Research Topics
| Harris GelbardSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinaseHarris A Gelbard
Center for Neural Development and Disease, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Neurotherapeutics 7:392-8. 2010....- Synapses and Sisyphus: life without parapleginHarris A Gelbard
Department of Neurology and the Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Clin Invest 113:185-7. 2004.... - HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarizationJohn P Norman
Center for Neural Development and Disease, The University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
PLoS ONE 3:e3731. 2008..Collectively, these data suggest that abnormal RyR signaling mediates the neuronal UPR with failure of mitochondrial energy metabolism, and is a critical locus for the neuropathogenesis of HIV-1 in the CNS... 
Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementiaZiye Sui
Interdepartmental Program in Neuroscience, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Immunol 178:3226-36. 2007..Taken together, our results show that CD40 signaling in microglia and monocytes can synergize with the effects of Tat, further amplifying inflammatory processes within the CNS and influencing neuronal survival...- Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neuronsZiye Sui
Interdepartmental Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
Eur J Neurosci 23:2623-34. 2006..These findings may have important therapeutic implications for the management of HIV-1-associated dementia... - Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavirRobert Dicenzo
University at Buffalo, Buffalo, New York, USA
Antimicrob Agents Chemother 52:3035-9. 2008..2). Minocycline coadministration resulted in decreased atazanavir exposure, and there was no evidence that the addition of valproic acid mediated this effect... - HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neuronsJohn P Norman
Department of Neurology Child Neurology Division, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Immunol 178:869-76. 2007..Based on these findings, we suggest that decreased NADPH and calcium concentration contribute to subsequent respiratory decline after exposure to Tat, with detrimental effects on neuronal signaling... - Protecting the synapse: evidence for a rational strategy to treat HIV-1 associated neurologic diseaseMatthew J Bellizzi
Department of Neurology Child Neurology Division, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Neuroimmune Pharmacol 1:20-31. 2006..Whereas patients with HAD beginning antiretroviral therapy have shown reversal of neurologic symptoms that is unique for patients with chronic neurodegenerative conditions, we propose that the potential for such reversal is not unique... - The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitationShao Ming Lu
Center for Aging and Developmental Biology, Aab Biomedical Institute, University of Rochester Medical Center, Box 645, 601, Elmwood Avenue, Rochester, NY 14642, USA
J Neuroimmune Pharmacol 2:194-201. 2007..Thus, the relative concentration and temporal pattern of PAF expression at glutamatergic synapses may govern whether it acts in a physiologic or pathophysiologic manner during striatal neurotransmission... - Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and VmaxSeth W Perry
Center for Neural Development and Disease, Department of Neurology, Child Neurology Division, Graduate Program in Pathology, and Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci 30:14153-64. 2010..Finally, we provide key translational relevance for these findings by highlighting published human data of increased DAT levels in striata of HAND patients and by demonstrating similar findings in Tat-expressing transgenic mice... - Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairmentGiovanni Schifitto
Department of Neurology, University of Rochester, Rochester, New York, USA
J Neurovirol 15:176-86. 2009.... - Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regionsKarl A Kasischke
Department of Neurology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
J Cereb Blood Flow Metab 31:68-81. 2011..Thus, two-photon NADH imaging can be applied to expose vascular supply regions and to localize functionally relevant microregional cortical hypoxia with micrometer spatial resolution... - Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activationZiye Sui
Interdepartmental Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Immunol 177:702-11. 2006..In aggregate, our data define MLK3 as a promising therapeutic target for intervention in HAD... - Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factorMatthew J Bellizzi
Department of Neurology, Child Neurology Division, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Clin Invest 115:3185-92. 2005..Furthermore, preconditioning may represent a novel therapeutic strategy for preventing excitotoxic injury while preserving physiologic plasticity... - HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosisSeth W Perry
Center for Aging and Developmental Biology, Interdepartmental Program in Neuroscience, Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 174:4333-44. 2005..Finally, Tat and platelet-activating factor also increased neuronal vesicular release, which may be related to increased mitochondrial bioenergetics and serve as a biomarker for early damage to neurons... - Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk?Seth W Perry
Center for Aging and Developmental Biology, Aab Biomedical Institute, and the Departments of Neurology, University of Rochester Medical Center, Rochester, New York, USA
