Michael K Georgieff

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Long-term brain and behavioral consequences of early iron deficiency
    Michael K Georgieff
    Center for Neurobehavioral Development, University of Minnesota School of Medicine and College of Education and Human Development, Minneapolis, Minnesota 55455, USA
    Nutr Rev 69:S43-8. 2011
  2. ncbi request reprint Controversial nutrients that potentially affect preterm neurodevelopment: essential fatty acids and iron
    Michael K Georgieff
    University of Minnesota School of Medicine, Minneapolis 55455, USA
    Pediatr Res 57:99R-103R. 2005
  3. pmc The role of iron in neurodevelopment: fetal iron deficiency and the developing hippocampus
    Michael K Georgieff
    Department of Pediatrics, Division of Neonatology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Biochem Soc Trans 36:1267-71. 2008
  4. ncbi request reprint Nutrition and the developing brain: nutrient priorities and measurement
    Michael K Georgieff
    Department of Pediatrics and Child Development, University of Minnesota School of Medicine, Minneapolis, MN, USA
    Am J Clin Nutr 85:614S-620S. 2007
  5. ncbi request reprint In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus
    Lakshmi Raman
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Brain Res Dev Brain Res 156:202-9. 2005
  6. pmc Iron supplementation dose for perinatal iron deficiency differentially alters the neurochemistry of the frontal cortex and hippocampus in adult rats
    Raghavendra Rao
    Department of Pediatrics, Neonatology Division, University of Minnesota, Minneapolis, MN, USA
    Pediatr Res 73:31-7. 2013
  7. pmc Perinatal iron deficiency predisposes the developing rat hippocampus to greater injury from mild to moderate hypoxia-ischemia
    Raghavendra Rao
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 27:729-40. 2007
  8. pmc Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis
    ERIK S CARLSON
    Department of Pediatrics, University of Minnesota School of Medicine, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Brain Res 1237:75-83. 2008
  9. pmc Fetal and neonatal iron deficiency causes volume loss and alters the neurochemical profile of the adult rat hippocampus
    Raghavendra Rao
    Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Nutr Neurosci 14:59-65. 2011
  10. pmc Using event-related potentials to study perinatal nutrition and brain development in infants of diabetic mothers
    Raye Ann deRegnier
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Dev Neuropsychol 31:379-96. 2007

Research Grants

  1. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2000
  2. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2009
  3. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2008
  4. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2007
  5. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2006
  6. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2005
  7. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2004
  8. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2003
  9. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2002
  10. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2002

Detail Information

Publications68

  1. pmc Long-term brain and behavioral consequences of early iron deficiency
    Michael K Georgieff
    Center for Neurobehavioral Development, University of Minnesota School of Medicine and College of Education and Human Development, Minneapolis, Minnesota 55455, USA
    Nutr Rev 69:S43-8. 2011
    ..Recent studies have demonstrated long-term genomic changes, which suggests the regulation of brain function is fundamentally altered...
  2. ncbi request reprint Controversial nutrients that potentially affect preterm neurodevelopment: essential fatty acids and iron
    Michael K Georgieff
    University of Minnesota School of Medicine, Minneapolis 55455, USA
    Pediatr Res 57:99R-103R. 2005
  3. pmc The role of iron in neurodevelopment: fetal iron deficiency and the developing hippocampus
    Michael K Georgieff
    Department of Pediatrics, Division of Neonatology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Biochem Soc Trans 36:1267-71. 2008
    ..Early iron sufficiency is critical for long-term neurological health...
  4. ncbi request reprint Nutrition and the developing brain: nutrient priorities and measurement
    Michael K Georgieff
    Department of Pediatrics and Child Development, University of Minnesota School of Medicine, Minneapolis, MN, USA
    Am J Clin Nutr 85:614S-620S. 2007
    ....
  5. ncbi request reprint In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus
    Lakshmi Raman
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Brain Res Dev Brain Res 156:202-9. 2005
    ..The altered hippocampal neurochemistry during its development may underlie some of the cognitive deficits present in human infants at risk of chronic hypoxia...
  6. pmc Iron supplementation dose for perinatal iron deficiency differentially alters the neurochemistry of the frontal cortex and hippocampus in adult rats
    Raghavendra Rao
    Department of Pediatrics, Neonatology Division, University of Minnesota, Minneapolis, MN, USA
    Pediatr Res 73:31-7. 2013
    ..Whether high-dose iron supplementation prevents these deficits is yet to be determined...
