W M Geisler

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Spontaneous resolution of genital Chlamydia trachomatis infection in women and protection from reinfection
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Infect Dis 207:1850-6. 2013
  2. doi request reprint Safety and efficacy of WC2031 versus vibramycin for the treatment of uncomplicated urogenital Chlamydia trachomatis infection: a randomized, double-blind, double-dummy, active-controlled, multicenter trial
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Clin Infect Dis 55:82-8. 2012
  3. doi request reprint Diagnosis and management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: summary of evidence reviewed for the 2010 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines
    William M Geisler
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, 703 19th St S, 242 Zeigler Research Bldg, Birmingham, AL 35294 0007, USA
    Clin Infect Dis 53:S92-8. 2011
  4. ncbi request reprint Pelvic examination findings and Chlamydia trachomatis infection in asymptomatic young women screened with a nucleic acid amplification test
    William M Geisler
    STD Program, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Sex Transm Dis 34:335-8. 2007
  5. ncbi request reprint Management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: evidence reviewed for the 2006 Centers for Disease Control and Prevention sexually transmitted diseases treatment guidelines
    William M Geisler
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Clin Infect Dis 44:S77-83. 2007
  6. ncbi request reprint The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatment
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Sex Transm Dis 35:119-23. 2008
  7. pmc Absence of lymphogranuloma venereum strains among rectal Chlamydia trachomatis outer membrane protein A genotypes infecting women and men who have sex with men in Birmingham, Alabama
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Sex Transm Dis 35:856-8. 2008
  8. pmc Chlamydia trachomatis OmpA genotyping as a tool for studying the natural history of genital chlamydial infection
    W M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Sex Transm Infect 84:541-4; discussion 544-5. 2008
  9. pmc Concordance of rectal and cervical Chlamydia trachomatis OmpA genotypes infecting women in Birmingham, Alabama
    William M Geisler
    Department of Medicine and Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Sex Transm Dis 37:32-3. 2010
  10. doi request reprint Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with chlamydia resolution: a review of human studies
    William M Geisler
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Infect Dis 201:S104-13. 2010

