Affiliation: University of California
- Rst1 and Rst2 are required for the a/alpha diploid cell type in yeastAngie Gelli
Department of Internal Medicine, Division of Infectious and Immunologic Diseases, University of California, Davis, 1 Shields Avenue, School of Medicine, Tupper Hall, Room 3326, Davis, CA 95616, USA
Mol Microbiol 46:845-54. 2002..Rst1 and Rst2 are required in order to prevent the amplification of a robust Ste12 transcriptional programme that appears to over-ride Matalpha2-dependent repression of haploid and a-specific genes...
- Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environmentsMin Liu
Department of Medical Pharmacology and Toxicology, University of California, Davis, Genome and Biomedical Sciences Facility, Davis, CA 95616, USA
Eukaryot Cell 5:1788-96. 2006..neoformans may have a limited requirement for Cch1 and that this requirement appears to include ion stress tolerance...
- Elongation factor 3, EF3, associates with the calcium channel Cch1 and targets Cch1 to the plasma membrane in Cryptococcus neoformansMin Liu
Genome and Biomedical Sciences Facility, Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, USA
Eukaryot Cell 7:1118-26. 2008..Collectively, these results suggest that EF3 and Cch1 are functionally coupled and that EF3 has a function apart from its role in the protein translation cycle...
- Extracellular glycosylphosphatidylinositol-anchored mannoproteins and proteases of Cryptococcus neoformansRichard A Eigenheer
Department of Medical Pharmacology and Toxicology Genome and Biomedical Sciences Facility, University of California, California 95616, USA
FEMS Yeast Res 7:499-510. 2007..This study suggests that Cry. neoformans has the machinery required to target glycosylphosphatidylinositol-anchored proteins to the cell wall, and it confirms the extracellular proteolytic ability of Cry. neoformans...
- Astemizole and an analogue promote fungicidal activity of fluconazole against Cryptococcus neoformans var. grubii and Cryptococcus gattiiKiem Vu
Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, California 95616, USA
Med Mycol 48:255-62. 2010..The findings reported here suggest that fungicidal combinations between azoles and other existing drugs may represent an alternative strategy for improving treatments for fungal infections...
- The functional expression of toxic genes: lessons learned from molecular cloning of CCH1, a high-affinity Ca2+ channelKiem Vu
Genome and Biomedical Sciences Facility, Department of Pharmacology, School of Medicine, University of California Davis, Davis, CA 95616, USA
Anal Biochem 393:234-41. 2009..This approach will be particularly useful for genes that encode ion channels and transporters that cannot be cloned by conventional techniques requiring E. coli...
- Cch1 restores intracellular Ca2+ in fungal cells during endoplasmic reticulum stressMin Pyo Hong
Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
J Biol Chem 285:10951-8. 2010..The inability of cryptococcal cells that lacked the Cch1-Mid1 channel to survive ER stress suggests that Cch1 and its co-regulator, Mid1, are critical players in the restoration of Ca(2+) homeostasis...
- Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformansKiem Vu
Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, CA, USA
Eukaryot Cell 8:1803-7. 2009..Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection...
- DNA array analyses of Arabidopsis thaliana lacking a vacuolar Na+/H+ antiporter: impact of AtNHX1 on gene expressionJordan B Sottosanto
Department of Pomology, University of California, One Shields Ave, Davis, CA 95616, USA
Plant J 40:752-71. 2004..In conclusion, in addition to the known role(s) of AtNHX1 on ion homeostasis, the vacuolar cation/proton antiporter plays a significant role in intracellular vesicular trafficking, protein targeting, and other cellular processes...
- Molecular study of calcium channels in fungal pathogens.ANGELA GELLI; Fiscal Year: 2007..abstract_text> ..
- Fungal calcium channels as therapeutic targets for AIDS-associated opportunisticANGELA GELLI; Fiscal Year: 2010..Because fungal infections are life threatening for patients with a suppressed immune response, the development of more efficacious and better-tolerated drugs is essential. ..