Gunda Georg

Summary

Affiliation: University of Kansas
Country: USA

Publications

  1. ncbi request reprint Enantiospecific formal total syntheses of (-)-salicylihalamides A and B from D-glucose and L-rhamnose
    KyoungLang Yang
    Department of Medicinal Chemistry, Center for Cancer Experimental Therapeutics and Drug Discovery Program, Higuchi Biosciences Center, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045 7582, USA
    Org Lett 5:4007-9. 2003
  2. ncbi request reprint Synthesis, modeling, and anti-tubulin activity of a D-seco paclitaxel analogue
    Luciano Barboni
    Dipartimento di Scienze Chimiche, Universita di Camerino, Via S Agostino 1, 62032 Camerino MC, Italy
    Org Lett 6:461-4. 2004
  3. doi request reprint Artificial neural network--based analysis of high-throughput screening data for improved prediction of active compounds
    Swapan Chakrabarti
    Department of Electrical Engineering and Computer Science, University of Kansas, Lawrence, KS 66045, USA
    J Biomol Screen 14:1236-44. 2009
  4. ncbi request reprint Support vector machines in HTS data mining: Type I MetAPs inhibition study
    Jianwen Fang
    Bioinformatics Core Facility, University of Kansas, Lawrence, KS 66045, USA
    J Biomol Screen 11:138-44. 2006
  5. ncbi request reprint A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach
    Yanbin Liu
    Department of Medicinal Chemistry, and the Drug Discovery Program, Higuchi Biosciences Center, University of Kansas, Lawrence, KS 66045, USA
    Comb Chem High Throughput Screen 5:39-48. 2002
  6. ncbi request reprint Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells
    Haibo Ge
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045 7582, USA
    Bioorg Med Chem Lett 16:433-6. 2006
  7. ncbi request reprint Synthesis and anti-tubulin activity of a 3'-(4-azidophenyl)-3'-dephenylpaclitaxel photoaffinity probe
    Jared T Spletstoser
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045 7582, USA
    J Med Chem 47:6459-65. 2004
  8. ncbi request reprint Synthetic studies with 13-deoxybaccatin III
    Yu Mi Ahn
    Department of Medicinal Chemistry and The Drug Discovery Program, Higuchi Biosciences Center, The University of Kansas, Lawrence, Kansas 66045 7582, USA
    J Org Chem 67:7140-3. 2002
  9. ncbi request reprint Synthesis of cryptophycins via an N-acyl-beta-lactam macrolactonization
    Ramdas Vidya
    Department of Medicinal Chemistry and Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA
    J Org Chem 68:9687-93. 2003
  10. pmc Synthesis of docetaxel and butitaxel analogues through kinetic resolution of racemic beta-lactams with 7-O-triethylsilylbaccatin III
    Haibo Ge
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, University of Kansas, Lawrence, Kansas 66045 7582, USA
    J Org Chem 72:756-9. 2007

Research Grants

  1. PHARMACOPHORE INTERACTIONS WITH TUBULIN OF CRYPTOPHYCINS
    Gunda Georg; Fiscal Year: 2001
  2. MEDICINAL CHEMISTRY
    Gunda Georg; Fiscal Year: 2000
  3. CENTER FOR CANCER EXPERIMENTAL THERAPEUTICS
    Gunda Georg; Fiscal Year: 2005
  4. TAXOL BRAIN DELIVERY
    Gunda Georg; Fiscal Year: 2003
  5. EPOTHILONE AFFINITY LABELS
    Gunda Georg; Fiscal Year: 2003
  6. Updating Laboratory Facilities Under P20 RR 15563
    Gunda Georg; Fiscal Year: 2003
  7. Libraries for HTS: Privileged Structures in Sparsely Populated Chemical Space
    Gunda Georg; Fiscal Year: 2007
  8. Tyloindicines: Chemistry and Biology
    Gunda Georg; Fiscal Year: 2006
  9. CENTER FOR CANCER EXPERIMENTAL THERAPEUTICS
    Gunda Georg; Fiscal Year: 2004