  7. pmc Perinatal iron deficiency predisposes the developing rat hippocampus to greater injury from mild to moderate hypoxia-ischemia
    Raghavendra Rao
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 27:729-40. 2007
    ....
  8. pmc Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis
    ERIK S CARLSON
    Department of Pediatrics, University of Minnesota School of Medicine, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Brain Res 1237:75-83. 2008
    ..Our results suggest a role for neonatal iron deficiency in dysregulation of genes that may set the stage for long-term neurodegenerative disease and that this may occur through a histone modification mechanism...
  9. pmc Fetal and neonatal iron deficiency causes volume loss and alters the neurochemical profile of the adult rat hippocampus
    Raghavendra Rao
    Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Nutr Neurosci 14:59-65. 2011
    ..The objective of the present study was to determine the long-term effects of perinatal iron deficiency and its treatment on hippocampal anatomy and neurochemistry in formerly iron-deficient young adult rats...
  10. pmc Using event-related potentials to study perinatal nutrition and brain development in infants of diabetic mothers
    Raye Ann deRegnier
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Dev Neuropsychol 31:379-96. 2007
    ..This study highlights the value of using ERPs to translate basic science information obtained from animal models to the development of the human infant...
  11. pmc Early-life iron deficiency anemia alters neurotrophic factor expression and hippocampal neuron differentiation in male rats
    Phu V Tran
    Department of Pediatrics, Center for Neurobehavioral Development, University of Minnesota, Minneapolis, MN 55455, USA
    J Nutr 138:2495-501. 2008
    ..Our findings suggest that fetal-neonatal iron deficiency lowers BDNF function and impairs neuronal differentiation in the hippocampus...
  12. pmc Long-term reduction of hippocampal brain-derived neurotrophic factor activity after fetal-neonatal iron deficiency in adult rats
    Phu V Tran
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Res 65:493-8. 2009
    ..These findings may underlie the persistence of learning deficits seen after fetal-neonatal iron deficiency...
  13. pmc Fetal iron deficiency alters the proteome of adult rat hippocampal synaptosomes
    Phu V Tran
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
    Am J Physiol Regul Integr Comp Physiol 305:R1297-306. 2013
    ..Importantly, the findings uncover previously unsuspected pathways, including neuronal nitric oxide synthase signaling, identifying additional mechanisms that may contribute to the long-term biobehavioral deficits. ..
  14. doi request reprint Iron deficiency after arrival is associated with general cognitive and behavioral impairment in post-institutionalized children adopted from Eastern Europe
    Anita J Fuglestad
    Institute of Child Development, University of Minnesota, 51 E River Parkway, Minneapolis, MN 55455, USA
    Matern Child Health J 17:1080-7. 2013
    ..Additionally, developmental evaluation is recommended in those with iron deficiency, even in children with good iron status at arrival...
  15. pmc Decelerated early growth in infants of overweight and obese mothers
    Katie Larson Ode
    Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    J Pediatr 161:1028-34. 2012
    ..To investigate the relationship between maternal prepregnancy body mass index and early infant growth and body composition...
  16. pmc Gestational and neonatal iron deficiency alters apical dendrite structure of CA1 pyramidal neurons in adult rat hippocampus
    Katyarina E Brunette
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minn, USA
    Dev Neurosci 32:238-48. 2010
    ....
  17. pmc Iron is essential for neuron development and memory function in mouse hippocampus
    ERIK S CARLSON
    Medical Scientist Training Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Nutr 139:672-9. 2009
    ..Deletion of Slc11a2 disrupts hippocampal neuronal development and spatial memory behavior...
  18. pmc Gestational and lactational iron deficiency alters the developing striatal metabolome and associated behaviors in young rats
    Kay L Ward
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    J Nutr 137:1043-9. 2007
    ..These novel data imply that alterations in the metabolite profile of the striatum likely influence later neural functioning in early iron deficiency...
  19. pmc Neuronal-specific iron deficiency dysregulates mammalian target of rapamycin signaling during hippocampal development in nonanemic genetic mouse models
    Stephanie J B Fretham
    Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, USA
    J Nutr 143:260-6. 2013
    ..05). Together, these findings implicate mTOR dysregulation as a cellular mechanism underlying the acute and persistent neurodevelopmental deficits that accompany early-life ID...
