Daniel Geschwind

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Autism: searching for coherence
    Daniel Geschwind
    Neurogenetics Program, Department of Neurology and Center for Autism Research and Treatment, Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biol Psychiatry 62:949-50. 2007
  2. pmc Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia
    Giovanni Coppola
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:2452-61. 2009
  3. pmc A systems level, functional genomics analysis of chronic epilepsy
    Kellen D Winden
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e20763. 2011
  4. pmc Modeling the functional genomics of autism using human neurons
    G Konopka
    Department of Neurology, Center for Autism Research and Treatment, Semel Institute and Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Mol Psychiatry 17:202-14. 2012
  5. pmc The organization of the transcriptional network in specific neuronal classes
    Kellen D Winden
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA, USA
    Mol Syst Biol 5:291. 2009
  6. pmc Cortical evolution: judge the brain by its cover
    Daniel H Geschwind
    Program in Neurogenetics, Department of Neurology, University of California, Los Angeles, Los Angeles, CA, 90095, USA Electronic address
    Neuron 80:633-47. 2013
  7. pmc Common genetic variants, acting additively, are a major source of risk for autism
    Lambertus Klei
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mol Autism 3:9. 2012
  8. pmc Transcriptome signature of the adult mouse choroid plexus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Fluids Barriers CNS 8:10. 2011
  9. pmc The choroid plexus response to a repeated peripheral inflammatory stimulus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    BMC Neurosci 10:135. 2009
  10. pmc Neuroscience in the era of functional genomics and systems biology
    Daniel H Geschwind
    Program in Neurogenetics and Neurobehavioural Genetics, Department of Neurology and Semel Institute, David Geffen School of Medicine, Los Angeles, California 90095, USA
    Nature 461:908-15. 2009

Detail Information

Publications100

  1. ncbi Autism: searching for coherence
    Daniel Geschwind
    Neurogenetics Program, Department of Neurology and Center for Autism Research and Treatment, Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biol Psychiatry 62:949-50. 2007
  2. pmc Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia
    Giovanni Coppola
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:2452-61. 2009
    ..Finally, we show that genetic modulation of the PPARgamma pathway affects frataxin levels in vitro, supporting PPARgamma as a novel therapeutic target in FRDA...
  3. pmc A systems level, functional genomics analysis of chronic epilepsy
    Kellen D Winden
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e20763. 2011
    ....
  4. pmc Modeling the functional genomics of autism using human neurons
    G Konopka
    Department of Neurology, Center for Autism Research and Treatment, Semel Institute and Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Mol Psychiatry 17:202-14. 2012
    ..These data also provide a step towards better understanding of the signaling pathways disrupted in ASD...
  5. pmc The organization of the transcriptional network in specific neuronal classes
    Kellen D Winden
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA, USA
    Mol Syst Biol 5:291. 2009
    ..These analyses provide a basis for understanding how specific aspects of neuronal phenotypic diversity are organized at the transcriptional level...
  6. pmc Cortical evolution: judge the brain by its cover
    Daniel H Geschwind
    Program in Neurogenetics, Department of Neurology, University of California, Los Angeles, Los Angeles, CA, 90095, USA Electronic address
    Neuron 80:633-47. 2013
    ..This knowledge provides essential insight into the pathogenesis of human-specific neuropsychiatric disorders...
  7. pmc Common genetic variants, acting additively, are a major source of risk for autism
    Lambertus Klei
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mol Autism 3:9. 2012
    ..abstract:..
  8. pmc Transcriptome signature of the adult mouse choroid plexus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Fluids Barriers CNS 8:10. 2011
    ..abstract:..
  9. pmc The choroid plexus response to a repeated peripheral inflammatory stimulus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    BMC Neurosci 10:135. 2009
    ..As part of the barriers that separate the blood from the brain, the choroid plexus conveys inflammatory immune signals into the brain, largely through alterations in the composition of the cerebrospinal fluid...
  10. pmc Neuroscience in the era of functional genomics and systems biology
    Daniel H Geschwind
    Program in Neurogenetics and Neurobehavioural Genetics, Department of Neurology and Semel Institute, David Geffen School of Medicine, Los Angeles, California 90095, USA
    Nature 461:908-15. 2009
    ..Methods for network analysis and systems biology offer the promise of integrating these multiple levels of data, connecting molecular pathways to nervous system function...
  11. ncbi Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg?
    Daniel H Geschwind
    The Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neuron 40:457-60. 2003
    ..Now, several animal models and data from human patients provide converging evidence that aberrant tau phosphorylation can cause a neurodegenerative phenotype similar to that seen in human neurodegenerative diseases...
