Roberto Gedaly

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways
    Roberto Gedaly
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Anticancer Res 30:4951-8. 2010
  2. ncbi Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/β-catenin pathways
    Roberto Galuppo
    800 Rose Street, Room C453, Lexington, Kentucky 40536 0293, U S A
    Anticancer Res 34:1709-13. 2014
  3. pmc PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation
    Roberto Gedaly
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, Kentucky Electronic address
    J Surg Res 185:225-30. 2013
  4. pmc Peri-operative challenges and long-term outcomes in liver transplantation for polycystic liver disease
    Roberto Gedaly
    Transplant Center, University of Kentucky College of Medicine, Lexington, KY 40536 0293, USA
    HPB (Oxford) 15:302-6. 2013
  5. doi PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation
    Roberto Gedaly
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, Kentucky 40536 0293, USA
    J Surg Res 176:542-8. 2012
  6. ncbi The role of PI3K/mTOR inhibition in combination with sorafenib in hepatocellular carcinoma treatment
    Roberto Gedaly
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY, USA
    Anticancer Res 32:2531-6. 2012
  7. doi Liver transplantation for the treatment of liver metastases from neuroendocrine tumors: an analysis of the UNOS database
    Roberto Gedaly
    Transplant Center, University of Kentucky College of Medicine, Lexington, KY 40536 0293, USA
    Arch Surg 146:953-8. 2011
  8. doi Predictors of relapse to alcohol and illicit drugs after liver transplantation for alcoholic liver disease
    Roberto Gedaly
    Transplant Center, University of Kentucky College of Medicine, University of Kentucky Hospital, Lexington, KY 40536 0293, USA
    Transplantation 86:1090-5. 2008
  9. doi Prevalent immunosuppressive strategies in liver transplantation for hepatitis C: results of a multi-center international survey
    Roberto Gedaly
    Transplant Center, Department of Surgery, University of Kentucky, Lexington, KY 40536 0293, USA
    Transpl Int 21:867-72. 2008
  10. pmc Surgical treatment of a rare primary renal carcinoid tumor with liver metastasis
    Roberto Gedaly
    Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky, USA
    World J Surg Oncol 6:41. 2008

Collaborators

Detail Information

Publications44

  1. pmc PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways
    Roberto Gedaly
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Anticancer Res 30:4951-8. 2010
    ..This study reports how sorafenib (a multi-kinase inhibitor) and PI-103 (a dual PI3K/mTOR inhibitor) alone and in combination inhibit the proliferation of the HCC cell line, Huh7...
  2. ncbi Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/β-catenin pathways
    Roberto Galuppo
    800 Rose Street, Room C453, Lexington, Kentucky 40536 0293, U S A
    Anticancer Res 34:1709-13. 2014
    ..The aim of this study is to find synergistic effect using FH535 and sorafenib by targeting the RAS/RAF/MAPK and WNT/β-catenin pathways...
  3. pmc PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation
    Roberto Gedaly
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, Kentucky Electronic address
    J Surg Res 185:225-30. 2013
    ....
  4. pmc Peri-operative challenges and long-term outcomes in liver transplantation for polycystic liver disease
    Roberto Gedaly
    Transplant Center, University of Kentucky College of Medicine, Lexington, KY 40536 0293, USA
    HPB (Oxford) 15:302-6. 2013
    ..The purpose of this study was to determine peri-operative mortality and long-term outcomes in patients undergoing liver transplantation in the US using the United Network for Organ Sharing (UNOS) database...
  5. doi PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation
    Roberto Gedaly
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, Kentucky 40536 0293, USA
    J Surg Res 176:542-8. 2012
    ..This study aimed to test the inhibitory effects of PKI-587 and sorafenib as single agents or in combination on HCC (Huh7 cell line) proliferation...
  6. ncbi The role of PI3K/mTOR inhibition in combination with sorafenib in hepatocellular carcinoma treatment
    Roberto Gedaly
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY, USA
    Anticancer Res 32:2531-6. 2012
    ..This study aimed to test the inhibitory effects of PI-103 (a small molecule inhibitor of PI3K and mTOR) and sorafenib as single agents and in combination on HCC tumorigenesis in an in vivo xenograft model...
  7. doi Liver transplantation for the treatment of liver metastases from neuroendocrine tumors: an analysis of the UNOS database
    Roberto Gedaly
    Transplant Center, University of Kentucky College of Medicine, Lexington, KY 40536 0293, USA
    Arch Surg 146:953-8. 2011
    ..To determine outcomes in patients undergoing liver transplantation (LT) for metastatic neuroendocrine tumors (NETs)...
