John E Gerich

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Clinical significance, pathogenesis, and management of postprandial hyperglycemia
    John E Gerich
    Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Arch Intern Med 163:1306-16. 2003
  2. ncbi request reprint Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 290:E67-E77. 2006
  3. ncbi request reprint Mechanisms for the deterioration in glucose tolerance associated with HIV protease inhibitor regimens
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Diabetes 52:918-25. 2003
  4. ncbi request reprint Renal compensation for impaired hepatic glucose release during hypoglycemia in type 2 diabetes: further evidence for hepatorenal reciprocity
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Diabetes 52:1386-92. 2003
  5. ncbi request reprint Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes
    Christian Meyer
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 287:E1049-56. 2004
  6. ncbi request reprint Effects of glimepiride and glyburide on glucose counterregulation and recovery from hypoglycemia
    Ervin Szoke
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Metabolism 55:78-83. 2006
  7. ncbi request reprint Pathways for glucose disposal after meal ingestion in humans
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 284:E716-25. 2003
  8. ncbi request reprint Effect of aging on glucose homeostasis: accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance
    Ervin Szoke
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Diabetes Care 31:539-43. 2008
  9. ncbi request reprint Diagnostic and therapeutic implications of relationships between fasting, 2-hour postchallenge plasma glucose and hemoglobin a1c values
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Arch Intern Med 164:1627-32. 2004
  10. ncbi request reprint Postprandial hyperglycemia and cardiovascular disease
    John E Gerich
    Department of Medicine, University of Rochester, New York, USA
    Endocr Pract 12:47-51. 2006

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Clinical significance, pathogenesis, and management of postprandial hyperglycemia
    John E Gerich
    Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Arch Intern Med 163:1306-16. 2003
    ..This review summarizes epidemiologic and experimental studies linking postprandial hyperglycemia to cardiovascular disease and therapeutic approaches available and in development to treat this disorder...
  2. ncbi request reprint Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 290:E67-E77. 2006
    ..g., liver and muscle) into other tissues...
  3. ncbi request reprint Mechanisms for the deterioration in glucose tolerance associated with HIV protease inhibitor regimens
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Diabetes 52:918-25. 2003
    ....
  4. ncbi request reprint Renal compensation for impaired hepatic glucose release during hypoglycemia in type 2 diabetes: further evidence for hepatorenal reciprocity
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Diabetes 52:1386-92. 2003
    ....
  5. ncbi request reprint Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes
    Christian Meyer
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 287:E1049-56. 2004
    ..The latter may provide an explanation for the renal glycogen accumulation characteristic of diabetes mellitus as well as a mechanism by which hyperglycemia may lead to diabetic nephropathy...
  6. ncbi request reprint Effects of glimepiride and glyburide on glucose counterregulation and recovery from hypoglycemia
    Ervin Szoke
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Metabolism 55:78-83. 2006
    ..This differential effect on insulin secretion may be an important factor in explaining why glyburide causes severe hypoglycemia more frequently than glimepiride...
  7. ncbi request reprint Pathways for glucose disposal after meal ingestion in humans
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 284:E716-25. 2003
    ..The majority of glycogen is formed via the direct pathway ( approximately 73%)...
  8. ncbi request reprint Effect of aging on glucose homeostasis: accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance
    Ervin Szoke
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Diabetes Care 31:539-43. 2008
    ..To examine the effect of aging on insulin secretion (first- and second-phase insulin release) and insulin sensitivity in people with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT)...
  9. ncbi request reprint Diagnostic and therapeutic implications of relationships between fasting, 2-hour postchallenge plasma glucose and hemoglobin a1c values
    Hans J Woerle
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Arch Intern Med 164:1627-32. 2004
    ....
  10. ncbi request reprint Postprandial hyperglycemia and cardiovascular disease
    John E Gerich
    Department of Medicine, University of Rochester, New York, USA
    Endocr Pract 12:47-51. 2006
    ..To review the role of postprandial hyperglycemia in the development of type 2 diabetes mellitus and cardiovascular disease...
  11. ncbi request reprint Clinicians can help their patients control postprandial hyperglycemia as a means of reducing cardiovascular risk
    John E Gerich
    General Clinical Research Center, University of Rochester, 601 Elmwood Avenue, Box MED CRC, Rochester, NY 14642, USA
    Diabetes Educ 32:513-4, 520-2. 2006
    ..Case studies are presented to aid clinicians in helping patients learn how to measure and control their postprandial glucose levels...
  12. pmc Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono)
    Vivian A Fonseca
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Diabetes Care 35:1225-31. 2012
    ..To assess efficacy and safety of lixisenatide monotherapy in type 2 diabetes...
  13. doi request reprint Is a history of gestational diabetes related to risk factors for coronary heart disease?
    Kathleen B King
    University of Rochester School of Nursing, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Res Nurs Health 32:298-306. 2009
    ..01. Two-hour post-load glucose indicated that 45% of hGDM cases were pre-diabetic versus 20% of controls, p < or = .05. Non-diabetic women with a distant hGDM are at increased risk for DM and may be at increased risk for CHD...
  14. ncbi request reprint Role of impaired insulin secretion and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    Ervin Szoke
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Compr Ther 31:106-12. 2005
    ..Targeting both insulin resistance and impaired insulin secretion is therefore appropriate to prevent T2DM and to improve glycemic control in those with the disorder...
  15. ncbi request reprint Role of the kidney in hyperglycemia in type 2 diabetes
    Christian Meyer
    Department of Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue, Box MED CRC, Rochester, NY 14642, USA
    Curr Diab Rep 2:237-41. 2002
    ....
