Research Topics
Genomes and Genes
Species | Elliot GershonSummaryAffiliation: University of Chicago Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Risk counselling for family members in bipolar disorder and schizophreniaElliot S Gershon
University of Chicago, Chicago, IL 60637, USA
Int J Neuropsychopharmacol 16:713-4. 2013..5%). Psychotherapeutic intervention may be needed for within-family stigma and conflicts over genetic test results. These findings also raise ethical issues on stigma prevention, population screening, and abortion based on genotype...- After GWAS: searching for genetic risk for schizophrenia and bipolar disorderElliot S Gershon
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, USA
Am J Psychiatry 168:253-6. 2011..Study groups even larger than the 10,000 subjects in current meta-analyses would be required, but the outcomes may lead to resolution of our current dilemma in common diseases: Where is the missing heritability?.. 
The challenges of genetic tests for human behaviorElliot S Gershon
Departments of Psychiatry and Human Genetics, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
Isr J Psychiatry Relat Sci 39:206-16. 2002..To review the potential benefits and adverse effects of genetic tests that may develop, that effectively predict mental illness or variation from the norm on behavior traits...
Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysisJiajun Shi
Department of Psychiatry, University of Chicago, Chicago, IL 60637, United States
Schizophr Res 98:89-97. 2008..0000253 for M18; adjusted P=0.009 for M22). No single maker showed evidence of overall association with BP. These results suggest that G72/G30 may influence susceptibility to schizophrenia with weak effects...- No evidence for association between 19 cholinergic genes and bipolar disorderJiajun Shi
Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet B Neuropsychiatr Genet 144:715-23. 2007..Thus, it is unlikely that these 19 cholinergic genes play a major role in the pre-disposition to BD in these pedigrees... - Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythmJiajun Shi
Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008..00000172). It remains significant after correcting for multiple testing using the False Discovery Rate method. Our results indicate an interaction between three circadian genes in susceptibility to bipolar disorder... - Novel submicroscopic chromosomal abnormalities detected in autism spectrum disorderSusan L Christian
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Biol Psychiatry 63:1111-7. 2008..e., microdeletions and microduplications that are undetectable at the level of traditional cytogenetic analysis, allows the potential association of submicroscopic chromosomal imbalances and human disease... - Neurotransmission and bipolar disorder: a systematic family-based association studyJiajun Shi
Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet B Neuropsychiatr Genet 147:1270-7. 2008.... - An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophreniaSusan L Christian
Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
Genomics 79:635-56. 2002..Overall, integration of the data from multiple sources is still needed for complete assembly of the 13q32-q33 region. (c).. - Ethical issues in the use of genetic informationStephen H Dinwiddie
Department of Psychiatry, University of Chicago, IL 60637 1470, USA
Int Rev Psychiatry 16:320-8. 2004..Relevant ethical issues include threats to patient privacy and confidentiality and the importance of fairly distributing the benefits and burdens of genetic advances... - Frequency Finder: a multi-source web application for collection of public allele frequencies of SNP markersTu H Nguyen
Department of Psychiatry, University of Chicago, IL 60616, USA
Bioinformatics 20:439-43. 2004..While limited to public databases that provide web-based access to allele frequencies, Frequency Finder provides a single, user-friendly interface for retrieving allele frequencies for large batches of SNPs from multiple data sources... - DNannotator: Annotation software tool kit for regional genomic sequencesChunyu Liu
Department of Psychiatry, University of Chicago, Chicago, IL, USA
Nucleic Acids Res 31:3729-35. 2003..Reference data (reports on the process) facilitating the user's evaluation of annotation quality are optionally provided. DNannotator can be accessed at http://sky.bsd.uchicago.edu/DNannotator.htm... - Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree seriesEiji Hattori
Department of Psychiatry, The University of Chicago, IL 60637, USA
Am J Hum Genet 72:1131-40. 2003..Taken together with the earlier report, this is the first demonstration of a novel gene(s), discovered through a positional approach, independently associated with both bipolar illness and schizophrenia... - Genetic associations with schizophrenia: meta-analyses of 12 candidate genesJiajun Shi
Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
Schizophr Res 104:96-107. 2008..Our results further support eight potential SZ candidate genes and suggest that family data can reasonably be included in the meta-analysis of genetic associations... - Genetic control of individual differences in gene-specific methylation in human brainDandan Zhang
Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL 60637, USA
