    ..Moreover, IHC should not be used as the standard against which all other immunodiagnostic techniques are compared because an immunoassay, such as the CDI, is substantially more sensitive...
  20. pmc Human prions and plasma lipoproteins
    Jiri G Safar
    Institute for Neurodegenerative Diseases, Department of Neurology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:11312-7. 2006
    ..Whether detection of PrP(Sc) in VLDL and LDL particles can be adapted into an antemortem diagnostic test for prions in the blood of humans, livestock, and free-ranging cervids remains to be determined...
  21. ncbi request reprint Human growth hormone-related iatrogenic Creutzfeldt-Jakob disease with abnormal imaging
    Aaron M Lewis
    Department of Neurology, University of California, San Francisco, USA
    Arch Neurol 63:288-90. 2006
    ....
  22. ncbi request reprint Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis
    Geoffrey S Young
    Department of Radiology, University of California, San Francisco, 74143, USA
    AJNR Am J Neuroradiol 26:1551-62. 2005
    ..To our knowledge, no large study has been conducted to determine the sensitivity and specificity of DWI and FLAIR imaging for diagnosing CJD...
  23. ncbi request reprint Psychiatric and neuroimaging findings in Creutzfeldt-Jakob disease
    Jennifer L Martindale
    Department of Neurology, University of California, San Francisco, Box 1207, 350 Parnassus 800, 94143, USA
    Curr Psychiatry Rep 5:43-6. 2003
    ..This article discusses how these advances may make neuroimaging the most valuable noninvasive tool for diagnosing CJD, which helps to track the progression of the disease course and provides insight into clinical-anatomic correlations...