Amy E Geddis

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Congenital amegakaryocytic thrombocytopenia
    Amy E Geddis
    Pediatric Hematology Oncology, University of California San Diego, Rady Children s Hospital San Diego, San Diego, California 92123, USA
    Pediatr Blood Cancer 57:199-203. 2011
  2. doi request reprint Inherited thrombocytopenias: an approach to diagnosis and management
    A E Geddis
    Rady Children s Hospital San Diego, University of California San Diego, 3020 Children s Way, Mailcode 5035, San Diego, CA 92123, USA
    Int J Lab Hematol 35:14-25. 2013
  3. ncbi request reprint Diagnosis of immune thrombocytopenic purpura in children
    Amy E Geddis
    Department of Pediatrics, University of California, San Diego, California 92107, USA
    Curr Opin Hematol 14:520-5. 2007
  4. ncbi request reprint Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression
    Amy E Geddis
    Department of Pediatrics, Hematology Oncology, University of California, San Diego, La Jolla, California 92093, USA
    Cell Cycle 6:455-60. 2007
  5. ncbi request reprint Inherited thrombocytopenia: Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii
    Amy E Geddis
    Department of Pediatrics, Division of Pediatric Hematology Oncology, University of California San Diego, La Jolla, CA, USA
    Semin Hematol 43:196-203. 2006
  6. pmc Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii
    Amy E Geddis
    Department of Pediatrics, University of California San Diego, Rady Children s Hospital, 9500 Gilman Dr, Mailcode 0671, San Diego, CA 92093, USA
    Hematol Oncol Clin North Am 23:321-31. 2009
  7. ncbi request reprint Megakaryocytes express functional Aurora-B kinase in endomitosis
    Amy E Geddis
    Division of Pediatric Hematology Oncology, University of California San Diego UCSD, 9500 Gilman Dr, Mailcode 0665, La Jolla, CA 92093, USA
    Blood 104:1017-24. 2004
  8. ncbi request reprint Inherited thrombocytopenias: toward a molecular understanding of disorders of platelet production
    Amy E Geddis
    Department of Pediatrics, University of California, San Diego, USA
    Curr Opin Pediatr 16:15-22. 2004
  9. pmc Megakaryopoiesis
    Amy E Geddis
    Pediatric Hematology Oncology, University of California, San Diego, La Jolla, CA 92023, USA
    Semin Hematol 47:212-9. 2010
  10. pmc F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents
    Norma E Fox
    Pediatric Hematology Oncology, University of California, San Diego, La Jolla, Calif 92017, USA
    Exp Hematol 38:384-91. 2010

