James Gern

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life
    Emma E Thompson
    Department of Human Genetics, University of Chicago, Chicago, Ill, USA
    J Allergy Clin Immunol 119:1423-9. 2007
  2. pmc Viral respiratory infection and the link to asthma
    James E Gern
    Division of Pediatric Allergy, Immunology, and Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Pediatr Infect Dis J 27:S97-103. 2008
  3. pmc Viral respiratory tract infections and asthma: the course ahead
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Allergy Clin Immunol 125:1212-7. 2010
  4. pmc Updates in the relationship between human rhinovirus and asthma
    Woo Kyung Kim
    Department of Pediatrics, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea
    Allergy Asthma Immunol Res 4:116-21. 2012
  5. pmc Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies
    Jason Matthew
    Department of Para Clinical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago
    Ital J Pediatr 35:16. 2009
  6. pmc Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma
    Anne Marie Singh
    Departments of Pediatrics, University of Wisconsin, 1111 Highland Avenue, 4139 WIMR, Madison, WI 53705 2275, USA
    Clin Mol Allergy 11:1. 2013
  7. pmc Comparison of the etiology of viral respiratory illnesses in inner-city and suburban infants
    James E Gern
    Department of Pediatrics, University of Wisconsin, Madison, WI, USA
    J Infect Dis 206:1342-9. 2012
  8. pmc Real-world comparison of two molecular methods for detection of respiratory viruses
    S Asad Ali
    Department of Pediatrics, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232, USA
    Virol J 8:332. 2011
  9. pmc A rat model of picornavirus-induced airway infection and inflammation
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA
    Virol J 6:122. 2009
  10. pmc Characterization of regulatory T cells in urban newborns
    Ngoc P Ly
    Pediatric Pulmonary Medicine, University of California San Francisco Children s Hospital and UCSF Medical School, San Francisco, CA, USA
    Clin Mol Allergy 7:8. 2009

Research Grants

  1. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2007
  2. T Regulatory Cells and Chilhood Asthma
    James Gern; Fiscal Year: 2004
  3. AADRC -- Mechanisms of Virus-Induced Asthma
    James Gern; Fiscal Year: 2005
  4. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2005
  5. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2006
  6. Wisconsin Allergy & Immunology Research Training Program
    James Gern; Fiscal Year: 2007

Detail Information

Publications81

  1. ncbi request reprint Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life
    Emma E Thompson
    Department of Human Genetics, University of Chicago, Chicago, Ill, USA
    J Allergy Clin Immunol 119:1423-9. 2007
    ..Previous work from our laboratory reported associations between single nucleotide polymorphisms (SNPs) in ITGB3 and asthma and allergic sensitization in 4 populations...
  2. pmc Viral respiratory infection and the link to asthma
    James E Gern
    Division of Pediatric Allergy, Immunology, and Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Pediatr Infect Dis J 27:S97-103. 2008
    ....
  3. pmc Viral respiratory tract infections and asthma: the course ahead
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Allergy Clin Immunol 125:1212-7. 2010
    ....
  4. pmc Updates in the relationship between human rhinovirus and asthma
    Woo Kyung Kim
    Department of Pediatrics, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea
    Allergy Asthma Immunol Res 4:116-21. 2012
    ..Here we review the current literature and discuss new advances in understanding the link between HRV and asthma...
  5. pmc Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies
    Jason Matthew
    Department of Para Clinical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago
    Ital J Pediatr 35:16. 2009
    ..We examined the distribution of respiratory viruses and their association with seasons in acute and stable asthmatic children in Trinidad...
  6. pmc Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma
    Anne Marie Singh
    Departments of Pediatrics, University of Wisconsin, 1111 Highland Avenue, 4139 WIMR, Madison, WI 53705 2275, USA
    Clin Mol Allergy 11:1. 2013
    ..The secondary aim was to explore the association between Treg cell frequency with allergen sensitization, disease severity and medication use...
  7. pmc Comparison of the etiology of viral respiratory illnesses in inner-city and suburban infants
    James E Gern
    Department of Pediatrics, University of Wisconsin, Madison, WI, USA
    J Infect Dis 206:1342-9. 2012
    ..Since inner-city infants have unique environmental exposures, we hypothesized that patterns of respiratory viral infections would also be distinct...
