E W Gerner

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells
    Natalia A Ignatenko
    Department of Cell Biology and Anatomy, Arizona Cancer Center, The University of Arizona, Tucson, Arizona, USA
    Mol Carcinog 39:221-33. 2004
  2. pmc Get the fat out!
    Natalia A Ignatenko
    Arizona Cancer Center, 1515 N Campbell Ave, P O Box 245024, Tucson, AZ 85724, USA
    Cancer Prev Res (Phila) 6:161-4. 2013
  3. pmc Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation
    Eugene W Gerner
    The University of Arizona, Arizona Cancer Center, Tucson, Arizona 85724, USA
    Clin Cancer Res 15:758-61. 2009
  4. ncbi A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene
    Eugene W Gerner
    The University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA
    Ann N Y Acad Sci 1059:97-105. 2005
  5. ncbi Changing winds in the war on cancer
    Eugene W Gerner
    Arizona Cancer Center, The University of Arizona, Tuscon, AZ 85724, USA
    Cancer Biol Ther 4:252-4. 2005
  6. pmc Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models
    E W Gerner
    Department of Cell Biology and Anatomy, The University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA
    Biochem Soc Trans 35:322-5. 2007
  7. ncbi Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention
    E W Gerner
    Arizona Cancer Center, Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85724, USA
    Amino Acids 33:189-95. 2007
  8. ncbi Polyamines and cancer: old molecules, new understanding
    Eugene W Gerner
    University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Cancer 4:781-92. 2004
  9. pmc Cancer chemoprevention locks onto a new polyamine metabolic target
    Eugene W Gerner
    Arizona Cancer Center and Department of Cell Biology and Anatomy, The University of Arizona, Tucson, USA
    Cancer Prev Res (Phila) 3:125-7. 2010
  10. ncbi Heat-inducible vectors for use in gene therapy
    E W Gerner
    Department of Radiation Oncology, Cancer Biology Section, Arizona Cancer Center, The University of Arizona, Tucson 85724, USA
    Int J Hyperthermia 16:171-81. 2000

Research Grants

Collaborators

Detail Information

Publications66

  1. ncbi The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells
    Natalia A Ignatenko
    Department of Cell Biology and Anatomy, Arizona Cancer Center, The University of Arizona, Tucson, Arizona, USA
    Mol Carcinog 39:221-33. 2004
    ..DFMO reversed these increases. The results indicated that the Ki-ras oncogene caused changes in experimental cell migration and cell-cell communication genes and that some of these changes could be reversed by DFMO...
  2. pmc Get the fat out!
    Natalia A Ignatenko
    Arizona Cancer Center, 1515 N Campbell Ave, P O Box 245024, Tucson, AZ 85724, USA
    Cancer Prev Res (Phila) 6:161-4. 2013
    ..Cancer Prev Res; 6(3); 161-4. ©2013 AACR...
  3. pmc Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation
    Eugene W Gerner
    The University of Arizona, Arizona Cancer Center, Tucson, Arizona 85724, USA
    Clin Cancer Res 15:758-61. 2009
    ....
  4. ncbi A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene
    Eugene W Gerner
    The University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA
    Ann N Y Acad Sci 1059:97-105. 2005
    ..APC and APC-dependent genes, such as c-Myc and ODC, may be useful as genetic markers of risk and as targets for chemoprevention and therapy for colorectal cancer...
  5. ncbi Changing winds in the war on cancer
    Eugene W Gerner
    Arizona Cancer Center, The University of Arizona, Tuscon, AZ 85724, USA
    Cancer Biol Ther 4:252-4. 2005
  6. pmc Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models
    E W Gerner
    Department of Cell Biology and Anatomy, The University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA
    Biochem Soc Trans 35:322-5. 2007
    ..These data suggest that reducing polyamine metabolism and dietary polyamine levels may enhance strategies for colon cancer chemoprevention...
  7. ncbi Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention
    E W Gerner
    Arizona Cancer Center, Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85724, USA
    Amino Acids 33:189-95. 2007
    ..Seventy percent of participants will have completed the three years of treatment in December 2006...
