Elliot Gershon

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. doi request reprint Risk counselling for family members in bipolar disorder and schizophrenia
    Elliot S Gershon
    University of Chicago, Chicago, IL 60637, USA
    Int J Neuropsychopharmacol 16:713-4. 2013
  2. doi request reprint After GWAS: searching for genetic risk for schizophrenia and bipolar disorder
    Elliot S Gershon
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, USA
    Am J Psychiatry 168:253-6. 2011
  3. ncbi request reprint The challenges of genetic tests for human behavior
    Elliot S Gershon
    Departments of Psychiatry and Human Genetics, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
    Isr J Psychiatry Relat Sci 39:206-16. 2002
  4. pmc Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, IL 60637, United States
    Schizophr Res 98:89-97. 2008
  5. pmc No evidence for association between 19 cholinergic genes and bipolar disorder
    Jiajun Shi
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 144:715-23. 2007
  6. pmc Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008
  7. pmc Novel submicroscopic chromosomal abnormalities detected in autism spectrum disorder
    Susan L Christian
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Biol Psychiatry 63:1111-7. 2008
  8. pmc Neurotransmission and bipolar disorder: a systematic family-based association study
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1270-7. 2008
  9. ncbi request reprint An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia
    Susan L Christian
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Genomics 79:635-56. 2002
  10. ncbi request reprint Ethical issues in the use of genetic information
    Stephen H Dinwiddie
    Department of Psychiatry, University of Chicago, IL 60637 1470, USA
    Int Rev Psychiatry 16:320-8. 2004

Research Grants

  1. Fine Genomic Mapping of 13q32 in Bipolar Disorder
    Elliot Gershon; Fiscal Year: 2006
  2. Collaborative Genetic Study of Bipolar Disorder
    Elliot Gershon; Fiscal Year: 2007
  3. Multidisciplinary Psychiatry Genetics Training Program
    Elliot Gershon; Fiscal Year: 2007
  4. COLLABORATIVE STUDY OF BIPOLAR DISORDER
    Elliot Gershon; Fiscal Year: 2001
  5. GENETIC LINKAGE STUDIES IN BIPOLAR DISORDERS
    Elliot Gershon; Fiscal Year: 2003
  6. Genetic Linkage Studies in Bipolar Disorder Families
    Elliot Gershon; Fiscal Year: 2009

