Genomes and Genes
Pablo V Gejman
Affiliation: University of Chicago
- Linkage analysis of schizophrenia to chromosome 15P V Gejman
Unit on Molecular Clinical Investigation, Clinical Neurogenetics Branch, National Institute of Mental Health, Natinaol Institutes of Health, Bethesda, Maryland, USA
Am J Med Genet 105:789-93. 2001..6%). The multipoint MLS scores were greater than 1.0 in the 30-52 cM interval delimited by ACTC and D15S150, with a maximum value of 2.0 with GENEHUNTER PLUS near D15S1039...
- [The etiology of schizophrenia]Pablo V Gejman
Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois, USA
Medicina (B Aires) 72:227-34. 2012..The current and upcoming resequencing programs - both exomes (all exons) and full genomes - and genome-wide transcriptional analyses will allow a more thorough dissection of the molecular genetics of the disorder...
- Genetics of schizophrenia: new findings and challengesPablo V Gejman
Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, Illinois 60201, USA
Annu Rev Genomics Hum Genet 12:121-44. 2011..A main challenge for the field is the translation of established genetic associations into a better pathophysiological understanding of schizophrenia...
- No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric geneticsAlan R Sanders
Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
Am J Psychiatry 165:497-506. 2008....
- DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the geneJubao Duan
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, Ill, USA
Hum Hered 64:97-106. 2007..We have performed an association study with two well-characterized family samples not previously investigated at the DTNBP1 locus...
- The Internet-based MGS2 control sample: self report of mental illnessAlan R Sanders
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, NorthShore University Healthsystem, Evanston, Ill 60201 3137, USA
Am J Psychiatry 167:854-65. 2010..The Molecular Genetics of Schizophrenia (MGS2) project recruited an adult control sample of non-Hispanic European-ancestry (N=3,364) and African American (N=1,301) subjects...
- Neuregulin 1 (NRG1 ) and schizophrenia: analysis of a US family sample and the evidence in the balanceJubao Duan
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare Research Institute, and Northwestern University, 1001 University Place, Evanston, IL 60201, USA
Psychol Med 35:1599-610. 2005..A gene from this region, neuregulin 1 (NRG1 ), known to be involved with glutamatergic function, has been found to be associated in some studied samples...
- Genome-wide survey of interindividual differences of RNA stability in human lymphoblastoid cell linesJubao Duan
Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute Evanston, Illinois 60201, USA
Sci Rep 3:1318. 2013..These results suggest widespread interindividual differences in RNA stability related to DNA sequence and composition variation...
- The role of genetics in the etiology of schizophreniaPablo V Gejman
Department of Psychiatry and Behavioral Sciences and Research Institute, Center for Psychiatric Genetics, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA
Psychiatr Clin North Am 33:35-66. 2010....
- Genome-wide approaches to schizophreniaJubao Duan
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem Research Institute, 1001 University Place, Evanston, IL 60201, USA
Brain Res Bull 83:93-102. 2010..Deep resequencing for rare variants and system biology approaches (e.g., integrating DNA sequence and functional data) are expected to further improve our understanding of the genetic architecture of SZ and its underlying biology...
- History of the eugenic movementPablo V Gejman
Schizophrenia Genetics Research Program, Department of Psychiatry, Jules F Knapp Research Center, University of Chicago, 924 East 57th Street, Room R 010, Chicago, IL 60637, USA
Isr J Psychiatry Relat Sci 39:217-31. 2002..We argue that the history of the 20th century eugenics movement and its leaders still require attention...
- DNA variation and psychopharmacology of the human serotonin receptor 1B (HTR1B) geneAlan R Sanders
Schizophrenia Genetics Research Program, Department of Psychiatry, The University of Chicago, Jules F Knapp Research Building, 924 East 57th Street, Room R 004, IL 60637, USA
Pharmacogenomics 3:745-62. 2002....
- Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architectureSonja I Berndt
1 US Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA 2
Nat Genet 45:501-12. 2013..Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups...
- Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophreniaJubao Duan
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL, USA
Am J Hum Genet 75:624-38. 2004..These data provide strong preliminary evidence that TRAR4 is a candidate gene for schizophrenia; replication is currently being attempted in additional clinical samples...
- Genomewide association for schizophrenia in the CATIE study: results of stage 1P F Sullivan
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7264, USA
Mol Psychiatry 13:570-84. 2008....
- No major schizophrenia locus detected on chromosome 1q in a large multicenter sampleDouglas F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 296:739-41. 2002..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
- Whole-genome association study of bipolar disorderP Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...