Werner Gellermann

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Measurement of carotenoids in the living primate eye using resonance Raman spectroscopy
    Paul S Bernstein
    Department of Ophthalmology, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA
    Methods Mol Biol 196:321-9. 2002
  2. ncbi request reprint In vivo resonant Raman measurement of macular carotenoid pigments in the young and the aging human retina
    Werner Gellermann
    Department of Physics and Dixon Laser Institute, University of Utah, Salt Lake City 84112, USA
    J Opt Soc Am A Opt Image Sci Vis 19:1172-86. 2002
  3. ncbi request reprint Noninvasive detection of macular pigments in the human eye
    Werner Gellermann
    Department of Physics and Dixon Laser Institute, University of Utah, Salt Lake City, Utah, USA
    J Biomed Opt 9:75-85. 2004
  4. pmc Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Ophthalmology 109:1780-7. 2002
  5. pmc Macular pigment imaging in AREDS2 participants: an ancillary study of AREDS2 subjects enrolled at the Moran Eye Center
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 53:6178-86. 2012
  6. pmc Blue-light reflectance imaging of macular pigment in infants and children
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 54:4034-40. 2013
  7. pmc Resonance Raman imaging of macular pigment distributions in the human retina
    Mohsen Sharifzadeh
    Department of Physics, University of Utah, Salt Lake City, Utah 84112, USA
    J Opt Soc Am A Opt Image Sci Vis 25:947-57. 2008
  8. pmc Simple Raman instrument for in vivo detection of macular pigments
    Igor V Ermakov
    Department of Physics, University of Utah, Salt Lake City, Utah 84112, USA
    Appl Spectrosc 59:861-7. 2005
  9. ncbi request reprint Resonance Raman measurement of macular carotenoids in the living human eye
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, USA
    Arch Biochem Biophys 430:163-9. 2004
  10. ncbi request reprint Production of deuterated zeaxanthin by Flavobacterium multivorum and its detection by resonance Raman and mass spectrometric methods
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Biotechnol Lett 27:1719-23. 2005