  8. doi Predictors of relapse to alcohol and illicit drugs after liver transplantation for alcoholic liver disease
    Roberto Gedaly
    Transplant Center, University of Kentucky College of Medicine, University of Kentucky Hospital, Lexington, KY 40536 0293, USA
    Transplantation 86:1090-5. 2008
    ..Alcoholic liver disease (ALD) is a common indication for transplantation worldwide. This study identifies factors predicting posttransplant recidivism...
  9. doi Prevalent immunosuppressive strategies in liver transplantation for hepatitis C: results of a multi-center international survey
    Roberto Gedaly
    Transplant Center, Department of Surgery, University of Kentucky, Lexington, KY 40536 0293, USA
    Transpl Int 21:867-72. 2008
    ..4 weeks, P<0.001). There is no consensus regarding the best immunosuppressive regimen and rejection treatments in HCV patients after LT. Our results reveal the most prevalent management practices in this difficult group of patients...
  10. pmc Surgical treatment of a rare primary renal carcinoid tumor with liver metastasis
    Roberto Gedaly
    Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky, USA
    World J Surg Oncol 6:41. 2008
    ..We report a case of a carcinoid of renal origin with synchronous single liver metastases on radiological studies...
  11. pmc Long-term outcome of patients undergoing liver transplantation for mixed hepatocellular carcinoma and cholangiocarcinoma: an analysis of the UNOS database
    Valery Vilchez
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY, 40536, USA
    HPB (Oxford) 18:29-34. 2016
    ..We aimed to evaluate long-term outcomes in patients undergoing LT for HCC-CC versus patients with hepatocellular carcinoma (HCC) or cholangiocarcinoma (CC)...
  12. doi An in vitro study of liposomal curcumin: stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells
    Changguo Chen
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Int J Pharm 366:133-9. 2009
    ..We conclude that liposomal curcumin may be useful for intravenous administration to improve the bioavailability and efficacy, facilitating in vivo studies that could ultimately lead to clinical application of curcumin...
  13. pmc Predictors of surgical site infection after liver resection: a multicentre analysis using National Surgical Quality Improvement Program data
    Almudena Moreno Elola-Olaso
    Transplantation and Hepatobiliary Center, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536 0293, USA
    HPB (Oxford) 14:136-41. 2012
    ..Surgical site infection (SSI) is the most common nosocomial infection in surgical patients, accounting for 38% of all such infections...
  14. pmc Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535
    Roberto Gedaly
    Department of Surgery, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 9:e99272. 2014
    ..Taken together, this data indicates that FH535 has potential therapeutic value in treatment of liver cancer. Importantly, these results suggest that this therapy may be effective at several levels by targeting both HCC and LCSC. ..
  15. doi Cyclosporin A up-regulates and activates protein kinase C-zeta in EBV-infected and EBV-transformed human B-cells
    Changguo Chen
    Department of Surgery, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    J Surg Res 153:156-61. 2009
    ..Here we show that CsA promoted atypical PKC isoform PKC-zeta in B cells...
  16. ncbi Kidney Transplant Outcomes in the Super Obese: A National Study From the UNOS Dataset
    Pooja Kanthawar
    Transplant Center, University of Kentucky College of Medicine, Lexington, KY, USA
    World J Surg 40:2808-2815. 2016
    ..We evaluated outcomes of super-obese patients (BMI > 50) undergoing kidney transplantation in the US...
  17. doi Cancer stem cell marker expression alone and in combination with microvascular invasion predicts poor prognosis in patients undergoing transplantation for hepatocellular carcinoma
    Valery Vilchez
    Department of Surgery, University of Kentucky, Lexington, KY, USA Department of Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Surg 212:238-45. 2016
    ..We investigated the expression of CD44 and CD133 alone and in combination with microvascular invasion (MVI) as predictors of prognosis in patients undergoing liver transplantation for HCC...
  18. doi Obesity, diabetes, and smoking are important determinants of resource utilization in liver resection: a multicenter analysis of 1029 patients
    Roberto Gedaly
    Department of Surgery, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Ann Surg 249:414-9. 2009
    ..To investigate independent contributions of obesity, diabetes, and smoking to resource utilization in patients following liver resection...
  19. pmc Alpha-fetoprotein and tumour size are associated with microvascular invasion in explanted livers of patients undergoing transplantation with hepatocellular carcinoma
    Patrick P McHugh
    Transplant Center, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA
    HPB (Oxford) 12:56-61. 2010
    ..To determine factors associated with outcomes and microvascular invasion (MVI) in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC)...