Collaborators

  • Qi Zhuang Ye
  • Luciano Barboni
  • Minmin Wang
  • Swapan Chakrabarti
  • Jianwen Fang
  • Gerald H Lushington
  • J P Snyder
  • Lester A Mitscher
  • MARK S CUSHMAN
  • A Safavy
  • SUNIL ABRAHAM DAVID
  • M Fischer
  • Richard H Himes
  • F Scott Kimball
  • Haibo Ge
  • Brandon J Turunen
  • Jared T Spletstoser
  • Punitha Vedantham
  • Jonathan M White
  • Jacquelyn K Huff
  • Yu Mi Ahn
  • Suzanne B Buck
  • Paul R Hanson
  • Hari K R Santhapuram
  • Ramdas Vidya
  • Kenneth L Audus
  • Antonie Rice
  • Torsten Haack
  • Yanbin Liu
  • Mohan L Gupta
  • Claudia J Bode
  • Min Huang
  • Parul J Gor
  • Joseph S Tash
  • Yanlei Zhang
  • Apurba Datta
  • Dinah Dutta
  • Veena Vasandani
  • Kriangsak Khownium
  • Anna Seelig
  • Ashok Rao Tunoori
  • KyoungLang Yang
  • MariJean Eggen
  • Jennifer Hughes
  • Jenna L Wang
  • S Kendall Smith
  • Brian S J Blagg
  • Leslie L Heckert
  • Micah J Niphakis
  • Terri Goss Kinzy
  • Sudhakar R Jakkaraj
  • Sedide B Ozturk
  • Kaori Hornbaker
  • Keith C Ellis
  • M Kyle Hadden
  • Jennifer M Guerra
  • Ramappa Chakrasali
  • Benjamin Neuenswander
  • Oliver E Hutt
  • Mianji Zhang
  • Frank Schoenen
  • Lakshminarayana Vogeti
  • Samuel F Victory
  • Katherine F Roby
  • Margaret Kayser
  • David Vander Velde
  • Chun Jing Liu
  • Adelbert Bacher
  • Boris Illarionov
  • Yan Yang
  • Douglas R Powell
  • Yunlong Song
  • Phillip E Fanwick
  • Kelly Desino
  • Kelly A Miller
  • Matthew R Kimbrell
  • Rajalakshmi Balakrishna
  • Stewart J Wood
  • Thuan B Nguyen
  • Mary Lou Michaelis
  • Patrick T Flaherty
  • Wibke E Diederich
  • Serdar Kurtkaya
  • Burchelle Blackman
  • Srinivas Pusuluri
  • Sajiv K Nair
  • Subho Roy
  • Kathy A Suprenant
  • Syed M Ali
  • Thomas C Boge