  12. ncbi GENSAT: a genomic resource for neuroscience research
    Dan Geschwind
    UCLA Department of Neurology, 710 Westwood Plaza, Los Angeles, California, USA
    Lancet Neurol 3:82. 2004
  13. pmc Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness
    Daniel H Geschwind
    Program in Neurogenetics, Department of Neurology, University of California School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Proc Natl Acad Sci U S A 99:3176-81. 2002
    ....
  14. ncbi Autism spectrum disorders: developmental disconnection syndromes
    Daniel H Geschwind
    Program in Neurogenetics, Department of Neurology and Semel Institute, David Geffen School of Medicine at University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Curr Opin Neurobiol 17:103-11. 2007
    ..This concept of developmental disconnection can accommodate the specific neurobehavioral features that are observed in autism, their emergence during development, and the heterogeneity of autism etiology, behaviors and cognition...
  15. pmc Autism: many genes, common pathways?
    Daniel H Geschwind
    Neurogenetics Program, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cell 135:391-5. 2008
    ..Unifying principles among cases of autism are likely to be at the level of brain circuitry in addition to molecular pathways...
  16. ncbi DNA microarrays: translation of the genome from laboratory to clinic
    Daniel H Geschwind
    Program in Neurogenetics, Department of Neurology, and the Center for Neurobehavioral Genetics, Neuropsychiatric Institute, The David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Lancet Neurol 2:275-82. 2003
    ..Progress in these studies will translate into array-based disease classification schemes and help optimise therapy for individual patients based on gene expression patterns or their genetic background...
  17. pmc Identification of a locus on chromosome 14q for idiopathic basal ganglia calcification (Fahr disease)
    D H Geschwind
    Neurogenetics Program, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Am J Hum Genet 65:764-72. 1999
    ..3-cM region by a recombination observed in a patient with probable affected status. The age at onset appeared to be decreasing by an average of >20 years with each transmission, which is consistent with genetic anticipation...
  18. ncbi Molecular approaches to cerebral laterality: development and neurodegeneration
    D H Geschwind
    Department of Neurology, University of California at Los Angeles, Los Angeles, California 90095 1769, USA
    Am J Med Genet 101:370-81. 2001
    ..Most of these data are preliminary and the models presented are highly speculative, reflecting the primitive stage of work defining the molecular basis of cerebral asymmetry...
  19. ncbi Sharing gene expression data: an array of options
    D H Geschwind
    Department of Neurology, University of California, Los Angeles, School of Medicine, 710 Westwood Plaza, Los Angeles, California 90095 1769, USA
    Nat Rev Neurosci 2:435-8. 2001
    ..These challenges are surmountable, and various sharing formats are possible. Centralized non-commercial databases are being developed to facilitate this process...
  20. ncbi A genetic analysis of neural progenitor differentiation
    D H Geschwind
    Neurogenetics Program, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neuron 29:325-39. 2001
    ..This combination of methods demonstrates the power of using custom microarrays derived from RDA-subtracted libraries for both gene discovery and gene expression analysis in the central nervous system...
  21. ncbi Neurobehavioral phenotype of Klinefelter syndrome
    D H Geschwind
    Department of Neurology and Program in Neurogenetics, UCLA School of Medicine, Los Angeles, California90095 1769, USA
    Ment Retard Dev Disabil Res Rev 6:107-16. 2000
    ..1997; Geschwind et al., 1998]. Furthermore, the interaction of genetic factors and hormonal influences in the cognitive phenotypes described remains an unexplored area for future investigation. MRDD Research Reviews 2000;6:117-124...
  22. ncbi Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia
    D H Geschwind
    Department of Neurology, University of California at Los Angeles School of Medicine, 90095 1769, USA
    Ann Neurol 50:741-6. 2001
    ....
  23. pmc The prevalence and wide clinical spectrum of the spinocerebellar ataxia type 2 trinucleotide repeat in patients with autosomal dominant cerebellar ataxia
    D H Geschwind
    Department of Neurology, University of California, Los Angeles, School of Medicine, 90095 1769, USA
    Am J Hum Genet 60:842-50. 1997
    ....
  24. ncbi Klinefelter's syndrome as a model of anomalous cerebral laterality: testing gene dosage in the X chromosome pseudoautosomal region using a DNA microarray
    D H Geschwind
    Department of Neurology, UCLA School of Medicine 90095, USA
    Dev Genet 23:215-29. 1998
    ....
  25. ncbi Identification and characterization of novel developmentally regulated proteins in rat spinal cord
    D H Geschwind
    Reed Neurological Research Center, Department of Neurology, UCLA School of Medicine, USA
    Brain Res Dev Brain Res 97:62-75. 1996
    ..This expression pattern, coupled with its recently discovered homology to two proteins implicated in axon pathfinding in the chick and nematode [5,3], suggests that TOAD-64 may have a fundamental role in axon pathfinding...
