W Brooks Gentry

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi request reprint Safety and efficiency of an anti-(+)-methamphetamine monoclonal antibody in the protection against cardiovascular and central nervous system effects of (+)-methamphetamine in rats
    W Brooks Gentry
    University of Arkansas for Medical Sciences, Department of Anesthesiology, College of Medicine, Little Rock, AR 72205, United States
    Int Immunopharmacol 6:968-77. 2006
  2. ncbi request reprint (+)-Methamphetamine-induced spontaneous behavior in rats depends on route of (+)METH administration
    W Brooks Gentry
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Pharmacol Biochem Behav 79:751-60. 2004
  3. pmc Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Drugs Aging 22:525-39. 2005
  4. ncbi request reprint Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats
    Alessandra Milesi-Hallé
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham 611, Little Rock, AR 72205, USA
    Toxicol Appl Pharmacol 209:203-13. 2005
  5. ncbi request reprint Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats
    Kelly A Byrnes-Blake
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Eur J Pharmacol 521:86-94. 2005
  6. pmc In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 522, Little Rock, AR 72205, USA
    Clin Pharmacol Ther 77:415-26. 2005
  7. pmc Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin
    Bill Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, 4301 West Markham Street, Slot 522 3, Little Rock, 72205, USA
    J Clin Pharmacol 46:201-13. 2006
  8. ncbi request reprint Use of anti-(+)-methamphetamine monoclonal antibody to significantly alter (+)-methamphetamine and (+)-amphetamine disposition in rats
    Elizabeth M Laurenzana
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 611, Little Rock, AR 72205, USA
    Drug Metab Dispos 31:1320-6. 2003
  9. ncbi request reprint Anti-phencyclidine monoclonal antibody binding capacity is not the only determinant of effectiveness, disproving the concept that antibody capacity is easily surmounted
    Grzegorz Pitas
    Department of Anesthesiology, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 515, Little Rock, AR 72205, USA
    Drug Metab Dispos 34:906-12. 2006
  10. pmc Functional and biological determinants affecting the duration of action and efficacy of anti-(+)-methamphetamine monoclonal antibodies in rats
    Elizabeth M Laurenzana
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States
    Vaccine 27:7011-20. 2009

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Safety and efficiency of an anti-(+)-methamphetamine monoclonal antibody in the protection against cardiovascular and central nervous system effects of (+)-methamphetamine in rats
    W Brooks Gentry
    University of Arkansas for Medical Sciences, Department of Anesthesiology, College of Medicine, Little Rock, AR 72205, United States
    Int Immunopharmacol 6:968-77. 2006
    ..These results are important because they indicate these antibody medications have simultaneous beneficial effects in multiple organ systems...
  2. ncbi request reprint (+)-Methamphetamine-induced spontaneous behavior in rats depends on route of (+)METH administration
    W Brooks Gentry
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Pharmacol Biochem Behav 79:751-60. 2004
    ..In conclusion, the overall pattern of (+)METH effects on locomotor activity depend on dose and the route of administration, which affects serum concentration and the time course of behavioral effects...
  3. pmc Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Drugs Aging 22:525-39. 2005
    ....
  4. ncbi request reprint Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats
    Alessandra Milesi-Hallé
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham 611, Little Rock, AR 72205, USA
    Toxicol Appl Pharmacol 209:203-13. 2005
    ..These findings show that the pharmacokinetic and metabolic profile of METH (slower METH clearance and lower AMP metabolite formation) plays a significant role in the differential pharmacological response to METH in male and female rats...
  5. ncbi request reprint Monoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats
    Kelly A Byrnes-Blake
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Eur J Pharmacol 521:86-94. 2005
    ..Thus, anti-(+)-methamphetamine monoclonal antibody affinity and administration time (relative to (+)-methamphetamine dosing) are critical determinants of therapeutic success...
  6. pmc In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 522, Little Rock, AR 72205, USA
    Clin Pharmacol Ther 77:415-26. 2005
    ....
  7. pmc Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin
    Bill Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, 4301 West Markham Street, Slot 522 3, Little Rock, 72205, USA
    J Clin Pharmacol 46:201-13. 2006
    ..Unlike those observed for rifampin and clarithromycin, midazolam pharmacokinetics was unaffected by milk thistle or black cohosh. Milk thistle and black cohosh appear to have no clinically relevant effect on CYP3A activity in vivo...
  8. ncbi request reprint Use of anti-(+)-methamphetamine monoclonal antibody to significantly alter (+)-methamphetamine and (+)-amphetamine disposition in rats
    Elizabeth M Laurenzana
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 611, Little Rock, AR 72205, USA
    Drug Metab Dispos 31:1320-6. 2003
    ..Finally, rapidly equilibrating tissues, like the brain, appear to be preferentially protected by the mAb...
  9. ncbi request reprint Anti-phencyclidine monoclonal antibody binding capacity is not the only determinant of effectiveness, disproving the concept that antibody capacity is easily surmounted
    Grzegorz Pitas
    Department of Anesthesiology, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 515, Little Rock, AR 72205, USA
    Drug Metab Dispos 34:906-12. 2006
    ....
