I C Gerling

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. doi request reprint Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism
    Yelena Selektor
    Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Med Sci 335:105-10. 2008
  2. pmc Approaches to reduce false positives and false negatives in the analysis of microarray data: applications in type 1 diabetes research
    Jian Wu
    Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
    BMC Genomics 9:S12. 2008
  3. ncbi request reprint Genomes, transcriptomes, and proteomes: molecular medicine and its impact on medical practice
    Ivan C Gerling
    Division of Endocrinology, University of Tennessee Health Science Center, VAMC Research 151, 1030 Jefferson Ave, Memphis, TN 38104, USA
    Arch Intern Med 163:190-8. 2003
  4. ncbi request reprint New data analysis and mining approaches identify unique proteome and transcriptome markers of susceptibility to autoimmune diabetes
    Ivan C Gerling
    Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 28104, USA
    Mol Cell Proteomics 5:293-305. 2006
  5. ncbi request reprint Characterization of early developments in the splenic leukocyte transcriptome of NOD mice
    I C Gerling
    Department of Medicine, University of Tennessee Health Science Center, and Research Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Ann N Y Acad Sci 1005:157-60. 2003
  6. doi request reprint TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndrome
    S S Solomon
    Department of Medicine, University of Tennessee Health Science Center, Veterans Affairs Medical Center, Memphis, USA
    Horm Metab Res 42:115-21. 2010
  7. ncbi request reprint Improved in vivo pancreatic islet function after prolonged in vitro islet culture
    A O Gaber
    Department of Surgery, University of Tennessee Health Science Center, College of Medicine, Memphis 38163, USA
    Transplantation 72:1730-6. 2001
  8. ncbi request reprint Toward a broader understanding of aldosterone in congestive heart failure
    Karl T Weber
    Division of Cardiovascular Diseases, University of Tennessee, Memphis, Tennessee, 38163, USA
    J Renin Angiotensin Aldosterone Syst 4:155-63. 2003
  9. ncbi request reprint Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone
    Manesh Thomas
    Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Heart Circ Physiol 293:H2361-6. 2007
  10. ncbi request reprint Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements
    Kayla D Goodwin
    Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center Memphis, Tennessee 38163, USA
    Am J Med Sci 332:73-8. 2006

Collaborators

  • Jian Wu
  • O M Sabek
  • S S Solomon
  • K T Weber
  • Yao Sun
  • Arnold Postlethwaite
  • D M Desiderio
  • Nilesh S Tannu
  • Kevin P Newman
  • L K Myers
  • Robert A Ahokas
  • Syamal K Bhattacharya
  • Vikram S Chhokar
  • Alex Vidal
  • Yelena Selektor
  • Manesh Thomas
  • Kayla D Goodwin
  • Gipsy Majumdar
  • Aliye L Runyan
  • Nataliya I Lenchik
  • Zhiqing Xing
  • Richard A Smith
  • Himanshu S Gadgil
  • A O Gaber
  • Rajendra Raghow
  • Adrienne Harrington
  • Laura D Carbone
  • James Hungerford
  • Antonio Martinez-Hernandez
  • Michael J Pabst
  • Li Lu
  • Francesco Giorgianni
  • Karen M Pabst
  • Paula A Herring
  • Linus A Wodi
  • Kenneth J Warrington
  • Sarka Beranova-Giorgianni
  • Edward S Umstot
  • C S Callicutt
  • M Y Kotb
  • D W Fraga