Detail Information

Publications32

  1. ncbi request reprint Enantiospecific formal total syntheses of (-)-salicylihalamides A and B from D-glucose and L-rhamnose
    KyoungLang Yang
    Department of Medicinal Chemistry, Center for Cancer Experimental Therapeutics and Drug Discovery Program, Higuchi Biosciences Center, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045 7582, USA
    Org Lett 5:4007-9. 2003
    ..reaction: see text] Two formal chiral pool syntheses of the (-)-salicylihalamides A and B were achieved from commercially available 1,2,5,6-diacetone-d-glucose and l-rhamnose...
  2. ncbi request reprint Synthesis, modeling, and anti-tubulin activity of a D-seco paclitaxel analogue
    Luciano Barboni
    Dipartimento di Scienze Chimiche, Universita di Camerino, Via S Agostino 1, 62032 Camerino MC, Italy
    Org Lett 6:461-4. 2004
    ..Compound 1 is as potent as paclitaxel at microtubule stabilization in vitro; however, it has only about one-four-hundredth the cytotoxicity of paclitaxel...
  3. doi request reprint Artificial neural network--based analysis of high-throughput screening data for improved prediction of active compounds
    Swapan Chakrabarti
    Department of Electrical Engineering and Computer Science, University of Kansas, Lawrence, KS 66045, USA
    J Biomol Screen 14:1236-44. 2009
    ..Thus, ANNs trained with limited HTS data might become useful in recovering active compounds from large data sets...
  4. ncbi request reprint Support vector machines in HTS data mining: Type I MetAPs inhibition study
    Jianwen Fang
    Bioinformatics Core Facility, University of Kansas, Lawrence, KS 66045, USA
    J Biomol Screen 11:138-44. 2006
    ..A training set with 10,000 member compounds is likely the minimum size required to build a model with reasonable predictive power...
  5. ncbi request reprint A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach
    Yanbin Liu
    Department of Medicinal Chemistry, and the Drug Discovery Program, Higuchi Biosciences Center, University of Kansas, Lawrence, KS 66045, USA
    Comb Chem High Throughput Screen 5:39-48. 2002
    ..It was also found that the presence of a nitrogen atom in the C10 substituent might play a role in the interaction of analogues with microtubules...
  6. ncbi request reprint Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells
    Haibo Ge
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045 7582, USA
    Bioorg Med Chem Lett 16:433-6. 2006
    ..They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel...
  7. ncbi request reprint Synthesis and anti-tubulin activity of a 3'-(4-azidophenyl)-3'-dephenylpaclitaxel photoaffinity probe
    Jared T Spletstoser
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045 7582, USA
    J Med Chem 47:6459-65. 2004
    ....
  8. ncbi request reprint Synthetic studies with 13-deoxybaccatin III
    Yu Mi Ahn
    Department of Medicinal Chemistry and The Drug Discovery Program, Higuchi Biosciences Center, The University of Kansas, Lawrence, Kansas 66045 7582, USA
    J Org Chem 67:7140-3. 2002
    ..The preparation of 13-oxo-7-O-(triethylsilyl)baccatin III from 13-epi-7-O-(triethylsilyl)baccatin III using tetrapropylammonium perruthenate and N-methylmorpholine N-oxide is also reported...
  9. ncbi request reprint Synthesis of cryptophycins via an N-acyl-beta-lactam macrolactonization
    Ramdas Vidya
    Department of Medicinal Chemistry and Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA
    J Org Chem 68:9687-93. 2003
    ..In this case, the cyanide-initiated ring opening of the bis-substituted 2-azetidinone followed by macrolactonization was achieved through a catalytic process...
  10. pmc Synthesis of docetaxel and butitaxel analogues through kinetic resolution of racemic beta-lactams with 7-O-triethylsilylbaccatin III
    Haibo Ge
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, University of Kansas, Lawrence, Kansas 66045 7582, USA
    J Org Chem 72:756-9. 2007
    ..In addition, it was found that the C4 beta-lactam substituents also influenced diastereoselectivity. The C4 tert-butyl-beta-lactams provided better diastereoselectivity than the corresponding C4 phenyl beta-lactams...
  11. pmc A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative
    Yanlei Zhang
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and the Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Org Chem 72:2769-76. 2007
    ..Ab initio calculations indicate that the meso form is slightly less stable than the enantiomeric form, and that the two forms interconvert rapidly at room temperature...
  12. pmc Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones
    F Scott Kimball
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA
    Bioorg Med Chem Lett 17:4703-7. 2007
    ..39 microM and displayed promising activity in vivo in the NCI's mouse hollow fiber assay...
  13. doi request reprint Studies towards the synthesis of methionine aminopeptidase inhibitors: diversification utilizing a ROMP-derived coupling reagent
    Punitha Vedantham
    Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA
    J Comb Chem 10:195-203. 2008
    ..In addition, in silico Lipinksi profiles and ADME properties of the library are also reported...
  14. doi request reprint Ionic immobilization, diversification, and release: application to the generation of a library of methionine aminopeptidase inhibitors
    Punitha Vedantham
    Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA
    J Comb Chem 10:185-94. 2008
    ..Qualitative SAR analysis, supplemented by molecular modeling studies, provides valuable information on structural elements responsible for potency and selectivity...
  15. doi request reprint Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells
    Joseph S Tash
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 78:1139-52. 2008
    ..A current model for gamendazole action posits that this pathway links interaction with HSP90AB1 and EEF1A1 to the loss of spermatids and resulting infertility...
  16. doi request reprint Palladium(II)-catalyzed direct arylation of enaminones using organotrifluoroborates
    Haibo Ge
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA
    J Am Chem Soc 130:3708-9. 2008
    ..It provides immediate access to arylpiperidine, indolizidine, and quinolizidine scaffolds from the corresponding mono- and bicyclic, unattenuated enaminones...
  17. pmc Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers
    F Scott Kimball
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA
    Bioorg Med Chem 16:4367-77. 2008