  20. ncbi Seatbelt injury resulting in functional loss of a transplanted kidney
    Patrick P McHugh
    University of Kentucky, Lexington, USA
    Prog Transplant 18:199-202. 2008
    ..As functional life spans of renal allografts improve, this type of injury will most likely be encountered with increasing frequency...
  21. doi Nonalcoholic steatohepatitis is strongly associated with sarcopenic obesity in patients with cirrhosis undergoing liver transplant evaluation
    Sandra Carias
    Department of Surgery, Division of Transplantation College of Medicine, University of Kentucky, Lexington, Kentucky, USA
    J Gastroenterol Hepatol 31:628-33. 2016
    ..We studied predictors of sarcopenia and sarcopenic obesity in patients with cirrhosis undergoing liver transplant (LT) evaluation...
  22. doi Donor positive blood culture is associated with delayed graft function in kidney transplant recipients: a propensity score analysis of the UNOS database
    Moises A Huaman
    Division of Infectious Diseases, Department of Medicine, University of Kentucky College of Medicine, Lexington, KY, USA
    Clin Transplant 30:415-20. 2016
    ..The effect of blood culture positive donor (BCPD) on delayed graft function (DGF) in kidney transplant recipients has not been well established...
  23. doi Combined liver-kidney transplantation for polycystic liver and kidney disease: analysis from the United Network for Organ Sharing dataset
    Cristin Coquillard
    Transplant Center, University of Kentucky College of Medicine, Lexington, KY, USA
    Liver Int 36:1018-25. 2016
    ..The purpose of this study was to evaluate predictors of outcomes in combined liver-kidney transplants for polycystic liver and kidney disease...
  24. doi Tipping the Scales: Liver Transplant Outcomes of the Super Obese
    Jose Alvarez
    Department of Surgery, University of Kentucky College of Medicine Transplant Center, 800 Rose Street, C451, Lexington, KY, 40536 0293, USA
    J Gastrointest Surg 20:1628-35. 2016
    ..We aim to study outcomes in liver transplant recipients with body mass index (BMI) ≥50 using the United Network for Organ Sharing (UNOS) database...
  25. pmc Decreased graft survival in liver transplant recipients of donors with positive blood cultures: a review of the United Network for Organ Sharing dataset
    Moises A Huaman
    Division of Infectious Diseases, Department of Medicine, University of Kentucky College of Medicine, Lexington, KY, USA
    Transpl Int . 2016
    ..BCPD was associated with decreased graft survival in liver transplant recipients. Studies are needed to identify subgroups of BCPD with the highest risk of graft failure and characterize the underlying pathogenic mechanisms...
  26. pmc A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation
    Anna Christina Dela Cruz
    Department of Internal Medicine, Gastroenterology and Hepatology, University of Kentucky, College of Medicine, Lexington, KY, USA
    Clin Transplant 29:958-64. 2015
    ..Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes...
  27. ncbi Predicting dry weight in patients with ascites and liver cirrhosis using computed tomography imaging
    Patrick P McHugh
    Transplant Section, Department of Surgery, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    Hepatogastroenterology 57:591-7. 2010
    ..In cirrhotic patients, ascites may increase weight and adversely impact liver transplant candidacy...
  28. ncbi Successful open pulmonary embolectomy for acute massive pulmonary embolism in a recent kidney transplant recipient
    Patrick P McHugh
    Section of Transplantation, Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Ann Transplant 13:19-22. 2008
    ..Patients with acute massive pulmonary embolus have a high mortality even with treatment. For patients in whom thrombolytic intervention is contraindicated, surgical pulmonary embolectomy is a viable option...
  29. doi Cyclosporin A-induced lipid and protein oxidation in human B-cells and in Epstein-Barr virus-infected B-cells is prevented by antioxidants
    Changguo Chen
    Department of Surgery, College of Medicine, University of Kentucky, Lexington, Kentucky40536, USA
    J Invest Surg 21:201-8. 2008
    ..A greater understanding of these cellular and molecular mechanisms may benefit the clinical practice and prevention of PTLD...
  30. doi The use of Dacron graft for cavo-cavostomy in orthotopic liver transplantation
    Hoonbae Jeon
    Transplant Section, Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Transplantation 85:651-3. 2008
    ..Unfortunately the patient became recidivous and expired ten months posttransplant, despite indications of satisfactory allograft function...