  26. ncbi FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains
    Mary Kay Lobo
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, 90095, USA
    Nat Neurosci 9:443-52. 2006
    ..Our study provides a general approach for profiling cell type-specific gene expression in the mature mammalian brain and identifies a set of genes critical to the function and dysfunction of the striatal projection neuron circuit...
  27. pmc Association of GSK3B with Alzheimer disease and frontotemporal dementia
    Barbara A J Schaffer
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 2506 Gonda, 695 Charles E Young Dr S, Los Angeles, CA 90095 1761, USA
    Arch Neurol 65:1368-74. 2008
    ..As a known tau kinase, GSK3B is a promising candidate gene in the remaining cases of FTD and in AD, for which tau mutations have not been found...
  28. ncbi Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction
    Ikuko Teramitsu
    Interdepartmental Programs in Molecular, Cellular, and Integrative Physiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Neurosci 24:3152-63. 2004
    ..The specific colocalization of FoxP1 and FoxP2 found in several structures in the bird and human brain predicts that mutations in FOXP1 could also be related to speech disorders...
  29. pmc Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration
    Giovanni Coppola
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neurobiol Dis 22:302-11. 2006
    ..The identification of a core set of genes changing early in the FRDA pathogenesis can be a useful tool in both clarifying the disease process and in evaluating new therapeutic strategies...
  30. ncbi Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks
    Stanislav L Karsten
    Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Dev Biol 261:165-82. 2003
    ..We propose a putative network of gene expression linking cell cycle control to cell fate pathways, providing a framework for further investigations of neural stem cell proliferation and differentiation...
  31. pmc Advances in autism genetics: on the threshold of a new neurobiology
    Brett S Abrahams
    Neurology Department, and Semel Institute for Neuroscience and Behaviour, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1769 USA
    Nat Rev Genet 9:341-55. 2008
    ..Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme...
  32. ncbi Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain
    Lili C Kudo
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Cereb Cortex 17:2108-22. 2007
    ..These data provide an important set of new candidates for studies of cortical patterning and maturation...
  33. pmc Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes
    Maja Bucan
    Autism Genetic Resource Exchange, Autism Speaks, Los Angeles, California, United States of America
    PLoS Genet 5:e1000536. 2009
    ..That hundreds of distinct rare variants were each seen only once further highlights complexity in the ASDs and points to the continued need for larger cohorts...
  34. ncbi A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration
    Stanislav L Karsten
    Program in Neurogenetics, Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 51:549-60. 2006
    ..Further investigation is warranted in defining the role of PSA and other genes identified here as potential therapeutic targets in tauopathy...
  35. pmc Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors
    Lorelei D Shoemaker
    Pasarow Mass Spectrometry Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9121. 2010
    ..The study of NSPC would be greatly facilitated by the identification of additional proteins that mediate their function and that would distinguish amongst different progenitor populations...
  36. pmc Language-related Cntnap2 gene is differentially expressed in sexually dimorphic song nuclei essential for vocal learning in songbirds
    S Carmen Panaitof
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    J Comp Neurol 518:1995-2018. 2010
    ..Ongoing functional work will provide important insights into the relationship between Cntnap2 and vocal communication in songbirds and thereby clarify mechanisms at play in disorders of human cognition and language...
  37. ncbi Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development
    Eva Hedlund
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurosci Res 75:307-19. 2004
    ....
  38. pmc Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
    J Alzheimers Dis 23:433-42. 2011
    ..Possession of the ε4 allele is associated with greater temporal and hippocampal volume reduction well before the onset of cognitive deficits...
  39. pmc Gene expression study on peripheral blood identifies progranulin mutations
    Giovanni Coppola
    Department of Neurology, Program in Neurogenetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Ann Neurol 64:92-6. 2008
    ..This proof-of-principle report supports the use of gene quantification as diagnostic screen for PGRN mutations and suggests a potential role for progranulin in Alzheimer's disease...
  40. pmc Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain
    Elizabeth Spiteri
    Program in Neurogenetics, Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 81:1144-57. 2007
    ....
  41. ncbi Gene expression analysis of neural cells and tissues using DNA microarrays
    Stanislav L Karsten
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Curr Protoc Neurosci . 2008
    ....
  42. pmc Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation
    Ichiro Nakano
    Department of Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Cell Biol 170:413-27. 2005
    ..These findings indicate that MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP-expressing progenitors to rapid amplifying progenitors in the postnatal brain...
