Joseph F Gera
Affiliation: University of California
- AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expressionJoseph F Gera
Department of Medicine, West Los Angeles Veteran s Administration UCLA Medical Center, University of California School of Medicine, Los Angeles, California 90073, USA
J Biol Chem 279:2737-46. 2004..These results identify two critical downstream molecular targets whose expression is regulated by AKT activity and whose down-regulation is required for rapamycin/CCI-779 sensitivity...
- IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1Yijiang Shi
Department of Medicine, Greater Los Angeles VA Healthcare System and University of California at Los Angeles Medical School, Los Angeles, California, USA
Cancer Res 68:10215-22. 2008..These data point to hnRNP A1 as a critical regulator of c-myc translation and a potential therapeutic target in multiple myeloma...