MERRILL E GERSHWIN

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Response to Dr. Roger's letter: further studies are necessary in order to conclude a causal association between the consumption of monosodium L-glutamate (MSG) and the prevalence of metabolic syndrome in the rural Thai population
    Tonkla Insawang
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand
    Nutr Metab (Lond) 10:10. 2013
  2. pmc Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population
    Tonkla Insawang
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Nutr Metab (Lond) 9:50. 2012
  3. doi request reprint The practical understanding and treatment of asthma
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Davis, CA 95616, USA
    Clin Rev Allergy Immunol 43:1-2. 2012
  4. pmc Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis
    Andrea T Borchers
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    Semin Immunopathol 31:309-22. 2009
  5. pmc The use of a commercial vegetable juice as a practical means to increase vegetable intake: a randomized controlled trial
    Sonia F Shenoy
    Department of Nutrition, University of California Davis, Davis, California 95616, USA
    Nutr J 9:38. 2010
  6. pmc Genomic variants associated with primary biliary cirrhosis
    Carlo Selmi
    Department of Translational Medicine, Universita degli Studi di Milano, Milan, Italy
    Genome Med 2:5. 2010
  7. pmc Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma
    Vincent A Ziboh
    Division of Rheumatology, Allergy and Clinical Immunology, Department of Dermatology, University of California at Davis School of Medicine, TB 192, Davis, CA 95616, USA
    Clin Dev Immunol 11:13-21. 2004
  8. ncbi request reprint The causes of primary biliary cirrhosis: Convenient and inconvenient truths
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 47:737-45. 2008
  9. ncbi request reprint Primary biliary cirrhosis: an orchestrated immune response against epithelial cells
    M E Gershwin
    Division of Allergy, Rheumatology, and Clinical Immunology, University of California, Davis, School of Medicine, 95616, USA
    Immunol Rev 174:210-25. 2000
  10. ncbi request reprint Phenotypic and functional considerations in the evaluation of immunity in nutritionally compromised hosts
    M E Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    J Infect Dis 182:S108-14. 2000

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Response to Dr. Roger's letter: further studies are necessary in order to conclude a causal association between the consumption of monosodium L-glutamate (MSG) and the prevalence of metabolic syndrome in the rural Thai population
    Tonkla Insawang
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand
    Nutr Metab (Lond) 10:10. 2013
    ..See related article: http://www.nutritionandmetabolism.com/content/10/1/14...
  2. pmc Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population
    Tonkla Insawang
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Nutr Metab (Lond) 9:50. 2012
    ..abstract:..
  3. doi request reprint The practical understanding and treatment of asthma
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Davis, CA 95616, USA
    Clin Rev Allergy Immunol 43:1-2. 2012
    ..This issue is dedicated to helping the many sufferers of asthma with the hope that this topic will eventually become a medical anachronism...
  4. pmc Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis
    Andrea T Borchers
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    Semin Immunopathol 31:309-22. 2009
    ..The relative importance of these chemokines in the recruitment or the retention of lymphocytes around the bile ducts remains unclear. The available data remain limited but underscore the importance of recruitment and homing...
  5. pmc The use of a commercial vegetable juice as a practical means to increase vegetable intake: a randomized controlled trial
    Sonia F Shenoy
    Department of Nutrition, University of California Davis, Davis, California 95616, USA
    Nutr J 9:38. 2010
    ..The secondary aim is to assess the effect of a vegetable juice on measures of cardiovascular health...
  6. pmc Genomic variants associated with primary biliary cirrhosis
    Carlo Selmi
    Department of Translational Medicine, Universita degli Studi di Milano, Milan, Italy
    Genome Med 2:5. 2010
    ..The aim of this present work is to critically review the numerous studies dedicated to revealing genetic associations in PBC, and to predict the potential for future studies based on these data...
  7. pmc Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma
    Vincent A Ziboh
    Division of Rheumatology, Allergy and Clinical Immunology, Department of Dermatology, University of California at Davis School of Medicine, TB 192, Davis, CA 95616, USA
    Clin Dev Immunol 11:13-21. 2004
    ..Nonetheless, the study demonstrated dietary fatty acid modulation of endogenous inflammatory mediators without side effects and thus warrant further explorations into the roles of GLA at higher doses, leukotrienes and asthma...
  8. ncbi request reprint The causes of primary biliary cirrhosis: Convenient and inconvenient truths
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 47:737-45. 2008
    ....
  9. ncbi request reprint Primary biliary cirrhosis: an orchestrated immune response against epithelial cells
    M E Gershwin
    Division of Allergy, Rheumatology, and Clinical Immunology, University of California, Davis, School of Medicine, 95616, USA
    Immunol Rev 174:210-25. 2000
    ..The data so far provide suggestive evidence that PBC is a mucosal disease; this thesis provides a basis for discussion of etiology via the enterohepatic circulation of toxins and/or infection...
  10. ncbi request reprint Phenotypic and functional considerations in the evaluation of immunity in nutritionally compromised hosts
    M E Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    J Infect Dis 182:S108-14. 2000
    ..This review summarizes interactions between nutrition and immunity and focuses on practical aspects for evaluation of the immune function in the field...
  11. doi request reprint Cutting-edge issues in organ-specific autoimmunity
    M Eric Gershwin
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis School of Medicine, Davis, USA
    Clin Rev Allergy Immunol 41:123-5. 2011
    ..Common themes on both etiology and effector mechanisms are described throughout these papers with an attempt to provide a cutting-edge overview...
  12. pmc Liver involvement in subjects with rheumatic disease
    Carlo Selmi
    Department of Medicine and Autoimmunity and Metabolism Unit, IRCCS Istituto Clinico Humanitas, University of Milan, Via A Manzoni 56, 20089 Rozzano MI, Italy
    Arthritis Res Ther 13:226. 2011
    ..We review herein the data on the role of the liver in the clinical management of systemic rheumatic diseases...
  13. doi request reprint Chella David: a lifetime contribution in translational immunology
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    J Autoimmun 37:59-62. 2011
    ..Chella David, at age 75, is an athlete in immunology and still keeps going with the same enthusiasm as manifest as a young post-doc...
  14. ncbi request reprint Primary biliary cirrhosis and autoimmunity: evaluating the genetic risk
    M E Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California at Davis, Davis, CA, USA
    Isr Med Assoc J 2:7-10. 2000
    ..In this review we place these concepts in perspective and highlight in particular the genetic associations in primary biliary cirrhosis...
  15. doi request reprint Macrophage activation syndrome in autoimmune disease
    Sean Deane
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Int Arch Allergy Immunol 153:109-20. 2010
    ..This review discusses the major aspects of the pathophysiology, diagnosis, and management of MAS with a focus on the association with autoimmune disease...
  16. doi request reprint Public safety and dietary supplementation
    M Eric Gershwin
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, California 95616, USA
    Ann N Y Acad Sci 1190:104-17. 2010
    ..More importantly, we provide a working plan for addressing this important issue...
  17. pmc Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 42:1194-202. 2005
    ..Exogenous estrogens may also contribute to explain the female predominance of the disease...
  18. doi request reprint Bone marrow transplantation, refractory autoimmunity and the contributions of Susumu Ikehara
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 E Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    J Autoimmun 30:105-7. 2008
  19. ncbi request reprint Cryptic antigenic determinants on the extracellular pyruvate dehydrogenase complex/mimeotope found in primary biliary cirrhosis. A probe by affinity mass spectrometry
    T T Yip
    Department of Food Science and Technology, Allergy and Clinical Immunology, University of California Davis, School of Medicine, Davis, California 95616, USA
    J Biol Chem 271:32825-33. 1996
    ..We believe AMS may be an important new approach with wide application to the identification of molecules associated with a number of disease states...