  43. pmc Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice
    Martina Wiedau-Pazos
    Department of Neurology, David Geffen School of Medicine at UCLA, 635 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Neurobiol Aging 30:14-21. 2009
    ..We demonstrate that this induces downstream Wnt signaling via the activation of nuclear transcription factors associated with beta-catenin, suggesting that Wnt-pathway activation is an early feature of the neurodegenerative process...
  44. pmc A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
    Jeremy A Miller
    Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 28:1410-20. 2008
    ..Finally, we found that presenilin 1 (PSEN1) is highly coexpressed with canonical myelin proteins, suggesting a role for PSEN1 in aspects of glial-neuronal interactions related to neurodegenerative processes...
  45. ncbi Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia
    George Bartzokis
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biol Psychiatry 62:1380-7. 2007
    ..Apolipoprotein E (ApoE) 4 allele is the second most important AD risk factor. We tested the hypothesis that ApoE4 accelerates age-related slowing in CPS through the process of myelin breakdown...
  46. pmc Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language
    Stephanie A White
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:10376-9. 2006
    ..Below, we describe genetic through behavioral techniques used currently to investigate FoxP2 in birds, rodents, and humans for discovery of the neural bases of vocal learning and language...
  47. pmc Out FOXing Parkinson disease: where development meets neurodegeneration
    Eric M Wexler
    Division of Geriatric Psychiatry and the Program in Neurobehavioral Genetics, University of California at Los Angeles, Los Angeles, California, United States of America
    PLoS Biol 5:e334. 2007
  48. pmc Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene
    Maricela Alarcon
    UCLA Center for Autism Research and Treatment, Semel Institute of Neuroscience, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Hum Genet 82:150-9. 2008
    ..Together, these results provide convergent evidence for involvement of CNTNAP2, a Neurexin family member, in autism, and demonstrate a connection between genetic risk for autism and specific brain structures...
  49. pmc Genomic profiles of damage and protection in human intracerebral hemorrhage
    S Thomas Carmichael
    Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Cereb Blood Flow Metab 28:1860-75. 2008
    ..These inflammatory and anti-inflammatory networks interact at several key points in neutrophil signaling, apoptotic cell death, and protease responses, and indicate that secondary damage in ICH activates opposing molecular systems...
  50. pmc Association of common variants in the Joubert syndrome gene (AHI1) with autism
    Ana I Alvarez Retuerto
    Center for Autism Research and Treatment Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Hum Mol Genet 17:3887-96. 2008
    ..These data suggest a role for AHI1 in common disorders affecting human cognition and behavior...
  51. pmc Endogenous Wnt signaling maintains neural progenitor cell potency
    Eric M Wexler
    Department of Psychiatry, The Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024 1759, USA
    Stem Cells 27:1130-41. 2009
    ..In sum, this study establishes that autonomous Wnt signaling is a conserved feature of the neurogenic niche that preserves the delicate balance between NSC maintenance and differentiation...
  52. pmc Functional organization of the transcriptome in human brain
    Michael C Oldham
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, California 90095, USA
    Nat Neurosci 11:1271-82. 2008
    ..Our findings provide a new foundation for neurogenetic inquiries by revealing a robust and previously unrecognized organization to the human brain transcriptome...
  53. pmc Advances in autism
    Daniel H Geschwind
    Program in Neurogenetics, Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1761, USA
    Annu Rev Med 60:367-80. 2009
    ..Therefore, development of targeted therapies based on pathophysiologically and etiologically defined subtypes of ASD remains an important and achievable goal of current research...
  54. pmc Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    J Alzheimers Dis 20:333-41. 2010
    ..Clarifying mechanisms of brain iron accumulation may help identify novel interventions for age-related neurodegenerative diseases...
  55. pmc Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro
    Theodore A Sarafian
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9532. 2010
    ..We have recently shown that STAT3 is an important regulator of astrocyte reactivity after spinal cord injury in vivo[1]...
  56. pmc Connecting genes to brain in the autism spectrum disorders
    Brett S Abrahams
    Neurogenetics Program, Neurology Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1769, USA
    Arch Neurol 67:395-9. 2010
    ..Understanding genetic data within an anatomical context will be critical to explain how individual risk factors operate to shape phenotypic presentation in patients...
  57. pmc Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, USA
    Cereb Cortex 21:877-83. 2011
    ..Our findings of increased fMRI activation associated with APOE genotype but not with FAD mutations suggest that APOE exerts an effect on the BOLD signal that is not readily explained as a compensatory phenomenon...
  58. ncbi Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways
    Yuhei Nishimura
    Center for Autism Research and Treatment, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Hum Mol Genet 16:1682-98. 2007
    ..These results provide evidence that blood derived lymphoblastoid cells gene expression is likely to be useful for identifying etiological subsets of autism and exploring its pathophysiology...
