Mara Gerloni

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi CD4 T cell priming in dendritic cell-deficient mice
    Paola Castiglioni
    Department of Medicine and Cancer Center, University of California San Diego, 9500 Gilman Drive, La Jolla CA 92093-0837, USA
    Int Immunol 15:127-36. 2003
  2. ncbi T cell immunity using transgenic B lymphocytes
    Mara Gerloni
    Department of Medicine and Cancer Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0837, USA
    Proc Natl Acad Sci U S A 101:3892-7. 2004
  3. ncbi CD4 T cells in tumor immunity
    Mara Gerloni
    The Laboratory of Immunology, Department of Medicine and Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0837, USA
    Springer Semin Immunopathol 27:37-48. 2005
  4. ncbi The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice
    Mara Gerloni
    Laboratory of Immunology, Department of Medicine and Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 175:6551-9. 2005
  5. ncbi TLR9-independent activation of B lymphocytes by bacterial DNA
    Xochitl Cortez-Gonzalez
    The Laboratory of Immunology, Department of Medicine and Cancer Center, University of California, San Diego, La Jolla, California 92093-0837, USA
    DNA Cell Biol 25:253-61. 2006
  6. ncbi CD8 T cell priming by B lymphocytes is CD4 help dependent
    Paola Castiglioni
    The Department of Medicine and Cancer Center, University of California in San Diego, La Jolla, USA
    Eur J Immunol 35:1360-70. 2005
  7. ncbi Genetically programmed B lymphocytes are highly efficient in inducing anti-virus protective immunity mediated by central memory CD8 T cells
    Paola Castiglioni
    The Department of Medicine and Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0837, USA
    Vaccine 23:699-708. 2004
  8. ncbi B lymphocytes as antigen-presenting cell-based genetic vaccines
    Maurizio Zanetti
    The Department of Medicine and Cancer Center, University of California, San Diego, La Jolla, CA 92093 0837, USA
    Immunol Rev 199:264-78. 2004
  9. ncbi The role of relB in regulating the adaptive immune response
    Maurizio Zanetti
    Department of Medicine and the Cancer Center, University of California, San Diego, La Jolla, California 92093 0837, USA
    Ann N Y Acad Sci 987:249-57. 2003
  10. ncbi In utero DNA immunisation. Immunity over tolerance in fetal life
    Marta Rizzia
    The Laboratory of Immunology, Department of Medicine and Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0837, USA
    Vaccine 23:4273-82. 2005

Research Grants

  1. Bacterial DNA Internalization in B Lymphocytes
    Mara Gerloni; Fiscal Year: 2006

Collaborators

Detail Information

Publications11

  1. ncbi CD4 T cell priming in dendritic cell-deficient mice
    Paola Castiglioni
    Department of Medicine and Cancer Center, University of California San Diego, 9500 Gilman Drive, La Jolla CA 92093-0837, USA
    Int Immunol 15:127-36. 2003
    ..These data demonstrate that CD4( +) T cells can be primed in the absence of functional DC and suggest that relB may gauge the T cell response in vivo...
  2. ncbi T cell immunity using transgenic B lymphocytes
    Mara Gerloni
    Department of Medicine and Cancer Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0837, USA
    Proc Natl Acad Sci U S A 101:3892-7. 2004
    ..These findings disclose aspects in the regulation of adaptive immunity and indicate possibilities for vaccination against viruses and cancer in humans...
  3. ncbi CD4 T cells in tumor immunity
    Mara Gerloni
    The Laboratory of Immunology, Department of Medicine and Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0837, USA
    Springer Semin Immunopathol 27:37-48. 2005
    ....
  4. ncbi The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice
    Mara Gerloni
    Laboratory of Immunology, Department of Medicine and Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 175:6551-9. 2005
    ..1 lacked cytolytic function, but produced IFN-gamma upon restimulation with Ag. We conclude that immunity against tumor self-Ags and tumor protection can be regulated exploiting an inherent property of the immune system...
  5. ncbi TLR9-independent activation of B lymphocytes by bacterial DNA
    Xochitl Cortez-Gonzalez
    The Laboratory of Immunology, Department of Medicine and Cancer Center, University of California, San Diego, La Jolla, California 92093-0837, USA
    DNA Cell Biol 25:253-61. 2006
    ..Collectively, these results suggest that plasmid DNA activates mammalian B lymphocytes through a TLR9 independent pathway...
  6. ncbi CD8 T cell priming by B lymphocytes is CD4 help dependent
    Paola Castiglioni
    The Department of Medicine and Cancer Center, University of California in San Diego, La Jolla, USA
    Eur J Immunol 35:1360-70. 2005
    ..Collectively, the data show the existence of different requirements for priming of CD4 and CD8 T cells and point to the previously unappreciated fact that the induction of CD8 T cell responses by B lymphocytes requires T cell help...
  7. ncbi Genetically programmed B lymphocytes are highly efficient in inducing anti-virus protective immunity mediated by central memory CD8 T cells
    Paola Castiglioni
    The Department of Medicine and Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0837, USA
    Vaccine 23:699-708. 2004
    ....
  8. ncbi B lymphocytes as antigen-presenting cell-based genetic vaccines
    Maurizio Zanetti
    The Department of Medicine and Cancer Center, University of California, San Diego, La Jolla, CA 92093 0837, USA
    Immunol Rev 199:264-78. 2004
    ..We suggest that these properties reflect on simple characteristics, such as time synchronization and initial localization to secondary lymphoid organs of APCs endowed with protracted synthesis and presentation of antigen to T cells...
  9. ncbi The role of relB in regulating the adaptive immune response
    Maurizio Zanetti
    Department of Medicine and the Cancer Center, University of California, San Diego, La Jolla, California 92093 0837, USA
    Ann N Y Acad Sci 987:249-57. 2003
    ..It is found that the DCs in these mice are profoundly deficient in their ability to both prime and cross-prime T cell responses. It was concluded that the relB gene is involved in regulating the APC function of DCs in vivo...
  10. ncbi In utero DNA immunisation. Immunity over tolerance in fetal life
    Marta Rizzia
    The Laboratory of Immunology, Department of Medicine and Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0837, USA
    Vaccine 23:4273-82. 2005
    ..Furthermore, our data suggest that under appropriate conditions the fetal immune system can be programmed to immunity...
  11. ncbi Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus
    Pierre Langlade-Demoyen
    Laboratoire d'Immunite Cellulaire Anti-Virale, Institut Pasteur, Paris, France
    Eur J Immunol 33:720-8. 2003
    ....

Research Grants1

  1. Bacterial DNA Internalization in B Lymphocytes
    Mara Gerloni; Fiscal Year: 2006
    ..Therefore, this application is based on two viable hypotheses and will have far reaching implications for future work with plasmid DNA in vaccination in humans. ..