  8. ncbi Polyamines and cancer: old molecules, new understanding
    Eugene W Gerner
    University of Arizona, Tucson, Arizona 85724, USA
    Nat Rev Cancer 4:781-92. 2004
    ..Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues...
  9. pmc Cancer chemoprevention locks onto a new polyamine metabolic target
    Eugene W Gerner
    Arizona Cancer Center and Department of Cell Biology and Anatomy, The University of Arizona, Tucson, USA
    Cancer Prev Res (Phila) 3:125-7. 2010
    ....
  10. ncbi Heat-inducible vectors for use in gene therapy
    E W Gerner
    Department of Radiation Oncology, Cancer Biology Section, Arizona Cancer Center, The University of Arizona, Tucson 85724, USA
    Int J Hyperthermia 16:171-81. 2000
    ....
  11. pmc Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis
    M E Tome
    Department of Radiation Oncology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ 85724, USA
    Biochem J 328:847-54. 1997
    ..Further, these data suggest that suppression of modified eIF-5A formation is one mechanism by which cells may be induced to undergo apoptosis...
  12. ncbi Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer
    Naveen Babbar
    Arizona Cancer Center, and Biochemistry, Molecular and Cellular Biology Graduate Program, The University of Arizona, Tucson, 85724, USA
    J Biol Chem 278:47762-75. 2003
    ..These data suggest that apoptosis induced by sulindac sulfone is mediated, in part, by the COX-independent, PPAR-dependent transcriptional activation of SSAT, leading to reduced tissue polyamine contents in human colon cancer cells...
  13. ncbi APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse
    S H Erdman
    Department of Radiation Oncology, Arizona Cancer Center and Steele Memorial Children s Research Center, The University of Arizona, Tucson, AZ 5724, USA
    Carcinogenesis 20:1709-13. 1999
    ..In the FAP population, DFMO may be of value in the chemoprevention of small intestinal adenocarcinoma that remains a risk following colectomy...
  14. ncbi Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model
    Lida P Hariri
    Division of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA
    Lasers Surg Med 38:305-13. 2006
    ..The diagnostic feasibility of optical coherence tomography (OCT) and laser-induced fluorescence (LIF) have been evaluated for human colorectal cancer. This study applies these technologies to a murine model of colorectal adenoma...
  15. ncbi Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis
    M E Tome
    Department of Biochemistry, University of Arizona, Tucson 85724, USA
    Biol Signals 6:150-6. 1997
    ..Treatment of DH23A/b cells with diaminoheptane also suppresses modified eIF-5A formation and induces apoptosis. These data suggest that suppression of modified eIF-5A formation may play a role in putrescine-induced apoptosis as well...
  16. ncbi The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis
    Hagit F Yerushalmi
    Gastrointestinal Cancer Program, Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Mol Carcinog 45:93-105. 2006
    ..In the colon, Nos2 is required for the arginine-induced increase in tumor number and incidence...
  17. pmc Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention
    Nathaniel S Rial
    Department of Internal Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Essays Biochem 46:111-24. 2009
    ..Toxicities from this combination may be limited to subsets of patients identified by either past medical history or clinical tests...
  18. ncbi Selective exclusion by the polyamine transporter as a mechanism for differential radioprotection of amifostine derivatives
    HERSON I QUINONES
    The University of Arizona, Arizona Cancer Center, Department of Radiation Oncology Cancer Biology Section, Tucson 85724, USA
    Clin Cancer Res 8:1295-300. 2002
    ..Selective exclusion of amifostine derivatives by the polyamine transporter could account for differential radio- or chemoprotection in normal versus neoplastic tissues in specific situations...
  19. pmc Hypusine modification in eukaryotic initiation factor 5A in rodent cells selected for resistance to growth inhibition by ornithine decarboxylase-inhibiting drugs
    M E Tome
    Department of Radiation Oncology, Arizona Health Sciences Center, University of Arizona, Tucson 85724, USA
    Biochem J 320:55-60. 1996
    ..These data support the hypothesis that one of the main effects of spermidine depletion is depletion of the modified eIF-5A pool, and that this is a critical factor in the cytostasis often observed after depletion of cellular polyamines...