Detail Information

Publications24

  1. pmc Spontaneous resolution of genital Chlamydia trachomatis infection in women and protection from reinfection
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Infect Dis 207:1850-6. 2013
    ..0, 95% confidence interval, 1.1-25.6; P = .034). Chlamydia treatment may attenuate protective immunity in some patients...
  2. doi request reprint Safety and efficacy of WC2031 versus vibramycin for the treatment of uncomplicated urogenital Chlamydia trachomatis infection: a randomized, double-blind, double-dummy, active-controlled, multicenter trial
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Clin Infect Dis 55:82-8. 2012
    ..Research investigating new antibiotic regimens for chlamydia has been sparse, especially regimens that may reduce adherence difficulties with the recommended twice-daily doxycycline regimen...
  3. doi request reprint Diagnosis and management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: summary of evidence reviewed for the 2010 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines
    William M Geisler
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, 703 19th St S, 242 Zeigler Research Bldg, Birmingham, AL 35294 0007, USA
    Clin Infect Dis 53:S92-8. 2011
    ....
  4. ncbi request reprint Pelvic examination findings and Chlamydia trachomatis infection in asymptomatic young women screened with a nucleic acid amplification test
    William M Geisler
    STD Program, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Sex Transm Dis 34:335-8. 2007
    ..Nucleic acid amplification tests (NAATs) allow chlamydia screening in asymptomatic women who otherwise may not have pelvic examinations. How often these women have examination findings that may prompt empiric therapy is unclear...
  5. ncbi request reprint Management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: evidence reviewed for the 2006 Centers for Disease Control and Prevention sexually transmitted diseases treatment guidelines
    William M Geisler
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Clin Infect Dis 44:S77-83. 2007
    ..Although there are more studies needed and barriers to be addressed before its widespread use, EPT will be recommended as an option for partner management...
  6. ncbi request reprint The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatment
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Sex Transm Dis 35:119-23. 2008
    ..An improved understanding of chlamydial natural history may influence recommendations for elements of control efforts such as chlamydia screening frequency or time parameters for partner notification...
  7. pmc Absence of lymphogranuloma venereum strains among rectal Chlamydia trachomatis outer membrane protein A genotypes infecting women and men who have sex with men in Birmingham, Alabama
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Sex Transm Dis 35:856-8. 2008
  8. pmc Chlamydia trachomatis OmpA genotyping as a tool for studying the natural history of genital chlamydial infection
    W M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Sex Transm Infect 84:541-4; discussion 544-5. 2008
    ..To investigate the relationship of Chlamydia trachomatis (CT) outer membrane protein A (OmpA) type to the clearance of CT infection before treatment...
  9. pmc Concordance of rectal and cervical Chlamydia trachomatis OmpA genotypes infecting women in Birmingham, Alabama
    William M Geisler
    Department of Medicine and Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Sex Transm Dis 37:32-3. 2010
    ..Two women had mixed infection at one site. Of 20 women infected with a single OmpA genotype at each site, four (20%) had discordant genotypes at these sites...
  10. doi request reprint Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with chlamydia resolution: a review of human studies
    William M Geisler
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Infect Dis 201:S104-13. 2010
    ..This article summarizes the key questions posed and the evidence reviewed on the duration of untreated, uncomplicated genital chlamydial infection in humans and the factors associated with chlamydia resolution...
  11. ncbi request reprint Association of Chlamydia trachomatis Serovar Ia infection with black race in a sexually transmitted diseases clinic patient population in Birmingham, Alabama
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Sex Transm Dis 33:621-4. 2006
    ..Our goal was to evaluate serovar distribution and associated demographic characteristics in a predominantly black population...
  12. ncbi request reprint Chlamydial and gonococcal infection in men without polymorphonuclear leukocytes on gram stain: implications for diagnostic approach and management
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Sex Transm Dis 32:630-4. 2005
    ..In the absence of signs, symptoms, or polymorphonuclear leukocytes (PMNs) on urethral Gram stain, treatment and sometimes testing is deferred...
  13. pmc Vaginal leucocyte counts in women with bacterial vaginosis: relation to vaginal and cervical infections
    W M Geisler
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Sex Transm Infect 80:401-5. 2004
    ..To evaluate whether an elevated vaginal leucocyte count in women with bacterial vaginosis (BV) predicts the presence of vaginal or cervical infections, and to assess the relation of vaginal WBC counts to clinical manifestations...
  14. ncbi request reprint Approaches to the management of uncomplicated genital Chlamydia trachomatis infections
    William M Geisler
    University of Alabama, University of Alabama at Birmingham STD Program, 703 19th Street South, 242 Zeigler Research Building, Birmingham, AL 35249 0007, USA
    Expert Rev Anti Infect Ther 2:771-85. 2004
    ....
  15. doi request reprint Chlamydial and gonococcal infections in women seeking pregnancy testing at family-planning clinics
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
    Am J Obstet Gynecol 198:502.e1-4. 2008
    ..The objective of the study was to assess genital chlamydia and gonorrhea prevalence and associated predictors in women seeking pregnancy testing...
  16. ncbi request reprint Health insurance coverage, health care-seeking behaviors, and genital chlamydial infection prevalence in sexually active young adults
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, USA
    Sex Transm Dis 33:389-96. 2006
    ..Differential access to health care and thus the opportunity for testing, treatment, sexual partner services, and risk reduction counseling may be among the factors contributing to variation in chlamydial prevalence...
  17. pmc Immunogenetic correlates of Neisseria gonorrhoeae infection in adolescents
    William M Geisler
    Department of Medicine, School of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 220A, Birmingham, AL 35294 0022, USA
    Sex Transm Dis 35:656-61. 2008
    ..Understanding host factors modulating immunity to Neisseria gonorrhoeae infection may benefit work on vaccine development...
  18. pmc Interleukin (IL)-2 and IL-12 responses to Chlamydia trachomatis infection in adolescents
    C Wang
    Department of Epidemiology, University of Alabama at Birmingham, 35294 0007, USA
    Clin Exp Immunol 142:548-54. 2005
    ..From these findings we infer that increased IL-12 and decreased IL-2, observed commonly during mucosal inflammation, are important features of mucosal immune defence against C. trachomatis infection...
  19. ncbi request reprint Chlamydia pneumoniae respiratory infection after allogeneic stem cell transplantation
    William M Geisler
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, 98195, USA
    Transplantation 73:1002-5. 2002
    ..Considering the infrequency of infections from this organism in this clinical setting, one must still rule out other more likely respiratory pathogens...
  20. ncbi request reprint Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescents
    William M Geisler
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    J Infect Dis 190:1723-9. 2004
    ..These findings suggest that antigen presentation in adaptive immune responses may serve as a major factor in effective control of C. trachomatis infection. The underlying mechanisms remain to be experimentally elucidated...
  21. ncbi request reprint Assessing the impact of a comprehensive sexually transmitted disease curriculum on learning outcomes
    Seine Chiang
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Ala, USA
    Am J Obstet Gynecol 191:1822-7. 2004
    ....
  22. ncbi request reprint Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents
    Chengbin Wang
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabam 35294 0022, USA
    J Infect Dis 191:1084-92. 2005
    ....
  23. ncbi request reprint The relationship of serovar to clinical manifestations of urogenital Chlamydia trachomatis infection
    William M Geisler
    Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington 98195, USA
    Sex Transm Dis 30:160-5. 2003
    ..Utilizing a large dataset and multivariate analysis to address confounding factors, we undertook this study of the relationship of chlamydial serovars to specific clinical manifestations of urogenital disease...
  24. ncbi request reprint Epidemiology of anorectal chlamydial and gonococcal infections among men having sex with men in Seattle: utilizing serovar and auxotype strain typing
    William M Geisler
    Division of Allergy and Infectious Diseases, University of Washington, 1959 Northeast Pacific Street, Seattle, WA 98195, USA
    Sex Transm Dis 29:189-95. 2002
    ..Bacterial sexually transmitted diseases (STDs) among men who have sex with men (MSM) have recently increased in Seattle...

Research Grants3

  1. Immune Responses in Genital Chlamydia Prior to Therapy
    WILLIAM GEISLER; Fiscal Year: 2005
    ..abstract_text> ..
  2. Role of Immunogenetic Determinants on Human Genital Chlamydial Infection
    WILLIAM GEISLER; Fiscal Year: 2007
    ..The proposed training and research will help Dr. Geisler become an independent translational researcher. Study findings will aid in study design and hypothesis generation for a future R01. ..