Pete Geisen

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, 103 Mason Farm Road, CB No 7041, 6135 NSRB, Chapel Hill, NC 27599, USA
    Exp Eye Res 82:608-19. 2006
  2. pmc Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 6109A Neuroscience Research Building, Chapel Hill, NC 27599, USA
    Invest Ophthalmol Vis Sci 47:4975-82. 2006
  3. pmc Reduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROP
    Steven Budd
    Department of Ophthalmology, University of North Carolina Chapel Hill, 103 Mason Farm Road, CB 7041, 6135 NSRB, Chapel Hill, NC 27599, USA
    Exp Eye Res 89:718-27. 2009
  4. pmc Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity
    Yuta Saito
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 13:840-53. 2007
  5. pmc Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1
    Lynda J Peterson
    Department of Ophthalmology, 6135 Neuroscience Research Building, University of North Carolina, 103 Mason Farm Road, CB 7041, 6135 NSRB, Chapel Hill, NC 27599 7041, USA
    Exp Eye Res 84:737-44. 2007
  6. ncbi request reprint Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Curr Eye Res 31:739-48. 2006
  7. pmc Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease
    M Elizabeth Hartnett
    Department of Ophthalmology, The University of North Carolina, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 49:3107-14. 2008
  8. pmc The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE
    Haibo Wang
    Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 52:570-8. 2011
  9. pmc Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, 6135 Neuroscience Research Building, 103 Mason Farm Road, Chapel Hill, NC 27599 7041, USA
    Exp Eye Res 83:438-46. 2006
  10. pmc Aqueous vascular endothelial growth factor as a predictor of macular thickening following cataract surgery in patients with diabetes mellitus
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Ophthalmol 148:895-901.e1. 2009

Detail Information

Publications11

  1. ncbi request reprint Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, 103 Mason Farm Road, CB No 7041, 6135 NSRB, Chapel Hill, NC 27599, USA
    Exp Eye Res 82:608-19. 2006
    ..These findings may have relevance to the transformation of occult CNV into CNV within the neurosensory retina in AMD...
  2. pmc Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 6109A Neuroscience Research Building, Chapel Hill, NC 27599, USA
    Invest Ophthalmol Vis Sci 47:4975-82. 2006
    ..To study the effects of intravitreous triamcinolone acetonide (TA) on neovascularization (NV), capillary density, and retinal endothelial cell (REC) viability in a model of oxygen-induced retinopathy (OIR)...
  3. pmc Reduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROP
    Steven Budd
    Department of Ophthalmology, University of North Carolina Chapel Hill, 103 Mason Farm Road, CB 7041, 6135 NSRB, Chapel Hill, NC 27599, USA
    Exp Eye Res 89:718-27. 2009
    ..Reducing the number and length of filopodia/endothelial tip cell may reduce guidance cues for endothelial cells to migrate into the vitreous without interfering with migration into the retina toward a VEGF gradient...
  4. pmc Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity
    Yuta Saito
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 13:840-53. 2007
    ....
  5. pmc Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1
    Lynda J Peterson
    Department of Ophthalmology, 6135 Neuroscience Research Building, University of North Carolina, 103 Mason Farm Road, CB 7041, 6135 NSRB, Chapel Hill, NC 27599 7041, USA
    Exp Eye Res 84:737-44. 2007
    ..We hypothesize that contact between CECs and RPE stimulates a signaling pathway involving PI 3-K, Akt1, and Rac1 that facilitates CEC transmigration across the RPE barrier, an important step in the development of neovascular AMD...
  6. ncbi request reprint Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Curr Eye Res 31:739-48. 2006
    ..To investigate and compare the characteristics of four different types of retinal pigment epithelium (RPE) cells cultured for 2 to 5 weeks to provide guidance when choosing RPE cells for experimentation...
  7. pmc Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease
    M Elizabeth Hartnett
    Department of Ophthalmology, The University of North Carolina, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 49:3107-14. 2008
    ..To study the effects of vascular endothelial growth factor (VEGF) on endothelial nitric oxide synthetase (eNOS) and retinal vascular tortuosity and cleavage planes in a rat model of retinopathy of prematurity (ROP)...
  8. pmc The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE
    Haibo Wang
    Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Invest Ophthalmol Vis Sci 52:570-8. 2011
    ..To determine the role of vascular endothelial growth factor 189 (VEGF₁₈₉) in choroidal endothelial cell (CEC) migration across the retinal pigment epithelium (RPE) and to explore the molecular mechanisms involved...
  9. pmc Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, 6135 Neuroscience Research Building, 103 Mason Farm Road, Chapel Hill, NC 27599 7041, USA
    Exp Eye Res 83:438-46. 2006
    ..Antibody to LIF restored the cell counts to untreated levels. LIF reduced the number of cells in S phase. LIF attenuates retinal vascular development in vivo through growth arrest, and not apoptosis, of endothelial cells...
  10. pmc Aqueous vascular endothelial growth factor as a predictor of macular thickening following cataract surgery in patients with diabetes mellitus
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Ophthalmol 148:895-901.e1. 2009
    ....
  11. pmc VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 10:512-20. 2004
    ..We also determined whether pigment epithelium-derived factor (PEDF) was dysregulated by oxygen fluctuations perhaps contributing to a delay in normal retinal vascular development...