  16. ncbi request reprint The rationale for paired pre- and postprandial self-monitoring of blood glucose: the role of glycemic variability in micro- and macrovascular risk
    John E Gerich
    University of Rochester School of Medicine, Rochester, NY 14642, USA
    Curr Med Res Opin 23:1791-8. 2007
    ..Recent studies suggest that newer therapies specifically targeting postprandial hyperglycemia can significantly reduce postprandial glucose levels and improve overall glycemic control...
  17. pmc Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk
    Ajikumar V Aryangat
    University of Rochester, Rochester, New York 14642, USA
    Vasc Health Risk Manag 6:145-55. 2010
    ....
  18. ncbi request reprint Insulin glargine: long-acting basal insulin analog for improved metabolic control
    John E Gerich
    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box MED CRC, Rochester, NY 14642, USA
    Curr Med Res Opin 20:31-7. 2004
    ..This review describes the unique pharmacokinetic properties and clinical efficacy of insulin glargine...
  19. ncbi request reprint Novel insulins: expanding options in diabetes management
    John E Gerich
    Department of Medicine, Physiology, and Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Med 113:308-16. 2002
    ..Other long-acting analogs, such as fatty acid acylated insulins, have been tested in animal models and are being evaluated in clinical studies...
  20. ncbi request reprint Type 2 diabetes mellitus is associated with multiple cardiometabolic risk factors
    John E Gerich
    Endocrinology and Metabolism Unit, University of Rochester School of Medicine, Rochester, New York 14627, USA
    Clin Cornerstone 8:53-68. 2007
    ....
  21. ncbi request reprint The importance of tight glycemic control
    John E Gerich
    University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Med 118:7S-11S. 2005
    ..Meal-related self-monitoring of blood glucose can inform patients and their healthcare providers about postprandial glycemic excursions so that diet, exercise, or medications can be adjusted...
  22. ncbi request reprint Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus
    John E Gerich
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mayo Clin Proc 78:447-56. 2003
    ..Therefore, clinicians managing type 2 diabetes must reduce insulin resistance and augment and/or replace beta-cell function...
  23. ncbi request reprint Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?
    John E Gerich
    Department of Medicine, University of Rochester, Rochester, NY, USA
    Diabetes 51:S117-21. 2002
    ....
  24. pmc Advances in diabetes for the millennium: understanding insulin resistance
    John E Gerich
    Clinical Research Center, University of Rochester School of Medicine, Rochester, New York, USA
    MedGenMed 6:11. 2004
    ..Therefore, agents that improve beta-cell function (such as sulfonylureas and meglitinides) and insulin sensitizers (such as metformin and thiazolidinediones) both are useful alone or in combination for treating type 2 diabetes...
  25. ncbi request reprint Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis
    Christian Meyer
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 282:E419-27. 2002
    ..We postulate that increases in postprandial renal glucose release may play a role in facilitating efficient liver glycogen repletion by permitting substantial suppression of hepatic glucose release...
  26. ncbi request reprint Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes Importance of postprandial glycemia to achieve target HbA1c levels
    Hans J Woerle
    Department of Internal Medicine II, Clinical Research Unit CRU, Ludwig Maximilian University Munich, Grosshadern Marchioninistr 15, Munich 81377, Germany
    Diabetes Res Clin Pract 77:280-5. 2007
    ..Cross-sectional studies suggest that attainment of HbA1c goals requires specific targeting of postprandial hyperglycemia...
  27. ncbi request reprint The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications
    Beth Elaine Dunning
    PharmaWrite, Princeton, New Jersey 08540, USA
    Endocr Rev 28:253-83. 2007
    ....
  28. ncbi request reprint Disturbances in beta-cell function in impaired fasting glycemia
    Timon W van Haeften
    Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes 51:S265-70. 2002
    ..05). We conclude that the early stages of glucose intolerance are associated with disturbances in beta-cell function, while insulin resistance is seen more markedly in later stages...
  29. ncbi request reprint Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes
    Zarmen Israelian
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, USA
    Diabetes Care 28:2691-6. 2005
    ..The present studies were therefore undertaken to test the hypothesis that these may be improved by increasing this decrement in insulin secretion...
  30. ncbi request reprint Autoregulation of endogenous glucose production during hyperglucagonemia
    Ingrid Toft
    Institute of Clinical Medicine, University of Tromsø, Norway
    Metabolism 51:1128-34. 2002
    ..5 +/- 0.6 versus 11.6 +/- 0.6 micromol/kg/min (P =.19). We conclude that in normal volunteers, neither hyperglucagonemia nor the combination of hyperglucagonemia and increased substrate availability alters the autoregulation of EGP...
  31. ncbi request reprint Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial
    Jay S Skyler
    University of Miami, School of Medicine, Miami, FL 33136, USA
    Diabetes Care 28:1630-5. 2005
    ..We investigated whether a basal/bolus insulin regimen involving rapid-acting, dry powder, inhaled insulin could provide glycemic control comparable with a basal/bolus subcutaneous regimen...
  32. ncbi request reprint Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans
    Niyaz R Gosmanov
    Carl T Hayden VA Medical Center, 650 E Indian School Road, Phoenix, AZ 85012, USA
    Diabetes Care 28:1124-31. 2005
    ..However, in humans this role of decreased intraislet insulin is still unclear...
  33. ncbi request reprint Multiple defects in counterregulation of hypoglycemia in modestly advanced type 2 diabetes mellitus
    Zarmen Israelian
    Department of Endocrinology, Carl T Hayden VA Medical Center, Phoenix, AZ 85012, and Department of Medicine, University of Rochester School of Medicine, NY 14642, USA
    Metabolism 55:593-8. 2006
    ..These include delayed and reduced decreases in insulin secretion, and impaired increases of plasma glucagon and growth hormone...