  20. ncbi Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation
    J D Martinez
    Department of Radiation Oncology, Arizona Cancer Center, Tucson 85724, USA
    Nutr Cancer 31:111-8. 1998
    ..These results indicate that different bile acids exhibit distinct biological activities and suggest that the cytotoxicity reported for DCA may be due to its capacity to induce apoptosis via a protein kinase C-dependent signaling pathway...
  21. pmc Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells
    Jan B Egan
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Mol Carcinog 49:337-52. 2010
    ..Collectively, these findings strengthen evidence favoring a direct effect on the Wnt-signaling molecule beta-catenin as one anti-cancer target of 1,25D-VDR action in the colorectum...
  22. ncbi Task-based imaging of colon cancer in the Apc(Min/+) mouse model
    James B McNally
    University of Arizona, Tuscon 85721 0104, USA
    Appl Opt 45:3049-62. 2006
    ..The magnitude of the 680 nm signal correlates with chlorophyll content in the mouse diet, suggesting that the autofluorescent compound is a dietary metabolite...
  23. doi Presence of a TA haplotype in the APC gene containing the common 1822 polymorphism and colorectal adenoma
    Jan B Egan
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Cancer Res 68:6006-13. 2008
    ..01-0.80) when compared with the common CC-AA diplotype (codons 486 and 1822, respectively). Our findings support an important role for germ-line allele sequence in the APC gene and individual risk of metachronous adenomatous polyps...
  24. pmc Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract
    Takeshi Uemura
    The Arizona Cancer Center, University of Arizona, Tucson, USA
    Am J Physiol Gastrointest Liver Physiol 299:G517-22. 2010
    ....
  25. doi Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc
    Upal K Basu Roy
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA
    Mol Carcinog 47:947-55. 2008
    ..Our results would be consistent with the interpretation that caveolin-1 may have tumor suppressing functions during early stages of colon carcinogenesis...
  26. ncbi Selenomethionine inhibits growth and suppresses cyclooxygenase-2 (COX-2) protein expression in human colon cancer cell lines
    Antonio Baines
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Biol Ther 1:370-4. 2002
    ..These data suggests that Se-Met-induced cell growth inhibition may be, in part, mediated by COX-2 dependent mechanisms. The results of this study support the use of selenium agents in colon cancer chemoprevention trials...
  27. ncbi Increased thioredoxin-1 inhibits SSAT expression in MCF-7 human breast cancer cells
    B Husbeck
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Biochem Biophys Res Commun 306:469-75. 2003
    ..The results suggest that Trx-1 may play a role in the redox regulation of SSAT expression and polyamine homeostasis that could contribute to the biological effects of Trx-1...
  28. ncbi Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography
    Lida P Hariri
    Division of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721, USA
    Cancer Biol Ther 6:1753-62. 2007
    ....
  29. ncbi Dietary putrescine reduces the intestinal anticarcinogenic activity of sulindac in a murine model of familial adenomatous polyposis
    Natalia A Ignatenko
    Department of Cell Biology and Anatomy, Arizona Cancer Center, The University of Arizona, Tucson, USA
    Nutr Cancer 56:172-81. 2006
    ..Because high concentrations of putrescine can be found in certain dietary components, it may be advantageous to restrict dietary putrescine consumption in patients undergoing treatment with sulindac...
  30. ncbi Pharmacogenomics of the polyamine analog 3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride, CGC-11093, in the colon adenocarcinoma cell line HCT1161
    Natalia A Ignatenko
    Department of Cell Biology and Anatomy, Arizona Cancer Center, The University of Arizona, 1515 N Campbell Avenue, Tucson, Arizona 85724, USA
    Technol Cancer Res Treat 5:553-64. 2006
    ....
  31. doi Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis
    Natalia A Ignatenko
    The University of Arizona, Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
    Nutr Cancer 60:30-5. 2008
    ....
  32. ncbi Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse
    Natalia A Ignatenko
    Department of Cell Biology and Anatomy, The University of Arizona, Tucson, Arizona 85724, USA
    Cancer Biol Ther 5:1658-64. 2006
    ..Thus, conditional inactivation of c-Myc, mediated by Fabpl4xat-132-driven Cre-recombinase, suppresses Apc-dependent intestinal tumorigenesis in adult ApcMin/+ mice, without apparent effect on normal intestinal mucosa...