Research Grants

Collaborators

Detail Information

Publications22

  1. doi request reprint Congenital amegakaryocytic thrombocytopenia
    Amy E Geddis
    Pediatric Hematology Oncology, University of California San Diego, Rady Children s Hospital San Diego, San Diego, California 92123, USA
    Pediatr Blood Cancer 57:199-203. 2011
    ..This review will summarize the diagnosis, pathophysiology, and management of CAMT...
  2. doi request reprint Inherited thrombocytopenias: an approach to diagnosis and management
    A E Geddis
    Rady Children s Hospital San Diego, University of California San Diego, 3020 Children s Way, Mailcode 5035, San Diego, CA 92123, USA
    Int J Lab Hematol 35:14-25. 2013
    ..As the genetic basis of more disorders is understood, it will be possible to diagnose a greater fraction of patients as well as learn more about the process of megakaryopoiesis and platelet production...
  3. ncbi request reprint Diagnosis of immune thrombocytopenic purpura in children
    Amy E Geddis
    Department of Pediatrics, University of California, San Diego, California 92107, USA
    Curr Opin Hematol 14:520-5. 2007
    ..This review updates the differential diagnosis between inherited and acquired immune thrombocytopenic purpura as well as clinical practice on the initial diagnosis of children with the disease...
  4. ncbi request reprint Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression
    Amy E Geddis
    Department of Pediatrics, Hematology Oncology, University of California, San Diego, La Jolla, California 92093, USA
    Cell Cycle 6:455-60. 2007
    ..This finding has important implications for the potential mechanisms for cytokinesis failure in endomitosis...
  5. ncbi request reprint Inherited thrombocytopenia: Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii
    Amy E Geddis
    Department of Pediatrics, Division of Pediatric Hematology Oncology, University of California San Diego, La Jolla, CA, USA
    Semin Hematol 43:196-203. 2006
    ..In this article we will review our molecular and clinical understanding of these two inherited disorders of amegakaryocytosis...
  6. pmc Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii
    Amy E Geddis
    Department of Pediatrics, University of California San Diego, Rady Children s Hospital, 9500 Gilman Dr, Mailcode 0671, San Diego, CA 92093, USA
    Hematol Oncol Clin North Am 23:321-31. 2009
    ..This article summarizes the current understanding of the pathophysiology and clinical course of CAMT and TAR...
  7. ncbi request reprint Megakaryocytes express functional Aurora-B kinase in endomitosis
    Amy E Geddis
    Division of Pediatric Hematology Oncology, University of California San Diego UCSD, 9500 Gilman Dr, Mailcode 0665, La Jolla, CA 92093, USA
    Blood 104:1017-24. 2004
    ..These results suggest that EnM MKs appropriately express functional Aurora-B kinase and related proteins in early anaphase, making a simple deficiency of this protein an unlikely explanation for polyploidy in this cell type...
  8. ncbi request reprint Inherited thrombocytopenias: toward a molecular understanding of disorders of platelet production
    Amy E Geddis
    Department of Pediatrics, University of California, San Diego, USA
    Curr Opin Pediatr 16:15-22. 2004
    ..To review the defined syndromes of inherited thrombocytopenia and discuss new genetic data for several disorders that shed light on the process of megakaryopoiesis...
  9. pmc Megakaryopoiesis
    Amy E Geddis
    Pediatric Hematology Oncology, University of California, San Diego, La Jolla, CA 92023, USA
    Semin Hematol 47:212-9. 2010
    ..Clinically, acquired and inherited mutations affecting megakaryocytic transcription factors and thrombopoietin signaling have been identified in disorders of thrombocytopenia and thrombocytosis...
  10. pmc F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents
    Norma E Fox
    Pediatric Hematology Oncology, University of California, San Diego, La Jolla, Calif 92017, USA
    Exp Hematol 38:384-91. 2010
    ..To determine whether specific c-Mpl mutations might respond to thrombopoietin receptor agonists...
  11. pmc Ubiquitination and degradation of the thrombopoietin receptor c-Mpl
    Sebastian J Saur
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Blood 115:1254-63. 2010
    ....
  12. ncbi request reprint Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation
    Amy E Geddis
    Department of Pediatrics, Hematology Oncology, University of California San Diego, San Diego, California, USA ageddis ucsd edu
    Cell Cycle 5:538-45. 2006
    ..This work explores the mechanism of a normally occurring furrowing defect in a nonmalignant primary cell...
  13. pmc Inhibition of GSK-3beta promotes survival and proliferation of megakaryocytic cells through a beta-catenin-independent pathway
    Mie Soda
    Department of Medicine, University of California, San Diego, La Jolla, CA, United States
    Cell Signal 20:2317-23. 2008
    ..We conclude that GSK-3beta is phosphorylated and inhibited by TPO-induced Akt, promoting survival and proliferation in megakaryocytic cells through a pathway that does not involve beta-catenin...
  14. pmc Compound heterozygous c-Mpl mutations in a child with congenital amegakaryocytic thrombocytopenia: functional characterization and a review of the literature
    Norma E Fox
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92017, USA
    Exp Hematol 37:495-503. 2009
    ..To genetically and functionally characterize mutations of c-Mpl that lead to thrombocytopenia in a child with congenital amegakaryocytic thrombocytopenia...
  15. ncbi request reprint PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1)
    Takafumi Nakao
    Department of Medicine, Division of Hematology Oncology, University of California San Diego, La Jolla, California, USA
    Cell Cycle 7:257-66. 2008
    ....
  16. ncbi request reprint Immunology. The root of platelet production
    Amy E Geddis
    Departments of Pediatrics and Medicine, University of California, San Diego, CA 92103 8811, USA
    Science 317:1689-91. 2007
  17. ncbi request reprint The Mpl receptor expressed on endothelial cells does not contribute significantly to the regulation of circulating thrombopoietin levels
    Amy E Geddis
    Department of Pediatrics, University of California San Diego, San Diego, 92037, USA
    Exp Hematol 34:82-6. 2006
    ..We hypothesized that the c-mpl expressed on ECs would contribute to the regulation of circulating TPO levels...
  18. ncbi request reprint The molecular basis of congenital thrombocytopenias: insights into megakaryopoiesis
    Amy E Geddis
    Department of Pediatrics, University of California, San Diego, USA
    Hematology 10:299-305. 2005
  19. ncbi request reprint Cross-reactivity between erythropoietin and thrombopoietin at the level of Mpl does not account for the thrombocytosis seen in iron deficiency
    Amy E Geddis
    J Pediatr Hematol Oncol 25:919-20; author reply 920. 2003
  20. ncbi request reprint Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation
    Jonathan G Drachman
    Puget Sound Blood Center, Seattle, Washington 98104, USA
    J Biol Chem 277:23544-53. 2002
    ..Although the nature of the signal transduction pathway is not yet known, this second proliferative event is likely to regulate c-myc expression...
  21. ncbi request reprint Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes
    Supantitra Chanprasert
    Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
    Cell Signal 18:1212-8. 2006
    ..Therefore, we conclude that TPO stimulates c-myc expression in primary megakaryocytes through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR...
  22. ncbi request reprint Thrombopoietin: a pan-hematopoietic cytokine
    Amy E Geddis
    Division of Hematology, University of Washington School of Medicine, Box 357710, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Cytokine Growth Factor Rev 13:61-73. 2002
    ..Our growing appreciation of how cytokine signaling pathways are translated into megakaryocyte development is discussed...

Research Grants1

  1. THE ROLE OF PL3K IN THROMBOPOIETIN SIGNALING
    Amy Geddis; Fiscal Year: 2005
    ..A defined plan of training is presented in which the applicant will develop the experience and skills necessary for success as an independent investigator in Hematology. ..