HOWARD GENDELMAN

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Mononuclear phagocyte biophysiology influences brain transendothelial and tissue migration: implication for HIV-1-associated dementia
    Induk Chung
    The Center for Neurovirology and Neurodegenerative Disorders, Departments of Pathology and Microbiology, University of Nebraska Medical Center, 985215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 122:40-54. 2002
  2. ncbi request reprint Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease
    Mark P Thomas
    Laboratory of Neuroregeneration, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 100:503-19. 2007
  3. pmc Proteomic modeling for HIV-1 infected microglia-astrocyte crosstalk
    Tong Wang
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, Omaha, Nebraska, United States of America
    PLoS ONE 3:e2507. 2008
  4. pmc Pulsed stable isotope labeling of amino acids in cell culture uncovers the dynamic interactions between HIV-1 and the monocyte-derived macrophage
    Stephanie D Kraft-Terry
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Proteome Res 10:2852-62. 2011
  5. pmc Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage
    Xiuyan Huang
    Department of Pharmacology, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States
    J Proteome Res 9:6759-73. 2010
  6. pmc Macrophage bridging conduit trafficking of HIV-1 through the endoplasmic reticulum and Golgi network
    Irena Kadiu
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
    J Proteome Res 10:3225-38. 2011
  7. pmc Comparative manufacture and cell-based delivery of antiretroviral nanoformulations
    Shantanu Balkundi
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    Int J Nanomedicine 6:3393-404. 2011
  8. pmc Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection
    Adrian A Epstein
    Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA
    J Neuroimmune Pharmacol 8:1224-38. 2013
  9. doi request reprint The 4th Annual Meeting of the American Society for Nanomedicine
    Howard E Gendelman
    985880 Nebraska Medical Center, Omaha, NE, 68198 5880
    J Neuroimmune Pharmacol 9:S1-3. 2014
  10. doi request reprint Interview: Nanomedicine and the fight against HIV/AIDS
    Andre Nel
    California NanoSystems Institute, David Geffen School of Medicine at UCLA, 52 175 Center for the Health Sciences, 10833 Le Conte Ave, Los Angeles, CA 90095 1736, USA
    Nanomedicine (Lond) 9:193-206. 2014

Research Grants

  1. Neuroprotective immunity and HIV dementia
    Howard E Gendelman; Fiscal Year: 2010
  2. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2001
  3. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2002
  4. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2003
  5. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2004
  6. Training Program in Neurovirology
    HOWARD GENDELMAN; Fiscal Year: 2006
  7. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2010
  8. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2001
  9. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2000
  10. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2000

Detail Information

Publications90

  1. ncbi request reprint Mononuclear phagocyte biophysiology influences brain transendothelial and tissue migration: implication for HIV-1-associated dementia
    Induk Chung
    The Center for Neurovirology and Neurodegenerative Disorders, Departments of Pathology and Microbiology, University of Nebraska Medical Center, 985215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 122:40-54. 2002
    ..The results suggest that potassium channels affect MDM brain migration through altering cell volume and shape. Such mechanisms likely affect MP-induced neuronal destruction during HAD...
  2. ncbi request reprint Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease
    Mark P Thomas
    Laboratory of Neuroregeneration, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 100:503-19. 2007
    ..Understanding these linkages may lead to novel therapeutics for Parkinson's disease where modulation of redox-related stress may slow disease progression...
  3. pmc Proteomic modeling for HIV-1 infected microglia-astrocyte crosstalk
    Tong Wang
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, Omaha, Nebraska, United States of America
    PLoS ONE 3:e2507. 2008
    ..In contrast, astrocytes can affect disease by modulating the nervous system's microenvironment. Interestingly, little is known how astrocytes communicate with MP to influence disease...
  4. pmc Pulsed stable isotope labeling of amino acids in cell culture uncovers the dynamic interactions between HIV-1 and the monocyte-derived macrophage
    Stephanie D Kraft-Terry
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Proteome Res 10:2852-62. 2011
    ..We conclude that HIV-1 regulates a range of host MDM proteins that affect its survival and abilities to contain infection...
  5. pmc Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage
    Xiuyan Huang
    Department of Pharmacology, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States
    J Proteome Res 9:6759-73. 2010
    ....
