Michael S German

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A mouse model for monitoring islet cell genesis and developing therapies for diabetes
    Yoshinori Shimajiri
    Diabetes Center, University of California San Francisco, San Francisco, CA 94143 0534, USA
    Dis Model Mech 4:268-76. 2011
  2. pmc Anonymous sources: where do adult β cells come from?
    Michael S German
    Diabetes Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, California, USA
    J Clin Invest 123:1936-8. 2013
  3. pmc Rfx6 directs islet formation and insulin production in mice and humans
    Stuart B Smith
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 463:775-80. 2010
  4. pmc Convergence of the insulin and serotonin programs in the pancreatic β-cell
    Yasuharu Ohta
    Diabetes Center, University of California, San Francisco, San Francisco, California, USA
    Diabetes 60:3208-16. 2011
  5. doi request reprint Signals from the neural crest regulate beta-cell mass in the pancreas
    Nada Nekrep
    Diabetes Center, Hormone Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
    Development 135:2151-60. 2008
  6. pmc Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a
    Takeshi Miyatsuka
    Diabetes Center, Hormone Research Institute and Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:185-90. 2011
  7. pmc Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 3:e2430. 2008
  8. ncbi request reprint The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas
    Maria E Wilson
    Diabetes Center, Hormone Research Institute, University of California at San Francisco, 513 Parnassus Ave, San Francisco, California 94143 0534, USA
    Diabetes 54:3402-9. 2005
  9. ncbi request reprint MicroRNA expression is required for pancreatic islet cell genesis in the mouse
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0534, USA
    Diabetes 56:2938-45. 2007
  10. ncbi request reprint Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors
    Yu Cheng Wang
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Endocr Relat Cancer 16:267-79. 2009

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc A mouse model for monitoring islet cell genesis and developing therapies for diabetes
    Yoshinori Shimajiri
    Diabetes Center, University of California San Francisco, San Francisco, CA 94143 0534, USA
    Dis Model Mech 4:268-76. 2011
    ..This model will be useful for studying signals involved in islet cell genesis in vivo and developing therapies that induce this process...
  2. pmc Anonymous sources: where do adult β cells come from?
    Michael S German
    Diabetes Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, California, USA
    J Clin Invest 123:1936-8. 2013
    ..This work adds to mounting evidence that in most physiological and pathological conditions, β cell neogenesis may not make large contributions to the postnatal β cell pool - at least not in rodents...
  3. pmc Rfx6 directs islet formation and insulin production in mice and humans
    Stuart B Smith
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 463:775-80. 2010
    ..These studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans. Rfx6 could prove useful in efforts to generate beta-cells for patients with diabetes...
  4. pmc Convergence of the insulin and serotonin programs in the pancreatic β-cell
    Yasuharu Ohta
    Diabetes Center, University of California, San Francisco, San Francisco, California, USA
    Diabetes 60:3208-16. 2011
    ..Therefore, we tested whether these developmental parallels have functional consequences...
  5. doi request reprint Signals from the neural crest regulate beta-cell mass in the pancreas
    Nada Nekrep
    Diabetes Center, Hormone Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
    Development 135:2151-60. 2008
    ..2 form a non-cell-autonomous feedback loop that links the neural crest with the pancreatic epithelium, regulates the size of the beta-cell population, and thereby impacts insulin-secretory capacity and energy homeostasis...
  6. pmc Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a
    Takeshi Miyatsuka
    Diabetes Center, Hormone Research Institute and Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:185-90. 2011
    ..These studies reveal a crucial role for Neurog3 in regulating the cell cycle during the differentiation of islet cells and demonstrate that the subsequent down-regulation of Neurog3 allows the mature islet cell population to expand...
  7. pmc Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 3:e2430. 2008
    ..Herein we have explored the role of Math6 during endocrine pancreas development...
  8. ncbi request reprint The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas
    Maria E Wilson
    Diabetes Center, Hormone Research Institute, University of California at San Francisco, 513 Parnassus Ave, San Francisco, California 94143 0534, USA
    Diabetes 54:3402-9. 2005
    ..We show here that several Sox transcription factors are expressed in the developing pancreas and in the islet, and that one of these factors, Sox4, is required for the normal development of pancreatic islets...
  9. ncbi request reprint MicroRNA expression is required for pancreatic islet cell genesis in the mouse
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0534, USA
    Diabetes 56:2938-45. 2007
    ..We tested the hypothesis that microRNAs (miRNAs), which limit gene expression through posttranscriptional silencing, modulate the gene expression cascades involved in pancreas development...
  10. ncbi request reprint Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors
    Yu Cheng Wang
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Endocr Relat Cancer 16:267-79. 2009
    ..2 functions in immature endocrine cells to control NE differentiation in normal intestine and is expressed in most NE tumors of the gut, and is therefore a novel target of diagnosis for patients with gastrointestinal NE tumors...
