ANGELA GELLI

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Rst1 and Rst2 are required for the a/alpha diploid cell type in yeast
    Angie Gelli
    Department of Internal Medicine, Division of Infectious and Immunologic Diseases, University of California, Davis, 1 Shields Avenue, School of Medicine, Tupper Hall, Room 3326, Davis, CA 95616, USA
    Mol Microbiol 46:845-54. 2002
  2. ncbi Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments
    Min Liu
    Department of Medical Pharmacology and Toxicology, University of California, Davis, Genome and Biomedical Sciences Facility, Davis, CA 95616, USA
    Eukaryot Cell 5:1788-96. 2006
  3. ncbi Elongation factor 3, EF3, associates with the calcium channel Cch1 and targets Cch1 to the plasma membrane in Cryptococcus neoformans
    Min Liu
    Genome and Biomedical Sciences Facility, Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, USA
    Eukaryot Cell 7:1118-26. 2008
  4. ncbi Extracellular glycosylphosphatidylinositol-anchored mannoproteins and proteases of Cryptococcus neoformans
    Richard A Eigenheer
    Department of Medical Pharmacology and Toxicology Genome and Biomedical Sciences Facility, University of California, California 95616, USA
    FEMS Yeast Res 7:499-510. 2007
  5. ncbi Astemizole and an analogue promote fungicidal activity of fluconazole against Cryptococcus neoformans var. grubii and Cryptococcus gattii
    Kiem Vu
    Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, California 95616, USA
    Med Mycol 48:255-62. 2010
  6. ncbi The functional expression of toxic genes: lessons learned from molecular cloning of CCH1, a high-affinity Ca2+ channel
    Kiem Vu
    Genome and Biomedical Sciences Facility, Department of Pharmacology, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Anal Biochem 393:234-41. 2009
  7. ncbi Cch1 restores intracellular Ca2+ in fungal cells during endoplasmic reticulum stress
    Min Pyo Hong
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 285:10951-8. 2010
  8. ncbi Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans
    Kiem Vu
    Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, CA, USA
    Eukaryot Cell 8:1803-7. 2009
  9. ncbi DNA array analyses of Arabidopsis thaliana lacking a vacuolar Na+/H+ antiporter: impact of AtNHX1 on gene expression
    Jordan B Sottosanto
    Department of Pomology, University of California, One Shields Ave, Davis, CA 95616, USA
    Plant J 40:752-71. 2004

Research Grants

  1. Molecular study of calcium channels in fungal pathogens.
    ANGELA GELLI; Fiscal Year: 2007
  2. Fungal calcium channels as therapeutic targets for AIDS-associated opportunistic
    ANGELA GELLI; Fiscal Year: 2010

Collaborators

  • Min Liu
  • G M Cox
  • Jordan B Sottosanto
  • Kiem Vu
  • Min Pyo Hong
  • Jennifer Bautos
  • Richard A Eigenheer
  • Babette Weksler
  • Ignacio Romero
  • Pierre Olivier Couraud
  • Eduardo Blumwald
  • Young Jin Lee
  • Brett S Phinney

Detail Information

Publications9

  1. ncbi Rst1 and Rst2 are required for the a/alpha diploid cell type in yeast
    Angie Gelli
    Department of Internal Medicine, Division of Infectious and Immunologic Diseases, University of California, Davis, 1 Shields Avenue, School of Medicine, Tupper Hall, Room 3326, Davis, CA 95616, USA
    Mol Microbiol 46:845-54. 2002
    ..Rst1 and Rst2 are required in order to prevent the amplification of a robust Ste12 transcriptional programme that appears to over-ride Matalpha2-dependent repression of haploid and a-specific genes...
  2. ncbi Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments
    Min Liu
    Department of Medical Pharmacology and Toxicology, University of California, Davis, Genome and Biomedical Sciences Facility, Davis, CA 95616, USA
    Eukaryot Cell 5:1788-96. 2006
    ..neoformans may have a limited requirement for Cch1 and that this requirement appears to include ion stress tolerance...
  3. ncbi Elongation factor 3, EF3, associates with the calcium channel Cch1 and targets Cch1 to the plasma membrane in Cryptococcus neoformans
    Min Liu
    Genome and Biomedical Sciences Facility, Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, USA
    Eukaryot Cell 7:1118-26. 2008
    ..Collectively, these results suggest that EF3 and Cch1 are functionally coupled and that EF3 has a function apart from its role in the protein translation cycle...
  4. ncbi Extracellular glycosylphosphatidylinositol-anchored mannoproteins and proteases of Cryptococcus neoformans
    Richard A Eigenheer
    Department of Medical Pharmacology and Toxicology Genome and Biomedical Sciences Facility, University of California, California 95616, USA
    FEMS Yeast Res 7:499-510. 2007
    ..This study suggests that Cry. neoformans has the machinery required to target glycosylphosphatidylinositol-anchored proteins to the cell wall, and it confirms the extracellular proteolytic ability of Cry. neoformans...
  5. ncbi Astemizole and an analogue promote fungicidal activity of fluconazole against Cryptococcus neoformans var. grubii and Cryptococcus gattii
    Kiem Vu
    Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, California 95616, USA
    Med Mycol 48:255-62. 2010
    ..The findings reported here suggest that fungicidal combinations between azoles and other existing drugs may represent an alternative strategy for improving treatments for fungal infections...
  6. ncbi The functional expression of toxic genes: lessons learned from molecular cloning of CCH1, a high-affinity Ca2+ channel
    Kiem Vu
    Genome and Biomedical Sciences Facility, Department of Pharmacology, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Anal Biochem 393:234-41. 2009
    ..This approach will be particularly useful for genes that encode ion channels and transporters that cannot be cloned by conventional techniques requiring E. coli...
  7. ncbi Cch1 restores intracellular Ca2+ in fungal cells during endoplasmic reticulum stress
    Min Pyo Hong
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 285:10951-8. 2010
    ..The inability of cryptococcal cells that lacked the Cch1-Mid1 channel to survive ER stress suggests that Cch1 and its co-regulator, Mid1, are critical players in the restoration of Ca(2+) homeostasis...
  8. ncbi Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans
    Kiem Vu
    Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, CA, USA
    Eukaryot Cell 8:1803-7. 2009
    ..Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection...
  9. ncbi DNA array analyses of Arabidopsis thaliana lacking a vacuolar Na+/H+ antiporter: impact of AtNHX1 on gene expression
    Jordan B Sottosanto
    Department of Pomology, University of California, One Shields Ave, Davis, CA 95616, USA
    Plant J 40:752-71. 2004
    ..In conclusion, in addition to the known role(s) of AtNHX1 on ion homeostasis, the vacuolar cation/proton antiporter plays a significant role in intracellular vesicular trafficking, protein targeting, and other cellular processes...

Research Grants6

  1. Molecular study of calcium channels in fungal pathogens.
    ANGELA GELLI; Fiscal Year: 2007
    ..abstract_text> ..
  2. Fungal calcium channels as therapeutic targets for AIDS-associated opportunistic
    ANGELA GELLI; Fiscal Year: 2010
    ..Because fungal infections are life threatening for patients with a suppressed immune response, the development of more efficacious and better-tolerated drugs is essential. ..