  6. pmc Macrophage bridging conduit trafficking of HIV-1 through the endoplasmic reticulum and Golgi network
    Irena Kadiu
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
    J Proteome Res 10:3225-38. 2011
    ..Disruption of the ER-Golgi network impaired HIV-1 trafficking in the conduit endosomes. This study provides, for the first time, mechanisms for how BC Golgi and ER direct cell-cell viral transfer...
  7. pmc Comparative manufacture and cell-based delivery of antiretroviral nanoformulations
    Shantanu Balkundi
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    Int J Nanomedicine 6:3393-404. 2011
    ..We posit that the choice of drug and formulation composition may ultimately affect clinical utility...
  8. pmc Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection
    Adrian A Epstein
    Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA
    J Neuroimmune Pharmacol 8:1224-38. 2013
    ..Metabolite responses were contingent on the animal model. Taken together, these studies integrate brain metabolomics with histopathology towards uncovering putative biomarkers for neuroAIDS. ..
  9. doi request reprint The 4th Annual Meeting of the American Society for Nanomedicine
    Howard E Gendelman
    985880 Nebraska Medical Center, Omaha, NE, 68198 5880
    J Neuroimmune Pharmacol 9:S1-3. 2014
    ..It will also serve as an incubator for developing investigators and broad new field discoveries. Welcome to the conference and enjoy!..
  10. doi request reprint Interview: Nanomedicine and the fight against HIV/AIDS
    Andre Nel
    California NanoSystems Institute, David Geffen School of Medicine at UCLA, 52 175 Center for the Health Sciences, 10833 Le Conte Ave, Los Angeles, CA 90095 1736, USA
    Nanomedicine (Lond) 9:193-206. 2014
    ..Finally, Professor Howard Gendelman looks to the future and assesses the potential and challenges of nanomedicine approaches for HIV eradication.
  11. pmc CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease
    Jessica A Hutter Saunders
    Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 7:927-38. 2012
    ..The association of T cell phenotypes with motor symptoms provides fresh avenues for novel biomarkers and therapeutic designs...
  12. pmc Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection
    Irena Kadiu
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198 5800, USA
    J Neuroimmune Pharmacol 6:658-75. 2011
    ..These data lead us to propose that HIV-1 hijacks macrophage endocytic and cytoskeletal machineries for high-speed cell-to-cell spread...
  13. ncbi request reprint Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis
    Huanyu Dou
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurosci 25:8375-85. 2005
    ..Electrophysiological recordings showed diminished long-term potentiation in hippocampal slices of HIVE mice that were restored by Li. Based on these data, the use of Li as an adjuvant for HIV-1-associated dementia is now being pursued...
  14. pmc Monocyte chemotactic protein-1 regulates voltage-gated K+ channels and macrophage transmigration
    Howard E Gendelman
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 4:47-59. 2009
    ..Together these data demonstrated that MCP-1 affects macrophage migratory movement through regulation of voltage-gated K+ channels and, as such, provides a novel therapeutic strategy for neuroAIDS...
  15. pmc The promise and perils of CNS drug delivery: a video debate
    Howard E Gendelman
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 3:58. 2008
    ..This debate by leading experts in the field highlights the promise and perils of CNS drug delivery. Click on Supplemental HTML to watch the streaming video...
  16. ncbi request reprint Biomarkers, laboratory, and animal models for the design and development of adjunctive therapies for HIV-1 dementia and other neuroinflammatory disorders
    Howard E Gendelman
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 2:8-13. 2007
    ..Multidisciplinary teams are likely required to see such research to fruition, and the developmental schemes from the molecule to the laboratory to the animal to the clinic were discussed and developed in the session...
  17. ncbi request reprint Infections of the nervous system
    Howard E Gendelman
    Center for Neurovirology and Neurodegenerative Disorders and Department of Pharmacology, University of Nebraska Medical Center, Omaha NE, USA
    Lancet Neurol 4:12-3. 2005
  18. ncbi request reprint Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis
    Huanyu Dou
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci 23:9162-70. 2003
    ..We conclude that VPA protects neurons against HIV-1 infected MDM neurotoxicity, possibly through its effects on the phosphorylation of tau and beta-catenin. The use of VPA as an adjuvant in treatment of human HAD is being pursued...
