Harris Gelbard

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization
    John P Norman
    Center for Neural Development and Disease, The University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    PLoS ONE 3:e3731. 2008
  2. pmc LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein
    Daniel F Marker
    Center for Neural Development and Disease, Department of Neurology, Child Neurology Division, University of Rochester, Rochester, NY, USA
    J Neuroinflammation 9:261. 2012
  3. pmc Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase
    Harris A Gelbard
    Center for Neural Development and Disease, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Neurotherapeutics 7:392-8. 2010
  4. pmc Synapses and Sisyphus: life without paraplegin
    Harris A Gelbard
    Department of Neurology and the Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Clin Invest 113:185-7. 2004
  5. ncbi request reprint Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia
    Ziye Sui
    Interdepartmental Program in Neuroscience, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 178:3226-36. 2007
  6. ncbi request reprint Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons
    Ziye Sui
    Interdepartmental Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Eur J Neurosci 23:2623-34. 2006
  7. pmc Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavir
    Robert Dicenzo
    University at Buffalo, Buffalo, New York, USA
    Antimicrob Agents Chemother 52:3035-9. 2008
  8. pmc Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment
    Giovanni Schifitto
    Department of Neurology, University of Rochester, Rochester, New York, USA
    J Neurovirol 15:176-86. 2009
  9. ncbi request reprint The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation
    Shao Ming Lu
    Center for Aging and Developmental Biology, Aab Biomedical Institute, University of Rochester Medical Center, Box 645, 601, Elmwood Avenue, Rochester, NY 14642, USA
    J Neuroimmune Pharmacol 2:194-201. 2007
  10. ncbi request reprint Protecting the synapse: evidence for a rational strategy to treat HIV-1 associated neurologic disease
    Matthew J Bellizzi
    Department of Neurology Child Neurology Division, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Neuroimmune Pharmacol 1:20-31. 2006