  8. pmc Real-world comparison of two molecular methods for detection of respiratory viruses
    S Asad Ali
    Department of Pediatrics, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232, USA
    Virol J 8:332. 2011
    ..We sought to perform a real-world comparison of two molecular respiratory viral diagnostic methods between two experienced respiratory virus research laboratories...
  9. pmc A rat model of picornavirus-induced airway infection and inflammation
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA
    Virol J 6:122. 2009
    ....
  10. pmc Characterization of regulatory T cells in urban newborns
    Ngoc P Ly
    Pediatric Pulmonary Medicine, University of California San Francisco Children s Hospital and UCSF Medical School, San Francisco, CA, USA
    Clin Mol Allergy 7:8. 2009
    ..The objective of this study was to compare Treg phenotype and function in cord blood (CB) of newborns to those in peripheral blood (PB) of a subset of participating mothers...
  11. pmc Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study
    Wayne G Shreffler
    Mount Sinai School of Medicine, Division of Pediatric Allergy and Immunology, New York, NY, USA
    BMC Immunol 7:29. 2006
    ....
  12. pmc The Urban Environment and Childhood Asthma study
    James E Gern
    Department of Pediatrics and Medicine, University of Wisconsin Madison, Madison, Wis 53792 9988, USA
    J Allergy Clin Immunol 125:545-9. 2010
    ..This review summarizes the study design, methods, and early findings of the URECA study...
  13. pmc Association of rhinovirus infections with asthma
    J E Gern
    Division of Allergy and Immunology, Department of Pediatrics, University of Wisconsin Madison, Madison, Wisconsin, USA
    Clin Microbiol Rev 12:9-18. 1999
    ..Finally, current and future strategies for treating rhinovirus infections and virus-induced exacerbations of asthma are discussed...
  14. pmc Rhinovirus and the initiation of asthma
    James E Gern
    Division of Pediatric Allergy, Immunology, and Rheumatology, University of Wisconsin Medical School, Madison, Wisconsin 53792 9988, USA
    Curr Opin Allergy Clin Immunol 9:73-8. 2009
    ..Virus-induced wheezing in infancy is a risk factor for asthma, and recent studies have highlighted the role of rhinoviruses in causing acute illnesses and as a possible contributing factor to chronic asthma...
  15. pmc The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population
    James E Gern
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Pulm Med 9:17. 2009
    ..This paper describes the study design, methods, and population of the Urban Environment and Childhood Asthma (URECA) study, which was established to investigate the immunologic causes of asthma among inner-city children...
  16. ncbi request reprint Effects of viral respiratory infections on lung development and childhood asthma
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, 600 Highland Avenue, Madison, WI 53792 9988, USA
    J Allergy Clin Immunol 115:668-74; quiz 675. 2005
    ..Greater understanding of the effects of viral infections on lung development and growth in early childhood might lead to the discovery of additional strategies for the prevention of recurrent wheezing and chronic asthma...
  17. ncbi request reprint Effect of upper respiratory tract infection on AIR inhaled insulin pharmacokinetics and glucodynamics in healthy subjects
    J E Gern
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Clin Pharmacol Ther 83:307-11. 2008
    ..The AIR Insulin system provides similar pharmacokinetic and glucodynamic responses under conditions of an experimentally induced RV infection and is regarded as suitable for use in diabetic patients during URIs...
  18. ncbi request reprint Inhibition of rhinovirus replication in vitro and in vivo by acid-buffered saline
    James E Gern
    Division of Allergy and Immunology, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA
    J Infect Dis 195:1137-43. 2007
    ..These findings demonstrate that low-pH buffers have antiviral activity in vivo and suggest that a larger clinical trial is warranted to determine whether this approach could reduce rates of viral transmission...
  19. pmc The ABCs of rhinoviruses, wheezing, and asthma
    James E Gern
    Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    J Virol 84:7418-26. 2010
    ..The close relationship between HRV infections and asthma suggests that antiviral treatments could have a major impact on the morbidity associated with this chronic respiratory disease...