  19. ncbi request reprint Impaired spatial cognition and synaptic potentiation in a murine model of human immunodeficiency virus type 1 encephalitis
    Walter E Zink
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci 22:2096-105. 2002
    ..Importantly, the findings demonstrate the value of the model in exploring the physiological basis and therapeutic potential for HIV-1-associated dementia...
  20. pmc Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis
    Raghava Potula
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    Blood 106:2382-90. 2005
    ..Thus, manipulation of immunosuppressive IDO activity in HIVE may enhance the generation of HIV-1-specific CTLs, leading to elimination of HIV-1-infected macrophages in brain...
  21. pmc Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration
    Jianuo Liu
    Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 182:3855-65. 2009
    ..Effector T cells showed contrary effects. These results, taken together, demonstrate the importance of Treg in disease control and raise the possibility of their utility for therapeutic strategies...
  22. ncbi request reprint Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease
    Michael D Boska
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci 25:1691-700. 2005
    ..These results demonstrate that 1H MRSI can evaluate dopaminergic degeneration and its protection by Cop-1 immunization strategies. Most importantly, the results provide a monitoring system to assess therapeutic outcomes for PD...
  23. ncbi request reprint Genomic and proteomic microglial profiling: pathways for neuroprotective inflammatory responses following nerve fragment clearance and activation
    Jason G Glanzer
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 102:627-45. 2007
    ..Most importantly, this molecular and biochemical signature supports a broad range of microglial functions for debris clearance and promotion of neural repair after injury...
  24. pmc HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: new insights into blood-brain barrier dysfunction for HIV-1-associated dementia
    Mary Ricardo-Dukelow
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 185:37-46. 2007
    ..Results were validated by Western blot analysis. We conclude that HIV-1-infected MDM affect the HBMEC proteome and, in this way, affect BBB dysfunction and the development of HIV-1 CNS disease...
  25. ncbi request reprint Generation of cytotoxic T cells against virus-infected human brain macrophages in a murine model of HIV-1 encephalitis
    Larisa Y Poluektova
    Center for Neurovirology and Neurodegenerative Disorders, and Department of Pathology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 168:3941-9. 2002
    ..The human PBL-NOD-SCID HIVE mouse provides a new tool for studies of cellular immune responses against HIV-1-infected brain mononuclear phagocytes during natural disease and after vaccination...
  26. pmc HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta
    Hui Peng
    Laboratory of Neurotoxicology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68195 5880, USA
    Glia 54:619-29. 2006
    ....
  27. pmc Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia
    Radhika Suryadevara
    Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Glia 44:47-56. 2003
    ..Our studies reveal new opportunities for repair-based therapeutic strategies in HAD...
  28. pmc Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery
    Huanyu Dou
    Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorder, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Blood 108:2827-35. 2006
    ..We conclude that a single dose of NP-IDV, using BMMs as a carrier, is effective and warrants consideration for human testing...
  29. pmc Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS
    Huanyu Dou
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, 68198, USA
    J Immunol 183:661-9. 2009
    ..We conclude that nanoART targeting to diseased brain through macrophage carriage is possible and can be considered in developmental therapeutics for HIV-associated neurological disease...
  30. pmc HIV-1 neuroimmunity in the era of antiretroviral therapy
    Stephanie D Kraft-Terry
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Neurobiol Dis 37:542-8. 2010
    ..Current therapeutic approaches are focused on adjunctive and brain-penetrating antiretroviral therapies. These may attenuate virus-associated neuroinflammatory activities thereby decreasing the severity and frequency of HAND...
  31. ncbi request reprint CD4+ T cells from Copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Chad Laurie
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    J Neuroimmunol 183:60-8. 2007
    ..CD4+ T cells elicited the most significant neuroprotective response while high titers of anti-Cop-1 antibodies showed no effect. These data further support the use of immunomodulatory strategies for Parkinson's disease...
  32. pmc Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice
    Santhi Gorantla
    Centere for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Virol 81:2700-12. 2007
    ..We conclude that humanized BALB/c-Rag2(-/-)gamma(c)(-/-) mice represent a unique and valuable resource for HIV-1 pathobiology studies...
