J N George

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. doi request reprint The Oklahoma Thrombotic Thrombocytopenic Purpura-haemolytic Uraemic Syndrome Registry. A model for clinical research, education and patient care
    J N George
    University of Oklahoma Health Sciences Center, Hematology Oncology Section, Oklahoma City, OK 73126 0901, USA
    Hamostaseologie 33:105-12. 2013
  2. doi request reprint Evaluation of patients with microangiopathic hemolytic anemia and thrombocytopenia
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Semin Thromb Hemost 39:153-60. 2013
  3. doi request reprint Diagnostic and therapeutic challenges in the thrombotic thrombocytopenic purpura and hemolytic uremic syndromes
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126 0901, USA
    Hematology Am Soc Hematol Educ Program 2012:604-9. 2012
  4. doi request reprint Ten patient stories illustrating the extraordinarily diverse clinical features of patients with thrombotic thrombocytopenic purpura and severe ADAMTS13 deficiency
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Clin Apher 27:302-11. 2012
  5. doi request reprint Corticosteroids and rituximab as adjunctive treatments for thrombotic thrombocytopenic purpura
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Am J Hematol 87:S88-91. 2012
  6. doi request reprint Sequence of treatments for adults with primary immune thrombocytopenia
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Am J Hematol 87:S12-5. 2012
  7. doi request reprint Thrombotic microangiopathic syndromes associated with drugs, HIV infection, hematopoietic stem cell transplantation and cancer
    James N George
    The University of Oklahoma Health Sciences Center, College of Public Health, Department of Biostatistics and Epidemiology, P O Box 73190, Oklahoma City, United States
    Presse Med 41:e177-88. 2012
  8. pmc Impact of chronic Immune Thrombocytopenic Purpura (ITP) on health-related quality of life: a conceptual model starting with the patient perspective
    Susan D Mathias
    Health Outcomes Solutions, P, O, Box 2343 Winter Park, Florida 32790, USA
    Health Qual Life Outcomes 6:13. 2008
  9. pmc A disease-specific measure of health-related quality of life for use in adults with immune thrombocytopenic purpura: its development and validation
    Susan D Mathias
    Ovation Research Group, 188 Embarcadero, San Francisco, CA 94105, USA
    Health Qual Life Outcomes 5:11. 2007
  10. doi request reprint Congenital thrombotic thrombocytopenic purpura: Lessons for recognition and management of rare syndromes
    James N George
    Colleges of Public Health and Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Pediatr Blood Cancer 50:947-8. 2008

Research Grants

  1. Clinical Research Training Institute
    James George; Fiscal Year: 2005
  2. 2006 Clinical Research Training Institute
    James George; Fiscal Year: 2006
  3. Oklahoma-UT Southwestern Hemostasis Consortium
    James George; Fiscal Year: 2007

Detail Information

Publications95

  1. doi request reprint The Oklahoma Thrombotic Thrombocytopenic Purpura-haemolytic Uraemic Syndrome Registry. A model for clinical research, education and patient care
    J N George
    University of Oklahoma Health Sciences Center, Hematology Oncology Section, Oklahoma City, OK 73126 0901, USA
    Hamostaseologie 33:105-12. 2013
    ..During our follow-up, patients have also educated Registry investigators about problems that persist after recovery from an acute episode of TTP. Most important, Registry data have resulted in important improvements for patient care...
  2. doi request reprint Evaluation of patients with microangiopathic hemolytic anemia and thrombocytopenia
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Semin Thromb Hemost 39:153-60. 2013
    ..Awareness of the many etiologies of TMA is essential for the appropriate evaluation of patients presenting with microangiopathic hemolytic anemia and thrombocytopenia and the appropriate diagnosis of TTP...
  3. doi request reprint Diagnostic and therapeutic challenges in the thrombotic thrombocytopenic purpura and hemolytic uremic syndromes
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126 0901, USA
    Hematology Am Soc Hematol Educ Program 2012:604-9. 2012
    ..Minor cognitive abnormalities are common, the frequency of depression is increased, and the frequency of hypertension is increased. Careful long-term follow-up of TTP patients is essential...
  4. doi request reprint Ten patient stories illustrating the extraordinarily diverse clinical features of patients with thrombotic thrombocytopenic purpura and severe ADAMTS13 deficiency
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Clin Apher 27:302-11. 2012
    ..These patients' stories illustrate the clinical spectrum of TTP with ADAMTS13 deficiency and emphasize the difficulties of clinical diagnosis...