  20. ncbi request reprint Infectious triggers of pediatric asthma
    James E Gern
    Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53792, USA
    Pediatr Clin North Am 50:555-75, vi. 2003
    ..In this article, the epidemiologic, mechanistic, and treatment implications of the association between respiratory infections and asthma are discussed...
  21. ncbi request reprint Mechanisms of virus-induced asthma
    James E Gern
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of Wisconsin Medical School, Madison, USA
    J Pediatr 142:S9-13; discussion S13-4. 2003
    ..It is hoped that these advances in our understanding of the relationship between viral infections and exacerbations of asthma will translate into new therapeutic targets for virus-induced exacerbations of asthma...
  22. ncbi request reprint Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection
    J E Gern
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53792 4108, USA
    Am J Respir Crit Care Med 162:2226-31. 2000
    ....
  23. ncbi request reprint Relationship of viral infections to wheezing illnesses and asthma
    James E Gern
    Department of Pediatrics, University of Wisconsin Hospital, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Nat Rev Immunol 2:132-8. 2002
    ..This article discusses the influence of viral infections on mechanisms of virus-induced airway inflammation in relationship to the development, persistence and severity of asthma...
  24. ncbi request reprint Serum and low-density lipoprotein enhance interleukin-8 secretion by airway epithelial cells
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI 53792 9988, USA
    Am J Respir Cell Mol Biol 29:483-9. 2003
    ..This effect may represent an innate mechanism for the recruitment of neutrophils to the airway in response to noxious stimuli, such as viral infections, that increase vascular permeability...
  25. ncbi request reprint Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cells
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison Medical School, Madison, Wisconsin, USA
    Am J Respir Cell Mol Biol 28:731-7. 2003
    ..Moreover, these data suggest that this may be an important mechanism for the selective secretion of chemokines by viruses (e.g., rhinovirus, respiratory syncytial virus, influenza) that synthesize dsRNA during replication...
  26. ncbi request reprint Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, USA
    Pediatr Allergy Immunol 13:386-93. 2002
    ..In contrast, for RSV and parainfluenza infections, factors in addition to IL-8 production appear to contribute to the generation of clinical symptoms...
  27. ncbi request reprint Interferon-gamma enhances rhinovirus-induced RANTES secretion by airway epithelial cells
    Shinichi Konno
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    Am J Respir Cell Mol Biol 26:594-601. 2002
    ..These findings suggest that IFN-gamma, by upregulating RANTES secretion, could be an important regulator of the initial immune response to rhinovirus infections...
  28. ncbi request reprint Viral respiratory infection and the link to asthma
    James E Gern
    Division of Pediatric Allergy, Immunology and Rheumatology, University of Wisconsin Medical School, Madison, USA
    Pediatr Infect Dis J 23:S78-86. 2004
    ..Acute wheezing secondary to viral infection is common in children. Whereas many children suffer primarily mild to moderate symptoms, others develop severe coughing and wheezing...
  29. ncbi request reprint Sex-related differences in immune development and the expression of atopy in early childhood
    Sara J Uekert
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI, USA
    J Allergy Clin Immunol 118:1375-81. 2006
    ..Sex and age are known to influence the clinical expression of asthma and allergic diseases...
  30. ncbi request reprint Rhinovirus respiratory infections and asthma
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, Madison, Wisconsin 53792 9988, USA
    Am J Med 112:19S-27S. 2002
    ..The precise direct and indirect mechanisms of viral contribution to exacerbations must still be elucidated. Understanding them will have an impact on the design of future treatment modalities...
  31. pmc Weekly monitoring of children with asthma for infections and illness during common cold seasons
    Jaime P Olenec
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 4108, USA
    J Allergy Clin Immunol 125:1001-1006.e1. 2010
    ..Exacerbations of childhood asthma and rhinovirus infections both peak during the spring and fall, suggesting that viral infections are major contributors to seasonal asthma morbidity...
  32. ncbi request reprint Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration
    Julie B Sedgwick
    Division of Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison, USA
    J Allergy Clin Immunol 110:752-6. 2002
    ..Some of these mediators might also affect the permeability of underlying vascular endothelium...