  33. pmc Novel delivery system enhances efficacy of antiretroviral therapy in animal model for HIV-1 encephalitis
    Timothy J Spitzenberger
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Cereb Blood Flow Metab 27:1033-42. 2007
    ..Our findings indicate major antiretroviral effects of P85 and enhanced in vivo efficacy of antiretroviral drugs when combined with P85 in a SCID mouse model of HIVE...
  34. pmc Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
    Eric J Benner
    Center for Neurovirology and Neurodegenerative Disorders and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198, USA
    Proc Natl Acad Sci U S A 101:9435-40. 2004
    ..Such vaccine treatment strategies may provide benefit for Parkinson's disease...
  35. pmc 4-Aminopyridine improves spatial memory in a murine model of HIV-1 encephalitis
    James P Keblesh
    Neurophysiology Laboratory, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmune Pharmacol 4:317-27. 2009
    ..These results support the importance of K(v) channel dysfunction in disease but, more importantly, provide a potential target for adjunctive therapies for HAND...
  36. pmc Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitis
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    Glia 56:223-32. 2008
    ..The data, taken together, demonstrate that Cop-1 can modulate innate immunity and, as such, improve disease outcomes in an animal model of HIVE...
  37. ncbi request reprint TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia
    Lisa A Ryan
    Laboratory of Neurotoxicology, University of Nebraska Medical Center, Omaha, NE 68195 5215, USA
    J Neuroimmunol 148:127-39. 2004
    ..Furthermore, TRAIL induced a dose-dependent effect on neuronal apoptosis. These results support a role for TRAIL in mononuclear phagocyte (MP)-mediated neurotoxicity in HIV-1-associated dementia (HAD)...
  38. pmc Macrophage delivery of therapeutic nanozymes in a murine model of Parkinson's disease
    Anna M Brynskikh
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA
    Nanomedicine (Lond) 5:379-96. 2010
    ..To this end, we developed a cell-based nanoformulation delivery system using the antioxidant enzyme catalase to attenuate neuroinflammatory processes linked to neuronal death...
  39. ncbi request reprint Memantine protects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis
    Eric R Anderson
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurosci 24:7194-8. 2004
    ..These results demonstrate that memantine attenuates hippocampal synaptic impairment in murine HIVE and provide a rationale for its use in infected humans who experience cognitive decline...
  40. pmc Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease
    Ashley D Reynolds
    Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 184:2261-71. 2010
    ..Taken together, these results demonstrate Treg control of N-alpha-syn-induced neurodestructive immunity and, as such, provide a sound rationale for future Parkinson's disease immunization strategies...
  41. pmc Neuroprotective activities of CEP-1347 in models of neuroAIDS
    Dawn Eggert
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 184:746-56. 2010
    ..These results demonstrate that CEP-1347 elicits anti-inflammatory and neuroprotective responses in an HIVE model of human disease and as such warrants further study as an adjunctive therapy for human disease...
  42. pmc Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders
    Dawn Eggert
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmunol 213:47-59. 2009
    ..These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders...
  43. pmc Ingress of blood-borne macrophages across the blood-brain barrier in murine HIV-1 encephalitis
    Yutong Liu
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5880, United States
    J Neuroimmunol 200:41-52. 2008
    ..The demonstration of robust BMM migration into areas of focal encephalitis provide 'proof of concept' for the use of MRI to monitor macrophage ingress into brain...
  44. pmc Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration
    Honghong Yao
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Blood 115:4951-62. 2010
    ..Understanding the regulation of MCP-1 expression and functional changes by cocaine/sigma receptor system may provide insights into the development of potential therapeutic targets for HIV-1-associated neurocognitive disorders...
  45. pmc CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice
    Santhi Gorantla
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 184:7082-91. 2010
    ..These data support a role of CD8+ cells in viral surveillance and the relevance of this humanized mouse model for the studies of HIV-1 pathobiology and virus-specific immunity...
  46. ncbi request reprint Proteomic fingerprints distinguish microglia, bone marrow, and spleen macrophage populations
    Yoshimi Enose
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    Glia 51:161-72. 2005
    ..The results provide a unique means to distinguish microglia from other MP subtypes...
