Mitchell E Geffner

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint The 88th Annual Meeting of the Endocrine Society, June 24-27, 2006, Boston MA, USA: selected pediatric presentations
    Mitchell E Geffner
    The Saban Research Institute of Childrens Hospital, Los Angeles, CA, USA
    Pediatr Endocrinol Rev 5:789-95. 2008
  2. pmc Factors associated with insulin resistance among children and adolescents perinatally infected with HIV-1 in the pediatric HIV/AIDS cohort study
    Mitchell E Geffner
    Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, Calif, USA
    Horm Res Paediatr 76:386-91. 2011
  3. ncbi request reprint For debate: Aromatase inhibitors to augment height: have we lost our inhibitions?
    Mitchell E Geffner
    USC Keck School of Medicine, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Pediatr Endocrinol Rev 5:756-9. 2008
  4. doi request reprint Use of recombinant human growth hormone in children with thalassemia
    Mitchell E Geffner
    Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, Calif, USA
    Horm Res 71:46-50. 2009
  5. pmc Growth hormone replacement therapy: transition from adolescence to adulthood
    Mitchell E Geffner
    Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, USA
    J Clin Res Pediatr Endocrinol 1:205-8. 2009
  6. pmc Aromatase inhibitors to augment height: continued caution and study required
    Mitchell E Geffner
    Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    J Clin Res Pediatr Endocrinol 1:256-61. 2009
  7. ncbi request reprint Transition to the adult endocrine clinic: testing pituitary function - what tests and when?
    Mitchell E Geffner
    Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, Mailstop 61, Los Angeles, CA 90027, USA
    Growth Horm IGF Res 13:S117-21. 2003
  8. ncbi request reprint Hypopituitarism in childhood
    Mitchell E Geffner
    Division of Endocrinology, Childrens Hospital Los Angeles, California 90027, USA
    Cancer Control 9:212-22. 2002
  9. doi request reprint Future directions: growth prediction models
    Mitchell E Geffner
    Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, Calif, USA
    Horm Res 68:51-6. 2007
  10. pmc Serum prolactin concentrations in relation to hypopituitarism and obesity in children with optic nerve hypoplasia
    Amy M Vedin
    Center for Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Keck School of Medicine of USC and Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Horm Res Paediatr 77:277-80. 2012

Detail Information

Publications35

  1. ncbi request reprint The 88th Annual Meeting of the Endocrine Society, June 24-27, 2006, Boston MA, USA: selected pediatric presentations
    Mitchell E Geffner
    The Saban Research Institute of Childrens Hospital, Los Angeles, CA, USA
    Pediatr Endocrinol Rev 5:789-95. 2008
  2. pmc Factors associated with insulin resistance among children and adolescents perinatally infected with HIV-1 in the pediatric HIV/AIDS cohort study
    Mitchell E Geffner
    Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, Calif, USA
    Horm Res Paediatr 76:386-91. 2011
    ....
  3. ncbi request reprint For debate: Aromatase inhibitors to augment height: have we lost our inhibitions?
    Mitchell E Geffner
    USC Keck School of Medicine, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Pediatr Endocrinol Rev 5:756-9. 2008
  4. doi request reprint Use of recombinant human growth hormone in children with thalassemia
    Mitchell E Geffner
    Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, Calif, USA
    Horm Res 71:46-50. 2009
    ..Growth failure occurs in children with chronic anemias and, in particular, in approximately 30% of those with thalassemia...
  5. pmc Growth hormone replacement therapy: transition from adolescence to adulthood
    Mitchell E Geffner
    Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, USA
    J Clin Res Pediatr Endocrinol 1:205-8. 2009
    ....
  6. pmc Aromatase inhibitors to augment height: continued caution and study required
    Mitchell E Geffner
    Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    J Clin Res Pediatr Endocrinol 1:256-61. 2009
    ..Furthermore, little is known about the short- and long-term safety of AIs in children. Thus, it is imperative that there be well-designed, long-term studies of efficacy and safety of AI use in pediatric populations...
  7. ncbi request reprint Transition to the adult endocrine clinic: testing pituitary function - what tests and when?