  5. doi request reprint Corticosteroids and rituximab as adjunctive treatments for thrombotic thrombocytopenic purpura
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Am J Hematol 87:S88-91. 2012
    ..Future potential options for adjuvant treatment, recombinant ADAMTS13 to correct severe ADAMTS13 deficiency, and agents to block von Willebrand factor-mediated platelet thrombosis are being investigated...
  6. doi request reprint Sequence of treatments for adults with primary immune thrombocytopenia
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Am J Hematol 87:S12-5. 2012
    ....
  7. doi request reprint Thrombotic microangiopathic syndromes associated with drugs, HIV infection, hematopoietic stem cell transplantation and cancer
    James N George
    The University of Oklahoma Health Sciences Center, College of Public Health, Department of Biostatistics and Epidemiology, P O Box 73190, Oklahoma City, United States
    Presse Med 41:e177-88. 2012
    ..Recognition that these syndromes may mimic TTP is important to provide appropriate management and to avoid the inappropriate use of plasma exchange treatment...
  8. pmc Impact of chronic Immune Thrombocytopenic Purpura (ITP) on health-related quality of life: a conceptual model starting with the patient perspective
    Susan D Mathias
    Health Outcomes Solutions, P, O, Box 2343 Winter Park, Florida 32790, USA
    Health Qual Life Outcomes 6:13. 2008
    ..The aim of this research is to develop a conceptual model to describe the impact of ITP and its treatment on patients' health-related quality of life (HRQoL)...
  9. pmc A disease-specific measure of health-related quality of life for use in adults with immune thrombocytopenic purpura: its development and validation
    Susan D Mathias
    Ovation Research Group, 188 Embarcadero, San Francisco, CA 94105, USA
    Health Qual Life Outcomes 5:11. 2007
    ..Therefore, we sought to develop and validate the ITP-Patient Assessment Questionnaire (ITP-PAQ) for adult subjects with ITP...
  10. doi request reprint Congenital thrombotic thrombocytopenic purpura: Lessons for recognition and management of rare syndromes
    James N George
    Colleges of Public Health and Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Pediatr Blood Cancer 50:947-8. 2008
  11. doi request reprint Lessons learned from the Oklahoma thrombotic thrombocytopenic purpura-hemolytic uremic syndrome registry
    James N George
    College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126 0901, USA
    J Clin Apher 23:129-37. 2008
    ....
  12. ncbi request reprint Overlapping features of thrombotic thrombocytopenic purpura and systemic lupus erythematosus
    James N George
    Hematology Oncology Section, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    South Med J 100:512-4. 2007
  13. ncbi request reprint Evaluation and management of patients with thrombotic thrombocytopenic purpura
    James N George
    Hematology Oncology Section, College of Medicine, Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    J Intensive Care Med 22:82-91. 2007
    ..The continuing mortality from TTP, the risks of plasma exchange treatment, and the potential for recurrent episodes of TTP are clinical challenges that remain to be solved...
  14. ncbi request reprint Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome following allogeneic HPC transplantation: a diagnostic dilemma
    James N George
    Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Transfusion 44:294-304. 2004
    ..Nevertheless, because multiple transplant-related sequela can cause the characteristic clinical features of TTP-HUS, the diagnosis is difficult...
  15. ncbi request reprint For low platelets, how low is dangerous?
    James N George
    Hematology Oncology Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Cleve Clin J Med 71:277-8. 2004
  16. ncbi request reprint Rituximab therapy for thrombotic thrombocytopenic purpura: a proposed study of the Transfusion Medicine/Hemostasis Clinical Trials Network with a systematic review of rituximab therapy for immune-mediated disorders
    James N George
    Hematology Oncology Section, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, 73190, USA
    J Clin Apher 21:49-56. 2006
    ..These observations from small uncontrolled case series provide the background and rationale for a randomized clinical trial to establish the role of rituximab in the management of patients with TTP...
  17. ncbi request reprint Management of patients with refractory immune thrombocytopenic purpura
    J N George
    Hematology Oncology Section, Department of Biostatistics and Epidemiology, Colleges of Medicine and Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    J Thromb Haemost 4:1664-72. 2006
    ..In preliminary reports, these agents have been effective in maintaining safe platelet counts in patients with chronic ITP that was refractory to splenectomy and other treatments...