  47. ncbi request reprint HIV-1-associated dementia: a metabolic encephalopathy perpetrated by virus-infected and immune-competent mononuclear phagocytes
    Eric Anderson
    The Center for Neurovirology and Neurodegenerative Disorders and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 5215, USA
    J Acquir Immune Defic Syndr 31:S43-54. 2002
    ....
  48. ncbi request reprint Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia
    David Erichsen
    Laboratory of Neurotoxicology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 138:144-55. 2003
    ..0345). These results demonstrate a possible role of FKN in HAD pathogenesis...
  49. ncbi request reprint Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis
    Adeline Nukuna
    Center for Neurovirology and Neurodegenerative Disorders, Omahan NE 68195 5215, USA
    J Neurovirol 10:82-90. 2004
    ..Virus infection, per se, may affect the ability of macrophages to respond to immune stimuli by overproduction of proinflammatory factors and neurotoxins, leading to neuronal dysfunction...
  50. pmc Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice
    Masaru Yamamoto
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Am J Pathol 170:680-92. 2007
    ..Taken together, these observations suggest that proinflammatory cytokines are directly linked to Alzheimer's disease pathogenesis...
  51. ncbi request reprint OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis
    Kimberly A Carlson
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 150:186-98. 2004
    ..Thus, OTK18 expression in brain mononuclear phagocytes is a signature for advanced HIV-1 encephalitis...
  52. pmc Nitrated alpha-synuclein and microglial neuroregulatory activities
    Ashley D Reynolds
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroimmune Pharmacol 3:59-74. 2008
    ..Inhibition of cathepsin B attenuated, in part, N-alpha-syn microglial neurotoxicity. These data support multifaceted microglia functions in PD-associated neurodegeneration...
  53. pmc STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier
    Anathbandhu Chaudhuri
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    Blood 111:2062-72. 2008
    ..Inhibition of STAT1 activation could provide a unique therapeutic strategy to attenuate HIV-1-induced BBB compromise and as such improve clinical outcomes...
  54. ncbi request reprint Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment
    Wojciech Rozek
    Center for Neurovirology and Neurodegenerative Disorders, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
    J Proteome Res 6:4189-99. 2007
    ..We posit that these proteins, alone or together, are potential HAD biomarkers...
  55. ncbi request reprint Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 179:4345-56. 2007
    ..Ingress of Foxp3- and IL-4-expressing lymphocytes into brains of COP-1-immunized animals was observed. We conclude that COP-1 may warrant therapeutic consideration for HIV-1-associated cognitive impairments...
  56. pmc Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4+CD25+ T cells
    Ashley D Reynolds
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
    J Proteome Res 8:3497-511. 2009
    ..We conclude that Treg modulate the N-alpha-syn microglial proteome and, in this way, can slow the tempo and course of PD...
  57. ncbi request reprint Macrophages, chemokines and neuronal injury in HIV-1-associated dementia
    Lisa A Ryan
    Laboratory of Neurotoxicology, Center for Neurovirology and Neurodegenerative Disorders, Omaha, NE 68198 5215, USA
    Cell Mol Biol (Noisy-le-grand) 48:137-50. 2002
    ..The elucidation of mechanisms involved in chemokine-mediated neural compromise will likely provide unique insights into the pathogenesis and treatment, not only of HAD, but of a wide range of neurodegenerative disorders...
  58. pmc Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 chal
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Virol 79:2124-32. 2005
    ..This mouse model may be a useful tool to evaluate human immune responses and protection against viral infection following vaccination...
  59. ncbi request reprint Diminished matrix metalloproteinase 9 secretion in human immunodeficiency virus-infected mononuclear phagocytes: modulation of innate immunity and implications for neurological disease
    Pawel Ciborowski
    Center for Neurovirology and Neurodegenerative Disorders, 985215 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 5215, U SA
    J Neuroimmunol 157:11-6. 2004
    ..These data further demonstrate immunoregulatory activities of HIV-1-infected MDM providing unique insights into cellular function in disease...
  60. pmc A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection
    Stephanie D Kraft-Terry
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Neuron 64:133-45. 2009
    ..Better understanding of the complexities of immune regulation during HAND can improve diagnosis and disease outcomes but is also relevant for the pathogenesis of a broad range of neurodegenerative disorders...