    Mitchell E Geffner
    Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, Mailstop 61, Los Angeles, CA 90027, USA
    Growth Horm IGF Res 13:S117-21. 2003
    ....
  8. ncbi request reprint Hypopituitarism in childhood
    Mitchell E Geffner
    Division of Endocrinology, Childrens Hospital Los Angeles, California 90027, USA
    Cancer Control 9:212-22. 2002
    ..Childhood hypopituitarism may be present at birth or may be acquired. Early diagnosis and treatment promote the best possible outcomes...
  9. doi request reprint Future directions: growth prediction models
    Mitchell E Geffner
    Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, Calif, USA
    Horm Res 68:51-6. 2007
    ....
  10. pmc Serum prolactin concentrations in relation to hypopituitarism and obesity in children with optic nerve hypoplasia
    Amy M Vedin
    Center for Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Keck School of Medicine of USC and Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Horm Res Paediatr 77:277-80. 2012
    ....
  11. ncbi request reprint Primary treatment regimen and diabetes insipidus as predictors of health outcomes in adults with childhood-onset craniopharyngioma
    Kevin C J Yuen
    Division of Endocrinology, Diabetes, and Clinical Nutrition K C J Y, D M C, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 Pfizer Endocrine Care M K H, P J J, Pfizer Inc, SE 190 91 Sollentuna, Sweden Pfizer Endocrine Care J L F, Pfizer, Inc, New York, New York 10017 The Saban Research Institute M E G, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California 90027 and Antwerp Centre for Endocrinology R A, Antwerp B 2600, Belgium
    J Clin Endocrinol Metab 99:1227-35. 2014
    ..Little is known of the effects of primary treatment regimen and diabetes insipidus (DI), a clinical surrogate of hypothalamic obesity, on health outcomes in adults with childhood-onset craniopharyngioma (COCP)...
  12. doi request reprint Pubertal onset in children with perinatal HIV infection in the era of combination antiretroviral treatment
    Paige L Williams
    aCenter for Biostatistics in AIDS Research bDepartment of Biostatistics, Harvard School of Public Health, Boston, Massachusetts cDepartment of Pediatrics Infectious Diseases, University of Colorado School of Medicine and Children s Hospital Colorado, Aurora, Colorado dTulane University School of Medicine, New Orleans, Louisiana eEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland fDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts gSection of Pediatric Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana hDepartment of Pediatrics, University of Colorado School of Medicine, Denver, Colorado iNew York University School of Medicine, New York jDepartment of Pediatrics, New Jersey Medical School, Newark, New Jersey kSaban Research Institute, Children s Hospital Los Angeles, Los Angeles, California, USA
    AIDS 27:1959-70. 2013
    ..To evaluate associations of perinatal HIV infection, HIV disease severity, and combination antiretroviral treatment with age at pubertal onset...
  13. pmc Newborn thyroid-stimulating hormone in children with optic nerve hypoplasia: associations with hypothyroidism and vision
    Cassandra Fink
    The Vision Center, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    J AAPOS 16:418-23. 2012
    ....
  14. doi request reprint Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children
    Pinchas Cohen
    Pediatric Endocrinology, Mattel Children s Hospital at University of California, Los Angeles, 10833 Le Conte Avenue, MDCC 22 315, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 95:2089-98. 2010
    ..We recently showed that, in IGF-based GH therapy, the IGF-I target chosen affects GH dose requirements, and higher IGF-I targets are associated with more robust growth parameters...
  15. doi request reprint Clinical characteristics and effects of GH replacement therapy in adults with childhood-onset craniopharyngioma compared with those in adults with other causes of childhood-onset hypothalamic-pituitary dysfunction
    Kevin C J Yuen
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mailcode L607, Portland, Oregon 97239 3098, USA
    Eur J Endocrinol 169:511-9. 2013
    ....