Detail Information

Publications27

  1. doi request reprint Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism
    Yelena Selektor
    Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Med Sci 335:105-10. 2008
    ..Parathyroidectomy prevents this scenario. Rats with ALDOST were cotreated with cinacalcet (Cina), a calcimimetic that raises the threshold of the parathyroids' Ca(2+)-sensing receptor...
  2. pmc Approaches to reduce false positives and false negatives in the analysis of microarray data: applications in type 1 diabetes research
    Jian Wu
    Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
    BMC Genomics 9:S12. 2008
    ....
  3. ncbi request reprint Genomes, transcriptomes, and proteomes: molecular medicine and its impact on medical practice
    Ivan C Gerling
    Division of Endocrinology, University of Tennessee Health Science Center, VAMC Research 151, 1030 Jefferson Ave, Memphis, TN 38104, USA
    Arch Intern Med 163:190-8. 2003
    ..Their potential use and impact are demonstrated by using diabetes mellitus as an example of a common and serious medical disorder. Finally, several potentially adverse consequences of "excessive" knowledge are discussed...
  4. ncbi request reprint New data analysis and mining approaches identify unique proteome and transcriptome markers of susceptibility to autoimmune diabetes
    Ivan C Gerling
    Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 28104, USA
    Mol Cell Proteomics 5:293-305. 2006
    ..The overall systems biology of prediabetic NOD mice points toward abnormalities in regulation of the opposing processes of cell renewal and cell death even before there are any clear signatures of immune system activation...
  5. ncbi request reprint Characterization of early developments in the splenic leukocyte transcriptome of NOD mice
    I C Gerling
    Department of Medicine, University of Tennessee Health Science Center, and Research Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Ann N Y Acad Sci 1005:157-60. 2003
    ..Herein, we report on characterization of the very earliest abnormalities in the transcriptome of leukocytes from young "prepathologic" NOD and NON female mice...
  6. doi request reprint TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndrome
    S S Solomon
    Department of Medicine, University of Tennessee Health Science Center, Veterans Affairs Medical Center, Memphis, USA
    Horm Metab Res 42:115-21. 2010
    ....
  7. ncbi request reprint Improved in vivo pancreatic islet function after prolonged in vitro islet culture
    A O Gaber
    Department of Surgery, University of Tennessee Health Science Center, College of Medicine, Memphis 38163, USA
    Transplantation 72:1730-6. 2001
    ....
  8. ncbi request reprint Toward a broader understanding of aldosterone in congestive heart failure
    Karl T Weber
    Division of Cardiovascular Diseases, University of Tennessee, Memphis, Tennessee, 38163, USA
    J Renin Angiotensin Aldosterone Syst 4:155-63. 2003
    ..The past decade has witnessed a revival of interest in this steroid molecule. In years to come, an even broader understanding of ALDOs contribution to the pathophysiology of congestive heart failure will undoubtedly emerge...
  9. ncbi request reprint Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone
    Manesh Thomas
    Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Heart Circ Physiol 293:H2361-6. 2007
    ..These findings may shed light on Zn dyshomeostasis found in patients with decompensated heart failure...
  10. ncbi request reprint Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements
    Kayla D Goodwin
    Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center Memphis, Tennessee 38163, USA
    Am J Med Sci 332:73-8. 2006
    ....
  11. ncbi request reprint Aldosteronism in heart failure: a proinflammatory/fibrogenic cardiac phenotype. Search for biomarkers and potential drug targets
    Karl T Weber
    Division of Cardiovascular Diseases, Department of Medicine, School of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Curr Drug Targets 4:505-16. 2003
    ....
  12. ncbi request reprint Hyperparathyroidism and the calcium paradox of aldosteronism
    Vikram S Chhokar
    Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Circulation 111:871-8. 2005
    ..We hypothesized that aldosterone/1% NaCl treatment (ALDOST) in rats enhances Ca2+ and Mg2+ excretion and leads to systemic effects, including bone loss...
  13. ncbi request reprint Two-dimensional gel electrophoresis characterization of the mouse leukocyte proteome, using a tri-reagent for protein extraction
    Nataliya I Lenchik
    Department of Medicine, University of Tennessee Health Science Center, Memphis, 38104, USA
    Proteomics 5:2202-9. 2005
    ..Furthermore, an average of 301 +/- 3.6 spots were found in gels from both sample preparation methods, whereas 71.7 +/- 8.1 and 49.7 +/- 2.3 spots were uniquely seen in tri-reagent and non-tri-reagent samples, respectively...
  14. pmc Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface
    Robert A Ahokas
    Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, Tenn, Memphis, Tenn 38163, USA
    Circ Res 93:e124-35. 2003
    ..ALDO receptor antagonism modulates this neuroendocrine-immune interface. The full text of this article is available online at http://www.circresaha.org...