Am J Hum Genet 86:411-9. 2010..Some of the genetically regulated DNA methylation is directly connected with genetically regulated gene expression variation... - Familial aggregation of postpartum mood symptoms in bipolar disorder pedigreesJennifer L Payne
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Bipolar Disord 10:38-44. 2008..We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees... - Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorderRicardo Segurado
Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
Am J Hum Genet 73:49-62. 2003..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region... - Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics InitiativeDanielle M Dick
Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA
Am J Hum Genet 73:107-14. 2003..10), on chromosomes 2p, 3q, and 8q. This study, which is based on the largest linkage sample for bipolar disorder analyzed to date, indicates that several genes contribute to bipolar disorder... - Association study of Wnt signaling pathway genes in bipolar disorderPeter P Zandi
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
Arch Gen Psychiatry 65:785-93. 2008..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder... - Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20Jessica Ross
Department of Psychiatry, University of California, San Francisco, CA 94132 0984, USA
Psychiatr Genet 18:191-8. 2008..Our aim is to map chromosomal regions that harbor loci that increase susceptibility to bipolar disorder... - Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigreesThomas G Schulze
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
Biol Psychiatry 56:18-23. 2004.... - Genes and environment in suicidalityElliot S Gershon
Am J Psychiatry 164:1460-1. 2007 - Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorderDilberto O Ferraren
Genetic Basis for Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 133:12-7. 2005.... - Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigreesMelvin G McInnis
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287-7463, USA
Biol Psychiatry 54:1265-73. 2003..Application of conditional analyses is potentially useful in larger sample collections to identify susceptibility genes of modest influence that may not be identified in a genome-wide scan aimed to identify single gene effects... - Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12Virginia L Willour
Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Biol Psychiatry 61:725-7. 2007..We are interested in identifying susceptibility genes that predispose subjects to attempted suicide... - Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
Am J Psychiatry 160:1696-8. 2003..The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder... - Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1James B Potash
Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008..Further work is needed to confirm these results and uncover the functional variation underlying the association signal... - Sequence variation in DOCK9 and heterogeneity in bipolar disorderSevilla D Detera-Wadleigh
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
Psychiatr Genet 17:274-86. 2007..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region... - Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33Fernando S Goes
Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
Am J Psychiatry 164:236-47. 2007..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features... - Genes for human behaviorElliot S Gershon
Isr J Psychiatry Relat Sci 39:203-5. 2002 - Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21Virginia L Willour
The Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35... - Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European originSven Cichon
Nat Genet 36:783-4; author reply 784-5. 2004
Research Grants
- Fine Genomic Mapping of 13q32 in Bipolar DisorderElliot Gershon; Fiscal Year: 2006..Further analysis of positive disequilibrium results will include additional genotyping and haplotyping to corroborate the result, and testing for clinical endophenotypes associated with disease. ..
- Collaborative Genetic Study of Bipolar DisorderElliot Gershon; Fiscal Year: 2007..Analysis of the existing sib pair families plus this large set of cases and controls should permit the confirmation of several vulnerability genes during this grant period. ..
- Multidisciplinary Psychiatry Genetics Training ProgramElliot Gershon; Fiscal Year: 2007..Based on the successes of this program during its initial training period, we request renewal of the T32 grant with increase of the number of Fellowship slots per year from two to three. ..
- COLLABORATIVE STUDY OF BIPOLAR DISORDERElliot Gershon; Fiscal Year: 2001..Genotypes will be shared with a consortium of investigators studying linkage in bipolar illness. Cell lines and interview data will be made freely available to the scientific community. ..
- GENETIC LINKAGE STUDIES IN BIPOLAR DISORDERSElliot Gershon; Fiscal Year: 2003..The enlargement, continued maintenance, and analysis of this unique family resource is important to the field and will form the basis for many future studies. ..
- Genetic Linkage Studies in Bipolar Disorder FamiliesElliot Gershon; Fiscal Year: 2009..These new variants would then be tested for association in our sample. The important findings that have already emerged from our very carefully assessed sample argue for the benefits of extending this valuable resource. ..