  18. ncbi request reprint Tibor Greenwalt Award. The Oklahoma Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome Registry: a program for patient care, education and research
    James N George
    Hematology Oncology Section, Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Transfusion 44:1384-92. 2004
    ..The Oklahoma TTP-HUS Registry provides educational and research opportunities, in addition to improved patient care, and serves as a model for productive collaboration of community blood centers and universities...
  19. ncbi request reprint The role of ADAMTS13 in the pathogenesis of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome
    James N George
    The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Clin Adv Hematol Oncol 3:627-32. 2005
    ..This interpretation is consistent with other vascular and thrombotic disorders in which multiple risk factors and associated conditions contribute to the etiology of acute events...
  20. doi request reprint Improved quality of life for romiplostim-treated patients with chronic immune thrombocytopenic purpura: results from two randomized, placebo-controlled trials
    James N George
    Colleges of Medicine and Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126 0901, USA
    Br J Haematol 144:409-15. 2009
    ..These results suggest that adult patients with chronic ITP have improved HRQoL following romiplostim therapy...
  21. ncbi request reprint Clinical practice. Thrombotic thrombocytopenic purpura
    James N George
    Hematology Oncology Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    N Engl J Med 354:1927-35. 2006
  22. doi request reprint Clinical insights from observations on ADAMTS13 deficiency in liver cirrhosis
    James N George
    College of Public Health and Medicine, The University of Oklahoma Health Sciences Center, Hematology Oncology Section, Oklahoma City, OK 73126 0901, USA
    Thromb Haemost 99:987-8. 2008
  23. ncbi request reprint Systemic malignancies as a cause of unexpected microangiopathic hemolytic anemia and thrombocytopenia
    James N George
    Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126 0901, USA
    Oncology (Williston Park) 25:908-14. 2011
    ..Recognition of a systemic malignancy is critical to the initiation of appropriate chemotherapy and avoidance of inappropriate use of plasma exchange treatment...
  24. doi request reprint The Oklahoma Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome Registry: the Swiss connection
    James N George
    Colleges of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Eur J Haematol 80:277-86. 2008
    ..With effective treatment it is more frequently diagnosed, the clinical presentations are more diverse, and long-term sequelae are becoming recognized...
  25. doi request reprint How I treat patients with thrombotic thrombocytopenic purpura: 2010
    James N George
    Department of Biostatistics and Epidemiology, College of Public Health, Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Blood 116:4060-9. 2010
    ..Although recovery may appear to be complete, many patients have persistent minor cognitive abnormalities. More effective as well as safer treatment for TTP is needed...
  26. ncbi request reprint Occult quinine-induced thrombocytopenia
    K Kojouri
    College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    J Okla State Med Assoc 93:519-21. 2000
    ..The diagnosis thrombocytopenia caused by common drugs can be difficult, requiring persistent, explicit questions...
  27. ncbi request reprint Unintentional platelet removal by plasmapheresis
    J J Perdue
    Hematology-Oncology Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Clin Apher 16:55-60. 2001
    ..40, P = 0.011). In these 39 patients, the platelet counts were significantly decreased at 24 hours (P = 0.002)...
  28. ncbi request reprint ADAMTS13, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome
    James N George
    The University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Curr Hematol Rep 4:167-9. 2005
  29. ncbi request reprint The Oklahoma Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome (TTP-HUS) Registry: a community perspective of patients with clinically diagnosed TTP-HUS
    James N George
    Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, 73190, USA
    Semin Hematol 41:60-7. 2004
    ..Prospective data from consecutive patients are essential to translate new observations on pathogenesis into improved patient care...
  30. ncbi request reprint Evaluation of women with clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome during pregnancy
    J R McMinn
    Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    J Clin Apher 16:202-9. 2001
    ..This review addresses the evaluation and management of these syndromes and describes a clinical approach for determining when plasma exchange is appropriate...
  31. ncbi request reprint Idiopathic thrombocytopenic purpura in adults: current issues for pathogenesis, diagnosis and management
    James N George
    University of Oklahoma Health Sciences Center, Oklahoma City, USA
    Hematol J 5:S12-4. 2004
  32. ncbi request reprint The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency
    D R Terrell
    Hematology Oncology Section, Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    J Thromb Haemost 3:1432-6. 2005
    ..Previous estimates have been indirect and have not reported data on patients with ADAMTS-13 deficiency...