J Neurovirol 8:611-24. 2002.... - Antioxidants are required during the early critical period, but not later, for neuronal survivalSeth W Perry
Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Neurosci Res 78:485-92. 2004..Together, these findings suggest a brief window of high vulnerability to reactive oxygen species, and have important implications for studies of oxidative stress and developmental neuroscience... - Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawalServio H Ramirez
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurosci Res 77:258-69. 2004..Taken together, these findings provide evidence that endogenous adenosine may be important in mediating protection of sympathetic neurons and that it may act via the A2A receptor subtype... - Effects of valproic acid coadministration on plasma efavirenz and lopinavir concentrations in human immunodeficiency virus-infected adultsRobert Dicenzo
University of Rochester Medical Center, Clinical Pharmacology Unit, 601 Elmwood Ave, Box 315, Room 1 6124, Rochester, NY 14642, USA
Antimicrob Agents Chemother 48:4328-31. 2004..LPV concentrations tended to be higher when the drug was combined with VPA. Results of VPA comparisons fail to raise concern that coadministration with EFV or LPV/r will significantly influence trough concentrations of VPA... - Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDSStephen Dewhurst
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Neuroimmune Pharmacol 2:93-6. 2007..These findings highlight the therapeutic potential of GSK-3beta blockade... - HIV-1-associated dementia: a basic science and clinical perspectiveThomas S Diesing
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
AIDS Read 12:358-68. 2002..Improvements in antiretroviral and adjunctive therapies have decreased HAD incidence, but cognitive dysfunction remains a cause of morbidity in many infected persons... - Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glandsLisa R Latchney
Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
J Histochem Cytochem 52:671-81. 2004..In contrast, HHV-7-infected epithelial cells did not always express fractalkine, suggesting that fractalkine may not be an absolute requirement for viral entry... - Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitisHuanyu Dou
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198-5215, USA
J Neurosci 23:9162-70. 2003..We conclude that VPA protects neurons against HIV-1 infected MDM neurotoxicity, possibly through its effects on the phosphorylation of tau and beta-catenin. The use of VPA as an adjuvant in treatment of human HAD is being pursued... - Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120Zhuying Wang
Molecular Virology Division, St Luke s Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, NY 10019, USA
Virology 312:60-73. 2003..Reduction of the ability of HIV-1-infected astrocytes to take up glutamate may contribute to the development of neurological disease... - Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesisZhuying Wang
Molecular Virology Division, St Luke s Roosevelt Hospital Center and College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA
J Neurovirol 10:25-32. 2004..These findings define new pathways through which HIV-1 may contribute to neuropathogenesis under conditions of limited virus replication in the brain... - Neuroprotective strategies for HIV-1 associated dementiaHuanyu Dou
Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE 68198-5215, USA
Neurotox Res 6:503-21. 2004..This review article provides a broad overview of neuroprotective strategies for HIV-1 infection and details how such strategies act and may be implemented for treatment of human disease... - Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitisHuanyu Dou
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
J Neurosci 25:8375-85. 2005..Electrophysiological recordings showed diminished long-term potentiation in hippocampal slices of HIVE mice that were restored by Li. Based on these data, the use of Li as an adjuvant for HIV-1-associated dementia is now being pursued...
Research Grants
- CORE--BIOSTATISTICS AND DATA MANAGEMENTHarris Gelbard; Fiscal Year: 2007..abstract not provided ..
- Platelet Activating Factor, Synaptic Failure & NeuroAIDSHarris Gelbard; Fiscal Year: 2009..These findings will significantly advance our understanding of how HIV-1 continues to induce neurologic disease despite advances in HAART. ..
- Photoconductive stimulation of synapses and HIV neurotoxinsHarris Gelbard; Fiscal Year: 2007....
- PLATELET ACTIVATING FACTOR AND HIV-1 DEMENTIAHarris Gelbard; Fiscal Year: 1999..These studies will help provide insights into the mechanisms of PAF-induced neuronal apoptosis. ..
- ROLE OF PAF IN HIV-1 NEUROPATHOGENESISHarris Gelbard; Fiscal Year: 2003..Taken together, results from these studies will advance our understanding of how excess production of PAF contributes to the neuropathogenesis of HIV-1. ..
- In Vitro Cell Models of NeuroAIDSHarris Gelbard; Fiscal Year: 2005..Results from these experiments will significantly advance our understanding of how vulnerable neurons respond to HIV-1 neurotoxicants prior to apoptosis. ..
- Platelet Activating Factor, Synaptic Failure & NeuroAIDSHarris A Gelbard; Fiscal Year: 2010..This in turn will help us gain greater insight into how HIV-1 continues to cause neurologic disease despite effective control of its life cycle by highly active antiretroviral therapy (HAART)...