Research Grants

  1. Photoconductive stimulation of synapses and HIV neurotoxins
    Harris Gelbard; Fiscal Year: 2007
  2. ROLE OF PAF IN HIV-1 NEUROPATHOGENESIS
    Harris Gelbard; Fiscal Year: 2003
  3. CORE--BIOSTATISTICS AND DATA MANAGEMENT
    Harris Gelbard; Fiscal Year: 2007
  4. PLATELET ACTIVATING FACTOR AND HIV-1 DEMENTIA
    Harris Gelbard; Fiscal Year: 1999
  5. Platelet Activating Factor, Synaptic Failure & NeuroAIDS
    Harris Gelbard; Fiscal Year: 2009
  6. In Vitro Cell Models of NeuroAIDS
    Harris Gelbard; Fiscal Year: 2005
  7. Platelet Activating Factor, Synaptic Failure & NeuroAIDS
    Harris A Gelbard; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. pmc HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization
    John P Norman
    Center for Neural Development and Disease, The University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    PLoS ONE 3:e3731. 2008
    ..Collectively, these data suggest that abnormal RyR signaling mediates the neuronal UPR with failure of mitochondrial energy metabolism, and is a critical locus for the neuropathogenesis of HIV-1 in the CNS...
  2. pmc LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein
    Daniel F Marker
    Center for Neural Development and Disease, Department of Neurology, Child Neurology Division, University of Rochester, Rochester, NY, USA
    J Neuroinflammation 9:261. 2012
    ....
  3. pmc Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase
    Harris A Gelbard
    Center for Neural Development and Disease, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Neurotherapeutics 7:392-8. 2010
    ....
  4. pmc Synapses and Sisyphus: life without paraplegin
    Harris A Gelbard
    Department of Neurology and the Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Clin Invest 113:185-7. 2004
    ....
  5. ncbi request reprint Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia
    Ziye Sui
    Interdepartmental Program in Neuroscience, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 178:3226-36. 2007
    ..Taken together, our results show that CD40 signaling in microglia and monocytes can synergize with the effects of Tat, further amplifying inflammatory processes within the CNS and influencing neuronal survival...
  6. ncbi request reprint Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons
    Ziye Sui
    Interdepartmental Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Eur J Neurosci 23:2623-34. 2006
    ..These findings may have important therapeutic implications for the management of HIV-1-associated dementia...
  7. pmc Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavir
    Robert Dicenzo
    University at Buffalo, Buffalo, New York, USA
    Antimicrob Agents Chemother 52:3035-9. 2008
    ..2). Minocycline coadministration resulted in decreased atazanavir exposure, and there was no evidence that the addition of valproic acid mediated this effect...
  8. pmc Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment
    Giovanni Schifitto
    Department of Neurology, University of Rochester, Rochester, New York, USA
    J Neurovirol 15:176-86. 2009
    ....
  9. ncbi request reprint The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation
    Shao Ming Lu
    Center for Aging and Developmental Biology, Aab Biomedical Institute, University of Rochester Medical Center, Box 645, 601, Elmwood Avenue, Rochester, NY 14642, USA
    J Neuroimmune Pharmacol 2:194-201. 2007
    ..Thus, the relative concentration and temporal pattern of PAF expression at glutamatergic synapses may govern whether it acts in a physiologic or pathophysiologic manner during striatal neurotransmission...
  10. ncbi request reprint Protecting the synapse: evidence for a rational strategy to treat HIV-1 associated neurologic disease
    Matthew J Bellizzi
    Department of Neurology Child Neurology Division, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Neuroimmune Pharmacol 1:20-31. 2006
    ..Whereas patients with HAD beginning antiretroviral therapy have shown reversal of neurologic symptoms that is unique for patients with chronic neurodegenerative conditions, we propose that the potential for such reversal is not unique...
  11. pmc Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions
    Karl A Kasischke
    Department of Neurology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cereb Blood Flow Metab 31:68-81. 2011
    ..Thus, two-photon NADH imaging can be applied to expose vascular supply regions and to localize functionally relevant microregional cortical hypoxia with micrometer spatial resolution...
  12. ncbi request reprint HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons
    John P Norman
    Department of Neurology Child Neurology Division, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 178:869-76. 2007
    ..Based on these findings, we suggest that decreased NADPH and calcium concentration contribute to subsequent respiratory decline after exposure to Tat, with detrimental effects on neuronal signaling...
  13. pmc Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax
    Seth W Perry
    Center for Neural Development and Disease, Department of Neurology, Child Neurology Division, Graduate Program in Pathology, and Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 30:14153-64. 2010
    ..Finally, we provide key translational relevance for these findings by highlighting published human data of increased DAT levels in striata of HAND patients and by demonstrating similar findings in Tat-expressing transgenic mice...
  14. ncbi request reprint Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation
    Ziye Sui
    Interdepartmental Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 177:702-11. 2006
    ..In aggregate, our data define MLK3 as a promising therapeutic target for intervention in HAD...
  15. pmc Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor
    Matthew J Bellizzi
    Department of Neurology, Child Neurology Division, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Clin Invest 115:3185-92. 2005
    ..Furthermore, preconditioning may represent a novel therapeutic strategy for preventing excitotoxic injury while preserving physiologic plasticity...
  16. ncbi request reprint HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis
    Seth W Perry
    Center for Aging and Developmental Biology, Interdepartmental Program in Neuroscience, Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 174:4333-44. 2005
    ..Finally, Tat and platelet-activating factor also increased neuronal vesicular release, which may be related to increased mitochondrial bioenergetics and serve as a biomarker for early damage to neurons...
  17. ncbi request reprint Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk?
    Seth W Perry
    Center for Aging and Developmental Biology, Aab Biomedical Institute, and the Departments of Neurology, University of Rochester Medical Center, Rochester, New York, USA
    J Neurovirol 8:611-24. 2002
    ....
  18. ncbi request reprint Antioxidants are required during the early critical period, but not later, for neuronal survival
    Seth W Perry
    Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci Res 78:485-92. 2004
    ..Together, these findings suggest a brief window of high vulnerability to reactive oxygen species, and have important implications for studies of oxidative stress and developmental neuroscience...
  19. ncbi request reprint Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
    Huang Guo
    Socratech Laboratories, Rochester, NY 14620, USA
    Neuron 41:563-72. 2004
    ..Thus, PAR1 and PAR3 mediate anti-apoptotic signaling by APC in neurons, which may suggest novel treatments for neurodegenerative disorders...
  20. ncbi request reprint Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal
    Servio H Ramirez
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci Res 77:258-69. 2004
    ..Taken together, these findings provide evidence that endogenous adenosine may be important in mediating protection of sympathetic neurons and that it may act via the A2A receptor subtype...
  21. ncbi request reprint HIV-1-associated dementia: a basic science and clinical perspective
    Thomas S Diesing
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    AIDS Read 12:358-68. 2002
    ..Improvements in antiretroviral and adjunctive therapies have decreased HAD incidence, but cognitive dysfunction remains a cause of morbidity in many infected persons...
  22. pmc Effects of valproic acid coadministration on plasma efavirenz and lopinavir concentrations in human immunodeficiency virus-infected adults
    Robert Dicenzo
    University of Rochester Medical Center, Clinical Pharmacology Unit, 601 Elmwood Ave, Box 315, Room 1 6124, Rochester, NY 14642, USA
    Antimicrob Agents Chemother 48:4328-31. 2004
    ..LPV concentrations tended to be higher when the drug was combined with VPA. Results of VPA comparisons fail to raise concern that coadministration with EFV or LPV/r will significantly influence trough concentrations of VPA...
  23. ncbi request reprint Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS
    Stephen Dewhurst
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Neuroimmune Pharmacol 2:93-6. 2007
    ..These findings highlight the therapeutic potential of GSK-3beta blockade...
  24. ncbi request reprint Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands
    Lisa R Latchney
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    J Histochem Cytochem 52:671-81. 2004
    ..In contrast, HHV-7-infected epithelial cells did not always express fractalkine, suggesting that fractalkine may not be an absolute requirement for viral entry...
  25. ncbi request reprint Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis
    Huanyu Dou
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci 23:9162-70. 2003
    ..We conclude that VPA protects neurons against HIV-1 infected MDM neurotoxicity, possibly through its effects on the phosphorylation of tau and beta-catenin. The use of VPA as an adjuvant in treatment of human HAD is being pursued...
  26. ncbi request reprint Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120
    Zhuying Wang
    Molecular Virology Division, St Luke s Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, NY 10019, USA
    Virology 312:60-73. 2003
    ..Reduction of the ability of HIV-1-infected astrocytes to take up glutamate may contribute to the development of neurological disease...
  27. ncbi request reprint Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis
    Zhuying Wang
    Molecular Virology Division, St Luke s Roosevelt Hospital Center and College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA
    J Neurovirol 10:25-32. 2004
    ..These findings define new pathways through which HIV-1 may contribute to neuropathogenesis under conditions of limited virus replication in the brain...
  28. ncbi request reprint Neuroprotective strategies for HIV-1 associated dementia
    Huanyu Dou
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    Neurotox Res 6:503-21. 2004
    ..This review article provides a broad overview of neuroprotective strategies for HIV-1 infection and details how such strategies act and may be implemented for treatment of human disease...
  29. ncbi request reprint Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis
    Huanyu Dou
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurosci 25:8375-85. 2005
    ..Electrophysiological recordings showed diminished long-term potentiation in hippocampal slices of HIVE mice that were restored by Li. Based on these data, the use of Li as an adjuvant for HIV-1-associated dementia is now being pursued...