  33. ncbi request reprint Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: diagnosis and treatment
    J N George
    Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Cleve Clin J Med 68:857-8, 860, 863-4 passim. 2001
    ..Nevertheless, death and long-term complications remain common. The recent relaxation of diagnostic criteria has dramatically increased the number of patients treated for clinically suspected TTP-HUS...
  34. ncbi request reprint Thrombotic thrombocytopenic purpura-like syndromes following bone marrow transplantation: an analysis of associated conditions and clinical outcomes
    V Roy
    Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Bone Marrow Transplant 27:641-6. 2001
    ..3) Urgent intervention with plasma exchange when TTP is suspected following BMT may not always be appropriate. Alternative explanations for the signs and symptoms should be considered and treated aggressively...
  35. doi request reprint Sporadic bloody diarrhoea-associated thrombotic thrombocytopenic purpura-haemolytic uraemic syndrome: an adult and paediatric comparison
    Charity A Karpac
    College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Br J Haematol 141:696-707. 2008
    ..05 for all differences). Awareness of the continuous occurrence of sporadic bloody diarrhoea-associated TTP-HUS in adults is important for prompt diagnosis and appropriate management...
  36. ncbi request reprint Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome
    P J Medina
    Department of Pharmacy, Clinical and Administrative Sciences, College of Pharmacy and Hematology Oncology Section, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73190, USA
    Curr Opin Hematol 8:286-93. 2001
    ..Recognition of a drug-associated etiology in a patient with TTP-HUS is critical to avoid re-exposure and recurrent illness...
  37. ncbi request reprint How I treat patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome
    J N George
    Hematology Oncology Section, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Blood 96:1223-9. 2000
    ..Multipractice clinical trials are required to define optimal management. (Blood. 2000;96:1223-1229)..
  38. ncbi request reprint Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: diagnosis and management
    J N George
    Oklahoma Blood Institute, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    J Clin Apher 13:120-5. 1998
    ..This review describes the evolution of the syndrome of TTP-HUS in the current era of effective treatment, and describes the management and clinical outcomes among patients treated by the Oklahoma Blood Institute...
  39. ncbi request reprint Platelets
    J N George
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Lancet 355:1531-9. 2000
    ..Thrombocytopenia and disorders of platelet function cause petechiae and mucocutaneous bleeding. Drugs causing specific inhibition of platelet function are important in the treatment of cardiovascular and cerebrovascular disease...
  40. ncbi request reprint Iron overload manifesting as apparent exacerbation of hepatic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    Rammurti T Kamble
    Oklahoma University Health Sciences Center, Oklahoma City, Oklahama 73190, USA
    Biol Blood Marrow Transplant 12:506-10. 2006
    ....
  41. doi request reprint The incidence of immune thrombocytopenic purpura in children and adults: A critical review of published reports
    Deirdra R Terrell
    Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, 73126 0901, USA
    Am J Hematol 85:174-80. 2010
    ..3 per 10(5) adults/year. An important limitation of these studies is that they are primarily from Europe and may not be generalizable to all regions...
  42. pmc Different disparities of gender and race among the thrombotic thrombocytopenic purpura and hemolytic-uremic syndromes
    Deirdra R Terrell
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126 0901, USA
    Am J Hematol 85:844-7. 2010
    ..These observations of different gender and race disparities among the TTP-HUS syndromes suggest the presence of different risk factors and may serve as starting points for novel investigations of pathogenesis...
  43. ncbi request reprint The association of pregnancy with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome
    James N George
    The University of Oklahoma Health Sciences Center, Hematology Oncology Section, PO Box 26901, Oklahoma City, OK 73190, USA
    Curr Opin Hematol 10:339-44. 2003
    ....
  44. ncbi request reprint Disseminated malignancy misdiagnosed as thrombotic thrombocytopenic purpura: A report of 10 patients and a systematic review of published cases
    Kristin K Francis
    Hematology Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Room CHB 358, PO Box 26901, Oklahoma City, Oklahoma 73190, USA
    Oncologist 12:11-9. 2007
    ....
