Research Topics
| I C GerlingSummaryAffiliation: University of Tennessee Country: USA Publications
| Collaborators
|
Detail Information
Publications
Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronismYelena Selektor
Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Am J Med Sci 335:105-10. 2008..Parathyroidectomy prevents this scenario. Rats with ALDOST were cotreated with cinacalcet (Cina), a calcimimetic that raises the threshold of the parathyroids' Ca(2+)-sensing receptor...
Approaches to reduce false positives and false negatives in the analysis of microarray data: applications in type 1 diabetes researchJian Wu
Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
BMC Genomics 9:S12. 2008....
Genomes, transcriptomes, and proteomes: molecular medicine and its impact on medical practiceIvan C Gerling
Division of Endocrinology, University of Tennessee Health Science Center, VAMC Research 151, 1030 Jefferson Ave, Memphis, TN 38104, USA
Arch Intern Med 163:190-8. 2003..Their potential use and impact are demonstrated by using diabetes mellitus as an example of a common and serious medical disorder. Finally, several potentially adverse consequences of "excessive" knowledge are discussed...- New data analysis and mining approaches identify unique proteome and transcriptome markers of susceptibility to autoimmune diabetesIvan C Gerling
Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 28104, USA
Mol Cell Proteomics 5:293-305. 2006..The overall systems biology of prediabetic NOD mice points toward abnormalities in regulation of the opposing processes of cell renewal and cell death even before there are any clear signatures of immune system activation... - Characterization of early developments in the splenic leukocyte transcriptome of NOD miceI C Gerling
Department of Medicine, University of Tennessee Health Science Center, and Research Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
Ann N Y Acad Sci 1005:157-60. 2003..Herein, we report on characterization of the very earliest abnormalities in the transcriptome of leukocytes from young "prepathologic" NOD and NON female mice... - TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndromeS S Solomon
Department of Medicine, University of Tennessee Health Science Center, Veterans Affairs Medical Center, Memphis, USA
Horm Metab Res 42:115-21. 2010.... - Improved in vivo pancreatic islet function after prolonged in vitro islet cultureA O Gaber
Department of Surgery, University of Tennessee Health Science Center, College of Medicine, Memphis 38163, USA
Transplantation 72:1730-6. 2001.... - Toward a broader understanding of aldosterone in congestive heart failureKarl T Weber
Division of Cardiovascular Diseases, University of Tennessee, Memphis, Tennessee, 38163, USA
J Renin Angiotensin Aldosterone Syst 4:155-63. 2003..The past decade has witnessed a revival of interest in this steroid molecule. In years to come, an even broader understanding of ALDOs contribution to the pathophysiology of congestive heart failure will undoubtedly emerge... - Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactoneManesh Thomas
Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Am J Physiol Heart Circ Physiol 293:H2361-6. 2007..These findings may shed light on Zn dyshomeostasis found in patients with decompensated heart failure... - Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplementsKayla D Goodwin
Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center Memphis, Tennessee 38163, USA
Am J Med Sci 332:73-8. 2006..SHPT in rats with aldosteronism can be prevented by calcitriol and a diet supplemented with Ca and Mg. These findings raise the prospect that the SHPT found in CHF could be managed with macro- and micronutrients... - Aldosteronism in heart failure: a proinflammatory/fibrogenic cardiac phenotype. Search for biomarkers and potential drug targetsKarl T Weber
Division of Cardiovascular Diseases, Department of Medicine, School of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Curr Drug Targets 4:505-16. 2003.... - Hyperparathyroidism and the calcium paradox of aldosteronismVikram S Chhokar
Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Circulation 111:871-8. 2005..Ca2+ overloading of PBMCs and cardiac tissue leads to oxi/nitrosative stress and a proinflammatory phenotype... - Two-dimensional gel electrophoresis characterization of the mouse leukocyte proteome, using a tri-reagent for protein extractionNataliya I Lenchik
Department of Medicine, University of Tennessee Health Science Center, Memphis, 38104, USA
Proteomics 5:2202-9. 2005..Furthermore, an average of 301 +/- 3.6 spots were found in gels from both sample preparation methods, whereas 71.7 +/- 8.1 and 49.7 +/- 2.3 spots were uniquely seen in tri-reagent and non-tri-reagent samples, respectively... - Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interfaceRobert A Ahokas
Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, Tenn, Memphis, Tenn 38163, USA
