Jason R Gerstner
Affiliation: University of Pennsylvania
- On the evolution of memory: a time for clocksJason R Gerstner
Center for Sleep and Circadian Neurobiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Front Mol Neurosci 5:23. 2012..Therefore, this notion predicts a model that LTP and metaplasticity may exist in neural circuits of other species, through phylogenetically conserved pathways, leading to several testable hypotheses...
- The nexus of Aβ, aging, and sleepJason R Gerstner
Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Sci Transl Med 4:150fs34. 2012..Roh et al. report a positive feedback loop between sleep-wake irregularities and aggregation of β-amyloid peptide, suggesting that sleep alterations could be an early event in Alzheimer's disease...
- Time of day regulates subcellular trafficking, tripartite synaptic localization, and polyadenylation of the astrocytic Fabp7 mRNAJason R Gerstner
Center for Sleep and Circadian Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 32:1383-94. 2012..These results implicate circadian, sleep, and/or metabolic control of CPEB-mediated subcellular trafficking and localized translation of Fabp7 mRNA in the tripartite synapse of mammalian brain...
- Fatty-acid binding proteins modulate sleep and enhance long-term memory consolidation in DrosophilaJason R Gerstner
Department of Genetics, University of Wisconsin Madison, Madison, Wisconsin, United States of America
PLoS ONE 6:e15890. 2011....
- Brain fatty acid binding protein (Fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brainJason R Gerstner
Neuroscience Training Program, University of Wisconsin Madison, Madison, Wisconsin, USA
PLoS ONE 3:e1631. 2008..Of clock or clock-regulated genes, the synchronized, global cycling pattern of Fabp7 expression is unique and implicates glial cells in the response or modulation of activity and/or circadian rhythms...
- Sleep symptoms associated with intake of specific dietary nutrientsMichael A Grandner
Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA, USA Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
J Sleep Res 23:22-34. 2014..04), potassium (OR = 0.70) and water (OR = 0.97). These results suggest novel associations between sleep symptoms and diet/metabolism, potentially explaining associations between sleep and cardiometabolic diseases. ..
- Regulation of neural specification from human embryonic stem cells by BMP and FGFTimothy M LaVaute
Neuroscience Training Program, School of Medicine, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
Stem Cells 27:1741-9. 2009..Blocking FGF signaling inhibited neural induction, but did not alter the phosphorylation of the linker region of Smad1, suggesting that FGF enhances human neural specification independently of BMP signaling...
- Circadian rhythms and memory formationJason R Gerstner
Department of Genetics, University of Wisconsin Madison, 3476 Genetics and Biotechnology, 425 Henry Mall, Madison, Wisconsin 53706, USA
Nat Rev Neurosci 11:577-88. 2010..Together, these studies suggest that common mechanisms underlie circadian rhythmicity and long-term memory formation...
- The zinc-binding protein chordc1 undergoes complex diurnal changes in mRNA expression during mouse brain developmentJason R Gerstner
Neuroscience Training Program and Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Neurochem Res 32:241-50. 2007..These results suggest that Chordc1 mRNA is under complex and widespread transcriptional regulation during development and implicate Chordc1 in circadian and/or homeostatic mechanisms in mammalian brain...
- Cycling behavior and memory formationJason R Gerstner
Department of Genetics, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Neurosci 29:12824-30. 2009..Conservation of a functional relationship between circadian rhythms with learning and memory formation across species provides a critical framework for future analysis of molecular mechanisms underlying complex behavior...
- Dietary nutrients associated with short and long sleep duration. Data from a nationally representative sampleMichael A Grandner
Center for Sleep and Circadian Neurobiology, University of Pennsylvania, 3624 Market Street, Suite 205, Philadelphia, PA 19104, USA
Appetite 64:71-80. 2013..In addition, these data may help us better understand the complex relationship between diet and sleep and the potential role of diet in the relationship between sleep and obesity and other cardiometabolic risks...
- dCREB2-mediated enhancement of memory formationThomas C Tubon
Department of Genetics and Neurology, Institute on Aging, Neuroscience Training Program, Wisconsin Institute of Medical Research, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Neurosci 33:7475-87. 2013..Our results reaffirm that overexpression of a dCREB2 activator can enhance memory formation and illustrate the complexity of this behavioral enhancement...