  61. ncbi request reprint Advances in neuroimaging for HIV-1 associated neurological dysfunction: clues to the diagnosis, pathogenesis and therapeutic monitoring
    Michael D Boska
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Curr HIV Res 2:61-78. 2004
    ..Such tests can facilitate dynamic measures of HIV-1 neuropathogenesis providing information for disease events that even 2 years ago were unattainable...
  62. pmc Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDS
    Santhi Gorantla
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198 5880, USA
    J Neuroimmune Pharmacol 5:456-68. 2010
    ..Gp1a down modulated CCR5 expression on human cells in the spleen with an increase in Fas ligand expression. Our results support the notion that CB2 receptor agonists may be a viable therapeutic candidate for HAND...
  63. ncbi request reprint Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection
    Yuri Persidsky
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Leukoc Biol 74:691-701. 2003
    ..New therapeutic strategies are discussed based on current knowledge of HIV-1-associated dementia pathogenesis...
  64. pmc Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets
    Ashley D Reynolds
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, 68198, USA
    J Immunol 182:4137-49. 2009
    ..These data support the importance of adaptive immunity in the regulation of Parkinson's disease-associated microglial inflammation...
  65. ncbi request reprint Activation of NR1a/NR2B receptors by monocyte-derived macrophage secretory products: implications for human immunodeficiency virus type one-associated dementia
    Huangui Xiong
    The Laboratory of Neurophysiology, University of Nebraska Medical Center, Omaha 68198 5215, USA
    Neurosci Lett 341:246-50. 2003
    ..Our experiments demonstrate that secretory factors from HIV-1-infected MDM activate NMDA receptors NR1a/NR2B and may contribute to neuronal demise during HAD...
  66. pmc Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease
    Michael D Boska
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 1045, USA
    Neurobiol Dis 26:590-6. 2007
    ..75, p=0.012). No differences were found in the striatum, corpus callosum, cerebral cortex, or ventricles. These results demonstrate that DTI may be used as a surrogate biomarker of nigral dopaminergic neuronal degeneration...
  67. pmc A macrophage-nanozyme delivery system for Parkinson's disease
    Elena V Batrakova
    Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Bioconjug Chem 18:1498-506. 2007
    ..0.6% of the injected dose were found in brain. We conclude that cell-mediated delivery of nanozymes can reduce oxidative stress in laboratory and animal models of PD...
  68. ncbi request reprint Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease
    Ashley D Reynolds
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Leukoc Biol 82:1083-94. 2007
    ..This neuroprotection was achieved through modulation of microglial oxidative stress and inflammation. As Tregs can be modulated in vivo, these data strongly support the use of such immunomodulatory strategies to treat PD...
  69. ncbi request reprint Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Leukoc Biol 80:1165-74. 2006
    ..These data show real-time kinetics and destinations of macrophage trafficking and demonstrate the feasibility of monitoring macrophage-based, nanoformulated ART...
  70. ncbi request reprint Isolation and HIV-1 infection of primary human microglia from fetal and adult tissue
    Kathleen Borgmann
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pathology, University of Nebraska Medical Center, Omaha, NE, USA
    Methods Mol Biol 304:49-70. 2005
    ....
  71. ncbi request reprint T cell independent mechanism for copolymer-1-induced neuroprotection
    Jianuo Liu
    Laboratory of Neuro Immune Regulation, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Eur J Immunol 37:3143-54. 2007
    ..These findings may facilitate the development of neuroprotective approaches using DC-mediated Cop-1 delivery to diseased nervous tissue...
  72. ncbi request reprint Murine models for human immunodeficiency virus type 1-associated dementia: the development of new treatment testing paradigms
    Yuri Persidsky
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurovirol 8:49-52. 2002
    ....
  73. ncbi request reprint Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia
    Huangui Xiong
    The Laboratory of Neurophysiology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci Res 71:600-7. 2003
    ..The induction of IL-8 in HAD, its inhibition of LTP, and the expression of its receptor, CXCR2, in the hippocampus all suggest that it plays a role in the cognitive dysfunction associated with HAD...