  20. doi request reprint The relationship of poor linear growth velocity with neonatal illness and two-year neurodevelopment in preterm infants
    Sara E Ramel
    Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA
    Neonatology 102:19-24. 2012
    ..Understanding this relationship is important because organ growth and differentiation are more tightly linked to lean body mass and thus linear growth...
  21. pmc The role of iron in learning and memory
    Stephanie J B Fretham
    Department of Pediatrics Neonatology Division, University of Minnesota, Minneapolis, MN 55455, USA
    Adv Nutr 2:112-21. 2011
    ..The learning deficits in adulthood likely result from interactions between direct and indirect effects that contribute to abnormal hippocampal structure and plasticity...
  22. pmc Effects of gestational iron deficiency on fear conditioning in juvenile and adult rats
    Jonathan C Gewirtz
    Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, USA
    Brain Res 1237:195-203. 2008
    ....
  23. ncbi request reprint Dissociating the long-term effects of fetal/neonatal iron deficiency on three types of learning in the rat
    Adam T Schmidt
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Behav Neurosci 121:475-82. 2007
    ..These findings likely reflect long-term reduction in but not abolition of hippocampus-dependent learning and preserved function in other brain structures (e.g., striatum and amygdala)...
  24. pmc The assessment of newborn iron stores at birth: a review of the literature and standards for ferritin concentrations
    Ashajyothi M Siddappa
    Division of Neonatology, Hennepin County Medical Center, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minn, USA
    Neonatology 92:73-82. 2007
    ..The lack of normative newborn serum ferritin concentration data between 23 and 41 weeks has led to difficulty in establishing the incidence and degree of abnormal iron status in the neonatal period...
  25. ncbi request reprint Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus
    Raghavendra Rao
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    J Nutr 133:3215-21. 2003
    ..An altered neurochemical profile of the developing hippocampus may underlie some of the cognitive deficits observed in human infants with perinatal iron deficiency...
  26. ncbi request reprint Exploratory study of the relationship of fat-free mass to speed of brain processing in preterm infants
    Katie M Pfister
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
    Pediatr Res 74:576-83. 2013
    ..The relationship between postnatal body composition and speed of brain processing in preterm infants is unknown...
  27. ncbi request reprint Fetal iron deficiency disrupts the maturation of synaptic function and efficacy in area CA1 of the developing rat hippocampus
    Lyric A Jorgenson
    Graduate Program in Neuroscience, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Hippocampus 15:1094-102. 2005
    ....
  28. pmc Iron in fetal and neonatal nutrition
    Raghavendra Rao
    Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Semin Fetal Neonatal Med 12:54-63. 2007
    ..However, due to the potential for oxidant-mediated tissue injury, iron overload should be avoided in the perinatal period, especially in preterm infants...
  29. pmc Delayed alternation performance in rats following recovery from early iron deficiency
    Adam T Schmidt
    University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
    Physiol Behav 101:503-8. 2010
    ..These findings may reflect an imbalance between hippocampal and prefrontal modulation of this behavior most likely emanating from long-term hippocampal disinhibition by early ID that persists in spite of early iron treatment from P 7...
  30. ncbi request reprint Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta
    Jenni Bradley
    University of Minnesota, Mayo Mail Code 39, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Am J Physiol Regul Integr Comp Physiol 287:R894-901. 2004
    ..IRP-1 may have a more dominant role than IRP-2 activity in regulating ferritin expression...
  31. ncbi request reprint Iron deficiency alters auditory recognition memory in newborn infants of diabetic mothers
    Ashajyothi M Siddappa
    Division of Neonatology, Department of Pediatrics, University of Minnesota, MN 55455, USA
    Pediatr Res 55:1034-41. 2004
    ..These impairments map onto areas of the developing brain known to be vulnerable to iron deficiency...
  32. pmc Metabolomic analysis of cerebrospinal fluid indicates iron deficiency compromises cerebral energy metabolism in the infant monkey
    Raghavendra Rao
    Department of Pediatrics, Division of Neonatology, University of Minnesota, Mayo Mail Code 391, 420 Delaware Street, SE, Minneapolis, MN 55455
    Neurochem Res 38:573-80. 2013
    ..This distinctive metabolomic profile associated with anemia in the young infant indicates that CSF can be employed to track the neurological effects of iron deficiency and benefits of iron supplementation...
  33. pmc Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus
    Phu V Tran
    Center for Neurobehavioral Development, University of Minnesota, Minneapolis MN, USA
    Am J Physiol Endocrinol Metab 302:E316-24. 2012
    ..Early postnatal iron treatment of gestational iron deficiency reactivates the IGF system and promotes neurogenesis and differentiation in the hippocampus during a critical developmental period...