  15. ncbi request reprint Aldosteronism: an immunostimulatory state precedes proinflammatory/fibrogenic cardiac phenotype
    Ivan C Gerling
    Division of Endocrinology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 285:H813-21. 2003
    ....
  16. ncbi request reprint Paraffin-wax-coated plates as matrix-assisted laser desorption/ionization sample support for high-throughput identification of proteins by peptide mass fingerprinting
    Nilesh S Tannu
    Department of Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, USA
    Anal Biochem 327:222-32. 2004
    ....
  17. ncbi request reprint Macro- and micronutrients in African-Americans with heart failure
    Syamal K Bhattacharya
    Department of Surgery, University of Tennessee Health Science Center, Memphis, USA
    Heart Fail Rev 11:45-55. 2006
    ..These findings call into question the need for nutriceutical treatment of heart failure and which is complementary to today's pharmaceuticals, especially in AA...
  18. ncbi request reprint Oxidative stress in aldosteronism
    Yao Sun
    Department of Medicine, Division of Cardiovascular Diseases, University of Tennessee Health Science Center, 920 Madison Ave, Suite 300, Memphis, 38163, USA
    Cardiovasc Res 71:300-9. 2006
    ..An emerging body of evidence suggests the nutritional management of CHF offers an approach that will be complementary to today's pharmaceutical-based strategies...
  19. ncbi request reprint Calcium paradox of aldosteronism and the role of the parathyroid glands
    Alex Vidal
    Division of Cardiovascular Diseases, Univ of Tennessee Health Science Center, 920 Madison Ave, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 290:H286-94. 2006
    ..SHPT plays a permissive role in the proinflammatory vascular phenotype...
  20. ncbi request reprint Insulin dynamically regulates calmodulin gene expression by sequential o-glycosylation and phosphorylation of sp1 and its subcellular compartmentalization in liver cells
    Gipsy Majumdar
    Research, Medical, and Pathology Services, Veterans Affairs Medical Center Memphis, Tennessee 38104, USA
    J Biol Chem 281:3642-50. 2006
    ..Thus, O-glycosylation of Sp1 appears to be critical for its localization into the nucleus, where it undergoes obligatory phosphorylation that is needed for Sp1 to activate calmodulin gene expression...
  21. ncbi request reprint Strain differences in allele and expression levels of CD72 on B-lymphocytes from NOD, AKR, NON and C57BL/6 mice
    Jian Wu
    Division of Endocrinology, Department of Medicine, University of Tennessee Health Sciences Center UTHSC, and Research Service, Veterans Affairs Medical Center, 151, 1030 Jefferson Avenue, Memphis, TN 38104, USA
    Immunol Lett 103:115-20. 2006
    ..The presence of the CD72c allele, as well as its low level of expression in NOD mice at 4 weeks of age, may be associated with B-lymphocyte hyper-responsiveness and resistance to activation-induced cell death...
  22. ncbi request reprint Loss of bone minerals and strength in rats with aldosteronism
    Vikram S Chhokar
    Division of Cardiovascular Diseases, Univ of Tennessee Health Science Center, 920 Madison Ave, Third Floor, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 287:H2023-6. 2004
    ..Thus the hypermagnesuria and hypercalciuria that accompany chronic Aldo-1% NaCl treatment contribute to the systemic appearance of oxidative/nitrosative stress and a wasting of bone minerals and strength...
  23. ncbi request reprint Responses in extracellular and intracellular calcium and magnesium in aldosteronism
    Aliye L Runyan
    Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee 38136, USA
    J Lab Clin Med 146:76-84. 2005
    ....
  24. ncbi request reprint Proteome of H-411E (liver) cells exposed to insulin and tumor necrosis factor-alpha: analysis of proteins involved in insulin resistance
    Solomon S Solomon
    Research and Medical Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    J Lab Clin Med 145:275-83. 2005
    ..Although one cannot detail the mechanism or mechanisms of TNF-alpha induced IR from this data alone, it is easy to relate all of these proteins to a role in insulin signal transduction and, hence, insulin resistance...
  25. ncbi request reprint Proteome of monocytes primed with lipopolysaccharide: analysis of the abundant proteins
    Himanshu S Gadgil
    Department of Molecular Sciences, The University of Tennessee Health Science Center, Memphis, USA
    Proteomics 3:1767-80. 2003
    ..Proteins that decreased in abundance were integrin alpha-IIB, protein disulfide isomerase, and platelet-activating factor acetylhydrolase. Many of these altered proteins have interesting functions in inflammation...
  26. ncbi request reprint Aldosteronism and a proinflammatory vascular phenotype: role of Mg2+, Ca2+, and H2O2 in peripheral blood mononuclear cells
    Robert A Ahokas
    Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, Tenn 38163, USA
    Circulation 111:51-7. 2005
    ....
  27. ncbi request reprint Functional characterization of two-dimensional gel-separated proteins using sequential staining
    Jian Wu
    Department of Medicine, University of Tennessee, Health Science Center, Memphis, TN 38104, USA
    Electrophoresis 26:225-37. 2005
    ....