  33. ncbi Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract
    Lida P Hariri
    Division of Biomedical Engineering, The University of Arizona, Tucson, AZ, USA
    Comp Med 57:175-85. 2007
    ..OCT and LIF appear to be useful and complementary modalities for ex vivo imaging of mouse GI tissues...
  34. pmc Regulation of deoxycholate induction of CXCL8 by the adenomatous polyposis coli gene in colorectal cancer
    Nathaniel S Rial
    Cancer Biology Graduate Interdisciplinary Program, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Int J Cancer 124:2270-80. 2009
    ..These data suggest that DCA-mediated CXCL8 occurs in initiated colonic epithelium and neutralizing CXCL8 could reduce the invasive potential of tumors...
  35. ncbi Role of polyamines in arginine-dependent colon carcinogenesis in Apc(Min) (/+) mice
    Hagit F Yerushalmi
    Gastrointestinal Cancer Program, Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Mol Carcinog 45:764-73. 2006
    ..Inhibition of polyamine synthesis suppresses the arginine-dependent risk of colon tumorigenesis, resulting in apoptosis induction and decreased tumorigenesis, in this murine model...
  36. pmc Gene expression analysis of HCT116 colon tumor-derived cells treated with the polyamine analog PG-11047
    Natalia A Ignatenko
    Department of Cell Biology and Anatomy, Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA
    Cancer Genomics Proteomics 6:161-75. 2009
    ..The objective of this study was to identify the molecular signature of genes responsive to PG-11047 treatment and the biochemical effects of this drug in the HCT116 colon cancer cell line...
  37. ncbi APC-dependent regulation of ornithine decarboxylase in human colon tumor cells
    Kimberly E Fultz
    Department of Molecular and Cellular Biology, University of Arizona, Arizona Cancer Center, Tucson, Arizona 85724, USA
    Mol Carcinog 34:10-8. 2002
    ..These proteins, in turn, regulated the transcription of target genes, including ODC. The data presented indicate that ODC is a modifier of APC-dependent signaling in intestinal cells and tissues...
  38. pmc Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene
    Maria Elena Martinez
    Arizona Cancer Center, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 100:7859-64. 2003
    ....
  39. ncbi Polyamine-mediated post-transcriptional regulation of COX-2
    Michele Taylor Parker
    Cancer Biology Interdisciplinary Graduate Program, Arizona Cancer Center, The University of Arizona, 1515 N Campbell Avenue, P O Box 245024, Tucson, Arizona 85724, USA
    Biochimie 84:815-9. 2002
    ..Depletion of polyamines by DL-alpha-difluoromethylornithine (DFMO) treatment caused an induction of COX-2 mRNA steady-state levels. Polyamines appear to regulate expression of COX-2 by a post-transcriptional mechanism...
  40. pmc Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma
    Patricia A Thompson
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724 5024, USA
    Gastroenterology 139:797-805, 805.e1. 2010
    ..We studied effects of the combination of difluoromethylornithine (DFMO) and sulindac on biomarkers and investigated factors that modify their efficacy...
  41. ncbi Regulation of the HIV1 long terminal repeat by mutant heat shock factor
    Natalia A Ignatenko
    Department of Radiation Oncology Cancer Biology Section, Arizona Cancer Center, The University of Arizona, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
    Exp Cell Res 288:1-8. 2003
    ..The ability of HSF1+ to suppress HIV1 promoter activity suggests that HSF1+ could serve as a tool for the treatment of AIDS...
  42. ncbi Polyamines as modifiers of genetic risk factors in human intestinal cancers
    N Babbar
    Department of Molecular and Cellular Biology, University of Arizona, Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, U S A
    Biochem Soc Trans 31:388-92. 2003
    ..g. NSAIDs) are potent inhibitors of intestinal carcinogenesis in rodent models. Clinical trials combining these classes of agent in humans with risk factors for colon cancer are in progress...
  43. ncbi Reactive nitrogen species in colon carcinogenesis
    C M Payne
    Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson 85724, USA
    Antioxid Redox Signal 1:449-67. 1999
    ....