  74. ncbi request reprint Glatiramer acetate immunization induces specific antibody and cytokine responses in ALS patients
    R Lee Mosley
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Amyotroph Lateral Scler 8:235-42. 2007
    ..These data show significant humoral responses and cytokine trends following GA immunization in ALS patients...
  75. pmc HIV-1 gp120 compromises blood-brain barrier integrity and enhances monocyte migration across blood-brain barrier: implication for viral neuropathogenesis
    Georgette D Kanmogne
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Cereb Blood Flow Metab 27:123-34. 2007
    ..Thus, gp120 can cause dysfunction of BBB via PKC pathways and receptor mediated [Ca(2+)](i) release leading to cytoskeletal alterations and increased monocyte migration...
  76. ncbi request reprint Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic function
    Annemarie Shibata
    Center for Neurovirology and Neurodegenerative Disorders and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 985215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 142:112-29. 2003
    ..MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration...
  77. ncbi request reprint Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages
    Huanyu Dou
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Virology 358:148-58. 2007
    ..These data provide "proof of concept" for the use of macrophage-based NP delivery systems for human HIV-1 infections...
  78. ncbi request reprint Molecular characterization of a putative antiretroviral transcriptional factor, OTK18
    Kimberly A Carlson
    Department of Pathology and Microbiology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 172:381-91. 2004
    ..Our findings suggest that one possible function of OTK18 is as a HIV type 1-inducible transcriptional suppressor...
  79. pmc Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome
    Pawel Ciborowski
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Virology 363:198-209. 2007
    ..This study, using a unique proteomics platform, provides novel insights into virus-host cell interactions that likely affect the functional role of macrophages in HIV disease...
  80. ncbi request reprint Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects
    Anuja Ghorpade
    Laboratory of Cellular Neuroimmunology, 985215 Nebraska Medical Center, Omaha, NE, 68198 5215, USA
    J Neuroimmunol 163:145-56. 2005
    ..Monocytes from seronegative donors paralleled these diminished immune responses following repeated LPS-activation. These results demonstrate changes in innate microglial function following viral infection or chronic immune activation...
  81. ncbi request reprint Macrophage-induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV-1 encephalitis
    Larisa Poluektova
    Laboratory of Neuroregeneration, Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Glia 52:344-53. 2005
    ..We posit that activated MDM induce inflammation and diminish DG neuronal plasticity. These data provide novel explanations for the cognitive impairments manifested during advanced HIV-1 infection...
  82. pmc Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons
    Eric J Benner
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA
    PLoS ONE 3:e1376. 2008
    ..We reasoned that PD-associated oxidative protein modifications create novel antigenic epitopes capable of peripheral adaptive T cell responses that could affect nigrostriatal degeneration...
  83. ncbi request reprint Human immunodeficiency virus-mononuclear phagocyte interactions: emerging avenues of biomarker discovery, modes of viral persistence and disease pathogenesis
    Pawel Ciborowski
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5800, USA
    Curr HIV Res 4:279-91. 2006
    ....
  84. ncbi request reprint Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitis
    Larisa Poluektova
    Laboratory of Neuroregeneration, Center for Neurovirology and Neurodegenerative Disorders, and Department of Pathology and Microbiology, University of Nebraska Medical Center, 958215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Immunol 172:7610-7. 2004
    ..This murine model of HIV-1 encephalitis can be useful in elucidating the role played by innate and adaptive immunity in disease progression and resolution...
  85. ncbi request reprint Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease
    Ashley D Reynolds
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 104:1504-25. 2008
    ..Taken together, the transcriptome and proteome of nitrated alpha-syn activated microglia, shown herein, provide new potential insights into disease mechanisms...
  86. ncbi request reprint Neuropathologic and neuroinflammatory activities of HIV-1-infected human astrocytes in murine brain
    Huanyu Dou
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    Glia 54:81-93. 2006
    ..We conclude that HIV-1 infection of astrocytes leads to limited neurodegeneration, underscoring the early and active role of macrophage-driven neurotoxicity in disease...
  87. pmc Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
    Anamitra Ghosh
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:18754-9. 2007
    ..These findings were specific because mutated NBD peptide had no effect. We conclude that selective inhibition of NF-kappaB activation by NBD peptide may be of therapeutic benefit for PD patients...