Circ Res 93:e124-35. 2003..ALDO receptor antagonism modulates this neuroendocrine-immune interface. The full text of this article is available online at http://www.circresaha.org... - Aldosteronism: an immunostimulatory state precedes proinflammatory/fibrogenic cardiac phenotypeIvan C Gerling
Division of Endocrinology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Am J Physiol Heart Circ Physiol 285:H813-21. 2003.... - Paraffin-wax-coated plates as matrix-assisted laser desorption/ionization sample support for high-throughput identification of proteins by peptide mass fingerprintingNilesh S Tannu
Department of Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, USA
Anal Biochem 327:222-32. 2004.... - Macro- and micronutrients in African-Americans with heart failureSyamal K Bhattacharya
Department of Surgery, University of Tennessee Health Science Center, Memphis, USA
Heart Fail Rev 11:45-55. 2006..These findings call into question the need for nutriceutical treatment of heart failure and which is complementary to today's pharmaceuticals, especially in AA... - Oxidative stress in aldosteronismYao Sun
Department of Medicine, Division of Cardiovascular Diseases, University of Tennessee Health Science Center, 920 Madison Ave, Suite 300, Memphis, 38163, USA
Cardiovasc Res 71:300-9. 2006..An emerging body of evidence suggests the nutritional management of CHF offers an approach that will be complementary to today's pharmaceutical-based strategies... - Calcium paradox of aldosteronism and the role of the parathyroid glandsAlex Vidal
Division of Cardiovascular Diseases, Univ of Tennessee Health Science Center, 920 Madison Ave, Memphis, TN 38163, USA
Am J Physiol Heart Circ Physiol 290:H286-94. 2006..SHPT plays a permissive role in the proinflammatory vascular phenotype... - Insulin dynamically regulates calmodulin gene expression by sequential o-glycosylation and phosphorylation of sp1 and its subcellular compartmentalization in liver cellsGipsy Majumdar
Research, Medical, and Pathology Services, Veterans Affairs Medical Center Memphis, Tennessee 38104, USA
J Biol Chem 281:3642-50. 2006..Thus, O-glycosylation of Sp1 appears to be critical for its localization into the nucleus, where it undergoes obligatory phosphorylation that is needed for Sp1 to activate calmodulin gene expression... - Strain differences in allele and expression levels of CD72 on B-lymphocytes from NOD, AKR, NON and C57BL/6 miceJian Wu
Division of Endocrinology, Department of Medicine, University of Tennessee-Health Sciences Center (UTHSC, and Research Service, Veterans Affairs Medical Center, 151, 1030 Jefferson Avenue, Memphis, TN 38104, USA
Immunol Lett 103:115-20. 2006..The presence of the CD72c allele, as well as its low level of expression in NOD mice at 4 weeks of age, may be associated with B-lymphocyte hyper-responsiveness and resistance to activation-induced cell death... - Loss of bone minerals and strength in rats with aldosteronismVikram S Chhokar
Division of Cardiovascular Diseases, Univ of Tennessee Health Science Center, 920 Madison Ave, Third Floor, Memphis, TN 38163, USA
Am J Physiol Heart Circ Physiol 287:H2023-6. 2004..Thus the hypermagnesuria and hypercalciuria that accompany chronic Aldo-1% NaCl treatment contribute to the systemic appearance of oxidative/nitrosative stress and a wasting of bone minerals and strength... - Responses in extracellular and intracellular calcium and magnesium in aldosteronismAliye L Runyan
Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee 38136, USA
J Lab Clin Med 146:76-84. 2005.... - Proteome of H-411E (liver) cells exposed to insulin and tumor necrosis factor-alpha: analysis of proteins involved in insulin resistanceSolomon S Solomon
Research and Medical Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
J Lab Clin Med 145:275-83. 2005..Although one cannot detail the mechanism or mechanisms of TNF-alpha induced IR from this data alone, it is easy to relate all of these proteins to a role in insulin signal transduction and, hence, insulin resistance... - Proteome of monocytes primed with lipopolysaccharide: analysis of the abundant proteinsHimanshu S Gadgil
Department of Molecular Sciences, The University of Tennessee Health Science Center, Memphis, USA
Proteomics 3:1767-80. 2003..Proteins that decreased in abundance were integrin alpha-IIB, protein disulfide isomerase, and platelet-activating factor acetylhydrolase. Many of these altered proteins have interesting functions in inflammation... - Aldosteronism and a proinflammatory vascular phenotype: role of Mg2+, Ca2+, and H2O2 in peripheral blood mononuclear cellsRobert A Ahokas
Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, Tenn 38163, USA
Circulation 111:51-7. 2005.... - Functional characterization of two-dimensional gel-separated proteins using sequential stainingJian Wu
Department of Medicine, University of Tennessee, Health Science Center, Memphis, TN 38104, USA
Electrophoresis 26:225-37. 2005....