  11. pmc Chronology of islet differentiation revealed by temporal cell labeling
    Takeshi Miyatsuka
    Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Diabetes 58:1863-8. 2009
    ....
  12. doi request reprint The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine
    Yu Cheng Wang
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California, 1600 Divisadero Street, A 724, San Francisco, California 94143 1932, USA
    Endocr Relat Cancer 17:283-91. 2010
    ..We conclude that FEV expression identifies serotonin-producing cells in normal and neoplastic SI and is a novel target for diagnosis of patients with NETs of the SI...
  13. ncbi request reprint Neurogenin3 activates the islet differentiation program while repressing its own expression
    Stuart B Smith
    Diabetes Center, Hormone Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0534, USA
    Mol Endocrinol 18:142-9. 2004
    ..In summary, while Neurogenin3 orchestrates islet cell differentiation by activating islet cell transcription factor genes, it simultaneously represses its own promoter...
  14. ncbi request reprint Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4
    Stuart B Smith
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    J Biol Chem 278:38254-9. 2003
    ..These data demonstrate how Neurogenin3 and HNF1alpha activate the pax4 gene during the cascade of gene expression events that control pancreatic endocrine cell development...
  15. pmc Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus
    Chad C MacArthur
    Primary and Stem Cell Systems, Life Technologies Corporation, Carlsbad, California, USA
    Stem Cells Dev 21:191-205. 2012
    ..This is a valuable tool for lineage development study, gain- and loss-of-function experiments, and human disease modeling using hESCs...
  16. pmc Dachshund homologues play a conserved role in islet cell development
    Anna Kalousova
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Biol 348:143-52. 2010
    ..Taken together, these data demonstrate a conserved role for Dachshund homologues in the production of insulin-producing cells...
  17. pmc Serotonin regulates pancreatic beta cell mass during pregnancy
    Hail Kim
    Diabetes Center, University of California San Francisco, San Francisco, California, USA
    Nat Med 16:804-8. 2010
    ..These studies reveal an integrated signaling pathway linking beta cell mass to anticipated insulin need during pregnancy. Modulators of this pathway, including medications and diet, may affect the risk of gestational diabetes...
  18. pmc Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome
    Gregory M Ku
    513 Parnassus Avenue, Box 0534, San Francisco, California 94143 0534, USA
    Mol Endocrinol 26:1783-92. 2012
    ..Many of these long intergenic noncoding RNA are β-cell specific, and we hypothesize that this large set of novel RNA may play important roles in β-cell function. Our data demonstrate unique features of the β-cell transcriptome...
  19. pmc Adenosine signaling promotes regeneration of pancreatic β cells in vivo
    Olov Andersson
    Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology and Program in Genetics and Human Genetics, Diabetes Center, Institute for Regeneration Medicine and Liver Center, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Cell Metab 15:885-94. 2012
    ..With this whole-organism screen, we identified components of the adenosine pathway that could be therapeutically targeted for the treatment of diabetes...
  20. ncbi request reprint Hedgehog signaling regulates expansion of pancreatic epithelial cells
    Hiroshi Kawahira
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Dev Biol 280:111-21. 2005
    ..epithelial tissue differentiation and that pathway activation impairs formation of epithelial progenitors. Thus, tight control of Hedgehog pathway activity throughout embryonic development ensures proper pancreas organogenesis...
  21. pmc Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice
    Li Jun Yao
    Departments of Medicine, and Molecular and Cellular Pharmacology, University of California, San Francisco, California 94107 2140, USA
    Mol Endocrinol 25:2106-18. 2011
    ....
  22. ncbi request reprint Derivation of insulin-producing cells from human embryonic stem cells
    Dennis Van Hoof
    Diabetes Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Stem Cell Res 3:73-87. 2009
    ..Mimicking normal pancreagenesis offers the best strategy for producing glucose-responsive insulin-producing cells in vitro for people with diabetes...
  23. ncbi request reprint Distinct gene expression programs function in progenitor and mature islet cells
    Hirotaka Watada
    Hormone Research Institute, University of California San Francisco, San Francisco, California 94143 0534, USA
    J Biol Chem 278:17130-40. 2003
    ..These studies reveal distinct mechanisms for directing the expression of a key differentiation factor in precursors versus mature islet cells...
  24. pmc An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production
    Gregory M Ku
    Diabetes Center, University of California San Francisco, CA, USA
    PLoS Genet 8:e1002449. 2012
    ..Using this system, we identify Gpr27 as a positive regulator of insulin production...
  25. doi request reprint Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters
    Dennis Van Hoof
    Diabetes Center, University of California San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA
    Stem Cell Res 6:276-85. 2011
    ..1. Controlling aggregate size allows efficient production of uniformly-clustered pancreatic endocrine precursors for in vivo engraftment or further in vitro maturation...