Detail Information

Publications32

  1. doi request reprint Risk counselling for family members in bipolar disorder and schizophrenia
    Elliot S Gershon
    University of Chicago, Chicago, IL 60637, USA
    Int J Neuropsychopharmacol 16:713-4. 2013
    ..5%). Psychotherapeutic intervention may be needed for within-family stigma and conflicts over genetic test results. These findings also raise ethical issues on stigma prevention, population screening, and abortion based on genotype...
  2. doi request reprint After GWAS: searching for genetic risk for schizophrenia and bipolar disorder
    Elliot S Gershon
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, USA
    Am J Psychiatry 168:253-6. 2011
    ..Study groups even larger than the 10,000 subjects in current meta-analyses would be required, but the outcomes may lead to resolution of our current dilemma in common diseases: Where is the missing heritability?..
  3. ncbi request reprint The challenges of genetic tests for human behavior
    Elliot S Gershon
    Departments of Psychiatry and Human Genetics, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
    Isr J Psychiatry Relat Sci 39:206-16. 2002
    ..To review the potential benefits and adverse effects of genetic tests that may develop, that effectively predict mental illness or variation from the norm on behavior traits...
  4. pmc Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, IL 60637, United States
    Schizophr Res 98:89-97. 2008
    ..0000253 for M18; adjusted P=0.009 for M22). No single maker showed evidence of overall association with BP. These results suggest that G72/G30 may influence susceptibility to schizophrenia with weak effects...
  5. pmc No evidence for association between 19 cholinergic genes and bipolar disorder
    Jiajun Shi
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 144:715-23. 2007
    ..Thus, it is unlikely that these 19 cholinergic genes play a major role in the pre-disposition to BD in these pedigrees...
  6. pmc Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008
    ..00000172). It remains significant after correcting for multiple testing using the False Discovery Rate method. Our results indicate an interaction between three circadian genes in susceptibility to bipolar disorder...
  7. pmc Novel submicroscopic chromosomal abnormalities detected in autism spectrum disorder
    Susan L Christian
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Biol Psychiatry 63:1111-7. 2008
    ..e., microdeletions and microduplications that are undetectable at the level of traditional cytogenetic analysis, allows the potential association of submicroscopic chromosomal imbalances and human disease...
  8. pmc Neurotransmission and bipolar disorder: a systematic family-based association study
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1270-7. 2008
    ....
  9. ncbi request reprint An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia
    Susan L Christian
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Genomics 79:635-56. 2002
    ..Overall, integration of the data from multiple sources is still needed for complete assembly of the 13q32-q33 region. (c)..
  10. ncbi request reprint Ethical issues in the use of genetic information
    Stephen H Dinwiddie
    Department of Psychiatry, University of Chicago, IL 60637 1470, USA
    Int Rev Psychiatry 16:320-8. 2004
    ..Relevant ethical issues include threats to patient privacy and confidentiality and the importance of fairly distributing the benefits and burdens of genetic advances...
  11. ncbi request reprint Frequency Finder: a multi-source web application for collection of public allele frequencies of SNP markers
    Tu H Nguyen
    Department of Psychiatry, University of Chicago, IL 60616, USA
    Bioinformatics 20:439-43. 2004
    ..While limited to public databases that provide web-based access to allele frequencies, Frequency Finder provides a single, user-friendly interface for retrieving allele frequencies for large batches of SNPs from multiple data sources...
  12. pmc DNannotator: Annotation software tool kit for regional genomic sequences
    Chunyu Liu
    Department of Psychiatry, University of Chicago, Chicago, IL, USA
    Nucleic Acids Res 31:3729-35. 2003
    ..Reference data (reports on the process) facilitating the user's evaluation of annotation quality are optionally provided. DNannotator can be accessed at http://sky.bsd.uchicago.edu/DNannotator.htm...
  13. pmc Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series
    Eiji Hattori
    Department of Psychiatry, The University of Chicago, IL 60637, USA
    Am J Hum Genet 72:1131-40. 2003
    ..Taken together with the earlier report, this is the first demonstration of a novel gene(s), discovered through a positional approach, independently associated with both bipolar illness and schizophrenia...
  14. pmc Genetic associations with schizophrenia: meta-analyses of 12 candidate genes
    Jiajun Shi
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Schizophr Res 104:96-107. 2008
    ..Our results further support eight potential SZ candidate genes and suggest that family data can reasonably be included in the meta-analysis of genetic associations...
  15. pmc Genetic control of individual differences in gene-specific methylation in human brain
    Dandan Zhang
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 86:411-9. 2010
    ..Some of the genetically regulated DNA methylation is directly connected with genetically regulated gene expression variation...
  16. doi request reprint Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Bipolar Disord 10:38-44. 2008
    ..We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees...
  17. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  18. pmc Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative
    Danielle M Dick
    Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Am J Hum Genet 73:107-14. 2003
    ..10), on chromosomes 2p, 3q, and 8q. This study, which is based on the largest linkage sample for bipolar disorder analyzed to date, indicates that several genes contribute to bipolar disorder...
  19. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
    ..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder...
  20. doi request reprint Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20
    Jessica Ross
    Department of Psychiatry, University of California, San Francisco, CA 94132 0984, USA
    Psychiatr Genet 18:191-8. 2008
    ..Our aim is to map chromosomal regions that harbor loci that increase susceptibility to bipolar disorder...
  21. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
    ....
  22. ncbi request reprint Genes and environment in suicidality
    Elliot S Gershon
    Am J Psychiatry 164:1460-1. 2007
  23. ncbi request reprint Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorder
    Dilberto O Ferraren
    Genetic Basis for Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 133:12-7. 2005
    ....
  24. ncbi request reprint Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
    ..The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied...
  25. ncbi request reprint Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12
    Virginia L Willour
    Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 61:725-7. 2007
    ..We are interested in identifying susceptibility genes that predispose subjects to attempted suicide...
  26. ncbi request reprint Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Psychiatry 160:1696-8. 2003
    ..The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder...
  27. ncbi request reprint Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1
    James B Potash
    Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
    Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008
    ..Further work is needed to confirm these results and uncover the functional variation underlying the association signal...
  28. ncbi request reprint Sequence variation in DOCK9 and heterogeneity in bipolar disorder
    Sevilla D Detera-Wadleigh
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
    Psychiatr Genet 17:274-86. 2007
    ..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region...
  29. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
    ..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...
  30. ncbi request reprint Genes for human behavior
    Elliot S Gershon
    Isr J Psychiatry Relat Sci 39:203-5. 2002
  31. ncbi request reprint Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21
    Virginia L Willour
    The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003
    ..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35...
  32. ncbi request reprint Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin
    Sven Cichon
    Nat Genet 36:783-4; author reply 784-5. 2004

Research Grants22

  1. Fine Genomic Mapping of 13q32 in Bipolar Disorder
    Elliot Gershon; Fiscal Year: 2006
    ..Further analysis of positive disequilibrium results will include additional genotyping and haplotyping to corroborate the result, and testing for clinical endophenotypes associated with disease. ..
  2. Collaborative Genetic Study of Bipolar Disorder
    Elliot Gershon; Fiscal Year: 2007
    ..Analysis of the existing sib pair families plus this large set of cases and controls should permit the confirmation of several vulnerability genes during this grant period. ..
  3. Multidisciplinary Psychiatry Genetics Training Program
    Elliot Gershon; Fiscal Year: 2007
    ..Based on the successes of this program during its initial training period, we request renewal of the T32 grant with increase of the number of Fellowship slots per year from two to three. ..
  4. COLLABORATIVE STUDY OF BIPOLAR DISORDER
    Elliot Gershon; Fiscal Year: 2001
    ..Genotypes will be shared with a consortium of investigators studying linkage in bipolar illness. Cell lines and interview data will be made freely available to the scientific community. ..
  5. GENETIC LINKAGE STUDIES IN BIPOLAR DISORDERS
    Elliot Gershon; Fiscal Year: 2003
    ..The enlargement, continued maintenance, and analysis of this unique family resource is important to the field and will form the basis for many future studies. ..
  6. Genetic Linkage Studies in Bipolar Disorder Families
    Elliot Gershon; Fiscal Year: 2009
    ..These new variants would then be tested for association in our sample. The important findings that have already emerged from our very carefully assessed sample argue for the benefits of extending this valuable resource. ..