    ..A biological assay utilizing the HCT-116 colon cancer cell line to determine the cytotoxicity of these analogs revealed that only the (R)-enantiomer exhibited appreciable cytotoxicity with an IC(50) value of 0.2 microM...
  18. pmc Synthesis and evaluation of heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones for cytotoxicity against the HCT-116 colon cancer cell line
    F Scott Kimball
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA
    Bioorg Med Chem Lett 18:3248-50. 2008
    ..The most active of the new analogs proved to be the C6 2-thiophene and 3-thiophene analogs with IC(50) values of 0.27 microM and 0.60 microM, respectively...
  19. doi request reprint N-methylation of the c3' amide of taxanes: synthesis of N-methyltaxol C and N-methylpaclitaxel
    Hari K R Santhapuram
    Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045 7582, USA
    J Org Chem 73:4705-8. 2008
    ..Subsequent reaction with potassium tert-butoxide and methyl iodide provided the corresponding N-methylated taxane derivatives. Removal of the silyl protecting groups furnished N-methyltaxol C and N-methylpaclitaxel...
  20. pmc Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues
    Yu Mi Ahn
    Department of Medicinal Chemistry, 1251 Wescoe Hall Drive, University of Kansas, Lawrence, KS 66045 7582, USA
    Bioorg Med Chem 15:702-13. 2007
    ..Molecular docking simulations were carried out and these studies suggested a different binding orientation inside the CDK2 binding pocket for these analogues compared to flavopiridol...
  21. pmc Amino acid-derived enaminones: a study in ring formation providing valuable asymmetric synthons
    Brandon J Turunen
    Department of Medicinal Chemistry and Center for Methodology and Library Development, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA
    J Am Chem Soc 128:8702-3. 2006
    ..Although disguised as a 6-endo-dig cyclization, the reagents employed in the transformation play a direct role in bond making and bond breaking, thus changing the mode of addition...
  22. ncbi request reprint Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules
    Claudia J Bode
    Department of Molecular Biosciences and the Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, USA
    Biochemistry 41:3870-4. 2002
    ..These results also indicate that mutagenesis of yeast tubulin could help define the sites of interaction with paclitaxel and the epothilones...
  23. ncbi request reprint Studies toward the synthesis of oximidines I and II
    Torsten Haack
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045 7582, USA
    Org Lett 5:5019-22. 2003
    ..The thermodynamic driving force for this unexpected isomerization was established by DFT and MP2 calculations. [reaction: see text]..
  24. ncbi request reprint Total synthesis and antitubulin activity of c10 analogues of cryptophycin-24
    Suzanne B Buck
    Department of Medicinal Chemistry and Department of Molecular Biosciences, University of Kansas, 1251 Wescoe Drive, Lawrence, Kansas 66045 7582, USA
    J Med Chem 47:696-702. 2004
    ..These results demonstrated that the 4'-MeO group in cryptophycin-24 is not essential and can be replaced with 3'-C1 or 4'-C1 substituents...
  25. ncbi request reprint [Bis(2-methoxyethyl)amino]sulfur trifluoride, the Deoxo-Fluor reagent: application toward one-flask transformations of carboxylic acids to amides
    Jonathan M White
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 60045 7582, USA
    J Org Chem 69:2573-6. 2004
    ..We have explored the utility of this reagent for the one-flask conversion of acids to amides and Weinreb amides and as a peptide-coupling reagent...
  26. ncbi request reprint Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24
    Suzanne B Buck
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Drive, Lawrence, KS 66045 7582, USA
    J Med Chem 47:3697-9. 2004
    ..The results demonstrate that the S configuration at the C3 stereocenter is not required to induce potent cytotoxicity and the m-Cl substituent present on the C10 side chain did not induce any large change in activity...
  27. ncbi request reprint Site-specifically traced drug release and biodistribution of a paclitaxel-antibody conjugate toward improvement of the linker structure
    Ahmad Safavy
    Department of Radiation Oncology and Medicine, Biostatistics and Bioinformatics Unit, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Bioconjug Chem 15:1264-74. 2004
    ..These results demonstrated the first time use of radioiodinated 3'-OH-PTX for in vivo tracing of a paclitaxel conjugate and application of the resulting information to the design of a therapeutically more useful PTX-MAb linker...
  28. pmc Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin
    Mohan L Gupta
    Department of Molecular Biosciences, University of Kansas, Lawrence 66045, USA
    Proc Natl Acad Sci U S A 100:6394-7. 2003
    ..Importantly, this experimental system can be used to reveal tubulin interactions with Taxol, the epothilones, and other Taxol-like compounds...
  29. ncbi request reprint Chemical modification of paclitaxel (Taxol) reduces P-glycoprotein interactions and increases permeation across the blood-brain barrier in vitro and in situ
    Antonie Rice
    Department of Pharmaceutical Chemistry, University of Kansas, 226 Simons, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Med Chem 48:832-8. 2005
    ..These results demonstrate that the Taxol analogue Tx-67 had a reduced interaction with Pgp and, as a consequence, enhanced permeation across the blood-brain barrier in vitro and in situ...
  30. ncbi request reprint Cryptophycin affinity labels: synthesis and biological activity of a benzophenone analogue of cryptophycin-24
    Ramdas Vidya
    Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA
    Bioorg Med Chem Lett 13:757-60. 2003
    ..In an in vitro tubulin assembly assay, the benzophenone analogue of the beta isomer (IC(50)=7.4 microM) is twice as active as cryptophycin-24 (IC(50)=15 microM)...
  31. ncbi request reprint Novel endotoxin-sequestering compounds with terephthalaldehyde-bis-guanylhydrazone scaffolds
    Kriangsak Khownium
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence KS 66045 7582, USA
    Bioorg Med Chem Lett 16:1305-8. 2006
    ..These first-generation compounds bind and neutralize lipopolysaccharide with a potency comparable to that of polymyxin B, a peptide antibiotic known to sequester LPS...
  32. ncbi request reprint Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells
    Jared T Spletstoser
    Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA
    Bioorg Med Chem Lett 16:495-8. 2006
    ....

