Anne Germain

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Effects of a brief behavioral treatment for PTSD-related sleep disturbances: a pilot study
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Behav Res Ther 45:627-32. 2007
  2. ncbi request reprint Treating complicated grief: effects on sleep quality
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Behav Sleep Med 4:152-63. 2006
  3. ncbi request reprint Clinical correlates of poor sleep quality in posttraumatic stress disorder
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Stress 17:477-84. 2004
  4. pmc Diurnal variation in regional brain glucose metabolism in depression
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 62:438-45. 2007
  5. ncbi request reprint Ecological study of sleep disruption in PTSD: a pilot study
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room E 1124, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1071:438-41. 2006
  6. ncbi request reprint Sleep quality in complicated grief
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Trauma Stress 18:343-6. 2005
  7. pmc Circadian rhythm disturbances in depression
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Hum Psychopharmacol 23:571-85. 2008
  8. pmc Sleep-specific mechanisms underlying posttraumatic stress disorder: integrative review and neurobiological hypotheses
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room E 1124, Pittsburgh, PA 15213, USA
    Sleep Med Rev 12:185-95. 2008
  9. ncbi request reprint Neurobiology of non-REM sleep in depression: further evidence for hypofrontality and thalamic dysregulation
    Anne Germain
    University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara St, E 1116, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:1856-63. 2004
  10. ncbi request reprint A brief sleep scale for Posttraumatic Stress Disorder: Pittsburgh Sleep Quality Index Addendum for PTSD
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    J Anxiety Disord 19:233-44. 2005

Detail Information

Publications46

  1. ncbi request reprint Effects of a brief behavioral treatment for PTSD-related sleep disturbances: a pilot study
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Behav Res Ther 45:627-32. 2007
    ..The goal of this pilot study was to explore the effects of a very brief intervention for PTSD-related nightmares and insomnia in victims of violent crimes with PTSD...
  2. ncbi request reprint Treating complicated grief: effects on sleep quality
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Behav Sleep Med 4:152-63. 2006
    ..Given that sleep disturbance is a risk factor for poor health outcomes, adjunctive sleep interventions may be necessary to enhance CGT outcomes...
  3. ncbi request reprint Clinical correlates of poor sleep quality in posttraumatic stress disorder
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Stress 17:477-84. 2004
    ..Results suggest that age, gender, and psychiatric comorbidity have minimal impact on sleep quality in this PTSD sample. The inclusion of PTSD patients who were not specifically seeking treatment for SD reinforces the study findings...
  4. pmc Diurnal variation in regional brain glucose metabolism in depression
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 62:438-45. 2007
    ..This study compared diurnal variation in mood and regional cerebral metabolic rate of glucose (rCMRglc) in depressed and healthy subjects...
  5. ncbi request reprint Ecological study of sleep disruption in PTSD: a pilot study
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room E 1124, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1071:438-41. 2006
    ..These preliminary findings suggest that ambulatory methods can capture objective signs of sleep disruption, and corroborate subjective complaints of disrupted sleep in PTSD...
  6. ncbi request reprint Sleep quality in complicated grief
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Trauma Stress 18:343-6. 2005
    ..Comorbid depression, but not PTSD, further worsened sleep quality. Further studies are required to investigate the potential role of poor sleep quality as a modifiable risk factor of complicated grief response...
  7. pmc Circadian rhythm disturbances in depression
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Hum Psychopharmacol 23:571-85. 2008
    ..The aim of this article is to review progress in understanding the mechanisms that underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of depression...
  8. pmc Sleep-specific mechanisms underlying posttraumatic stress disorder: integrative review and neurobiological hypotheses
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room E 1124, Pittsburgh, PA 15213, USA
    Sleep Med Rev 12:185-95. 2008
    ..Testable hypotheses regarding the neurobiological underpinnings of PTSD across the sleep-wake cycle are offered...
  9. ncbi request reprint Neurobiology of non-REM sleep in depression: further evidence for hypofrontality and thalamic dysregulation
    Anne Germain
    University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara St, E 1116, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:1856-63. 2004
    ..The goal of this study was to investigate the functional neuroanatomical correlates of non-REM sleep relative to presleep wakefulness in depressed patients and healthy subjects...
  10. ncbi request reprint A brief sleep scale for Posttraumatic Stress Disorder: Pittsburgh Sleep Quality Index Addendum for PTSD
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    J Anxiety Disord 19:233-44. 2005
    ..The PSQI-A is a valid instrument for PTSD applicable to both clinical and research settings...
  11. ncbi request reprint Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:387-96. 2005
    ..Non-rapid eye movement sleep is associated with decreases in frontal, parietal, and temporal cortex metabolic activity compared with wakefulness...
  12. ncbi request reprint Functional neuroimaging evidence for hyperarousal in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 161:2126-8. 2004
    ..The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia...