  26. pmc Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line
    Gerard Honig
    Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA
    J Biomed Sci 17:82. 2010
    ..1Dam), in which the expression of Cre recombinase is driven by regulatory elements upstream of the pdx1 (pancreatic-duodenal homeobox 1) gene...
  27. ncbi request reprint Gene expression cascades in pancreatic development
    Maria E Wilson
    Department of Medicine, UCSF Diabetes Center, Hormone Research Institute, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0534, USA
    Mech Dev 120:65-80. 2003
    ..As we develop an understanding of the pancreatic transcription factors, we are also acquiring the tools with which we can ultimately control pancreatic cell differentiation...
  28. ncbi request reprint Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas
    Maria E Wilson
    UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0534, USA
    Mech Dev 115:171-6. 2002
    ..The early production of atypical peptide hormones by these cells suggests that they could play an important role locally or systemically in the development of the embryo...

Research Grants20

  1. The Role of microRNA in Pancreas Development
    Michael S German; Fiscal Year: 2010
    ..A better understanding of how islet cells differentiate will help in developing methods for producing islet cells for patients with diabetes. ..
  2. The Role of microRNA in Pancreas Development
    Michael German; Fiscal Year: 2007
    ..A better understanding of how islet cells differentiate will help in developing methods for producing islet cells for patients with diabetes. ..
  3. DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREAS
    Michael German; Fiscal Year: 2007
    ..In addition, the focus on the beta cell has particular relevance to diabetes. A better understanding of how beta-cells differentiate will help us develop methods for producing beta-cells for patients with diabetes. ..
  4. DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREAS
    Michael German; Fiscal Year: 2006
    ..In addition, the focus on the beta cell has particular relevance to diabetes. A better understanding of how beta-cells differentiate will help us develop methods for producing beta-cells for patients with diabetes. ..
  5. DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREAS
    Michael German; Fiscal Year: 2005
    ..In addition, the focus on the beta cell has particular relevance to diabetes. A better understanding of how beta-cells differentiate will help us develop methods for producing beta-cells for patients with diabetes. ..
  6. DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREAS
    Michael German; Fiscal Year: 2004
    ..In addition, the focus on the beta cell has particular relevance to diabetes. A better understanding of how beta-cells differentiate will help us develop methods for producing beta-cells for patients with diabetes. ..
  7. PATTERNING OF THE DEVELOPING ENDROCRINE PANCREAS
    Michael German; Fiscal Year: 2002
    ..The knowledge gained from these studies will illuminate the mechanisms underlying pattern formation in the developing pancreas. This information can eventually be applied to engineering new Beta-cells for patients with diabetes. ..
  8. PATTERNING OF THE DEVELOPING ENDROCRINE PANCREAS
    Michael German; Fiscal Year: 2000
    ..The knowledge gained from these studies will illuminate the mechanisms underlying pattern formation in the developing pancreas. This information can eventually be applied to engineering new Beta-cells for patients with diabetes. ..
  9. DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREAS
    Michael German; Fiscal Year: 1999
    ..The cloned structural genes will also be used to study changes in their expression during embryonic development as well as alteration in expression accompanying pathogenic states. ..
  10. PATTERNING OF THE DEVELOPING ENDROCRINE PANCREAS
    Michael German; Fiscal Year: 2001
    ..The knowledge gained from these studies will illuminate the mechanisms underlying pattern formation in the developing pancreas. This information can eventually be applied to engineering new Beta-cells for patients with diabetes. ..
  11. DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREAS
    Michael S German; Fiscal Year: 2010
    ..To achieve that goal, we are studying the essential beta-cell differentiation gene nkx2.2. Ultimately this information will guide efforts to generate beta-cells for patients with diabetes. ..
  12. The Role of microRNA in Pancreas Development
    Michael German; Fiscal Year: 2009
    ..A better understanding of how islet cells differentiate will help in developing methods for producing islet cells for patients with diabetes. ..
  13. PATTERNING OF THE DEVELOPING ENDROCRINE PANCREAS
    Michael German; Fiscal Year: 1999
    ..The knowledge gained from these studies will illuminate the mechanisms underlying pattern formation in the developing pancreas. This information can eventually be applied to engineering new Beta-cells for patients with diabetes. ..
  14. DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREAS
    Michael German; Fiscal Year: 2000
    ..The cloned structural genes will also be used to study changes in their expression during embryonic development as well as alteration in expression accompanying pathogenic states. ..
  15. DIFFERENTIATION IN THE ENDOCRINE AND EXOCRINE PANCREAS
    Michael German; Fiscal Year: 2001
    ..The cloned structural genes will also be used to study changes in their expression during embryonic development as well as alteration in expression accompanying pathogenic states. ..
  16. The Role of microRNA in Pancreas Development
    Michael S German; Fiscal Year: 2010
    ..A better understanding of how islet cells differentiate will help in developing methods for producing islet cells for patients with diabetes. ..