Mary B Genter

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Distribution and systemic effects of intranasally administered 25 nm silver nanoparticles in adult mice
    Mary Beth Genter
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Toxicol Pathol 40:1004-13. 2012
  2. ncbi request reprint Update on olfactory mucosal metabolic enzymes: age-related changes and N-acetyltransferase activities
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    J Biochem Mol Toxicol 18:239-44. 2004
  3. ncbi request reprint Reduction of alachlor-induced olfactory mucosal neoplasms by the matrix metalloproteinase inhibitor Ro 28-2653
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Toxicol Pathol 33:593-9. 2005
  4. ncbi request reprint Molecular biology of the nasal airways: how do we assess cellular and molecular responses in the nose?
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Toxicol Pathol 34:274-80. 2006
  5. ncbi request reprint Localization of CYP4B1 in the rat nasal cavity and analysis of CYPs as secreted proteins
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, ML 670056, Cincinnati, OH 45267 0056, USA
    J Biochem Mol Toxicol 20:139-41. 2006
  6. ncbi request reprint Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs
    Mary Beth Genter
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 348:120-3. 2006
  7. ncbi request reprint Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Physiol Genomics 16:67-81. 2003
  8. pmc Progression of alachlor-induced olfactory mucosal tumours
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, ML 670056, Cincinnati, OH 45267 0056, USA
    Int J Exp Pathol 83:303-8. 2002
  9. ncbi request reprint Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa
    Mary Beth Genter
    Departmet of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Physiol Genomics 12:35-45. 2002
  10. pmc Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides
    M B Genter
    Department of Environmental Health and Center for Environmental Genetics, 3223 Eden Ave, ML 670056, University of Cincinnati, Cincinnati, OH 45267 0056, United States
    Food Chem Toxicol 47:1051-7. 2009

Research Grants

  1. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
  2. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
  3. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004