  45. doi request reprint Demographic and ADAMTS13 biomarker data as predictors of early recurrences of idiopathic thrombotic thrombocytopenic purpura
    Spero R Cataland
    Department of Medicine, Columbus, OH, USA
    Eur J Haematol 83:559-64. 2009
    ..We studied the clinical utility of demographic and ADAMTS13 biomarker data to predict the risk for exacerbation...
  46. ncbi request reprint ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients
    Sara K Vesely
    Hematology Oncology Section, The University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Blood 102:60-8. 2003
    ..Therefore, severe ADAMTS13 deficiency does not detect all patients who may be appropriately diagnosed with TTP-HUS and who may respond to plasma exchange treatment...
  47. ncbi request reprint Treatment of drug-induced thrombocytopenia
    Stacey D Zondor
    College of Pharmacy, Department of Pharmacy, University of Oklahoma Health Sciences Center, 1110 North Stonewall, Post Office Box 26901, Oklahoma City, OK 73190 5040, USA
    Expert Opin Drug Saf 1:173-80. 2002
    ....
  48. ncbi request reprint Initial management of immune thrombocytopenic purpura in adults: a randomized controlled trial comparing intermittent anti-D with routine care
    James N George
    Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Am J Hematol 74:161-9. 2003
    ..However, compliance with this anti-D regimen was not feasible for many patients and/or their physicians...
  49. ncbi request reprint Idiopathic thrombocytopenic purpura: current issues for pathogenesis, diagnosis, and management in children and adults
    James N George
    Hematology Oncology Section, The University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Curr Hematol Rep 2:381-7. 2003
    ..Because major bleeding in ITP is rare, physicians must be certain that the adverse effects of treatment are not worse than the risks of bleeding caused by ITP...
  50. ncbi request reprint Thrombotic thrombocytopenic purpura: a syndrome that keeps evolving
    James N George
    Hematology Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Clin Apher 19:63-5. 2004
  51. ncbi request reprint Recent advances in the treatment of chronic refractory immune thrombocytopenic purpura
    Kiarash Kojouri
    Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Int J Hematol 81:119-25. 2005
    ..An alternative approach, the stimulation of platelet production with thrombopoietic agents, has been successful in investigational studies and may provide a new management option...
  52. ncbi request reprint Quinine-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: frequency, clinical features, and long-term outcomes
    K Kojouri
    Hematology-Oncology Section, Department of Medicine, University of Oklahoma Health Sciences Center, Box 26901, Oklahoma City, OK 73190, USA
    Ann Intern Med 135:1047-51. 2001
    ..If recurrent disease is to be prevented, clinicians must recognize quinine as a possible cause...
  53. ncbi request reprint Idiopathic thrombocytopenic purpura: diagnosis and management
    J N George
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Am J Med Sci 316:87-93. 1998
    ..This review describes the clinical features of ITP in adults, emphasizes the principal unresolved issues in diagnosis and management, and outlines the critical areas for future research...
  54. doi request reprint Corticosteroid side-effects and risk for bleeding in immune thrombocytopenic purpura: patient and hematologist perspectives
    Jacqueline A Guidry
    Department of Biostatistics and Epidemiology, College of Public Health University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126 0901, USA
    Eur J Haematol 83:175-82. 2009
    ..We hypothesized that patients with ITP may have more concern about corticosteroid side-effects and less concern about serious bleeding than hematologists...
  55. ncbi request reprint Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports
    Karen K Swisher
    Hematology Oncology Section, Department of Medicine, College of Medicine, The University of Oklahoma Health Science Center, Oklahoma City, OK 73190, USA
    Haematologica 92:936-43. 2007
    ..We describe the occurrence of TTP-HUS following pancreatitis and consider whether pancreatitis may be a triggering event for acute episodes of TTP-HUS...
  56. ncbi request reprint Pregnancy outcomes after recovery from thrombotic thrombocytopenic purpura-hemolytic uremic syndrome
    Sara K Vesely
    Hematology Oncology Section, Department of Medicine, College of Medicine, The University of Oklahoma Health Science Center, Oklahoma City, Oklahoma
    Transfusion 44:1149-58. 2004
    ..Recurrent thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) during a subsequent pregnancy is an important concern because pregnancy may increase the risk for relapse...
  57. doi request reprint Long-term deficits in health-related quality of life after recovery from thrombotic thrombocytopenic purpura
    Qurana F Lewis
    Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Transfusion 49:118-24. 2009
    ..After recovery from thrombotic thrombocytopenic purpura (TTP), patients commonly describe persistent problems with memory, concentration, and endurance...