  44. ncbi Polyamine-dependent gene expression
    A C Childs
    Department of Biochemistry and Biophysics, Arizona Cancer Center, University of Arizona, 1515 N Campbell Avenue, P O Box 245024, Tucson, Arizona 85724, USA
    Cell Mol Life Sci 60:1394-406. 2003
    ..Recently, it has become apparent that the polyamines are able to influence the action of the protein kinase casein kinase 2. Here we address several roles of polyamines in gene expression...
  45. ncbi Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells
    Natalia A Ignatenko
    Department of Cell Biology, Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Mol Carcinog 39:91-102. 2004
    ..We concluded that mutated Ki-ras suppressed SSAT via a transcriptional mechanism involving the PPARgamma signaling pathway...
  46. pmc Identification and characterization of a diamine exporter in colon epithelial cells
    Takeshi Uemura
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    J Biol Chem 283:26428-35. 2008
    ..The interaction between SLC3A2 and SAT1 suggests that these proteins may facilitate excretion of acetylated polyamines...
  47. pmc Current concepts in colorectal cancer prevention
    Patricia A Thompson
    The University of Arizona, Gastrointestinal Cancer Program, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Expert Rev Gastroenterol Hepatol 3:369-82. 2009
    ..We discuss the importance of risk stratification for identifying subjects at moderate-to-high risk for colorectal cancer who are most likely to benefit from chemoprevention at an acceptable level of risk...
  48. ncbi Hypusine formation in protein by a two-step process in cell lysates
    R J Murphey
    Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson 85724
    J Biol Chem 262:15033-6. 1987
    ..Other mammalian amine oxidase inhibitors had little or no effect on this reaction. Thus, deoxyhypusine formation in eIF-4D is catalyzed by a guazatine-sensitive enzyme with a basic pH optimum...
  49. pmc Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells
    Rebecca S Henkhaus
    Cancer Biology Interdisciplinary Program, Arizona Cancer Center, The University of Arizona, 1515 N Campbell Ave, Tucson, AZ 85724, USA
    Biol Chem 389:757-64. 2008
    ..These data support the oncogenic role of KLK6 in colorectal cancer...
  50. pmc Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis
    Upal K Basu Roy
    Biochemistry and Molecular and Cellular Biology Graduate Program, University of Arizona, Tucson, Arizona, USA
    Mol Carcinog 47:538-53. 2008
    ..These data indicate that polyamine transport follows a dynamin-dependent and clathrin-independent endocytic uptake route, and this route is positively regulated by the oncogenic expression of K-RAS in a caveolin-1 dependent manner...
  51. ncbi Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase
    Kathryn R Lawson
    Department of Radiation Oncology and Biochemistry, The University of Arizona, Arizona Cancer Center, Tucson 85724, USA
    Clin Cancer Res 8:1241-7. 2002
    ....
  52. pmc Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine
    Ning Qu
    Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA
    Biochem J 375:465-70. 2003
    ..The D-enantiomer may have advantages, such as decreased normal tissue toxicity, over L- or D/L-DFMO in some clinical applications...
  53. ncbi Preclinical models for chemoprevention of colon cancer
    Eugene W Gerner
    Arizona Radiation Oncology, The University of Arizona, 1515 N Campbell, P O Box 240524, Tucson, AZ 85724, USA
    Recent Results Cancer Res 163:58-71; discussion 264-6. 2003
    ..In this chapter, we will discuss the strengths and limitations of these models to further our understanding of basic mechanisms of colon carcinogenesis and to develop strategies for colon cancer chemoprevention...
  54. ncbi Emerging concepts in targeting the polyamine metabolic pathway in epithelial cancer chemoprevention and chemotherapy
    Upal K Basuroy
    Biochemistry and Molecular and Cellular Biology Gradaute Program, University of Arizona, Tucson, AZ 85724, USA
    J Biochem 139:27-33. 2006
    ..Genetic variability affecting expression of the ornithine decarboxylase gene suggests an association between ODC expression and cancer risk, and prediction of response to treatment in certain epithelial cancers...
  55. pmc HuRrying colon cancer progression
    Natalia A Ignatenko
    University of Arizona, Arizona Cancer Center, Tucson, Arizona 85724, USA
    Cancer Biol Ther 7:428-9. 2008
  56. ncbi Heat shock-induced shedding of cell surface integrins in A549 human lung tumor cells in culture
    J A Majda
    Department of Radiation Oncology, University of Arizona, Tucson 85724
    Exp Cell Res 210:46-51. 1994
    ..These findings may be relevant to the heterogeneous patterns of invasion and metastasis of human tumors following fevers or hyperthermia therapy...