  33. ncbi request reprint Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge
    Lin Ying Liu
    Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison 53792, USA
    J Immunol 169:6452-8. 2002
    ..These observations provide a potential explanation for the inability of anti-IL-5 therapy to suppress airway hyperresponsiveness to inhaled Ag, despite a reduction in eosinophil recruitment...
  34. ncbi request reprint Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life
    William A Neaville
    Department of Pediatrics, University of Wisconsin Madison, USA
    J Allergy Clin Immunol 112:740-6. 2003
    ..Allergic diseases have been linked to abnormal patterns of immune development, and this has stimulated efforts to define the precise patterns of cytokine dysregulation that are associated with specific atopic phenotypes...
  35. pmc Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 126:545-51.e1-4. 2010
    ..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...
  36. ncbi request reprint Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life
    James E Gern
    Department of Pediatrics, University of Wisconsin Hospital, 600 Highland Avenue, Madison, WI 53792, USA
    J Allergy Clin Immunol 117:72-8. 2006
    ..Viral infections are the major cause of acute wheezing illnesses in childhood. Variations in immunologic responses at birth may be determinants of the risk of acquiring these illnesses...
  37. pmc Detection of viral and bacterial pathogens in acute respiratory infections
    Chidi N Obasi
    Department of Family Medicine, University of Wisconsin Madison, School of Medicine and Public Health, 1100 Delaplaine Ct, Madison, WI 53715, USA Electronic address
    J Infect 68:125-30. 2014
    ..This study tested the hypothesis that bacterial co-infection during ARI adds to airway inflammation and illness severity...
  38. ncbi request reprint Similar frequency of rhinovirus-infectible cells in upper and lower airway epithelium
    Anne G Mosser
    Department of Medicine, Division of Allergy and Immunology, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Infect Dis 185:734-43. 2002
    ..In confirming that RV can infect cells in the lower airway, these results suggest that lower airway dysfunction occurs through this mechanism in susceptible persons...
  39. ncbi request reprint Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life
    Christopher C Copenhaver
    Department of Pediatrics, University of Wisconsin Hospital, Madison, WI 53792 9988, USA
    Am J Respir Crit Care Med 170:175-80. 2004
    ..Conversely, the frequency of viral infections in infancy can influence IFN-gamma responses...
  40. pmc Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children
    Daniel J Jackson
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI, USA
    Am J Respir Crit Care Med 178:667-72. 2008
    ..Virus-induced wheezing episodes in infancy often precede the development of asthma. Whether infections with specific viral pathogens confer differential future asthma risk is incompletely understood...
  41. pmc Serial culture of murine primary airway epithelial cells and ex vivo replication of human rhinoviruses
    Rebecca A Brockman-Schneider
    Department of Pediatrics and Medicine, University of Wisconsin Madison, Madison, WI, USA
    J Immunol Methods 339:264-9. 2008
    ..This model will be useful in experiments to define mechanisms of viral replication and host/virus interactions within airway epithelial cells...
  42. pmc Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control
    Loren C Denlinger
    Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, P O Box 9988, Madison, WI 53792, USA
    Am J Respir Crit Care Med 179:265-70. 2009
    ..Upper respiratory tract infection is a guideline accepted risk domain for the loss of asthma control. The ionotrophic nucleotide receptor P2X(7) regulates compartmentalized acute inflammation and the immune response to airway pathogens...
  43. ncbi request reprint Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues
    Anne G Mosser
    University of Wisconsin, K4 928 CSC 9988, 600 Highland Avenue, Madison, WI 53792, USA
    Am J Respir Crit Care Med 171:645-51. 2005
    ..These results confirm that infection of lower airway tissues is a frequent finding during a cold and further demonstrate a patchy distribution of infected cells, a pattern similar to that reported in upper airway tissues...
  44. pmc Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16
    Jennifer P DeMore
    Department of Medicine, University of Wisconsin Madison, Madison, Wis, USA
    J Allergy Clin Immunol 124:245-52, 252.e1-3. 2009
    ..Rhinovirus infections are frequent causes of asthma exacerbations...
  45. pmc Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children
    Daniel J Jackson
    Department of Pediatrics, University of Wisconsin Madison, Madison, Wis, USA
    J Allergy Clin Immunol 124:949-53. 2009
    ..Factors affecting fractional exhaled nitric oxide (FeNO) in early childhood are incompletely understood...