Detail Information

Publications33

  1. ncbi request reprint Distribution and systemic effects of intranasally administered 25 nm silver nanoparticles in adult mice
    Mary Beth Genter
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Toxicol Pathol 40:1004-13. 2012
    ..Therefore, IN administration of AgNP permits systemic distribution, produces reversible oxidative stress in the nose and in blood, and mildly enhances macrophage-mediated erythrocyte destruction in the spleen...
  2. ncbi request reprint Update on olfactory mucosal metabolic enzymes: age-related changes and N-acetyltransferase activities
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    J Biochem Mol Toxicol 18:239-44. 2004
    ....
  3. ncbi request reprint Reduction of alachlor-induced olfactory mucosal neoplasms by the matrix metalloproteinase inhibitor Ro 28-2653
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Toxicol Pathol 33:593-9. 2005
    ....
  4. ncbi request reprint Molecular biology of the nasal airways: how do we assess cellular and molecular responses in the nose?
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Toxicol Pathol 34:274-80. 2006
    ..In each instance, precise sampling is emphasized and proper controls are discussed, and examples of independent means of validation of genomics experiments are presented...
  5. ncbi request reprint Localization of CYP4B1 in the rat nasal cavity and analysis of CYPs as secreted proteins
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, ML 670056, Cincinnati, OH 45267 0056, USA
    J Biochem Mol Toxicol 20:139-41. 2006
    ..The observation that multiple human cytochrome P450s appear to be secreted proteins helps to explain the appearance of anti-cytochrome P450 antigens in cases of human autoimmune liver diseases...
  6. ncbi request reprint Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs
    Mary Beth Genter
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 348:120-3. 2006
    ..In contrast, CYP1A1- and CYP1A2-null mice pretreated with 5-phenyl-1-pentyne exhibited no NP olfactory toxicity. These results suggest that AHR-mediated enzymes do not contribute significantly to NP bioactivation in the intact animal...
  7. ncbi request reprint Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Physiol Genomics 16:67-81. 2003
    ..Further exploration of this database will provide additional insights into genes and pathways critical for olfactory neurogenesis, neuronal differentiation, olfaction, and mucosal defense...
  8. pmc Progression of alachlor-induced olfactory mucosal tumours
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, ML 670056, Cincinnati, OH 45267 0056, USA
    Int J Exp Pathol 83:303-8. 2002
    ..This study demonstrated that abbreviated alachlor exposure did not result in subsequent tumour formation within the 6-month observation period...
  9. ncbi request reprint Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa
    Mary Beth Genter
    Departmet of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Physiol Genomics 12:35-45. 2002
    ....
  10. pmc Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides
    M B Genter
    Department of Environmental Health and Center for Environmental Genetics, 3223 Eden Ave, ML 670056, University of Cincinnati, Cincinnati, OH 45267 0056, United States
    Food Chem Toxicol 47:1051-7. 2009
    ..Except for similar gene responses in alachlor- and butachlor-treated rats, we did not identify clear-cut differences that would predict OM carcinogenicity in this study...
  11. ncbi request reprint Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse
    M B Genter
    Department of Molecular and Cellular Physiology, University of Cincinnati, OH 45267 0576, USA
    Biochem Pharmacol 55:1819-26. 1998
    ..These studies provide strong evidence that, in addition to CYP2E1, CYP2A5 and 2G1 are important in AP bioactivation in the mouse olfactory mucosa and that CYP1A2 appears to be of minor importance for AP olfactory toxicity...
  12. ncbi request reprint Age-related susceptibility to 3,3'-iminodipropionitrile-induced olfactory mucosal damage
    M B Genter
    Department of Molecular and Cellular Physiology, University of Cincinnati, OH 45267 0576, USA
    Neurobiol Aging 19:569-74. 1998
    ..The mechanism underlying the increased susceptibility of older rats is likely a complex interaction between the activities of one or more of the enzymes involved in IDPN metabolism in OM and liver...
  13. pmc Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Drug Metab Dispos 38:1644-7. 2010
    ..OATP3 immunoreactivity was high in olfactory epithelium and olfactory nerve bundles, which suggests that substrates transported by OATP3 may be candidates for intranasal administration...
  14. ncbi request reprint Evolution of alachlor-induced nasal neoplasms in the Long-Evans rat
    M B Genter
    Department of Environmental Health, University of Cincinnati, Ohio 45267 0056, USA
    Toxicol Pathol 28:770-81. 2000
    ..These data suggest that local metabolism is important in alachlor-induced olfactory tumors and support the concept that metaplastic respiratory epithelial cells give rise to the observed neoplasms...
  15. doi request reprint Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level?
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Ann N Y Acad Sci 1170:623-8. 2009
    ..We summarize here a representative sample of transporter proteins found in olfactory mucosa and/or nasal respiratory mucosa and the substrates that they transport into the brain and/or bloodstream...
  16. ncbi request reprint Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, ML 670056, Cincinnati, OH 45267 0056, USA
    J Biochem Mol Toxicol 16:128-34. 2002
    ..These results demonstrate that environmental exposures can influence the levels and activity of nasal mucosal enzymes and impact the pharmacology of drugs administered via the nasal route...
  17. ncbi request reprint Strain-specific of alachlor on murine olfactory mucosal responses
    Mary Beth Genter
