R M Gemmill

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8
    R M Gemmill
    Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 95:9572-7. 1998
  2. ncbi request reprint RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene
    A Brauweiler
    Division of Medical Oncology, Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045 0511, USA
    Oncogene 26:2263-71. 2007
  3. pmc Altered HOX and WNT7A expression in human lung cancer
    R Calvo
    Division of Medical Oncology, and Department of Pathology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 97:12776-81. 2000
  4. pmc Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma
    R M Gemmill
    Division of Medical Oncology, University of Colorado at Denver and Health Sciences and Cancer Centers, Mail Stop 8117, PO Box 6511, Aurora, CO 80045 0511, USA
    Br J Cancer 92:2266-77. 2005
  5. ncbi request reprint High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer
    R M Bremnes
    Department of Pathology, Division of Medical Oncology, University of Colorado Cancer Center, Denver, CO, USA
    J Clin Oncol 20:2417-28. 2002
  6. ncbi request reprint DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC
    H A Drabkin
    Division of Medical Oncology, University of Colorado Health Sciences Center, Denver 80262, USA
    Oncogene 18:2589-97. 1999
  7. ncbi request reprint Assignment of the human slow twitch skeletal muscle/cardiac troponin C gene (TNNC1) to human chromosome 3p21.3-->3p14.3 using somatic cell hybrids
    W J Song
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0650, USA
    Cytogenet Cell Genet 75:36-7. 1996
  8. ncbi request reprint Report of the sixth international workshop on human chromosome 3 mapping 1995
    S L Naylor
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78284 7762, USA
    Cytogenet Cell Genet 72:255-70. 1996
  9. pmc Positional cloning of the hereditary renal carcinoma 3;8 chromosome translocation breakpoint
    F L Boldog
    University of Colorado Cancer Center, Division of Medical Oncology, Denver 80262
    Proc Natl Acad Sci U S A 90:8509-13. 1993
  10. pmc Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas
    M Ueda
    Department of Obstetrics and Gynecology, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka 569 8686, Japan
    Br J Cancer 85:64-8. 2001

Collaborators

Detail Information

Publications14

  1. pmc The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8
    R M Gemmill
    Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 95:9572-7. 1998
    ..By analogy to patched, TRC8 might function as a signaling receptor and other pathway members, to be defined, are mutation candidates in malignant diseases involving the kidney and thyroid...
  2. ncbi request reprint RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene
    A Brauweiler
    Division of Medical Oncology, Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045 0511, USA
    Oncogene 26:2263-71. 2007
    ..These data suggest that TRC8 modulation of SREBP activity comprises a novel regulatory link between growth control and the cholesterol/lipid homeostasis pathway...
  3. pmc Altered HOX and WNT7A expression in human lung cancer
    R Calvo
    Division of Medical Oncology, and Department of Pathology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 97:12776-81. 2000
    ..Our results suggest that alterations in regulatory circuits involving HOX, WNT, and possibly fibroblast growth factor pathways occur frequently in lung cancer...
  4. pmc Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma
    R M Gemmill
    Division of Medical Oncology, University of Colorado at Denver and Health Sciences and Cancer Centers, Mail Stop 8117, PO Box 6511, Aurora, CO 80045 0511, USA
    Br J Cancer 92:2266-77. 2005
    ..We propose that combined EGFR and mTOR inhibitors may be useful in the subset of RCCs with wt-VHL. However, apparent differences between primary tumours and cell lines require further investigation...
  5. ncbi request reprint High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer
    R M Bremnes
    Department of Pathology, Division of Medical Oncology, University of Colorado Cancer Center, Denver, CO, USA
    J Clin Oncol 20:2417-28. 2002
    ..We constructed tissue microarrays (TMAs) to investigate the expression of cadherins and catenins and their prognostic significance in NSCLC...
  6. ncbi request reprint DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC
    H A Drabkin
    Division of Medical Oncology, University of Colorado Health Sciences Center, Denver 80262, USA
    Oncogene 18:2589-97. 1999
    ..They are co-deleted in some lung cancers and immunologically distinct from the Hu proteins...
  7. ncbi request reprint Assignment of the human slow twitch skeletal muscle/cardiac troponin C gene (TNNC1) to human chromosome 3p21.3-->3p14.3 using somatic cell hybrids
    W J Song
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0650, USA
    Cytogenet Cell Genet 75:36-7. 1996
  8. ncbi request reprint Report of the sixth international workshop on human chromosome 3 mapping 1995
    S L Naylor
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78284 7762, USA
    Cytogenet Cell Genet 72:255-70. 1996
  9. pmc Positional cloning of the hereditary renal carcinoma 3;8 chromosome translocation breakpoint
    F L Boldog
    University of Colorado Cancer Center, Division of Medical Oncology, Denver 80262
    Proc Natl Acad Sci U S A 90:8509-13. 1993
    ..We have identified a gene, referred to as HRCA1 (hereditary renal cancer associated 1), that maps immediately adjacent to the breakpoint. On the basis of its chromosomal position, HRCA1 may be a candidate tumor suppressor gene...
  10. pmc Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas
    M Ueda
    Department of Obstetrics and Gynecology, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka 569 8686, Japan
    Br J Cancer 85:64-8. 2001
    ..These results suggest that beta- and gamma-catenins are infrequent mutational targets during development of human lung, breast, kidney, cervical and ovarian carcinomas...
  11. ncbi request reprint Minimal residual disease (MRD) in remission t(8;21) AML and in vivo differentiation detected by FISH and CD34+ cell sorting
    M Varella-Garcia
    Division of Medical Oncology, University of Colorado Health Sciences and Cancer Centers, Denver 80262, USA
    Leukemia 15:1408-14. 2001
    ..Thus, FISH can identify MRD in a majority of t(8;21) patients and, combined with CD34+ selection, may provide an indirect assessment of the differentiation state of residual t(8;21) cells...
  12. ncbi request reprint Transcription initiation sites of the leucine operons of Salmonella typhimurium and Escherichia coli
    R M Gemmill
    J Mol Biol 170:39-59. 1983
    ..Under such conditions, about 20% of the total soluble protein of strain CV605 is alpha-isopropylmalate synthase and another 20% is beta-isopropylmalate dehydrogenase (leuB product)...
  13. pmc Molecular cloning of alpha-amylase genes from Drosophila melanogaster. I. Clone isolation by use of a mouse probe
    R M Gemmill
    Genetics 110:299-312. 1985
    ..No RNA homologous to lambda Dm32 was detected. We suggest that the class B clone, lambda Dm65, contains the functional Amy structural gene(s) and that class A clones contain an amylase pseudogene...
  14. ncbi request reprint Report of the Second International Workshop on Human Chromosome 3 mapping
    R M Gemmill
    Eleanor Roosevelt Institute for Cancer Research, Denver, CO 80206
    Cytogenet Cell Genet 57:162-6. 1991