  16. ncbi request reprint Evolving central hypothyroidism in children with optic nerve hypoplasia
    Nina S Ma
    Division of Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Childrens Hospital Los Angeles and Keck School of Medicine of the University of Southern California, USA
    J Pediatr Endocrinol Metab 23:53-8. 2010
    ..Children with optic nerve hypoplasia (ONH) are at high risk for early-onset congenital central hypothyroidism (CH); however, reports of evolving, late-onset CH are rare and poorly documented...
  17. pmc Optic nerve hypoplasia in North America: a re-appraisal of perinatal risk factors
    Pamela Garcia-Filion
    The Vision Center at Childrens Hospital Los Angeles, and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA
    Acta Ophthalmol 88:527-34. 2010
    ..The purpose of this study is to describe and clarify the birth and prenatal characteristics of a large cohort of children with optic nerve hypoplasia...
  18. pmc Obese adolescents show impaired meal responses of the appetite-regulating hormones ghrelin and PYY
    Steven D Mittelman
    Division of Endocrinology, Diabetes and Metabolism, Children s Hospital Los Angeles, Los Angeles, California, USA
    Obesity (Silver Spring) 18:918-25. 2010
    ..Thus, meal-related changes in active ghrelin and PYY are blunted in obese as compared to lean Hispanic subjects. This blunting could contribute to the development or worsening of obesity...
  19. ncbi request reprint Rathke's cleft cyst in two girls with precocious puberty
    Roshanak Monzavi
    Division of Endocrinology, Diabetes, and Metabolism, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Pediatr Endocrinol Metab 17:781-5. 2004
    ..We report here two patients, both of whom presented with precocious puberty, and were found to have Rathke's cleft cysts...
  20. pmc Hereditary vitamin D resistant rickets: identification of a novel splice site mutation in the vitamin D receptor gene and successful treatment with oral calcium therapy
    Nina S Ma
    Division of Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Childrens Hospital Los Angeles and Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027, USA
    Bone 45:743-6. 2009
    ....
  21. pmc Presenting features and long-term effects of growth hormone treatment of children with optic nerve hypoplasia/septo-optic dysplasia
    Amy M Vedin
    Center for Endocrinology, Diabetes, and Metabolism, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop 61, Los Angeles, CA 90027, USA
    Int J Pediatr Endocrinol 2011:17. 2011
    ..abstract:..
  22. doi request reprint Neuroradiographic, endocrinologic, and ophthalmic correlates of adverse developmental outcomes in children with optic nerve hypoplasia: a prospective study
    Pamela Garcia-Filion
    Division of Pediatric Ophthalmology, Department of Ophthalmology, University of Southern California Keck School of Medicine and Childrens Hospital Los Angeles, Los Angeles, California, USA
    Pediatrics 121:e653-9. 2008
    ....
  23. ncbi request reprint A hypocalcemic child with a novel activating mutation of the calcium-sensing receptor gene: successful treatment with recombinant human parathyroid hormone
    Steven D Mittelman
    Division of Endocrinology, Diabetes, and Metabolism, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Mail Stop Number 61, Los Angeles, California 90027, USA
    J Clin Endocrinol Metab 91:2474-9. 2006
    ..Treatment with replacement PTH may be warranted, although this has yet to be evaluated in children...
  24. doi request reprint Igf-I stimulates in vivo thymopoiesis after stem cell transplantation in a child with Omenn syndrome
    Nina S Ma
    Division of Endocrinology, Diabetes, and Metabolism, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    J Clin Immunol 30:114-20. 2010
    ..Children with severe combined immunodeficiency who receive a T cell-depleted hematopoietic stem cell transplantation (HSCT) have delayed immune reconstitution...
  25. ncbi request reprint Improvement in risk factors for metabolic syndrome and insulin resistance in overweight youth who are treated with lifestyle intervention
    Roshanak Monzavi
    Center for Diabetes, Endocrinology, and Metabolism, Los Angeles, California, USA
    Pediatrics 117:e1111-8. 2006
    ....
  26. doi request reprint Gynecomastia in prepubertal and pubertal men
    Nina S Ma
    Division of Endocrinology, Diabetes, and Metabolism, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Curr Opin Pediatr 20:465-70. 2008
    ..Understanding its pathogenesis is crucial to distinguish a normal developmental variant from pathological causes...
