D C German

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Degeneration of neurons and glia in the Niemann-Pick C mouse is unrelated to the low-density lipoprotein receptor
    D C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuroscience 105:999-1005. 2001
  2. pmc Nuclear localization of Klotho in brain: an anti-aging protein
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas Texas, USA
    Neurobiol Aging 33:1483.e25-30. 2012
  3. ncbi Serum biomarkers for Alzheimer's disease: proteomic discovery
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Biomed Pharmacother 61:383-9. 2007
  4. ncbi The PDAPP mouse model of Alzheimer's disease: locus coeruleus neuronal shrinkage
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, 75390 9070, USA
    J Comp Neurol 492:469-76. 2005
  5. ncbi Mouse models of Alzheimer's disease: insight into treatment
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390 9070, USA
    Rev Neurosci 15:353-69. 2004
  6. ncbi Cholinergic neuropathology in a mouse model of Alzheimer's disease
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, Texas 75390 9070, USA
    J Comp Neurol 462:371-81. 2003
  7. ncbi Neurodegeneration in the Niemann-Pick C mouse: glial involvement
    D C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuroscience 109:437-50. 2002
  8. ncbi Pharmacological inactivation of the vesicular monoamine transporter can enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of midbrain dopaminergic neurons, but not locus coeruleus noradrenergic neurons
    D C German
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390 9070, USA
    Neuroscience 101:1063-9. 2000
  9. pmc Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease
    D C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Comp Neurol 433:415-25. 2001
  10. ncbi Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease
    Michael H Donovan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Comp Neurol 495:70-83. 2006

