STEVE NICHOLAS GEORAS
Affiliation: University of Rochester
- Lysophosphatidic acid and autotaxin: emerging roles in innate and adaptive immunitySteve N Georas
Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, NY 14610, USA
Immunol Res 45:229-38. 2009..New gene-targeted and transgenic mice, receptor-specific antibodies, and pathway antagonists should rapidly enhance our understanding of this versatile lysolipid in immune responses in the near future...
- Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challengeS N Georas
Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
Clin Exp Allergy 37:311-22. 2007..LPA binds to receptors expressed on circulating and structural lung cells and affects cell growth and activation. Whether LPA is present in the lung has not been previously reported...
- Dangerous allergens: why some allergens are bad actorsSteve N Georas
Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 692, Rochester, NY 14642 8692, USA
Curr Allergy Asthma Rep 10:92-8. 2010....
- Dangerous allergens: innate immunity, dendritic cells and allergic asthmaSteve N Georas
Professor of Medicine and Environmental Medicine, Director of the Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 692, Rochester, NY 14642 8692, USA
Expert Rev Clin Immunol 4:777-85. 2008..This review summarizes current thinking regarding the role of dendritic cells in allergic asthma and concludes with a summary of emerging concepts in the field...
- T-cell activation under hypoxic conditions enhances IFN-gamma secretionJessica Roman
University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642 8692, USA
Am J Respir Cell Mol Biol 42:123-8. 2010..We conclude that hypoxia is a previously underappreciated modulator of effector cytokine secretion in CD4(+) T cells...
- Lysophosphatidic acid stimulates inflammatory cascade in airway epithelial cellsElizabeth Barekzi
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
Prostaglandins Leukot Essent Fatty Acids 74:357-63. 2006..Our results suggest epithelial cells undergo rapid proliferation in response to LPA resulting in a transient decrease in inflammatory cytokines followed by an upregulation of these cytokines that could lead to increased inflammation...
- Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cellsYutong Zhao
Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 282:10172-9. 2007..Our data suggest a novel mechanism of regulation of IL-13Ralpha2 and IL-13 signaling that may be of physiological relevance to airway inflammation and remodeling...
- Lysophosphatidic acid enhances interleukin-13 gene expression and promoter activity in T cellsJoshua Rubenfeld
Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
Am J Physiol Lung Cell Mol Physiol 290:L66-74. 2006..The effects of LPA on IL-13 promoter activation appeared to be distinct from those mediated by GATA-3. LPA can augment IL-13 gene expression in T cells, especially under conditions of submaximal activation...
- Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cellsLixin Wang
Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland 21224, USA
J Biol Chem 278:39931-40. 2003..These results show for the first time that transactivation of PDGF-R beta by LPA in HBEpCs is regulated by PLD2...
- LPA and Edg Receptors in the Pulmonary Immune ResposeSTEVE NICHOLAS GEORAS; Fiscal Year: 2010..The goal of our research program is to define the role of new molecules that cause lung inflammation in asthma with the hope that this will lead to the use of new therapeutic agents in this disease. ..
- LPA and Edg Receptors in the Pulmonary Immune ResposeSteve Georas; Fiscal Year: 2007..Taken together, these studies will provide the first comprehensive analysis of a novel lysophospholipid and signal transduction pathway in allergic inflammatory diseases. ..
- Yin-Yang-1:a novel transcription factor in Th responsesSteve Georas; Fiscal Year: 2006..Taken together, our studies will define novel factors and pathways involved in the molecular regulation of Th2 gene expression and in the pulmonary response to allergen. ..
- INHIBITION OF IL4 EXPRESSION IN CELLS RELEVANT TO ASTHMASteve Georas; Fiscal Year: 2002..Second, we will test the hypothesis that YY1 inhibits the IL-4 promoter in a sequence- specific manner. These studies should enhance our understanding of IL-4 gene expression. ..