Research Grants27

  1. Photoconductive stimulation of synapses and HIV neurotoxins
    Harris Gelbard; Fiscal Year: 2007
    ....
  2. ROLE OF PAF IN HIV-1 NEUROPATHOGENESIS
    Harris Gelbard; Fiscal Year: 2003
    ..Taken together, results from these studies will advance our understanding of how excess production of PAF contributes to the neuropathogenesis of HIV-1. ..
  3. CORE--BIOSTATISTICS AND DATA MANAGEMENT
    Harris Gelbard; Fiscal Year: 2007
    ..abstract not provided ..
  4. PLATELET ACTIVATING FACTOR AND HIV-1 DEMENTIA
    Harris Gelbard; Fiscal Year: 1999
    ..These studies will help provide insights into the mechanisms of PAF-induced neuronal apoptosis. ..
  5. Platelet Activating Factor, Synaptic Failure & NeuroAIDS
    Harris Gelbard; Fiscal Year: 2009
    ..These findings will significantly advance our understanding of how HIV-1 continues to induce neurologic disease despite advances in HAART. ..
  6. In Vitro Cell Models of NeuroAIDS
    Harris Gelbard; Fiscal Year: 2005
    ..Results from these experiments will significantly advance our understanding of how vulnerable neurons respond to HIV-1 neurotoxicants prior to apoptosis. ..
  7. Platelet Activating Factor, Synaptic Failure & NeuroAIDS
    Harris A Gelbard; Fiscal Year: 2010
    ..This in turn will help us gain greater insight into how HIV-1 continues to cause neurologic disease despite effective control of its life cycle by highly active antiretroviral therapy (HAART)...