  46. ncbi request reprint Rhinovirus-induced interferon-gamma and airway responsiveness in asthma
    G Daniel Brooks
    Departments of Medicine and Pediatrics, University of Wisconsin, Madison, Wisconsin, USA
    Am J Respir Crit Care Med 168:1091-4. 2003
    ....
  47. ncbi request reprint The hygiene hypothesis revisited
    Jeremy D Bufford
    Department of Pediatrics, University of Wisconsin Madison, K4 910 CSC, 600 Highland Avenue, Madison, WI 53792 9988, USA
    Immunol Allergy Clin North Am 25:247-62, v-vi. 2005
    ..Collectively, these advances raise hope that the concepts espoused in original hygiene hypothesis may soon lead to new preventive approaches to atopic diseases...
  48. ncbi request reprint Ligation of intercellular adhesion molecule 3 inhibits GM-CSF production by human eosinophils
    Julie M Kessel
    Departments of Pediatrics and Medicine, University of Wisconsin Medical School, Madison, WI 53792 4108, USA
    J Allergy Clin Immunol 111:1024-31. 2003
    ..Intercellular adhesion molecule 3 (ICAM-3) has recently been identified on the surface of eosinophils...
  49. pmc Role of viral respiratory infections in asthma and asthma exacerbations
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Lancet 376:826-34. 2010
    ....
  50. pmc Virus/allergen interactions and exacerbations of asthma
    Kirsten M Kloepfer
    Department of Pediatrics, University of Wisconsin Madison School of Medicine and Public Health, K4 910 CSC 9988, 600 Highland Avenue, Madison, WI 53792, USA
    Immunol Allergy Clin North Am 30:553-63, vii. 2010
    ..In addition, the authors discuss clinical evidence that treatment of allergic inflammation could help to reduce the frequency and severity of virus-induced exacerbations of asthma...
  51. pmc Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53719, USA
    N Engl J Med 364:1005-15. 2011
    ..It has also revealed the limitations of environmental remediation and guidelines-based therapy in achieving greater disease control...
  52. ncbi request reprint Rationale and methods for a trial assessing placebo, echinacea, and doctor-patient interaction in the common cold
    Bruce Barrett
    Department of Family Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Explore (NY) 3:561-72. 2007
    ....
  53. pmc Evaluation of a multiplexed PCR assay for detection of respiratory viral pathogens in a public health laboratory setting
    David J Marshall
    EraGen Biosciences Inc, Madison, WI 53717, USA
    J Clin Microbiol 45:3875-82. 2007
    ..In total, the PLx-RVP assay detected an additional 40 viral infections, of which 11 were mixed infections...
  54. pmc A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants
    Wai Ming Lee
    Department of Pediatrics and Medicine, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 2:e966. 2007
    ..Defining the role of specific strains in various HRV illnesses has been difficult because traditional serology, which requires viral culture and neutralization tests using 101 serotype-specific antisera, is insensitive and laborious...
  55. pmc High-throughput, sensitive, and accurate multiplex PCR-microsphere flow cytometry system for large-scale comprehensive detection of respiratory viruses
    Wai Ming Lee
    Department of Pediatrics and Medicine, University of Wisconsin, Madison, Wisconsin, USA
    J Clin Microbiol 45:2626-34. 2007
    ..8%) compared to only 24 (23.3%) by traditional culture and immunofluorescent-staining techniques. These results show that RMA is an accurate, sensitive, and practical test for respiratory-virus infections...
  56. ncbi request reprint The role of T regulatory cells in asthma
    Christine M Seroogy
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin Madison, USA
    J Allergy Clin Immunol 116:996-9. 2005
    ..Collectively, this new information suggests that a greater understanding of these pathways might lead to new therapeutic targets for asthma and other diseases of chronic airway inflammation...
  57. ncbi request reprint Bronchiolitis to asthma: a review and call for studies of gene-virus interactions in asthma causation
    Anne Marie Singh
    Department of Medicine, University of Wisconsin Madison, Madison, WI 53792, USA
    Am J Respir Crit Care Med 175:108-19. 2007
    ..Characterizing these relationships offers the potential of identifying at-risk hosts in whom preventing or delaying infection could alter the phenotypic expression of asthma...