  88. ncbi request reprint Proteomic fingerprinting of human immunodeficiency virus type 1-associated dementia from patient monocyte-derived macrophages: A case study
    Valerie Wojna
    The Departments of Microbiology and Specialized NeuroSciences Program, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
    J Neurovirol 10:74-81. 2004
    ..Each of these proteins were abrogated after HAART. Additional studies extending this one time point determination would serve to confirm the general utility of MDM protein profiling for the diagnosis and monitoring of HAD...
  89. ncbi request reprint Development of a rapid autopsy program for studies of brain immunity
    Anuja Ghorpade
    Laboratory of Cellular Neuroimmunology, 985215 Nebraska Medical Center, Omaha, NE, 68198 5215, USA
    J Neuroimmunol 163:135-44. 2005
    ..The challenges in developing this initiative, reflecting experiences from 69 autopsies over 4 years, are presented...

Research Grants39

  1. Neuroprotective immunity and HIV dementia
    Howard E Gendelman; Fiscal Year: 2010
    ....
  2. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2001
    ....
  3. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2002
    ....
  4. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2003
    ..This project serves as an extension of our previous works seeking to determine how microglial immunity affects the pathogenesis, progression and the therapeutic options for HAD. ..
  5. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2004
    ..This project serves as an extension of our previous works seeking to determine how microglial immunity affects the pathogenesis, progression and the therapeutic options for HAD. ..
  6. Training Program in Neurovirology
    HOWARD GENDELMAN; Fiscal Year: 2006
    ....
  7. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2010
    ..To address this issue, we plan to develop nanoformulations of commonly used ART with variable brain entry profiles and deliver them directly to diseased brain tissue inside blood-borne macrophages. ..
  8. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2001
    ....
  9. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2000
    ....
  10. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2000
    ....
  11. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2000
    ....
  12. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 1999
    ....
  13. HIV-1, MONOCYTES AND THE BLOOD/BRAIN BARRIER
    HOWARD GENDELMAN; Fiscal Year: 2000
    ..The combined efforts are designed to determine the viral and immune determinants for BBB dysfunction in AIDS, information that could be helpful in adapting strategies to prevent migration of monocytes into the brain during HIV dementia. ..
  14. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 1999
    ....
  15. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 1999
    ....
  16. Blood Brain Barrier Physiology and HIV Dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
    ..The data acquired could provide new insights and therapeutic intervention strategies for monocyte BBB trafficking during progressive HIV-1 infection in brain tissue. ..
  17. Neuroprotective immunity and HIV dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
    ....
  18. Nanomedicine and NeuroAIDS
    HOWARD GENDELMAN; Fiscal Year: 2009
    ..To address this issue, we plan to develop nanoformulations of commonly used ART with variable brain entry profiles and deliver them directly to diseased brain tissue inside blood-borne macrophages. ..
  19. Neuroprotective immunity and HIV dementia
    HOWARD GENDELMAN; Fiscal Year: 2009
    ....
  20. Neuroprotective immunity and HIV dementia
    Howard E Gendelman; Fiscal Year: 2010
    ....
  21. Neuronal Immunity in HIV Dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
    ..Results of these works should have implications for monitoring disease and in developing novel therapeutics (for example, Alzheimer's disease) which now has few treatment options. ..
  22. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2006
    ..This project serves as an extension of our previous works seeking to determine how microglial immunity affects the pathogenesis, progression and the therapeutic options for HAD. ..
  23. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 1999
    ....
  24. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2000
    ....
  25. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2000
    ....
  26. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 1999
    ....
  27. HIV-1, MONOCYTES AND THE BLOOD/BRAIN BARRIER
    HOWARD GENDELMAN; Fiscal Year: 1999
    ..The combined efforts are designed to determine the viral and immune determinants for BBB dysfunction in AIDS, information that could be helpful in adapting strategies to prevent migration of monocytes into the brain during HIV dementia. ..
  28. MOLECULAR MECHANISMS OF HIV NEUROPATHOGENESIS
    HOWARD GENDELMAN; Fiscal Year: 2005
    ..This project serves as an extension of our previous works seeking to determine how microglial immunity affects the pathogenesis, progression and the therapeutic options for HAD. ..