Research Grants29

  1. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2007
    ..Finally, because this murine model of PBC is pathologically and immunologically similar to human PBC, it opens the possibility of discriminative analysis of initiating events and eventually study of therapeutic interventions. ..
  2. EPIDEMIOLOGY OF PBC: A GENOME-WIDE ASSOCIATION STUDY
    MERRILL GERSHWIN; Fiscal Year: 2007
    ..Lay Summary: In this application we hope to determine the genetic basis that leads to a prototypic autoimmune disease, called primary biliary cirrhosis. ..
  3. EPIDEMIOLOGY OF PBC: A GENOME-WIDE ASSOCIATION STUDY
    MERRILL GERSHWIN; Fiscal Year: 2009
    ..Lay Summary: In this application we hope to determine the genetic basis that leads to a prototypic autoimmune disease, called primary biliary cirrhosis. ..
  4. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..abstract_text> ..
  5. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..We will also immunize mice with these chemicals and believe that these mice will develop the clinical features of afflicted human patients that will allow us to focus and define disease etiology and future potential treatment. ..
  6. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2009
    ..We will also immunize mice with these chemicals and believe that these mice will develop the clinical features of afflicted human patients that will allow us to focus and define disease etiology and future potential treatment. ..
  7. EPIDEMIOLOGY OF PBC: A GENOME-WIDE ASSOCIATION STUDY
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..Lay Summary: In this application we hope to determine the genetic basis that leads to a prototypic autoimmune disease, called primary biliary cirrhosis. ..
  8. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2007
    ..We submit that this rigorous dissection of PBC will define pathways that will direct us to potential: mmunotherapeutic agents. ..
  9. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2006
    ..These studies are also critical for determining whether the immune response alone is essential for disease induction, or whether the unique milieu of human liver is required. ..
  10. BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMA
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..It is hoped that findings from these studies will evolve relatively non-toxic therapeutic alternatives for attenuating bronchial hyperresponsiveness and inflammation in patients with asthma. ..
  11. EPIDEMIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..abstract_text> ..
  12. dnTGF Beta RII Mice and PBC
    William M Ridgway; Fiscal Year: 2010
    ..Our lab proposes to take advantage of a model that recapitulates many of the features of human PBC and study the mechanisms of disease with the belief that such data will lead to a breakthrough in human PBC. ..