  58. ncbi request reprint The Oklahoma Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome Registry: a community service
    Kristina K Johnson
    Department of Biostatistics and Epidemiology, College of Public Health, OUHSC, Oklahoma City, OK 73190, USA
    J Okla State Med Assoc 100:273-8. 2007
    ..Registry data are an important source of information for physicians and their patients, providing a complete community perspective of these uncommon disorders...
  59. ncbi request reprint Idiopathic thrombocytopenic purpura: a guideline for diagnosis and management of children and adults. American Society of Hematology
    J N George
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Ann Med 30:38-44. 1998
    ..This review describes the principle features of ITP in children and adults, the process of development of the practice guideline for ITP, and the implications of the guideline for the diagnosis and management of patients with ITP...
  60. doi request reprint Clinical outcomes after platelet transfusions in patients with thrombotic thrombocytopenic purpura
    Karen K Swisher
    Hematology Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Transfusion 49:873-87. 2009
    ..Reports of deterioration and death after platelet (PLT) transfusions in patients with thrombotic thrombocytopenic purpura (TTP) have led to recommendations that they should not be given except for life-threatening hemorrhage...
  61. ncbi request reprint Management of adult patients with persistent idiopathic thrombocytopenic purpura following splenectomy: a systematic review
    Sara K Vesely
    University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Ann Intern Med 140:112-20. 2004
    ..Treatment of chronic refractory idiopathic thrombocytopenic purpura is a dilemma because many patients have minimal symptoms, response to treatment is uncertain, and treatments may have serious adverse effects...
  62. ncbi request reprint Thrombotic microangiopathy following allogeneic hematopoietic stem cell transplantation
    Kiarash Kojouri
    Hematology Oncology Section, Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Curr Opin Oncol 19:148-54. 2007
    ..The aim of this article is to assess the current understanding and uncertainties about the evaluation and management of thrombotic microangiopathy that occurs following allogeneic hematopoietic stem cell transplantation...
  63. ncbi request reprint Twice-daily plasma exchange for patients with refractory thrombotic thrombocytopenic purpura: the experience of the Oklahoma Registry, 1989 through 2006
    Loan Nguyen
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Science Center, Oklahoma City, OK 73190, USA
    Transfusion 48:349-57. 2008
    ..Twice-daily plasma exchange has been used for patients with thrombotic thrombocytopenic purpura (TTP) who are unresponsive to treatment with daily plasma exchange for many years but with no clear evidence of effectiveness...
  64. ncbi request reprint Endemic Esherichia coil O157:H7 infections and hemolytic-uremic syndrome in Oklahoma, 2002-2005
    Charity A Karpac
    Department of Health Administration and Policy, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    J Okla State Med Assoc 100:429-33. 2007
    ..Although interpretation is limited by the few reports to OSDH, our data suggest that E. coli O157:H7 infections and HUS, presumably related to contaminated food, are endemic throughout Oklahoma...
  65. doi request reprint Frequency and significance of HIV infection among patients diagnosed with thrombotic thrombocytopenic purpura
    Melody Benjamin
    Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126 0901, USA
    Clin Infect Dis 48:1129-37. 2009
    ..Case series of patients with a diagnosis of thrombotic thrombocytopenic purpura (TTP) have reported different frequencies of human immunodeficiency virus (HIV) infection; some series suggest that HIV infection may cause TTP...
  66. ncbi request reprint A support group for patients who have recovered from thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS): The six-year experience of the Oklahoma TTP-HUS Study Group
    Mark A Howard
    Hematology Oncology Section, Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    J Clin Apher 18:16-20. 2003
    ..The experience of The Oklahoma TTP-HUS Study Group suggests that it serves a previously unmet need...
  67. pmc Identifying drugs that cause acute thrombocytopenia: an analysis using 3 distinct methods
    Jessica A Reese
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Blood 116:2127-33. 2010
    ..Multiple methods, each with a distinct perspective, can contribute to the identification of drugs that can cause thrombocytopenia...