Research Grants41

  1. PHARMACOPHORE INTERACTIONS WITH TUBULIN OF CRYPTOPHYCINS
    Gunda Georg; Fiscal Year: 2001
    ..Suitable candidates will be selected and used to study the ligand-protein interactions in fluorescent, photoaffinity and electrophilic labeling studies. ..
  2. MEDICINAL CHEMISTRY
    Gunda Georg; Fiscal Year: 2000
    ..In addition, Core will carry out the synthesis of a potentially promising novel anti-tumor agent, octalactin A, to assess its potential for cancer therapy. ..
  3. CENTER FOR CANCER EXPERIMENTAL THERAPEUTICS
    Gunda Georg; Fiscal Year: 2005
    ..The three COBRE Core laboratories will become University-supported research service laboratories. ..
  4. TAXOL BRAIN DELIVERY
    Gunda Georg; Fiscal Year: 2003
    ..In vivo studies with an in situ rat perfusion model will be used to assess their in vivo protein to cross the BBB. ..
  5. EPOTHILONE AFFINITY LABELS
    Gunda Georg; Fiscal Year: 2003
    ..Fluorescent epothilones will be used to study the interaction with microtubules and tubulin and the epothilone photo affinity will identify the ligand binding sites in the receptor. ..
  6. Updating Laboratory Facilities Under P20 RR 15563
    Gunda Georg; Fiscal Year: 2003
    ..The availability of new research tools is expected to also have a positive impact on the number of NIH grants, NIH program projects, and SBIR/STTR grant submissions from KU faculty. ..
  7. Libraries for HTS: Privileged Structures in Sparsely Populated Chemical Space
    Gunda Georg; Fiscal Year: 2007
    ....
  8. Tyloindicines: Chemistry and Biology
    Gunda Georg; Fiscal Year: 2006
    ..Their cytotoxicity and cellular mechanisms will be studied as well. In addition it is proposed to characterize the interaction of the tyloindicines with their biological targets with the help of photoaffinity labels. ..
  9. CENTER FOR CANCER EXPERIMENTAL THERAPEUTICS
    Gunda Georg; Fiscal Year: 2004
    ..abstract_text> ..