  59. pmc Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis
    Joanna C Jen
    Department of Neurology, University of California, Los Angeles, CA 90095, USA
    Science 304:1509-13. 2004
    ..Like its murine homolog Rig1/Robo3, but unlike other Robo proteins, ROBO3 is required for hindbrain axon midline crossing...
  60. pmc Evidence for sex-specific risk alleles in autism spectrum disorder
    Jennifer L Stone
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    Am J Hum Genet 75:1117-23. 2004
    ..01). These results suggest that sexual dichotomy is an important factor in the genetics of autism; the same strategy can be used to explore this possibility in other complex disorders that exhibit significant sex biases...
  61. ncbi Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters
    Anatol Bragin
    Department of Neurology, Seizure Disorder Center, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    J Neurosci Methods 133:49-55. 2004
    ....
  62. ncbi Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    George R Jackson
    Neurogenetics Program, Department of Neurology, University of California Los Angeles, School of Medicine, 710 Westwood Plaza, 90095, USA
    Neuron 34:509-19. 2002
    ..The genetic system we have established provides a powerful reagent for identification of novel modifiers of tau-induced neurodegeneration that may serve as future therapeutic targets...
  63. ncbi Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations
    Mathew C Easterday
    Interdepartmental Program for Neuroscience, UCLA, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Biol 264:309-22. 2003
    ..Taken together, these studies identify many genes not previously associated with neural progenitor cell biology and also provide a rational scheme for stratification of microarray data for functional analysis...
  64. ncbi Late-onset Friedreich ataxia: phenotypic analysis, magnetic resonance imaging findings, and review of the literature
    Roongroj Bhidayasiri
    Department of Neurology, UCLA Medical Center, Los Angeles, Calif, USA
    Arch Neurol 62:1865-9. 2005
    ..Late-onset FA (LOFA) is defined as onset after age 25 years...
  65. ncbi Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, USA
    Arch Gen Psychiatry 63:63-72. 2006
    ..This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD...
  66. pmc Microarrays and the microscope: balancing throughput with resolution
    Giovanni Coppola
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Physiol 575:353-9. 2006
    ..Here we review representative examples of currently available methods that allow high resolution and specificity in brain microarray studies, while maintaining the goal of comprehensive, high-throughput analysis...
  67. ncbi Working memory and relational reasoning in Klinefelter syndrome
    Christina L Fales
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    J Int Neuropsychol Soc 9:839-46. 2003
    ..These results suggest that men with KS have intact nonverbal reasoning abilities, but that a difficulty in encoding verbal information into working memory may underlie their executive and linguistic impairments...
  68. pmc An evaluation of tyramide signal amplification and archived fixed and frozen tissue in microarray gene expression analysis
    Stanislav L Karsten
    Department of Neurology, Program in Neurogenetics, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Nucleic Acids Res 30:E4. 2002
    ..Consistent results are more easily obtainable using ethanol-fixed tissues, whereas formalin-fixed tissue does not typically provide a useful substrate for cDNA synthesis and labeling...
  69. pmc Replication of autism linkage: fine-mapping peak at 17q21
    Rita M Cantor
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 7088, USA
    Am J Hum Genet 76:1050-6. 2005
    ..Fine mapping at 2-centimorgan (cM) intervals in the combined sample of families with no affected females reveals a linkage peak at 66.85 cM, which places this locus at 17q21...
  70. ncbi Association between human mu-opioid receptor gene polymorphism, pain tolerance, and opioid addiction
    Peggy Compton
    Acute Care Section, UCLA School of Nursing, Los Angeles, California 90095 6918, USA
    Am J Med Genet B Neuropsychiatr Genet 121:76-82. 2003
    ....
  71. ncbi Thresholding rules for recovering a sparse signal from microarray experiments
    Chiara Sabatti
    Department of Human Genetics, UCLA, 695 Charles Young Dr South, Los Angeles, CA 90095 7088, USA
    Math Biosci 176:17-34. 2002
    ..Given the amount of information actually available, the thresholding rule described provides a reasonable estimator for the change in expression of any gene in two compared cell lines...
  72. ncbi Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations
    John M Ringman
    UCLA Department of Neurology, Alzheimer s Disease Research Center, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095 7226, USA
    Brain 130:1767-76. 2007
    ..Decreased FA in of the columns of the fornix is particularly robust in early FAD and may provide a biomarker for early disease in sporadic Alzheimer's disease...
  73. ncbi Middle-aged children of Alzheimer parents, a pilot study: stable neurocognitive performance at 20-year follow-up
    Lissy F Jarvik
    University of California, Los Angeles UCLA, Department of Psychiatry and Biobehavioral Sciences and Neuropsychiatric Institute and Hospital, Los Angeles, California 90095 1759, USA
    J Geriatr Psychiatry Neurol 18:187-91. 2005
    ....