Research Grants

  1. RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTS
    Werner Gellermann; Fiscal Year: 2002

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Measurement of carotenoids in the living primate eye using resonance Raman spectroscopy
    Paul S Bernstein
    Department of Ophthalmology, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA
    Methods Mol Biol 196:321-9. 2002
  2. ncbi request reprint In vivo resonant Raman measurement of macular carotenoid pigments in the young and the aging human retina
    Werner Gellermann
    Department of Physics and Dixon Laser Institute, University of Utah, Salt Lake City 84112, USA
    J Opt Soc Am A Opt Image Sci Vis 19:1172-86. 2002
    ....
  3. ncbi request reprint Noninvasive detection of macular pigments in the human eye
    Werner Gellermann
    Department of Physics and Dixon Laser Institute, University of Utah, Salt Lake City, Utah, USA
    J Biomed Opt 9:75-85. 2004
    ....
  4. pmc Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Ophthalmology 109:1780-7. 2002
    ..We used a novel noninvasive objective method to quantify lutein and zeaxanthin in the human macula using resonance Raman spectroscopy and compared macular pigment levels in AMD and normal subjects...
  5. pmc Macular pigment imaging in AREDS2 participants: an ancillary study of AREDS2 subjects enrolled at the Moran Eye Center
    Paul S Bernstein
    Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 53:6178-86. 2012
    ....
  6. pmc Blue-light reflectance imaging of macular pigment in infants and children
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 54:4034-40. 2013
    ..We therefore developed a protocol using a digital video fundus camera (RetCam) to measure macular pigment optical density (MPOD) and distributions in premature infants and in children...
  7. pmc Resonance Raman imaging of macular pigment distributions in the human retina
    Mohsen Sharifzadeh
    Department of Physics, University of Utah, Salt Lake City, Utah 84112, USA
    J Opt Soc Am A Opt Image Sci Vis 25:947-57. 2008
    ..RRI imaging can be carried out with undilated pupils and provides a highly molecule-specific diagnostic imaging approach for MP distributions in human subjects...
  8. pmc Simple Raman instrument for in vivo detection of macular pigments
    Igor V Ermakov
    Department of Physics, University of Utah, Salt Lake City, Utah 84112, USA
    Appl Spectrosc 59:861-7. 2005
    ....
  9. ncbi request reprint Resonance Raman measurement of macular carotenoids in the living human eye
    Paul S Bernstein
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, USA
    Arch Biochem Biophys 430:163-9. 2004
    ..We have recently extended this technology to an imaging mode which will further enhance our understanding of the roles of lutein and zeaxanthin in normal macular function and in the prevention of age-related visual loss...
  10. ncbi request reprint Production of deuterated zeaxanthin by Flavobacterium multivorum and its detection by resonance Raman and mass spectrometric methods
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Biotechnol Lett 27:1719-23. 2005
    ..HPLC/APCI-MS and HPLC/RRS were specific and sensitive with limits of detection of 2.5 pg and 50 ng, respectively...
  11. ncbi request reprint Resonance Raman quantification of nutritionally important carotenoids in fruits, vegetables, and their juices in comparison to high-pressure liquid chromatography analysis
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, Utah 84132, USA
    J Agric Food Chem 52:3281-5. 2004
    ..A strong correlation was observed between the two methods when evaluating juices and when comparing different strains of intact tomatoes at the same stage of ripening...
  12. ncbi request reprint Resonant Raman quantification of zeaxanthin production from Flavobacterium multivorum
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, 50 North Medical Drive, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Biotechnol Lett 25:1007-11. 2003
    ..A striking correlation was observed between the carotenoid level as estimated by HPLC and by resonance Raman spectroscopy...
  13. ncbi request reprint Noninvasive selective detection of lycopene and beta-carotene in human skin using Raman spectroscopy
    Igor V Ermakov
    University of Utah, Department of Physics and Dixon Laser Institute, Salt Lake City, Utah 84112, USA
    J Biomed Opt 9:332-8. 2004
    ..6. The technique holds promise as a method for rapid screening of carotenoid compositions in human skin in large populations and should be suitable for clinical studies correlating carotenoid status with risk for cutaneous diseases...
  14. pmc Macular pigment Raman detector for clinical applications
    Igor Ermakov
    Department of Physics and Dixon Laser Institute, University of Utah, Salt Lake City, UT 84112, USA
    J Biomed Opt 9:139-48. 2004
    ....
  15. doi request reprint Purification and partial characterization of a lutein-binding protein from human retina
    Prakash Bhosale
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Biochemistry 48:4798-807. 2009
    ..Our results suggest that HR-LBP may facilitate lutein's localization to a region of the cell subject to considerable oxidative stress...
  16. doi request reprint Validation model for Raman based skin carotenoid detection
    Igor V Ermakov
    Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, USA
    Arch Biochem Biophys 504:40-9. 2010
    ..The obtained results provide proof that resonance Raman spectroscopy is a valid non-invasive objective methodology for the quantitative assessment of carotenoid antioxidants in human skin in vivo...
  17. pmc Nonmydriatic fluorescence-based quantitative imaging of human macular pigment distributions
    Mohsen Sharifzadeh
    Department of Physics, University of Utah, Salt Lake City, Utah 84112, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2373-87. 2006
    ....
  18. pmc Interrelationships between maternal carotenoid status and newborn infant macular pigment optical density and carotenoid status
    Bradley S Henriksen
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah
    Invest Ophthalmol Vis Sci 54:5568-78. 2013
    ..As a secondary measure, we also evaluated the effects of intrauterine growth restriction (IUGR) on carotenoid status in term newborn infants...
  19. doi request reprint Resonance Raman spectroscopy and the preterm infant carotenoid status
    Gary M Chan
    Department of Pediatrics, Division of Neonatology, University of Utah Health Science Center, Salt Lake City, UT 84158, USA
    J Pediatr Gastroenterol Nutr 56:556-9. 2013
    ....
  20. doi request reprint Dermal carotenoid measurements via pressure mediated reflection spectroscopy
    Igor V Ermakov
    Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112, USA
    J Biophotonics 5:559-70. 2012
    ....
  21. ncbi request reprint Resonance Raman measurement of macular carotenoids in retinal, choroidal, and macular dystrophies
    Da You Zhao
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA
    Arch Ophthalmol 121:967-72. 2003
    ..It has been hypothesized that the macular carotenoid pigments lutein and zeaxanthin may protect against macular and retinal degenerations and dystrophies...
  22. ncbi request reprint Assessment of the validity of in vivo methods of measuring human macular pigment optical density
    Werner Gellermann
    Optom Vis Sci 83:254-5; author reply 256-9. 2006

Research Grants1

  1. RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTS
    Werner Gellermann; Fiscal Year: 2002
    ..Furthermore, we propose a series of clinical studies in humans to validate its function and to begin to establish its role as a possible screening test for AMD. PROPOSED COMMERCIAL APPLICATION: Screening of macular pigment levels. ..