  58. ncbi request reprint Viral infections, cytokine dysregulation and the origins of childhood asthma and allergic diseases
    Samuel L Friedlander
    Department of Medicine, Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison, WI, USA
    Pediatr Infect Dis J 24:S170-6, discussion S174-5. 2005
    ..The origins of asthma and allergic disease begin in early life for many individuals. It is vital to understand the factors and/or events leading to their development...
  59. ncbi request reprint Analysis of tracheal secretions for rhinovirus during natural colds
    Elinor Simons
    Department of Pediatrics, The University of Wisconsin Madison, WI, USA
    Pediatr Allergy Immunol 16:276-8. 2005
    ..In addition, these findings suggest that children with tracheostomies carry subclinical viral infections in their tracheas, rather than their noses...
  60. ncbi request reprint Effects of dog ownership and genotype on immune development and atopy in infancy
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, Madison, Wis, USA
    J Allergy Clin Immunol 113:307-14. 2004
    ..Exposure to furred pets might confer protection against the development of allergic sensitization through a mechanism that is incompletely understood...
  61. pmc Meditation or exercise for preventing acute respiratory infection: a randomized controlled trial
    Bruce Barrett
    Department of Family Medicine, University of Wisconsin Madison, 1100 Delaplaine Ct, Madison, WI 53715, USA
    Ann Fam Med 10:337-46. 2012
    ..This study was designed to evaluate potential preventive effects of meditation or exercise on incidence, duration, and severity of acute respiratory infection (ARI) illness...
  62. ncbi request reprint Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process
    Lin Ying Liu
    Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison 53792, USA
    J Immunol 169:6459-66. 2002
    ..These findings suggest that IL-5-activated eosinophils may lose mIL-5Ralpha and release sIL-5Ralpha in vivo, which may limit IL-5-dependent inflammatory events in diseases such as asthma...
  63. ncbi request reprint Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunction
    Ronald L Sorkness
    Morris Institute for Respiratory Research, Department of Medicine, School of Pharmacy, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    J Allergy Clin Immunol 110:607-9. 2002
    ..The persistent increase in IL-13 suggests instead that the strain-related variability in virus-associated airway pathology might be determined by the host response to infection rather than by the intensity or duration of infection...
  64. ncbi request reprint Rhinovirus illnesses during infancy predict subsequent childhood wheezing
    Robert F Lemanske
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 9988, USA edu
    J Allergy Clin Immunol 116:571-7. 2005
    ..The contribution of viral respiratory infections during infancy to the development of subsequent wheezing and/or allergic diseases in early childhood is not established...
  65. doi request reprint Identification of amino acids in the HA of H3 influenza viruses that determine infectivity levels in primary swine respiratory epithelial cells
    Marc G Busch
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI, USA
    Virus Res 133:269-79. 2008
    ..In particular, amino acid 138 is the dominant factor in determining infectivity levels in SRECs...
  66. ncbi request reprint Newborn immunology: relevance to the clinician
    David B Lewis
    Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA
    Curr Probl Pediatr Adolesc Health Care 36:189-204. 2006
  67. ncbi request reprint Association between CD4(+)CD25(high) T cells and atopy in children
    Tuomas Jartti
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 4108, USA
    J Allergy Clin Immunol 120:177-83. 2007
    ..There is evidence that CD4(+)CD25(high) T-regulatory cells are important for establishing tolerance to allergens, but information in children is limited...
  68. ncbi request reprint Food allergy masquerading as foreign body obstruction
    Anh Dai K Nguyen
    Department of Medicine, University of Wisconsin Madison Medical School, Madison, Wisconsin, USA
    Ann Allergy Asthma Immunol 90:271-2. 2003
    ..Allergic reactions to peanut and tree nuts can present as upper airway obstruction...
  69. ncbi request reprint Early exposure to pets: good or bad?