  74. pmc Stratification based on language-related endophenotypes in autism: attempt to replicate reported linkage
    Sarah J Spence
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, California 90095, USA
    Am J Med Genet B Neuropsychiatr Genet 141:591-8. 2006
    ..However, the inconsistencies in regions identified across studies highlight the importance of increasing sample sizes to provide adequate power to test replications in independent samples...
  75. ncbi Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning
    A Abu-Khalil
    Program in Neurogenetics, Neurology Department, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095 1769, USA
    J Comp Neurol 474:276-88. 2004
    ....
  76. ncbi Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation
    Ichiro Nakano
    Department of Neurological Surgery, UCLA, Los Angeles, CA 90095 1769, USA
    Stem Cells 25:1975-84. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  77. pmc Human-specific transcriptional regulation of CNS development genes by FOXP2
    Genevieve Konopka
    Program in Neurogenetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nature 462:213-7. 2009
    ..Because FOXP2 has an important role in speech and language in humans, the identified targets may have a critical function in the development and evolution of language circuitry in humans...
  78. ncbi Microarray platforms: introduction and application to neurobiology
    Stanislav L Karsten
    Department of Neurology, Program in Neurogenetics, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    Int Rev Neurobiol 60:1-23. 2004
  79. ncbi Progress in realizing the promise of microarrays in systems neurobiology
    Joseph D Dougherty
    Interdepartmental Program in the Neurosciences, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Neuron 45:183-5. 2005
    ..We discuss these findings and the implications of this development for both systems and molecular neuroscience...
  80. pmc Conservation and evolution of gene coexpression networks in human and chimpanzee brains
    Michael C Oldham
    Interdepartmental Program for Neuroscience, Program in Neurogenetics, and Semel Institute, David Geffen School of Medicine, Los Angeles, CA 90095 6814, USA
    Proc Natl Acad Sci U S A 103:17973-8. 2006
    ..Our results provide insights into the molecular bases of primate brain organization and demonstrate the general utility of weighted gene coexpression network analysis...
  81. ncbi Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain
    Lijuan Fu
    Department of Neurology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Comp Neurol 462:265-73. 2003
    ..The current study suggests that HEGFR and HFGFR1 are likely to play different roles during human brain development, but that these roles will be similar to those observed in the rodent brain...
  82. pmc PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry
    Matthias Groszer
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:111-6. 2006
    ..Therefore, loss of PTEN leads to cell physiological changes, which collectively are sufficient to increase the pool of self-renewing neural stem cells and promote their escape from the homeostatic mechanisms of proliferation control...
  83. pmc Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families
    Maricela Alarcon
    Center for Neurobehavioral Genetics and Neuropsychiatric Research Institute, and Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Am J Hum Genet 70:60-71. 2002
    ..The putative autism-susceptibility locus on chromosome 7 may be the result of separate QTLs for the language and repetitive or stereotyped behavior deficits that are associated with the disorder...
  84. ncbi A quantitative trait locus analysis of social responsiveness in multiplex autism families
    Jacqueline A Duvall
    Department of Neurology, University of California, Los Angeles, USA
    Am J Psychiatry 164:656-62. 2007
    ..The authors present the first genome-wide scan for a social endophenotype in autism using the Social Responsiveness Scale, which provides a quantitative measure of autistic-like behavior, primarily focused on social relatedness...
  85. ncbi Apolipoprotein epsilon4 status is associated with behavioral symptoms in nursing home residents with dementia
    Diana Lynn Woods
    School of Nursing, University of California, Los Angeles 90095 6919, USA
    Int Psychogeriatr 21:722-8. 2009
    ..The aim of this study was to examine the association between APOE genotype and BSD in NH residents using direct observation...
  86. pmc Elevated gene expression levels distinguish human from non-human primate brains
    Mario Cáceres
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:13030-5. 2003
    ..The increased expression of these genes could provide the basis for extensive modifications of cerebral physiology and function in humans and suggests that the human brain is characterized by elevated levels of neuronal activity...
  87. pmc Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementia
    Maria Jesus Sobrido
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 9095, USA
    Arch Neurol 60:698-702. 2003
    ..A subset of familial cases (FTDP-17) of frontotemporal dementia (FTD) are caused by mutations in the tau gene. The role of tau gene mutations and haplotypes in sporadic FTD and the functional consequences of tau polymorphisms are unknown...
  88. pmc A genomewide screen of 345 families for autism-susceptibility loci
    Amanda L Yonan
    Department of Genetics and Development and Columbia Genome Center, Columbia University, New York, NY 10032, USA
    Am J Hum Genet 73:886-97. 2003
    ....