  68. ncbi request reprint Self-reported initial management of childhood idiopathic thrombocytopenic purpura: results of a survey of members of the American Society of Pediatric Hematology/Oncology, 2001
    Sara K Vesely
    Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    J Pediatr Hematol Oncol 25:130-3. 2003
    ..This information provides the basis for designing a randomized clinical trial to compare the effect of different management strategies on the outcomes of bleeding symptoms, side effects of therapy, costs, and quality of life...
  69. ncbi request reprint Salmonella sepsis caused by a platelet transfusion from a donor with a pet snake
    Mehrdad Jafari
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    N Engl J Med 347:1075-8. 2002
  70. ncbi request reprint Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications
    Kiarash Kojouri
    Hematology Oncology Section, Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, USA
    Blood 104:2623-34. 2004
    ..6% (88 of 921 patients) with laparoscopic splenectomy. Although the risk of surgery is an important consideration, splenectomy provides a high frequency of durable responses for adult patients with ITP...
  71. doi request reprint Thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation: an autopsy study
    Koushan Siami
    Department of Pathology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73190, USA
    Transplantation 85:22-8. 2008
    ..The aims of this autopsy study were to determine the correlation between clinical and pathologic diagnosis of PTMA, to define the precise morphologic spectrum of PTMA, and to seek for potential etiologic factors...
  72. ncbi request reprint Initial management of adults with idiopathic (immune) thrombocytopenic purpura
    J N George
    Hematology Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Blood Rev 16:37-8. 2002
    ..The use of WinRho may also reveal the occurrence of spontaneous remissions, a previously unrecognized subgroup of adults with chronic ITP...
  73. doi request reprint Cognitive deficits after recovery from thrombotic thrombocytopenic purpura
    April S Kennedy
    Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126 0901, USA
    Transfusion 49:1092-101. 2009
    ..Patients with apparent complete recovery from thrombotic thrombocytopenic purpura (TTP) often complain of problems with memory, concentration, and fatigue...
  74. ncbi request reprint Clinical cardiac involvement in thrombotic thrombocytopenic purpura: a systematic review
    Beau M Hawkins
    Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Transfusion 48:382-92. 2008
    ..Autopsy studies consistently demonstrate cardiac involvement in thrombotic thrombocytopenic purpura (TTP), but clinical evidence for cardiac abnormalities is rarely reported...
  75. ncbi request reprint Complete recovery from refractory immune thrombocytopenic purpura in three patients treated with etanercept
    J R McMinn
    Hematology Oncology Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Am J Hematol 73:135-40. 2003
    ..On the basis of these case reports, a clinical trial has been initiated to systematically evaluate the efficacy and risks of etanercept in the management of children and adults with chronic ITP...
  76. doi request reprint Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages
    Derek J Royer
    Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Eur J Haematol 84:421-9. 2010
    ....
  77. ncbi request reprint Bilateral nephrectomy for treatment resistant systemic lupus erythematosis and thrombotic thrombocytopenic purpura: a case report
    Michael Feldman
    Am J Hematol 82:496-7. 2007
  78. ncbi request reprint Idiopathic thrombocytopenic purpura and myelodysplastic syndrome: distinct entities or overlapping syndromes?
    James N George
    Leuk Res 26:789-90. 2002
  79. ncbi request reprint An evaluation of cyclosporin and corticosteroids individually as adjuncts to plasma exchange in the treatment of thrombotic thrombocytopenic purpura
    Spero R Cataland
    Division of Hematology Oncology, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    Br J Haematol 136:146-9. 2007
    ..042). These data suggest that cyclosporin may have advantages over corticosteroids as an adjunct to PE therapy in the initial treatment of idiopathic TTP...
  80. ncbi request reprint Complications of plasma exchange in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: a study of 78 additional patients
    J R McMinn
    Transfusion 43:415-6. 2003
  81. ncbi request reprint Complications of plasma exchange in patients treated for clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome
    Mark A Howard
    Transfusion 46:154-6. 2006
  82. ncbi request reprint Thrombotic thrombocytopenic purpura: from the bench to the bedside, but not yet to the community
    James N George
    Ann Intern Med 138:152-3. 2003
  83. ncbi request reprint Thrombotic thrombocytopenic purpura: advances in pathophysiology, diagnosis, and treatment--introduction
    Bernhard Lammle
    Central Hematology Laboratory, Inselspital, University of Bern, Switzerland
    Semin Hematol 41:1-3. 2004
  84. ncbi request reprint Immune thrombocytopenic purpura--let the treatment fit the patient
    James N George
    N Engl J Med 349:903-5. 2003
  85. ncbi request reprint Cyclosporin and plasma exchange in thrombotic thrombocytopenic purpura: long-term follow-up with serial analysis of ADAMTS13 activity
    Spero R Cataland
    Division of Hematology Oncology, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    Br J Haematol 139:486-93. 2007
    ..These data suggest that the efficacy of CSA is at least in part related to its suppression of the antibody inhibitor of ADAMTS13 and a subsequent improvement in ADAMTS13 activity and antigen...