    Jeremy D Bufford
    University of Wisconsin Hospital and Clinics, 600 Highland Avenue, K4 918, CSC Box 9988, Madison, WI 53792, USA
    Curr Allergy Asthma Rep 7:375-82. 2007
    ..The mechanisms behind the protective pet effect remain under investigation but may include alterations in immune development, pet-specific tolerance, and exposure to innate immune stimuli...
  70. ncbi request reprint CD14-dependent activation of NF-kappaB by filarial parasitic sheath proteins
    Kishore Narayanan
    Center for Biotechnology, Anna University, Chennai, 600 025, India
    Cell Biol Int 26:43-54. 2002
    ....
  71. pmc Basal cells of differentiated bronchial epithelium are more susceptible to rhinovirus infection
    Bogdan Jakiela
    Correspondence and requests for reprints should be addressed to Bogdan Jakiela, Department of Medicine, Jagiellonian University, ul Skawinska 8, 31 066 Krakow, Poland
    Am J Respir Cell Mol Biol 38:517-23. 2008
    ..These results suggest the possibility that epithelial cell differentiation is associated with the maturation of antiviral defense mechanisms...
  72. pmc Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function
    Carole Ober
    University of Chicago, Chicago, IL 60637, USA
    N Engl J Med 358:1682-91. 2008
    ..We hypothesized that single-nucleotide polymorphisms (SNPs) that affect YKL-40 levels also influence asthma status and lung function...
  73. ncbi request reprint Modernization of the medical Sherlock Holmes
    James E Gern
    J Infect Dis 196:810-1. 2007
  74. doi request reprint Early identification of atopy in the prediction of persistent asthma in children
    Peter D Sly
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, WA, Australia
    Lancet 372:1100-6. 2008
    ..Identification of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, and sets the basis for future preventative strategies...
  75. pmc Rhinovirus replication in human macrophages induces NF-kappaB-dependent tumor necrosis factor alpha production
    Vasile Laza-Stanca
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    J Virol 80:8248-58. 2006
    ..They also confirm inhibition of NF-kappaB as a promising target for development of new therapeutic intervention strategies...
  76. pmc Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations
    Lauren A Weiss
    Department of Human Genetics, University of Chicago, 920 East 58th Street, CSLC 507C, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 172:67-73. 2005
    ..We therefore evaluated the integrin-beta3 gene (ITGB3), an integrin gene within an asthma linkage peak on chromosome 17, as a candidate for susceptibility to asthma- and atopy-related phenotypes...
  77. pmc Gene-environment interaction effects on the development of immune responses in the 1st year of life
    Sabine Hoffjan
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 76:696-704. 2005
    ....
  78. ncbi request reprint Is interleukin-10 a "10" in virus-provoked asthma?
    William W Busse
    Am J Respir Crit Care Med 172:405-6. 2005
  79. ncbi request reprint The spectrum of severe wheezing in childhood
    James E Gern
    J Allergy Clin Immunol 114:236-8. 2004
  80. ncbi request reprint Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy
    Sabine Hoffjan
    Department of Human Genetics, University of Chicago, IL 60637, USA
    J Allergy Clin Immunol 113:511-8. 2004
    ..Although candidate gene studies have identified many potential asthma susceptibility genes in adult populations, few have studied associations with immune phenotypes in the first year that might be early clinical markers of asthma...
  81. pmc Allele-specific targeting of microRNAs to HLA-G and risk of asthma
    Zheng Tan
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 81:829-34. 2007
    ....

Research Grants9

  1. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2007
    ..abstract_text> ..
  2. T Regulatory Cells and Chilhood Asthma
    James Gern; Fiscal Year: 2004
    ..abstract_text> ..
  3. AADRC -- Mechanisms of Virus-Induced Asthma
    James Gern; Fiscal Year: 2005
    ..It is proposed that these collaborative studies will provide new insight into mechanisms of respiratory-virus-induced asthma, the possible role of diminished IFN-gamma production in this process, and possibilities for new treatment...
  4. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2005
    ..abstract_text> ..
  5. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2006
    ..abstract_text> ..
  6. Wisconsin Allergy & Immunology Research Training Program
    James Gern; Fiscal Year: 2007
    ..Given these opportunities, the WISCART program can continue to provide trainees with a comprehensive mentored research training experience that will prepare them for successful research careers in Allergy and Immunology. ..