  31. pmc Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment
    Valery Vilchez
    Valery Vilchez, Lilia Turcios, Francesc Marti, Roberto Gedaly, Department of Surgery, Division of Transplantation, College of Medicine, University of Kentucky, Lexington, KY 40536 0284, United States
    World J Gastroenterol 22:823-32. 2016
    ..We also evaluated the use of small molecules targeting the Wnt/β-catenin pathway with potential application for treatment of HCC...
  32. doi Liver transplantation for the treatment of neuroendocrine liver metastases
    Valery Vilchez
    Department of Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA
    Best Pract Res Clin Endocrinol Metab 30:141-7. 2016
    ..The aim of this study is to review the existing literature emphasizing on the role of transplantation to treat patients with liver metastases from NET. ..
  33. doi Liver transplantation for fibrolamellar hepatocellular carcinoma: A national perspective
    Leonardo Garcia Atienza
    Division of Transplant, Department of Surgery, University of Kentucky, College of Medicine, Lexington, Kentucky
    J Surg Oncol . 2016
    ..Fibrolamellar Hepatocellular Carcinoma (FL-HCC) is a rare primary liver tumor that usually presents in younger patients without underlying liver disease...
  34. pmc Risk factors for increased resource utilization and critical care complications in patients undergoing hepaticojejunostomy for biliary injuries
    Nicholas Jackson
    Transplant Center, University of Kentucky College of Medicine, Lexington, KY, USA
    HPB (Oxford) 18:712-7. 2016
    ..This project aimed to study resource utilization and surgical outcomes after hepaticojejunostomy (HJ) for biliary injuries utilizing data from ACS NSQIP...
  35. ncbi A pharmacoeconomic analysis of liver transplant charges
    Timothy M Clifford
    UK HealthCare, University of Kentucky, Lexington, KY, USA
    Prog Transplant 17:310-4. 2007
    ..To analyze hospital charges for all liver transplant admissions to determine major cost drivers of the total charge...
  36. doi Role of transplantation in the treatment of benign solid tumors of the liver: a review of the United Network of Organ Sharing data set
    Sayee Sundar Alagusundaramoorthy
    Department of Surgery, College of Medicine, University of Kentucky, Lexington
    JAMA Surg 150:337-42. 2015
    ..The role of orthotopic liver transplantation for the treatment of benign solid liver tumors (BSLT) is not well defined...
  37. pmc Arteriovenous malformation of the pancreas: A case report and review of literature
    Fadi Makhoul
    General Surgery, University of Kentucky, Lexington, Kentucky
    Int J Angiol 17:211-3. 2008
    ..It is important to remember that these lesions shunt blood between the high-pressure arterial system and the low-pressure portal system, which leads to the much-dreaded consequence of portal hypertension...
  38. doi Risk factors for 30-day readmissions after hepatectomy: analysis of 2444 patients from the ACS-NSQIP database
    Sooyeon Kim
    Department of Surgery, Section of Transplant Surgery, University of Kentucky College of Medicine, 800 Rose Street, Room C453, Lexington, KY, 40508, USA
    J Gastrointest Surg 19:266-71. 2015
    ..The aim of this study was to identify risk factors associated with unplanned readmissions after hepatectomies...
  39. pmc N-Aryl benzenesulfonamide inhibitors of [3H]-thymidine incorporation and β-catenin signaling in human hepatocyte-derived Huh-7 carcinoma cells
    Liliia M Kril
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536 0509, United States Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0596, United States
    Bioorg Med Chem Lett 25:3897-9. 2015
    ..The absence of a clear SAR pattern in activity suggested a multiplicity of target effectors for N-aryl benzenesulfonamides. ..
  40. pmc Molecular therapies in hepatocellular carcinoma: what can we target?
    Roberto Galuppo
    Division of Transplantation Surgery, Department of Surgery, College of Medicine, University of Kentucky, 800 Rose Street, Room C453, Lexington, KY, 40536 0293, USA
    Dig Dis Sci 59:1688-97. 2014
    ....
  41. ncbi Treatment of liver metastases from a solid pseudopapillary tumor of the pancreas
    Roberto Gedaly
    Division of Transplantation, University of Tennessee, 3192 Hemingway LN, Lexington, KY 40513, USA
    J Hepatobiliary Pancreat Surg 13:587-90. 2006
  42. doi Importance of local infection in hepatic artery pseudoaneurysms
    Thomas Johnston
    Liver Transpl 14:388. 2008
  43. ncbi Liver transplantation for the treatment of nonresectable metastatic duodenal paraganglioma
    Roberto Gedaly
    Transpl Int 19:848-50. 2006