STEVE NICHOLAS GEORAS

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Lysophosphatidic acid and autotaxin: emerging roles in innate and adaptive immunity
    Steve N Georas
    Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, NY 14610, USA
    Immunol Res 45:229-38. 2009
  2. ncbi Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge
    S N Georas
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
    Clin Exp Allergy 37:311-22. 2007
  3. ncbi Dangerous allergens: why some allergens are bad actors
    Steve N Georas
    Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 692, Rochester, NY 14642 8692, USA
    Curr Allergy Asthma Rep 10:92-8. 2010
  4. ncbi Dangerous allergens: innate immunity, dendritic cells and allergic asthma
    Steve N Georas
    Professor of Medicine and Environmental Medicine, Director of the Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 692, Rochester, NY 14642 8692, USA
    Expert Rev Clin Immunol 4:777-85. 2008
  5. ncbi T-cell activation under hypoxic conditions enhances IFN-gamma secretion
    Jessica Roman
    University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642 8692, USA
    Am J Respir Cell Mol Biol 42:123-8. 2010
  6. ncbi Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells
    Lixin Wang
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Biol Chem 278:39931-40. 2003
  7. ncbi Lysophosphatidic acid enhances interleukin-13 gene expression and promoter activity in T cells
    Joshua Rubenfeld
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 290:L66-74. 2006
  8. ncbi Lysophosphatidic acid stimulates inflammatory cascade in airway epithelial cells
    Elizabeth Barekzi
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Prostaglandins Leukot Essent Fatty Acids 74:357-63. 2006
  9. ncbi Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells
    Yutong Zhao
    Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:10172-9. 2007

Research Grants

  1. LPA and Edg Receptors in the Pulmonary Immune Respose
    STEVE NICHOLAS GEORAS; Fiscal Year: 2010
  2. LPA and Edg Receptors in the Pulmonary Immune Respose
    Steve Georas; Fiscal Year: 2007
  3. Yin-Yang-1:a novel transcription factor in Th responses
    Steve Georas; Fiscal Year: 2006
  4. INHIBITION OF IL4 EXPRESSION IN CELLS RELEVANT TO ASTHMA
    Steve Georas; Fiscal Year: 2002

Collaborators

  • Lisa Beck
  • M Liu
  • Yutong Zhao
  • John W Steinke
  • Jessica Roman
  • Jia Guo
  • Joshua Rubenfeld
  • Elizabeth Barekzi
  • Viswanathan Natarajan
  • Lixin Wang
  • Gopinath Packirisamy
  • Tirumalai Rangasamy
  • Amit Golding
  • Larissa A Shimoda
  • Siva Sugunan
  • Gregg Semenza
  • Nida Meednu
  • Vincenzo Casolaro
  • Kathleen Hise
  • Nitat Sookrung
  • Wanpen Chaicumpa
  • Rongbing Chen
  • Andrius Kazlauskas
  • Andrew Morris
  • Rhett Cummings
  • James K S Sham
  • David N Brindley

Detail Information

Publications9

  1. ncbi Lysophosphatidic acid and autotaxin: emerging roles in innate and adaptive immunity
    Steve N Georas
    Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, NY 14610, USA
    Immunol Res 45:229-38. 2009
    ..New gene-targeted and transgenic mice, receptor-specific antibodies, and pathway antagonists should rapidly enhance our understanding of this versatile lysolipid in immune responses in the near future...
  2. ncbi Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge
    S N Georas
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
    Clin Exp Allergy 37:311-22. 2007
    ..LPA binds to receptors expressed on circulating and structural lung cells and affects cell growth and activation. Whether LPA is present in the lung has not been previously reported...
  3. ncbi Dangerous allergens: why some allergens are bad actors
    Steve N Georas
    Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 692, Rochester, NY 14642 8692, USA
    Curr Allergy Asthma Rep 10:92-8. 2010
    ....
  4. ncbi Dangerous allergens: innate immunity, dendritic cells and allergic asthma
    Steve N Georas
    Professor of Medicine and Environmental Medicine, Director of the Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 692, Rochester, NY 14642 8692, USA
    Expert Rev Clin Immunol 4:777-85. 2008
    ..This review summarizes current thinking regarding the role of dendritic cells in allergic asthma and concludes with a summary of emerging concepts in the field...
  5. ncbi T-cell activation under hypoxic conditions enhances IFN-gamma secretion
    Jessica Roman
    University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642 8692, USA
    Am J Respir Cell Mol Biol 42:123-8. 2010
    ..We conclude that hypoxia is a previously underappreciated modulator of effector cytokine secretion in CD4(+) T cells...
  6. ncbi Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells
    Lixin Wang
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Biol Chem 278:39931-40. 2003
    ..These results show for the first time that transactivation of PDGF-R beta by LPA in HBEpCs is regulated by PLD2...
  7. ncbi Lysophosphatidic acid enhances interleukin-13 gene expression and promoter activity in T cells
    Joshua Rubenfeld
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 290:L66-74. 2006
    ..The effects of LPA on IL-13 promoter activation appeared to be distinct from those mediated by GATA-3. LPA can augment IL-13 gene expression in T cells, especially under conditions of submaximal activation...
  8. ncbi Lysophosphatidic acid stimulates inflammatory cascade in airway epithelial cells
    Elizabeth Barekzi
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Prostaglandins Leukot Essent Fatty Acids 74:357-63. 2006
    ..Our results suggest epithelial cells undergo rapid proliferation in response to LPA resulting in a transient decrease in inflammatory cytokines followed by an upregulation of these cytokines that could lead to increased inflammation...
  9. ncbi Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells
    Yutong Zhao
    Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:10172-9. 2007
    ..Our data suggest a novel mechanism of regulation of IL-13Ralpha2 and IL-13 signaling that may be of physiological relevance to airway inflammation and remodeling...

Research Grants13

  1. LPA and Edg Receptors in the Pulmonary Immune Respose
    STEVE NICHOLAS GEORAS; Fiscal Year: 2010
    ..The goal of our research program is to define the role of new molecules that cause lung inflammation in asthma with the hope that this will lead to the use of new therapeutic agents in this disease. ..
  2. LPA and Edg Receptors in the Pulmonary Immune Respose
    Steve Georas; Fiscal Year: 2007
    ..Taken together, these studies will provide the first comprehensive analysis of a novel lysophospholipid and signal transduction pathway in allergic inflammatory diseases. ..
  3. Yin-Yang-1:a novel transcription factor in Th responses
    Steve Georas; Fiscal Year: 2006
    ..Taken together, our studies will define novel factors and pathways involved in the molecular regulation of Th2 gene expression and in the pulmonary response to allergen. ..
  4. INHIBITION OF IL4 EXPRESSION IN CELLS RELEVANT TO ASTHMA
    Steve Georas; Fiscal Year: 2002
    ..Second, we will test the hypothesis that YY1 inhibits the IL-4 promoter in a sequence- specific manner. These studies should enhance our understanding of IL-4 gene expression. ..