Scott A Gerber

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Local expression of interleukin-2 by B16 melanoma cells results in decreased tumour growth and long-term tumour dormancy
    Scott A Gerber
    University of Rochester School of Medicine and Dentistry, Department of Microbiology and Immunology, Rochester, NY, USA
    Immunology 138:280-92. 2013
  2. pmc IFN-γ mediates the antitumor effects of radiation therapy in a murine colon tumor
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Pathol 182:2345-54. 2013
  3. pmc IL-12 suppresses vascular endothelial growth factor receptor 3 expression on tumor vessels by two distinct IFN-gamma-dependent mechanisms
    Elizabeth W Sorensen
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 184:1858-66. 2010
  4. ncbi request reprint Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity
    Amit A Lugade
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 180:3132-9. 2008
  5. pmc Omental immune aggregates and tumor metastasis within the peritoneal cavity
    Elizabeth W Sorensen
    Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
    Immunol Res 45:185-94. 2009
  6. pmc Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    Am J Pathol 169:1739-52. 2006
  7. ncbi request reprint Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor
    Amit A Lugade
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 174:7516-23. 2005
  8. doi request reprint G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation
    Syamantak Majumder
    From the Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY S M, M P S, T T, C K C, A M G Y, B C B, J P and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY S A G, E M L
    Arterioscler Thromb Vasc Biol 34:419-26. 2014
  9. doi request reprint Radio-responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY
    Int J Cancer 134:2383-92. 2014
  10. ncbi request reprint Characterization of a lymph node within the mouse prostate: Detailed analysis using whole mount histology
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York
    Prostate 63:105-16. 2005

Collaborators

  • Shawn P Murphy
  • Jinjiang Pang
  • Troy D Randall
  • Leonard D Shultz
  • Edith M Lord
  • John G Frelinger
  • Elizabeth W Sorensen
  • Amit A Lugade
  • Abigail L Sedlacek
  • James P Moran
  • Syamantak Majumder
  • Joanne Y H Lim
  • Sandra J Yokota
  • Ryan J Cummings
  • Tamlyn Thomas
  • Bradford C Berk
  • Amy Mohan
  • Mark P Sowden
  • Christine K Christie
  • Guoyong Yin
  • Robert R Parsons
  • Nico Van Rooijen
  • Kunle Odunsi
  • Richard B Bankert
  • Jenni L Loyall
  • John G Facciponte
  • Sathy V Balu-Iyer
  • Raymond J Kelleher
  • Jennifer L Judge
  • Alice P Pentland
  • Julie L Ryan
  • Viktoriya Y Rybalko
  • Winnie M Chan
  • Robert C Rose
  • Celeste A Martin

Detail Information

Publications15

  1. pmc Local expression of interleukin-2 by B16 melanoma cells results in decreased tumour growth and long-term tumour dormancy
    Scott A Gerber
    University of Rochester School of Medicine and Dentistry, Department of Microbiology and Immunology, Rochester, NY, USA
    Immunology 138:280-92. 2013
    ..Surprisingly however, the B16 tumours were not completely eliminated but instead were controlled for an extended period of time, suggesting that a form of tumour dormancy was established...
  2. pmc IFN-γ mediates the antitumor effects of radiation therapy in a murine colon tumor
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Pathol 182:2345-54. 2013
    ..More importantly, elimination of CD8(+) T cells completely abrogated the effects of radiation therapy. Our data suggest that IFN-γ plays a pivotal role in mediating the antitumor effects of IR therapy...
  3. pmc IL-12 suppresses vascular endothelial growth factor receptor 3 expression on tumor vessels by two distinct IFN-gamma-dependent mechanisms
    Elizabeth W Sorensen
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 184:1858-66. 2010
    ..Our data indicate a mechanism in which tumor-infiltrating immune cells regulate tumor vessel phenotype...
  4. ncbi request reprint Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity
    Amit A Lugade
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 180:3132-9. 2008
    ..These increases in MHC class I expression correlated with greater levels of activated STAT1. Thus, IFN-gamma is instrumental in creating a tumor microenvironment conducive for T cell infiltration and tumor cell target recognition...
  5. pmc Omental immune aggregates and tumor metastasis within the peritoneal cavity
    Elizabeth W Sorensen
    Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
    Immunol Res 45:185-94. 2009
    ....
  6. pmc Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    Am J Pathol 169:1739-52. 2006
    ..These sites provide metastatic cells with a microenvironment highly conducive to survival and subsequent growth...
  7. ncbi request reprint Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor
    Amit A Lugade
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 174:7516-23. 2005
    ..Together these results suggest that localized radiation can increase both the generation of antitumor immune effector cells and their trafficking to the tumor site...
  8. doi request reprint G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation
    Syamantak Majumder
    From the Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY S M, M P S, T T, C K C, A M G Y, B C B, J P and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY S A G, E M L
    Arterioscler Thromb Vasc Biol 34:419-26. 2014
    ..We have showed previously that GIT1 is required for postnatal angiogenesis during lung development. However, the functional role of GIT1 in pathological angiogenesis during tumor growth is unknown...
  9. doi request reprint Radio-responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY
    Int J Cancer 134:2383-92. 2014
    ..Therefore, the efficacy of RT may depend on the strength of the immune response induced after radiotherapy. Additionally, immunotherapy that further stimulates the immune cells may enhance the effectiveness of RT. ..
  10. ncbi request reprint Characterization of a lymph node within the mouse prostate: Detailed analysis using whole mount histology
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York
    Prostate 63:105-16. 2005
    ..Due to the prevalence of prostate disease, there is a growing interest in the immunobiology of the prostate and its contribution to such pathologies. Further study is needed to fully characterize immune responses within the prostate...
  11. doi request reprint Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8(+) T cells
    Joanne Y H Lim
    Department of Microbiology and Immunology, University of Rochester, Rochester, 601 Elmwood Ave, Box 672, Rochester, NY, 14642, USA
    Cancer Immunol Immunother 63:259-71. 2014
    ..Our preclinical approach to study the effects of local increase in IFN-α levels can be used to further optimize the combination therapy strategy in terms of dosing and scheduling, which may lead to better clinical outcome. ..
  12. pmc Generation of a dual-functioning antitumor immune response in the peritoneal cavity
    Abigail L Sedlacek
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York
    Am J Pathol 183:1318-28. 2013
    ..Collectively, these data demonstrate that the peritoneal cavity has a unique environment capable of eliciting potent specific and nonspecific antitumor immune responses. ..
  13. pmc Exposure to ionizing radiation induces the migration of cutaneous dendritic cells by a CCR7-dependent mechanism
    Ryan J Cummings
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 189:4247-57. 2012
    ..Taken together, these data suggest that IR exposure may result in diminished immunosurveillance in the skin, which could render the host more susceptible to pathogens...
  14. pmc Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model
    Sandra J Yokota
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA
    Cancer Immun 13:11. 2013
    ..The OTX model provides for the first time the opportunity to study in vivo the cellular and molecular events contributing to the arrest in T cell function in human ovarian tumors. ..
  15. ncbi request reprint Transfection of the genes for interleukin-12 into the K1735 melanoma and the EMT6 mammary sarcoma murine cell lines reveals distinct mechanisms of antitumor activity
    James P Moran
    Department of Microbiology and Immunology and James P Wilmot Cancer Center, University of Rochester, Rochester, NY, USA
    Int J Cancer 106:690-8. 2003
    ..In contrast, IL-12 does not induce protective immunity to K1735 tumors. However, an antiangiogenic mechanism may be responsible for controlling tumor growth...