  34. ncbi request reprint Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus
    ERIK S CARLSON
    Medical Scientist Training Program, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Hippocampus 17:679-91. 2007
    ..The study provides targets for future studies in elucidating molecular mechanisms underpinning iron's role in cognitive development and function...
  35. pmc Sodium depletion increases sympathetic neurite outgrowth and expression of a novel TMEM35 gene-derived protein (TUF1) in the rat adrenal zona glomerulosa
    Phu V Tran
    Center for Neurobehavioral Development, Department of Pediatrics, University of Minnesota, MMC 39 Mayo, 420 Delaware Street SE, Minneapolis, Minnesota 55455
    Endocrinology 151:4852-60. 2010
    ..Moreover, TUF1 mRNA in rat ZG cells increased after angiotensin II exposure in vitro. Collectively, these findings suggest that TMEM35/TUF1 is a candidate for modulating neurite outgrowth in the ZG after sodium depletion...
  36. pmc Reticulocyte enrichment of zinc protoporphyrin/heme discriminates impaired iron supply during early development
    Sharon E Blohowiak
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53715, USA
    Pediatr Res 64:63-7. 2008
    ....
  37. ncbi request reprint Body composition changes in preterm infants following hospital discharge: comparison with term infants
    Sara E Ramel
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    J Pediatr Gastroenterol Nutr 53:333-8. 2011
    ....
  38. ncbi request reprint Electrographic imaging of recognition memory in 34-38 week gestation intrauterine growth restricted newborns
    Linda S Black
    Department of Pediatrics, Emory University, Atlanta, GA 30032, USA
    Exp Neurol 190:S72-83. 2004
    ....
  39. ncbi request reprint Perinatal iron deficiency alters apical dendritic growth in hippocampal CA1 pyramidal neurons
    Lyric A Jorgenson
    Department of Pediatrics, Center for Neurobehavioral Development, University of Minnesota, Minneapolis, Minn, USA
    Dev Neurosci 25:412-20. 2003
    ..These structural abnormalities may contribute to the learning and memory deficits that occur during and following early iron deficiency...
  40. pmc Iron therapy for preterm infants
    Raghavendra Rao
    Division of Neonatology, Department of Pediatrics, University of Minnesota, Mayo Mail Code 39, 420 Delaware Street, SE, Minneapolis, MN 55455, USA
    Clin Perinatol 36:27-42. 2009
    ....
  41. ncbi request reprint The role of chronic hypoxia in the development of neurocognitive abnormalities in preterm infants with bronchopulmonary dysplasia
    Lakshmi Raman
    Department of Pediatrics, Hennepin County Medical Center, Minneapolis, MN, USA
    Dev Sci 9:359-67. 2006
    ..However, due to the simultaneous occurrence of multiple neurodevelopmental risk factors, a primary or potentiating role for chronic hypoxia in these impairments has yet to be conclusively established...
  42. doi request reprint Evidence for a hyporesponsive limbic-hypothalamic-pituitary-adrenal axis following early-life repetitive hypoglycemia in adult male rats
    Ashton E Lehmann
    Center for Neurobehavioral Development, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Physiol Regul Integr Comp Physiol 301:R484-90. 2011
    ..The findings are consistent with the developmental origins of disease and underscore the influences of early-life events on the programming of a major regulatory system...
  43. doi request reprint Iron deficiency in international adoptees from Eastern Europe
    Anita J Fuglestad
    Department of Pediatrics, Institute of Child Development, International Adoption Program, Center for Neurobehavioral Development, University of Minnesota, Minneapolis, MN 55455, USA
    J Pediatr 153:272-7. 2008
    ..To assess iron deficiency (ID) in international adoptees after adoption...
  44. pmc Early-life iron deficiency anemia alters the development and long-term expression of parvalbumin and perineuronal nets in the rat hippocampus
    Liam S N Callahan
    Department of Pediatrics, Center for Neurobehavioral Development, University of Minnesota, Minneapolis, Minn, USA
    Dev Neurosci 35:427-36. 2013
    ..The findings provide additional potential cellular bases for previously described electrophysiologic and behavioral abnormalities found during and following early-life IDA...
  45. ncbi request reprint The effect of maternal diabetes during pregnancy on the neurodevelopment of offspring
    Michael K Georgieff
    Center for Neurobehavioral Development, University of Minnesota, USA
    Minn Med 89:44-7. 2006
    ....