  86. doi request reprint Acquired thrombotic thrombocytopenic purpura: ADAMTS13 activity, anti-ADAMTS13 autoantibodies and risk of recurrent disease
    Bernhard Lammle
    Haematologica 93:172-7. 2008
  87. ncbi request reprint Thrombotic thrombocytopenic purpura: 2008 update
    Mark A Crowther
    Division of Hematology, McMaster University, Hamilton, Ontario, Canada
    Cleve Clin J Med 75:369-75. 2008
    ..Unless TTP is recognized promptly and treated aggressively, most patients die of it...
  88. doi request reprint Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial
    David J Kuter
    Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 371:395-403. 2008
    ..We assessed the long-term administration of romiplostim in splenectomised and non-splenectomised patients with ITP...
  89. ncbi request reprint AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP
    James B Bussel
    New York Presbyterian Hospital, New York, USA
    N Engl J Med 355:1672-81. 2006
    ..Most current treatments for chronic immune thrombocytopenic purpura (ITP) act by decreasing platelet destruction. In a phase 1-2 study, we administered a thrombopoiesis-stimulating protein, AMG 531, to patients with ITP...
  90. ncbi request reprint A disease-specific measure of health-related quality of life in adults with chronic immune thrombocytopenic purpura: psychometric testing in an open-label clinical trial
    Susan D Mathias
    Ovation Research Group, San Francisco, CA 94105, USA
    Clin Ther 29:950-62. 2007
    ..A previous study reported preliminary evidence of its reliability and validity...
  91. ncbi request reprint Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group
    Tapani Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Haematologica 92:95-100. 2007
    ..An International Working Group was formed to develop a consensus formulation of criteria for diagnosing clinically significant TAM...
  92. ncbi request reprint Drug-induced thrombocytopenia: an updated systematic review, 2006
    Xiaoning Li
    Drug Saf 30:185-6. 2007
  93. ncbi request reprint How can we provide the best care for our patients with immune thrombocytopenic pupura?
    James N George
    Mayo Clin Proc 79:456-7. 2004
  94. ncbi request reprint The child with immune thrombocytopenic purpura: is pharmacotherapy or watchful waiting the best initial management? A panel discussion from the 2002 meeting of the American Society of Pediatric Hematology/Oncology
    Paula Bolton-Maggs
    Royal Liverpool Children s Hospital, Liverpool, UK
    J Pediatr Hematol Oncol 26:146-51. 2004
    ..The panel, composed of experts on both sides of the debate, presented the rationale, benefits, and risks of both pharmacotherapy and the watchful waiting strategy...
  95. ncbi request reprint Use of erythropoietin in cancer patients: assessment of oncologists' practice patterns in the United States and other countries
    Jared R Adams
    Department of Veterans Affairs, the MidWest Center for Health Services and Policy Research and the Veterans Affairs Chicago Healthcare System Lakeside Division, Chicago, Illinois, USA
    Am J Med 116:28-34. 2004
    ..To assess physician use of erythropoietin in cancer patients before publication of the American Society of Clinical Oncology/American Society of Hematology guidelines...

Research Grants3

  1. Clinical Research Training Institute
    James George; Fiscal Year: 2005
    ..It is through this near one to one ratio with the trainees that ASH intends to foster and sustain interest in clinical hematologic research and thereby help stimulate the career development of future clinical researchers in hematology. ..
  2. 2006 Clinical Research Training Institute
    James George; Fiscal Year: 2006
    ....
  3. Oklahoma-UT Southwestern Hemostasis Consortium
    James George; Fiscal Year: 2007
    ..A valuable outcome of the past four years has been the extension of collaborative relationship to the junior faculty members and trainees in our programs. OKLAHOMA-UT SOUTHWESTERN HEMOSTASIS CONSORTIUM CRITIQUES ..