  13. pmc EEG spectral analysis in primary insomnia: NREM period effects and sex differences
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center and Sleep Medicine Institute, University ofPittsburgh School ofMedicine, Pittsburgh, PA, USA
    Sleep 31:1673-82. 2008
    ..To compare NREM EEG power in primary insomnia (PI) and good sleeper controls (GSC), examining both sex and NREM period effects; to examine relationships between EEG power, clinical characteristics, and self-reports of sleep...
  14. ncbi request reprint Regional cerebral metabolic correlates of WASO during NREM sleep in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    J Clin Sleep Med 2:316-22. 2006
    ..To investigate the non-rapid eye movement (NREM) sleep-related regional cerebral metabolic correlates of wakefulness after sleep onset (WASO) in patients with primary insomnia...
  15. ncbi request reprint Regional brain glucose metabolism during morning and evening wakefulness in humans: preliminary findings
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Sleep 27:1245-54. 2004
    ..The goal of this pilot study was to examine regional relative brain glucose metabolism during morning and evening wakefulness in healthy humans...
  16. ncbi request reprint Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression
    Eric A Nofzinger
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Arch Gen Psychiatry 61:695-702. 2004
    ....
  17. pmc Efficacy of brief behavioral treatment for chronic insomnia in older adults
    Daniel J Buysse
    Sleep Medicine Institute, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Arch Intern Med 171:887-95. 2011
    ..Cognitive behavioral treatments are efficacious but not widely available. The aim of this study was to test the efficacy of brief behavioral treatment for insomnia (BBTI) vs an information control (IC) condition...
  18. pmc A quantitative approach to distinguishing older adults with insomnia from good sleeper controls
    Jessica C Levenson
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Sleep Med 9:125-31. 2013
    ..The purpose of this study was to identify the optimal quantitative thresholds for actigraphy and sleep diary that differentiate older adults (> 60 years) with insomnia from good sleeper controls...
  19. pmc Daytime symptoms in primary insomnia: a prospective analysis using ecological momentary assessment
    Daniel J Buysse
    Neuroscience Clinical and Translational Research Center, Department of Psychiatry, University of Pittsburgh, School of Medicine, USA
    Sleep Med 8:198-208. 2007
    ....
  20. ncbi request reprint Effects of a brief behavioral treatment for late-life insomnia: preliminary findings
    Anne Germain
    Department Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Sleep Med 2:403-6. 2006
    ..This preliminary report addresses the effects of a brief behavioral treatment for insomnia in older adults who present with the typical psychiatric and medical comorbidities of aging...
  21. ncbi request reprint Psychological stress is associated with heightened physiological arousal during NREM sleep in primary insomnia
    Martica Hall
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Behav Sleep Med 5:178-93. 2007
    ..Perceived stress and stress-related avoidance behaviors were associated with multiple indexes of physiological arousal during NREM sleep in patients with chronic, primary insomnia...
  22. pmc Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances in US Military Veterans
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychosom Res 72:89-96. 2012
    ..This randomized controlled trial compared the effects of prazosin vs. a behavioral sleep intervention (BSI), targeting nightmares and insomnia against a placebo pill control condition on sleep and daytime symptoms...
  23. pmc Development of short forms from the PROMIS™ sleep disturbance and Sleep-Related Impairment item banks
    Lan Yu
    Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Behav Sleep Med 10:6-24. 2011
    ....
  24. pmc Night-to-night sleep variability in older adults with and without chronic insomnia
    Daniel J Buysse
    Sleep Medicine Institute and Neuroscience Clinical and Translational Research Center, Department of Psychiatry, School of Medicine, University of Pittsburgh, PA 15213, USA
    Sleep Med 11:56-64. 2010
    ....
  25. ncbi request reprint A pilot study of subjective daytime alertness and mood in primary insomnia participants using ecological momentary assessment
    Helena Levitt
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Behav Sleep Med 2:113-31. 2004
    ..Coefficients of variation for DSD domains were greater in the insomnia group. Frequent measures of daytime symptoms may be useful outcomes in insomnia studies...
  26. ncbi request reprint Functional neuroanatomical correlates of eye movements during rapid eye movement sleep in depressed patients
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, E 1116, Pittsburgh, PA 15213, USA
    Psychiatry Res 130:259-68. 2004
    ..The observed pattern of correlations suggests that average RC may be a marker of hypofrontality during REM sleep in depressed patients...
  27. pmc Post-traumatic stress symptoms correlate with smaller subgenual cingulate, caudate, and insula volumes in unmedicated combat veterans
    RYAN HERRINGA
    Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Psychiatry Res 203:139-45. 2012
    ..PTSS are associated with abnormalities in limbic structures that may underlie the pathophysiology of PTSD. These abnormalities exist on a continuum with PTSS, beyond a diagnosis of PTSD...
  28. pmc Examining initial sleep onset in primary insomnia: a case-control study using 4-second epochs
    Douglas E Moul
    University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA
    J Clin Sleep Med 3:479-88. 2007
    ..Conventional scorings in 20-second and 60-second epochs were also obtained...
  29. pmc Clinical management of insomnia with brief behavioral treatment (BBTI)
    Wendy M Troxel
    Department of Psychiatry and Psychology, University of Pittsburgh, PA 15213, USA
    Behav Sleep Med 10:266-79. 2012
    ....