Collaborators

Detail Information

Publications24

  1. ncbi Degeneration of neurons and glia in the Niemann-Pick C mouse is unrelated to the low-density lipoprotein receptor
    D C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuroscience 105:999-1005. 2001
    ....
  2. pmc Nuclear localization of Klotho in brain: an anti-aging protein
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas Texas, USA
    Neurobiol Aging 33:1483.e25-30. 2012
    ..This new finding suggests that in addition to Klotho being secreted from cells in brain, it also has a nuclear function...
  3. ncbi Serum biomarkers for Alzheimer's disease: proteomic discovery
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Biomed Pharmacother 61:383-9. 2007
    ..The identification of these peptides/proteins, and their direct measurement in patient serum, may allow the development of a simple, cost-effective test for AD...
  4. ncbi The PDAPP mouse model of Alzheimer's disease: locus coeruleus neuronal shrinkage
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, 75390 9070, USA
    J Comp Neurol 492:469-76. 2005
    ..However, the selective size reduction of the LC neuronal population projecting to cortical and hippocampal regions containing Abeta-related neuropathology implies that these cells may be subjected to a retrograde-mediated stress...
  5. ncbi Mouse models of Alzheimer's disease: insight into treatment
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390 9070, USA
    Rev Neurosci 15:353-69. 2004
    ..If such treatments can be shown to stop the neurodegenerative process and restore hippocampal neurogenesis, damaged brain circuits may be replaceable in patients with AD...
  6. ncbi Cholinergic neuropathology in a mouse model of Alzheimer's disease
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, Texas 75390 9070, USA
    J Comp Neurol 462:371-81. 2003
    ..These data indicated that the homozygous PDAPP mouse exhibits cholinergic nerve terminal degenerative pathology and that the cortical neurodegenerative changes occur before the deposition of Abeta-containing neuritic plaques...
  7. ncbi Neurodegeneration in the Niemann-Pick C mouse: glial involvement
    D C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuroscience 109:437-50. 2002
    ..The activation of astrocytes in regions that undergo neurodegeneration is also consistent with a role for these glial cells in the neurodegenerative process...
  8. ncbi Pharmacological inactivation of the vesicular monoamine transporter can enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of midbrain dopaminergic neurons, but not locus coeruleus noradrenergic neurons
    D C German
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390 9070, USA
    Neuroscience 101:1063-9. 2000
    ....
  9. pmc Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease
    D C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Comp Neurol 433:415-25. 2001
    ..There was no evidence for neurofibrillary tangles in the NPC mouse, and therefore the degenerative process in the mouse is unrelated to the neurofibrillary tangle...
  10. ncbi Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease
    Michael H Donovan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Comp Neurol 495:70-83. 2006
    ..The altered neurogenesis in the PDAPP mouse may contribute to the age-related cognitive deficits reported in this model of AD and may be a useful adjunct target for assessing the impact of AD therapies...
  11. ncbi Mesopontine cholinergic and non-cholinergic neurons in schizophrenia
    D C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235 9070, USA
    Neuroscience 94:33-8. 1999
    ..The present data do not support the previous observation of increased numbers of mesopontine cholinergic neurons in schizophrenia...
  12. ncbi The neurotoxin MPTP increases calbindin-D28k levels in mouse midbrain dopaminergic neurons
    M C Ng
    Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, TX 75266 067, USA
    Brain Res Mol Brain Res 36:329-36. 1996
    ..These data support the hypothesis that MPTP is neurotoxic by causing increases in free intracellular Ca2+ and that increased CALB in the midbrain dopaminergic neurons is a protective response to elevated intracellular free Ca2+...
  13. ncbi Upregulation of estrogen receptors in the forebrain of aromatase knockout (ArKO) mice
    V R Agarwal
    Department of Ob Gyn and Biochemistry, Green Center for Reproductive Biological Sciences, University of Texas Southwestern Medical Center, Dallas 75235 9051, USA
    Mol Cell Endocrinol 162:9-16. 2000
    ..Thus, estrogens can down-regulate ERalpha in brain...
  14. ncbi Rat model of Parkinson's disease: chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+)
    U Yazdani
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Exp Neurol 200:172-83. 2006
    ..This model of progressive neurodegeneration of nigrostriatal dopamine neurons may be useful for studying neuroprotective therapeutic agents for PD...
  15. ncbi A robust biomarker discovery pipeline for high-performance mass spectrometry data
    Wayne G Fisher
    Division of Translational Research, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Bioinform Comput Biol 5:1023-45. 2007
    ..While the generalizability of these markers is currently unknown, we have demonstrated the ability of our analytical package to extract biomarker candidates from high-performance mass spectral data...
  16. ncbi Validation of a near-infrared probe for detection of thin intracranial white matter structures
    Cole A Giller
    Department of Neurosurgery, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8855, USA
    J Neurosurg 98:1299-306. 2003
    ..In this study, the authors determined the spatial resolution of this new probe by using a rodent model supplemented with phantom measurements and computer simulation...
  17. pmc Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions
    Sreeganga Chandra
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:14966-71. 2004
    ..These results show that synucleins are not essential components of the basic machinery for neurotransmitter release but may contribute to the long-term regulation and/or maintenance of presynaptic function...
  18. ncbi Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter-2: human midbrain dopamine neurons
    Chang Lin Liang
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Comp Neurol 473:97-106. 2004
    ....
  19. ncbi Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease
    Hao Li
    Department of Internal Medicine University of Texas Southwestern Medical Center, Dallas, Texas 75390 8887, USA
    J Neuropathol Exp Neurol 64:323-33. 2005
    ..Nevertheless, neurodegeneration proceeds utilizing apoptosis with activation of glial cells, increased apoE and apoD synthesis, and increased cholesterol turnover across the CNS...
  20. doi A stereotactic near-infrared probe for localization during functional neurosurgical procedures: further experience
    Cole A Giller
    Baylor Radiosurgery Center, Baylor University Medical Center, Dallas, TX 75246, USA
    J Neurosurg 110:263-73. 2009
    ..In the current study they extend and further validate this technology...
  21. ncbi Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease
    Chang Lin Liang
    Department of Psychiatry, University of Texas, Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Exp Neurol 203:370-80. 2007
    ..The low mitochondria mass in SNC DA neurons may contribute to the selective vulnerability of these neurons in certain rodent models of PD...
  22. ncbi 5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system
    Keith A Young
    Neuropsychiatry Research Program, Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    Biol Psychiatry 61:813-8. 2007
    ..The pulvinar nucleus of the thalamus projects to important limbic nuclei including the amygdala and cingulate cortex, is involved in the processing of stimuli with emotional content, and contains an abundance of SERT...
  23. ncbi Elevated neuron number in the limbic thalamus in major depression
    Keith A Young
    Neuropsychiatry Research Program 151N, Central Texas Veterans Health Care System, 1901 S First Street, Temple, TX 76504, USA
    Am J Psychiatry 161:1270-7. 2004
    ..Neuroanatomical studies of the thalamus have rarely been conducted in patients with mood disorders...