  46. ncbi request reprint Childhood cancer following neonatal oxygen supplementation
    Logan G Spector
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 54555, USA
    J Pediatr 147:27-31. 2005
    ..To evaluate the relationship between neonatal oxygen supplementation (O2) and childhood cancer in the Collaborative Perinatal Project (CPP)...
  47. ncbi request reprint Electrophysiologic evidence of impaired cross-modal recognition memory in 8-month-old infants of diabetic mothers
    Charles A Nelson
    Center for Neurobehavioral Development, the Institute of Child Development, Minneapolis, MN 55455, USA
    J Pediatr 142:575-82. 2003
    ..The purpose of this study was to further investigate memory development in infants of diabetic mothers (IDMs) by evaluating cross-modal recognition memory followed by behavioral memory testing at 8 months of age...
  48. doi request reprint Early postnatal weight gain, intellectual performance, and body mass index at 7 years of age in term infants with intrauterine growth restriction
    Mary Pylipow
    Division of Neonatology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Pediatr 154:201-6. 2009
    ..To determine whether the postnatal growth rate of infants with intrauterine growth restriction (IUGR) is associated with later cognitive function and body mass index (BMI)...
  49. doi request reprint Nutritional practices in the neonatal intensive care unit: analysis of a 2006 neonatal nutrition survey
    Deborah M Hans
    Departments of aPediatrics and cEducational Psychology, University of Minnesota, Minneapolis, Minnesota, USA
    Pediatrics 123:51-7. 2009
    ..The goal of this investigation was to determine how current parenteral nutrition and enteral nutrition practice intentions for preterm infants compare with published recommendations and previous feeding practices...
  50. ncbi request reprint Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy
    Ivan Tkac
    Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 50:24-32. 2003
    ..The current data may serve as a reference for studies focused on developmental defects and pathologies using neonatal rat models...
  51. pmc Maternal pregnancy events and exposures and risk of hepatoblastoma: a Children's Oncology Group (COG) study
    Jessica R B Musselman
    Department of Pediatrics, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Epidemiol 37:318-20. 2013
    ..Hepatoblastoma is a rare childhood liver cancer with an obscure etiology, however it is potentially associated with selected pregnancy events and hepatoblastoma risk in offspring...
  52. ncbi request reprint Infants of diabetic mothers
    Joan L Nold
    Department of Pediatrics and Child Development, University of Minnesota, MMC 39, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Pediatr Clin North Am 51:619-37, viii. 2004
    ..Clinicians must continue to have a high degree of suspicion for the diagnosis of diabetes during gestation and screen offspring of women with gestational diabetes for neonatal sequelae...
  53. ncbi request reprint Iron status at 9 months of infants with low iron stores at birth
    Michael K Georgieff
    Departments of Pediatrics, The Institute for Child Development, and the Center for Neurobehavioral Development, University of Minnesota, Minneapolis, USA
    J Pediatr 141:405-9. 2002
    ..The mean follow-up ferritins, incidences of iron deficiency and iron-deficiency anemia, and growth rates from 0 to 12 months were compared between the two groups...
  54. ncbi request reprint Neurobehavioural functioning in neonatal intensive care unit graduates in late childhood and early adolescence
    W John Curtis
    Institute of Child Development, University of Minnesota, Minneapolis 55455, USA
    Brain 125:1646-59. 2002
    ..The implications of this finding for discerning the effects of neural plasticity over and above normal brain maturational processes are discussed...
  55. ncbi request reprint Preterm nutrition and the brain
    Sara E Ramel
    Division of Neonatology, University of Minnesota Amplatz Children s Hospital, University of Minnesota School of Medicine, Minneapolis, Minn, USA
    World Rev Nutr Diet 110:190-200. 2014
    ....
  56. pmc Managing incidental findings in human subjects research: analysis and recommendations
    Susan M Wolf
    University of Minnesota, MN, USA
    J Law Med Ethics 36:219-48, 211. 2008
    ..We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed...
  57. ncbi request reprint Influences of postconceptional age and postnatal experience on the development of auditory recognition memory in the newborn infant
    Raye Ann deRegnier
    Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA
    Dev Psychobiol 41:216-25. 2002
    ..Maturation of the auditory recognition memory pathway is not contingent upon maturation of the "P2" peak thought to arise from primary auditory cortex...