  30. ncbi request reprint Focusing on the experience of insomnia
    Thomas J Carey
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Behav Sleep Med 3:73-86. 2005
    ..Daytime problems are salient descriptors of the insomnia experience. Assessing the patient's daytime experiences is valued by patients with insomnia and may be used as a benchmark for treatment response...
  31. pmc Quantitative electroencephalography during rapid eye movement (REM) and non-REM sleep in combat-exposed veterans with and without post-traumatic stress disorder
    Daniel J Cohen
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Sleep Res 22:76-82. 2013
    ....
  32. pmc Development and validation of patient-reported outcome measures for sleep disturbance and sleep-related impairments
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Sleep 33:781-92. 2010
    ....
  33. pmc K-complexes are not preferentially evoked to combat sounds in combat-exposed Vietnam veterans with and without post-traumatic stress disorder
    Peter L Franzen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Psychophysiol 83:393-8. 2012
    ....
  34. pmc Insecure attachment is an independent correlate of objective sleep disturbances in military veterans
    Wendy M Troxel
    University of Pittsburgh, Department of Psychiatry and Psychology, Pittsburgh, PA, USA
    Sleep Med 12:860-5. 2011
    ..This study examines the association between interpersonal attachment styles and sleep in a high-risk cohort of military veterans with PTSD symptoms...
  35. ncbi request reprint Psychophysiological reactivity and coping styles influence the effects of acute stress exposure on rapid eye movement sleep
    Anne Germain
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Psychosom Med 65:857-64. 2003
    ....
  36. pmc Sleep and circadian rhythms in spousally bereaved seniors
    Timothy H Monk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Chronobiol Int 25:83-98. 2008
    ..However, this disruption does not appear to be due to bereavement-related disruptions in the circadian system...
  37. doi request reprint Sleep disturbances as the hallmark of PTSD: where are we now?
    Anne Germain
    Department of Psychiatry, University of Pittsburgh, USA
    Am J Psychiatry 170:372-82. 2013
    ..The field is ripe for prospective and longitudinal studies in high-risk groups to clarify how changes in sleep physiology and neurobiology contribute to increased risk of poor psychiatric outcomes...
  38. pmc Chronotype and diurnal patterns of positive affect and affective neural circuitry in primary insomnia
    Brant P Hasler
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Sleep Res 21:515-26. 2012
    ....
  39. ncbi request reprint Impact of imagery rehearsal treatment on distressing dreams, psychological distress, and sleep parameters in nightmare patients
    Anne Germain
    Department of Psychology, University of Montreal
    Behav Sleep Med 1:140-54. 2003
    ..The results independently replicate the efficacy of IRT for alleviating disturbing dreams and psychological distress. Sleep improvement may occur later in the recovery process...
  40. pmc Validation of the Pittsburgh Sleep Quality Index Addendum for posttraumatic stress disorder (PSQI-A) in U.S. male military veterans
    Salvatore P Insana
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Trauma Stress 26:192-200. 2013
    ..Assessment of disruptive nocturnal behaviors may provide a cost-effective, nonstigmatizing approach to PTSD screening without directly probing for trauma exposure(s)...
  41. pmc A window into the invisible wound of war: functional neuroimaging of REM sleep in returning combat veterans with PTSD
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 211:176-9. 2013
    ..Hypermetabolism in brain regions involved in arousal regulation, fear responses, and reward processing persist during REM sleep in combat veterans with PTSD...
  42. pmc Event-related distress in kidney disease patients
    Sarah Ramer
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Nephrol Dial Transplant 27:299-303. 2012
    ..This study aimed to determine the prevalence of stressful life events in CKD and CKD5 patients and identify the factors correlated with high levels of event-related distress...
  43. pmc Early-life trauma is associated with rapid eye movement sleep fragmentation among military veterans
    Salvatore P Insana
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Biol Psychol 89:570-9. 2012
    ....
  44. pmc Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: further evidence for circadian misalignment in non-seasonal depression
    Brant P Hasler
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 178:205-7. 2010
    ..Two markers of circadian misalignment correlated with depression severity in the depressed group...
  45. doi request reprint Predictors of acute posttraumatic stress disorder symptoms following civilian trauma: highest incidence and severity of symptoms after assault
    Louis H Alarcon
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 72:629-35; discussion 635-7. 2012
    ..The incidence and risk factors for PTSD are not well described in the civilian trauma population. We proposed to screen all trauma patients in the outpatient trauma clinic for acute PTSD symptoms and identify risk factors for PTSD...
  46. ncbi request reprint Sleep pathophysiology in posttraumatic stress disorder and idiopathic nightmare sufferers
    Anne Germain
    Sleep Research Center, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Biol Psychiatry 54:1092-8. 2003
    ..The aim of the present study was to investigate whether sleep anomalies in PTSD sufferers with frequent nightmares (P-NM) differ from those observed in non-PTSD, idiopathic nightmare (I-NM) sufferers and healthy individuals...