  27. ncbi request reprint Craniopharyngioma in childhood
    Joshua A May
    Division of Endocrinology, Diabetes, and Metabolism, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, MS 61, Los Angeles, CA 90027, USA
    Adv Pediatr 53:183-209. 2006
    ....
  28. ncbi request reprint Obesity and fat quantification in lean tissues using three-point Dixon MR imaging
    Arzu Kovanlikaya
    Department of Radiology, Children s Hospital of Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Pediatr Radiol 35:601-7. 2005
    ..It has been suggested that increased hepatic and intramuscular fat is associated with insulin resistance, and that increased pancreatic fat is related to impaired insulin secretion...
  29. ncbi request reprint Simultaneous development of pheochromocytomas in prepubertal siblings with von Hippel-Lindau syndrome
    Sherry Lynn Franklin
    Division of Endocrinology, Department of Pediatrics, Mattel Children s Hospital at UCLA, Los Angeles, California 90095, USA
    J Pediatr 140:625-8. 2002
    ..We report 2 siblings with a known von Hippel-Lindau mutation who simultaneously developed asymptomatic pheochromocytomas at significantly younger ages than are typically seen in this setting...
  30. ncbi request reprint Precocious puberty secondary to topical testosterone exposure
    Sherry Lynn Franklin
    Mattel Children s Hospital at UCLA, Los Angeles, CA, USA
    J Pediatr Endocrinol Metab 16:107-10. 2003
    ..67 year-old boy resulting from presumed inadvertent, long-term exposure to a topical testosterone cream being used by his father...
  31. ncbi request reprint Cognitive and behavioral characteristics of turner syndrome: exploring a role for ovarian hormones in female sexual differentiation
    Marcia L Collaer
    University of California, Los Angeles, California 90095, USA
    Horm Behav 41:139-55. 2002
    ..These results are consistent with a role for ovarian hormones acting on the brain to influence cognitive and behavioral development, although they do not rule out other possible interpretations...
  32. ncbi request reprint Hypothalamic-pituitary-adrenal activity among Armenian adolescents with PTSD symptoms
    Armen K Goenjian
    Department of Psychiatry and Biobehavioral Sciences, UCLA Duke University National Center for Child Traumatic Stress, UCLA School of Medicine Los Angles, California 90064, USA
    J Trauma Stress 16:319-23. 2003
    ..The pre- to postexercise increase in GH, TSH, and cortisol suggests that exercise challenge may be useful in the field investigation of neurohormonal activity among traumatized individuals...
  33. ncbi request reprint Growth hormone treatment in children with familial dysautonomia
    Manmohan K Kamboj
    Department of Pediatrics, New York University Medical Center, New York, New York 10016, USA
    J Pediatr 144:63-7. 2004
    ..Growth velocity was analyzed before and during GH treatment at 0 to 6 months, 6 to 12 months, 1 to 2 years, and >2 years...
  34. ncbi request reprint Growth hormone treatment of early growth failure in toddlers with Turner syndrome: a randomized, controlled, multicenter trial
    Marsha L Davenport
    Division of Pediatric Endocrinology, University of North Carolina, CB 7039, 3341 Medical Biomolecular Research Building, Chapel Hill, North Carolina 27599 7039, USA
    J Clin Endocrinol Metab 92:3406-16. 2007
    ..Typically, growth failure in Turner syndrome (TS) begins prenatally, and height sd score (SDS) declines progressively from birth...
  35. ncbi request reprint Compound heterozygosity of a frameshift mutation in the coding region and a single base substitution in the promoter of the ACTH receptor gene in a family with isolated glucocorticoid deficiency
    Panayoula C Tsiotra
    Hellenic National Diabetes Center, Athens, Greece
    J Pediatr Endocrinol Metab 19:1157-66. 2006
    ..In conclusion, we provide evidence that the IGD in this previously unreported family with ACTH resistance appears to be secondary to compound heterozygosity of a coding region and a promoter mutation in the MC2R gene...