GEORGE GEORGIOU GEORGIOU
Affiliation: University of Texas
Lee J, Paparoditis P, Horton A, Frühwirth A, McDaniel J, Jung J, et al
. Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations. Cell Host Microbe. 2019;25:367-376.e5 pubmed publisher
..This analysis reveals how "serological imprinting" impacts responses to influenza and suggests that once elicited, cross-reactive antibodies targeting the HA stem can persist for years. ..
Johnson E, Doria Rose N, Gorman J, Bhiman J, Schramm C, Vu A, et al
. Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation. Nat Commun. 2018;9:4136 pubmed publisher
..Our results thus underscore the utility of analyzing exons and introns simultaneously for studying antibody maturation and repertoire selection. ..
Georgiou G, Masip L. Biochemistry. An overoxidation journey with a return ticket. Science. 2003;300:592-4 pubmed
Georgiou G, Segatori L. Preparative expression of secreted proteins in bacteria: status report and future prospects. Curr Opin Biotechnol. 2005;16:538-45 pubmed
..In parallel, protein design and directed evolution approaches are beginning to be exploited for engineering of the cellular protein folding machinery to achieve further improvements in protein expression. ..
Kelton W, Mehta N, Charab W, Lee J, Lee C, Kojima T, et al
. IgGA: a "cross-isotype" engineered human Fc antibody domain that displays both IgG-like and IgA-like effector functions. Chem Biol. 2014;21:1603-9 pubmed publisher
..The multitude of IgGA effector functions could be important for therapeutic purposes and highlights the concept of engineering antibodies that combine effector functions from multiple antibody isotypes. ..
Wine Y, Horton A, Ippolito G, Georgiou G. Serology in the 21st century: the molecular-level analysis of the serum antibody repertoire. Curr Opin Immunol. 2015;35:89-97 pubmed publisher
..Additionally, these technologies also hold great promise for therapeutic antibody and biomarker discovery in a variety of settings. ..
Georgiou G, Jeong K. Proteins from PHB granules. Protein Sci. 2005;14:1385-6 pubmed
DeKosky B, Lungu O, Park D, Johnson E, Charab W, Chrysostomou C, et al
. Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires. Proc Natl Acad Sci U S A. 2016;113:E2636-45 pubmed publisher
..The data reported here address several longstanding questions regarding antibody repertoire selection and development and provide a benchmark for future repertoire-scale analyses of antibody responses to vaccination and disease. ..