  89. pmc High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, The University of Oxford, Oxford, OX3 7BN, UK
    Am J Hum Genet 81:1232-50. 2007
    ..The identified targets suggest roles in modulating synaptic plasticity, neurodevelopment, neurotransmission, and axon guidance and represent novel entry points into in vivo pathways that may be disturbed in speech and language disorders...
  90. pmc Cancerous stem cells can arise from pediatric brain tumors
    Houman D Hemmati
    Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 100:15178-83. 2003
    ..This finding may have important implications for treatment by means of specific targeting of stem-like cells within brain tumors...
  91. ncbi Cloning, genomic structure, and expression profiles of TULIP1 (GARNL1), a brain-expressed candidate gene for 14q13-linked neurological phenotypes, and its murine homologue
    Thomas Schwarzbraun
    Institute of Medical Biology and Human Genetics, Medical University of Graz, Harrachgasse 21 8, A 8010 Graz, Austria
    Genomics 84:577-86. 2004
    ..We identified two novel SNPs in the intron-exon boundaries; however, they did not segregate only with affected subjects in the predicted model of an autosomal dominant disease such as IBGC...
  92. ncbi Identification of process-localized mRNAs from cultured rodent hippocampal neurons
    Michael M Poon
    Interdepartmental Program in Neuroscience, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 26:13390-9. 2006
    ..These findings indicate that there is a rich repertoire of mRNAs whose translation can be locally regulated and support the emerging idea that local protein synthesis serves to boost the translational capacity of synapses...
  93. pmc Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders
    Betul Bakkaloglu
    Program on Neurogenetics, Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 82:165-73. 2008
    ....
  94. ncbi Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism
    Christa Lese Martin
    Department of Human Genetics, Emory University, Atlanta, GA 30322, USA
    Am J Med Genet B Neuropsychiatr Genet 144:869-76. 2007
    ..Further investigations in a larger sample may provide additional information regarding the involvement of this gene in the autistic phenotype...
  95. pmc ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo
    Philipp S Lange
    Burke Medical Research Institute, White Plains, NY 10605, USA
    J Exp Med 205:1227-42. 2008
    ..Collectively, these findings establish ATF4 as a redox-regulated, prodeath transcriptional activator in the nervous system that propagates death responses to oxidative stress in vitro and to stroke in vivo...
  96. pmc HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model
    Myriam Rai
    Laboratoire de Neurologie Expérimentale, Hopital Erasme, Universite Libre de Bruxelles ULB, Brussels, Belgium
    PLoS ONE 3:e1958. 2008
    ....
  97. pmc X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment
    Leanne M Dibbens
    Department of Genetic Medicine, Level 9 Rieger Building, Women s and Children s Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia
    Nat Genet 40:776-81. 2008
    ..PCDH19 is expressed in developing brains of human and mouse and is the first member of the cadherin superfamily to be directly implicated in epilepsy or mental retardation...
  98. pmc Early asymmetry of gene transcription in embryonic human left and right cerebral cortex
    Tao Sun
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, and Department of Neurology, Harvard Medical School, New Research Building Room 0266, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 308:1794-8. 2005
    ....
  99. ncbi Exercise your amyloid
    Stanislav L Karsten
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Cell 120:572-4. 2005
    ..Now, Lazarov and coworkers show that a simple paradigm of environmental enrichment alleviates amyloid burden and alters disease-associated gene expression changes in a double transgenic mouse model of AD...
  100. pmc Strong association of de novo copy number mutations with autism
    Jonathan Sebat
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 316:445-9. 2007
    ..Affected genomic regions were highly heterogeneous and included mutations of single genes. These findings establish de novo germline mutation as a more significant risk factor for ASD than previously recognized...

Research Grants30

  1. ASYMMETRICALLY EXPRESSED GENES IN THE DEVELOPING CEREBRU
    Daniel Geschwind; Fiscal Year: 1999
    ..abstract_text> ..
  2. A Genomewide Search for Autism Susceptibilty Loci
    Daniel Geschwind; Fiscal Year: 2006
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, further enhancing the value of this resource to the community. ..
  3. Identification of Novel Genetic Risk Factors for AD and*
    Daniel Geschwind; Fiscal Year: 2006
    ..abstract_text> ..
  4. Identification of targets of FoxP2 in the brain
    Daniel Geschwind; Fiscal Year: 2006
    ..This proposal has a strong screening component in an area where no molecular mechanisms have been identified and fits well within the R21 framework. ..
  5. Training Grant in Neurobehavioral Genetics
    Daniel Geschwind; Fiscal Year: 2007
    ....