  58. ncbi request reprint Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain
    Asha Jyothi M Siddappa
    Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis 55455, USA
    Pediatr Res 53:800-7. 2003
    ..Brain iron distribution during ID seems to be locally rather than globally regulated...
  59. ncbi request reprint Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain
    Asha Jyothi M Siddappa
    Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    J Neurosci Res 68:761-75. 2002
    ..These developmental changes in IRP and transporter expression suggest potentially different time periods of brain structure vulnerability to iron deficiency or iron overload...
  60. pmc Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats
    Barbara T Felt
    Center for Human Growth and Development and Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, 48109, USA
    Behav Brain Res 171:261-70. 2006
    ..We recently reported that rats with chronic perinatal IDA, had altered regional brain iron, monoamines, and sensorimotor skill emergence during early development...
  61. pmc Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeys
    Mari S Golub
    University of California, Davis, Davis, CA 95616, USA
    Am J Clin Nutr 83:647-56. 2006
    ..Iron deficiency anemia (IDA) is relatively common in the third trimester of pregnancy, but causal associations with low birth weight and compromised neonatal iron status are difficult to establish in human populations...
  62. ncbi request reprint Moderate iron deficiency in infancy: biology and behavior in young rats
    John L Beard
    Department of Nutrition, Penn State University, PA 16802, USA
    Behav Brain Res 170:224-32. 2006
    ..Similar developmental delays in iron deficient human infants suggest to us that alterations in iron status during this developmental period likely affects developing brain monaminergic systems in these infants...
  63. ncbi request reprint Effects of prenatal betamethasone exposure on regulation of stress physiology in healthy premature infants
    Elysia Poggi Davis
    Department of Psychiatry and Human Behavior, University of California Irvine, City Tower, 333 City Boulevard West, Orange, CA 92868, USA
    Psychoneuroendocrinology 29:1028-36. 2004
    ..These findings suggest that antenatal corticosteroids suppress infants' HPA response to a stressor typically encountered in a neonatal intensive care situation...
  64. pmc Explicit memory performance in infants of diabetic mothers at 1 year of age
    Tracy DeBoer
    Institute of Child Development and Center for Neurobehavioral Development, University of Minnesota, USA
    Dev Med Child Neurol 47:525-31. 2005
    ....
  65. ncbi request reprint The effect of adverse intrauterine and newborn environments on cognitive development: the experiences of premature delivery and diabetes during pregnancy
    Heather Whitney Sesma
    University of Minnesota, USA
    Dev Psychopathol 15:991-1015. 2003
    ..Finally we offer an integrated model for investigating cognitive outcomes in infants of diabetic mothers that incorporates data from animal, electrophysiological, and behavioral measures...
  66. ncbi request reprint Iron deficiency and brain development
    Betsy Lozoff
    Center for Human Growth and Development, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109 0406, USA
    Semin Pediatr Neurol 13:158-65. 2006
    ..This body of research emphasizes the importance of protecting the developing brain from ID...

Research Grants12

  1. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2000
    ..4 T magnetic resonance spectroscopy to identify hippocampal abnormalities due to iron deficiency. The metabolic results will be correlated with behavior and histochemical changes. ..
  2. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2009
    ..abstract_text> ..
  3. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2008
    ..abstract_text> ..
  4. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2007
    ..abstract_text> ..
  5. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2006
    ..abstract_text> ..
  6. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2005
    ..abstract_text> ..
  7. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2004
    ..4 T magnetic resonance spectroscopy to identify hippocampal abnormalities due to iron deficiency. The metabolic results will be correlated with behavior and histochemical changes. ..
  8. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2003
    ..4 T magnetic resonance spectroscopy to identify hippocampal abnormalities due to iron deficiency. The metabolic results will be correlated with behavior and histochemical changes. ..
  9. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2002
    ..4 T magnetic resonance spectroscopy to identify hippocampal abnormalities due to iron deficiency. The metabolic results will be correlated with behavior and histochemical changes. ..
  10. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2002
    ..4 T magnetic resonance spectroscopy to identify hippocampal abnormalities due to iron deficiency. The metabolic results will be correlated with behavior and histochemical changes. ..
  11. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2001
    ..4 T magnetic resonance spectroscopy to identify hippocampal abnormalities due to iron deficiency. The metabolic results will be correlated with behavior and histochemical changes. ..
  12. NEWBORN IRON DEFICIENCY
    Michael Georgieff; Fiscal Year: 2009
    ..abstract_text> ..