    Department of Environmental Health, ML 670056, 3223 Eden Ave, 144 Kettering, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Toxicol Pathol 32:719-25. 2004
    ....
  18. ncbi request reprint 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes
    Howard G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Carcinogenesis 28:1371-8. 2007
    ..e. skin, gastric, i.p.), low hepatic expression of CYP1A2 and CYP1A1, together with high expression levels of lung CYP1B1 and CYP1A1, may define a phenotype for high susceptibility to carcinogens such as DBC...
  19. pmc Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole
    H G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Int J Obes (Lond) 34:970-9. 2010
    ..Therefore, we examined the ability of APAP and THII to prevent metabolic changes in mice receiving OLZ...
  20. ncbi request reprint Evaluation of olfactory and auditory system effects of the antihyperthyroid drug carbimazole in the Long-Evans rat
    M B Genter
    Department of Molecular and Cellular Physiology, University of Cincinnati, OH 45267 0576, USA
    J Biochem Mol Toxicol 12:305-14. 1998
    ..Evaluation of the auditory startle response in carbimazole-treated rats revealed no deficits, demonstrating that carbimazole does not cause a global loss of hearing in rats...
  21. ncbi request reprint Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery
    T P Dalton
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio, 45267 0056, USA
    Biochem Biophys Res Commun 267:184-9. 2000
    ..We postulate that CYP1A1 and CYP1A2 might have overlapping substrate specificity for metabolism of the EL, such that basal CYP1A2 in the liver can compensate for the loss of CYP1A1...
  22. ncbi request reprint Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels
    S Uno
    Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0056, USA
    Biochem Biophys Res Commun 289:1049-56. 2001
    ....
  23. ncbi request reprint Dioxin increases reactive oxygen production in mouse liver mitochondria
    Albert P Senft
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Toxicol Appl Pharmacol 178:15-21. 2002
    ..To our knowledge, this is the first report to show that dioxin increases mitochondrial respiration-dependent reactive oxygen production, which may play an important role in dioxin-induced toxicity and disease...
  24. ncbi request reprint Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor
    Albert P Senft
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, OH 45267, USA
    Free Radic Biol Med 33:1268-78. 2002
    ..These results suggest that both constitutive and dioxin-induced mitochondrial reactive oxygen production is associated with a function of the AHR, and these effects are independent of either CYP1A1 or CYP1A2...
  25. doi request reprint Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet
    Eric L Kendig
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Biochem Pharmacol 76:216-24. 2008
    ..We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition...
  26. ncbi request reprint Regulation of cytochrome P450 gene expression in the olfactory mucosa
    Guoyu Ling
    Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Empire State Plaza, Box 509, Albany, NY 12201 0509, USA
    Chem Biol Interact 147:247-58. 2004
    ....
  27. ncbi request reprint Antioxidant perturbations in the olfactory mucosa of alachlor-treated rats
    Dawn M Burman
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Biochem Pharmacol 66:1707-15. 2003
    ..Dietary exposure to alachlor depletes olfactory mucosa antioxidants, which may contribute to DNA damage and tissue-specific tumor formation...
  28. pmc TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone
    Howard G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056 Cincinnati, OH 45267 0056, USA
    Toxicol Appl Pharmacol 217:363-74. 2006
    ..This acts in concert with glutathione to increase membrane potential and reactive oxygen production. The proposed defect in ATP synthase explains both the greater respiratory rates and the lower tissue ATP levels...
  29. ncbi request reprint Cyp1a2 protects against reactive oxygen production in mouse liver microsomes
    Howard G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Free Radic Biol Med 36:605-17. 2004
    ..Our results suggest that possibly acting as an "electron sink," CYP1A2 might decrease CYP2E1-and CYP1A1-mediated H(2)O(2) production and oxidative stress. In this regard, CYP1A2 may be considered an antioxidant enzyme...
  30. ncbi request reprint Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes
    Howard G Shertzer
    Department of Environmental Health, University of Cincinnati, Medical Center, 123 East Shields Street, Cincinnati, OH 45267 0056, USA
    Free Radic Biol Med 36:618-31. 2004
    ..This pathway is likely to contribute to the oxidative stress response and associated toxicity produced by many of these environmental chemicals...
  31. ncbi request reprint Neural system-enriched gene expression: relationship to biological pathways and neurological diseases
    Jianhua Zhang
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati 45267, USA
    Physiol Genomics 18:167-83. 2004
    ..Together, our data indicate the power of profiling an individual biologic system in a multisystem context to gain insight into the genomic basis of its structure and function...
  32. ncbi request reprint Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment
    Mary Beth Genter
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 342:1375-81. 2006
    ..We speculate that such mitochondrial CYPs may be involved in the generation, or mitigation, of the well-known TCDD-inducible oxidative stress response...
  33. doi request reprint Acetaminophen normalizes glucose homeostasis in mouse models for diabetes
    Howard G Shertzer
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Biochem Pharmacol 75:1402-10. 2008
    ....

Research Grants8

  1. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  2. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  3. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..