  6. Identification and Characterization of Asymmetrically-Expressed Genes
    Daniel Geschwind; Fiscal Year: 2007
    ..All of this will clearly inform the study of human neurodevelopmental disorders that are related to speech and language, as well as probe the utility and limitations of animal models for these disorders. ..
  7. Novel Genetic Risk Factors for Alzheimer's Disease (AD) & Frontotemporal Dementia
    Daniel Geschwind; Fiscal Year: 2007
    ..abstract_text> ..
  8. A Comprehensive Approach to Identification of Autism Susceptibility Genes
    Daniel Geschwind; Fiscal Year: 2009
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, including minority families, further enhancing the value of this resource to the community. ..
  9. Novel Genetic Risk Factors for Alzheimer's Disease (AD) & Frontotemporal Dementia
    Daniel Geschwind; Fiscal Year: 2009
    ..abstract_text> ..
  10. A Comprehensive Approach to Identification of Autism Susceptibility Genes
    Daniel H Geschwind; Fiscal Year: 2010
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, including minority families, further enhancing the value of this resource to the community. ..
  11. Identification of Genetic Risk Factors for AD and FTD
    Daniel Geschwind; Fiscal Year: 2005
    ..abstract_text> ..
  12. A Genomewide Search for Autism Susceptibilty Loci
    Daniel Geschwind; Fiscal Year: 2005
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, further enhancing the value of this resource to the community. ..
  13. ASYMMETRICALLY EXPRESSED GENES IN DEVELOPING CEREBRUM
    Daniel Geschwind; Fiscal Year: 2000
    ..abstract_text> ..
  14. THE GENETICS OF IDIOPATHIC BASAL GANGLIA CALCIFICATION
    Daniel Geschwind; Fiscal Year: 2001
    ..Physical mapping and candidate screening for mutations will be pursued as the region is narrowed to identify the IBGC gene. A genome scan will be performed in families who are not linked to the chr.14 locus. ..
  15. ASYMMETRICALLY EXPRESSED GENES IN DEVELOPING CEREBRUM
    Daniel Geschwind; Fiscal Year: 2001
    ..abstract_text> ..
  16. A Genomewide Search for Autism Susceptibilty Loci
    Daniel Geschwind; Fiscal Year: 2002
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, further enhancing the value of this resource to the community. ..
  17. THE GENETICS OF IDIOPATHIC BASAL GANGLIA CALCIFICATION
    Daniel Geschwind; Fiscal Year: 2002
    ..Physical mapping and candidate screening for mutations will be pursued as the region is narrowed to identify the IBGC gene. A genome scan will be performed in families who are not linked to the chr.14 locus. ..
  18. ASYMMETRICALLY EXPRESSED GENES IN DEVELOPING CEREBRUM
    Daniel Geschwind; Fiscal Year: 2002
    ..abstract_text> ..
  19. A Genomewide Search for Autism Susceptibilty Loci
    Daniel Geschwind; Fiscal Year: 2002
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, further enhancing the value of this resource to the community. ..
  20. Genomewide Search--Autism Susceptibility Loci-supplement
    Daniel Geschwind; Fiscal Year: 2003
    ..This work is a direct response to Title 1 of the Pediatric Health Act of 2000 which authorizes and mandates an increased NIH commitment to autism gene banking. ..
  21. ASYMMETRICALLY EXPRESSED GENES IN DEVELOPING CEREBRUM
    Daniel Geschwind; Fiscal Year: 2003
    ..abstract_text> ..
  22. A Genomewide Search for Autism Susceptibilty Loci
    Daniel Geschwind; Fiscal Year: 2003
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, further enhancing the value of this resource to the community. ..
  23. THE GENETICS OF IDIOPATHIC BASAL GANGLIA CALCIFICATION
    Daniel Geschwind; Fiscal Year: 2003
    ..Physical mapping and candidate screening for mutations will be pursued as the region is narrowed to identify the IBGC gene. A genome scan will be performed in families who are not linked to the chr.14 locus. ..
  24. A Genomewide Search for Autism Susceptibilty Loci
    Daniel Geschwind; Fiscal Year: 2004
    ..All phenotypic and genotype data will be made accessible via the Internet on a rolling basis, further enhancing the value of this resource to the community. ..
  25. THE GENETICS OF IDIOPATHIC BASAL GANGLIA CALCIFICATION
    Daniel Geschwind; Fiscal Year: 2004
    ..Physical mapping and candidate screening for mutations will be pursued as the region is narrowed to identify the IBGC gene. A genome scan will be performed in families who are not linked to the chr.14 locus. ..
  26. Novel Genetic Risk Factors for Alzheimer's Disease (AD) & Frontotemporal Dementia
    Daniel Geschwind; Fiscal Year: 2009
    ..abstract_text> ..