  10. pmc Functional and biological determinants affecting the duration of action and efficacy of anti-(+)-methamphetamine monoclonal antibodies in rats
    Elizabeth M Laurenzana
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States
    Vaccine 27:7011-20. 2009
    ..The combination of broad specificity for methamphetamine-like drugs, high affinity, and prolonged action in vivo suggests mAb4G9 is a potentially efficacious medication for treating human methamphetamine-related medical diseases...
  11. ncbi request reprint Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats
    Kelly A Byrnes-Blake
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 611, Little Rock, AR 72205, USA
    Eur J Pharmacol 461:119-28. 2003
    ..These data indicate that anti-(+)-methamphetamine monoclonal antibody-induced pharmacodynamics are complex, but are related to time-dependent changes in (+)-methamphetamine brain distribution...
  12. ncbi request reprint Treatment with a Monoclonal Antibody against Methamphetamine and Amphetamine Reduces Maternal and Fetal Rat Brain Concentrations in Late Pregnancy
    Sarah J White
    Department of Pharmacology and Toxicology, College of Medicine S J W, W T A, E M L, W B G, S M O, Department of Anesthesiology, College of Medicine W B G, Department of Pharmaceutical Sciences, College of Pharmacy H P H, and Department of Biostatistics, College of Public Health D K W, University of Arkansas for Medical Sciences, Little Rock, Arkansas and Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, Pennsylvania State University, State College, Pennsylvania E M L
    Drug Metab Dispos 42:1285-91. 2014
    ..05), respectively. These results show anti-METH/AMP mAb4G9 therapy in dams can offer maternal and fetal brain protection from the potentially harmful effects of METH and AMP. ..
  13. ncbi request reprint Treatment of adverse effects of excessive phencyclidine exposure in rats with a minimal dose of monoclonal antibody
    Elizabeth M Laurenzana
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Pharmacol Exp Ther 306:1092-8. 2003
    ..These results could help establish the feasibility of using carefully designed monoclonal antibody medications to treat drug abuse and addiction, a chronic and re-occurring illness of the central nervous system...
  14. pmc The fate and function of therapeutic antiaddiction monoclonal antibodies across the reproductive cycle of rats
    JONATHAN J HUBBARD
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Pharmacol Exp Ther 336:414-22. 2011
    ..g., irritable bowel diseases, multiple sclerosis, breast cancer, rheumatoid arthritis)...
  15. pmc Development of active and passive human vaccines to treat methamphetamine addiction
    W Brooks Gentry
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Hum Vaccin 5:206-13. 2009
    ..Both of these vaccines could play an essential role in a well planned recovery program from human METH addiction by providing long-lasting protection from the rewarding and reinforcing effect of METH...
  16. ncbi request reprint Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans
    Bill J Gurley
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Clin Pharmacol Ther 72:276-87. 2002
    ..Single-time point phenotypic metabolic ratios were used to determine whether long-term supplementation of St John's wort, garlic oil, Panax ginseng, and Ginkgo biloba affected CYP1A2, CYP2D6, CYP2E1, or CYP3A4 activity...
  17. pmc Monoclonal antibodies as pharmacokinetic antagonists for the treatment of (+)-methamphetamine addiction
    S Michael Owens
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    CNS Neurol Disord Drug Targets 10:892-8. 2011
    ..In this review, we discuss the discovery process of anti-METH mAbs, with a focus on the preclinical development leading to high affinity anti-METH mAb antagonists...
  18. pmc Gestation time-dependent pharmacokinetics of intravenous (+)-methamphetamine in rats
    Sarah White
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
    Drug Metab Dispos 39:1718-26. 2011
    ..In conclusion, late-gestational clearance reductions lengthen METH exposure time, possibly increasing susceptibility to adverse effects, including death...
  19. ncbi request reprint Customizing monoclonal antibodies for the treatment of methamphetamine abuse: current and future applications
    Eric C Peterson
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Adv Pharmacol 69:107-27. 2014
    ..Finally, we discuss clinical trial progress of the first in kind anti-METH mAb, for which METH is the disease target instead of vulnerable central nervous system networks of receptors, binding sites, and neuronal connections. ..
  20. ncbi request reprint In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, 72205, USA
    Clin Pharmacol Ther 76:428-40. 2004
    ....
  21. pmc Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure
    Nichole C Sanders
    Department of Psychiatry and Behavioral Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Exp Clin Psychopharmacol 21:294-302. 2013
    ..73, p = .004). These results suggest that gabapentin reduces opioid use during a 10-day buprenorphine detoxification procedure...
  22. ncbi request reprint Transpleural subclavian central venous catheter placement in a child with scoliosis discovered during a thoracotomy
    Abid U Ghafoor
    Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Clin Anesth 15:142-4. 2003
    ..Although a conventional roentgenogram was consistent with correct placement, the catheter was found to traverse the pleural space before entering the subclavian vein...