  57. pmc Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells
    Rebecca S Henkhaus
    Department of Cancer Biology, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Neoplasia 10:140-8. 2008
    ..This study demonstrates that proteins such as CAV-1 and AKT, which are known to be altered in colon cancer, affect KLK6 expression and KLK6 secretion...
  58. pmc Components of metabolic syndrome and metachronous colorectal neoplasia
    Erin L Ashbeck
    Arizona Cancer Center, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 18:1134-43. 2009
    ..The consistent association between obesity and colorectal cancer is thought to be explained by metabolic disturbances common, but not exclusive, to the obese...
  59. ncbi Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase
    Woonyoung Choi
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Mol Carcinog 45:685-93. 2006
    ..Further, dominant negative IkappaB attenuated the CHX and DENSPM-induced SSAT expression and mitochondria damage. These results taken together suggest that the inhibition of IkappaB and activation of NFkappaB activate SSAT...
  60. ncbi Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival
    Jason A Zell
    Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA 92697 7550, USA
    Int J Cancer 120:459-68. 2007
    ..Our results suggest important roles for arginine and meat consumption in CRC pathogenesis, and have implications for CRC prevention...
  61. pmc Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells
    Naveen Babbar
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Biochem J 394:317-24. 2006
    ..These results suggest that activation of SSAT by aspirin and different NSAIDs may be a common property of NSAIDs that plays an important role in their chemopreventive actions in colorectal cancer...
  62. pmc Development of a polyamine database for assessing dietary intake
    Christine Zoumas-Morse
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0901, USA
    J Am Diet Assoc 107:1024-7. 2007
    ..Development of this database linked to an FFQ provides a means of estimating polyamine intake and contributes to investigations relating polyamines to cancer...
  63. ncbi Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells
    Rongcai Jiang
    Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 6:1644-8. 2007
    ..We conclude that the activation of polyamine catabolism alters the cellular location of mTOR, thus negatively affecting mTOR-mediated protein synthesis and leading to the death of glioblastoma cells...
  64. pmc The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial
    Anne R Simoneau
    Department of Medicine, University of California, Irvine, 101 The City Drive, Route 81, Building 55, Room 304, Orange, CA 92868, USA
    Cancer Epidemiol Biomarkers Prev 17:292-9. 2008
    ..The prostate has high levels of tissue polyamines and has shown sensitivity to DFMO both in vitro and in vivo...
  65. pmc Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells
    Woonyoung Choi
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:3295-304. 2005
    ..Our findings demonstrate the importance of the polyamine pathway in 5-FU effects and suggest that the combination of 5-FU with DENSPM has potential for development as therapy for colorectal carcinoma...
  66. ncbi Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma
    Rongcai Jiang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 31:431-40. 2007
    ..Taken together, our studies indicate that DENSPM kills GBM cells through induction of SSAT coupled with H2O2 production, which is a potential target for GBM therapy...

Research Grants11

  1. Specialized Program Research Excellence (SPORE) in Gastrointestinal Cancer
    Eugene Gerner; Fiscal Year: 2007
    ..D. Anderson Cancer Center and the Translational Genomics Research Institute (TGEN) to offer unique opportunities to achieve our goal of reducing mortality due to Gl cancers in the United States. ..
  2. Gordon Research Conference of Polyamine
    Eugene Gerner; Fiscal Year: 2005
    ..abstract_text> ..
  3. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene W Gerner; Fiscal Year: 2010
    ..The long-term goal of this work is to develop safe and effective strategies for the prevention of colon cancer in people at risk for this disease. ..
  4. APOPTOSIS IN COLON CANCER CHEMOPREVENTION
    Eugene Gerner; Fiscal Year: 2005
    ..abstract_text> ..
  5. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene W Gerner; Fiscal Year: 2010
    ..The long-term goal of this work is to develop safe and effective strategies for the prevention of colon cancer in people at risk for this disease. ..