Research Topics

Genomes and Genes


Roberto Gedaly


Affiliation: University of Kentucky
Country: USA


  1. Gedaly R, Angulo P, Hundley J, Daily M, Chen C, Koch A, et al. PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways. Anticancer Res. 2010;30:4951-8 pubmed
    ..The combination of sorafenib and PI-103 can significantly inhibit EGF-stimulated Huh7 proliferation by blocking both Ras/Raf/MAPK and PI3K/AKT/mTOR pathways. ..
  2. Acosta L, Chacón E, Eman P, Dugan A, Davenport D, Gedaly R. Risk of Infectious Complications After Simultaneous Gastrointestinal and Liver Resections for Neuroendocrine Tumor Metastases. J Surg Res. 2019;235:244-249 pubmed publisher
    ..Neuroendocrine liver metastases requiring liver resection with concomitant colorectal resection or pancreaticoduodenectomy are at significantly increased risk of developing infectious complications. ..
  3. Chacón E, Vilchez V, Eman P, Marti F, Morris Stiff G, Dugan A, et al. Effect of critical care complications on perioperative mortality and hospital length of stay after hepatectomy: A multicenter analysis of 21,443 patients. Am J Surg. 2018;: pubmed publisher
    ..0001). ASA class, diabetes, COPD, pre-operative weight loss >10% and pre-operative sepsis are the strongest predictors of CCC after hepatectomy. The presence of CCC significantly increased the risk of peri-operative mortality 26-fold. ..
  4. De Stefano F, Garcia C, Gupta M, Marti F, Turcios L, Dugan A, et al. Outcomes in patients with portal hypertension undergoing gastrointestinal surgery: A propensity score matched analysis from the NSQIP dataset. Am J Surg. 2018;: pubmed publisher
    ..5 was the most predictive of peri-operative mortality in elective PH cases. PH is associated with an increased risk of poor surgical outcomes in patients undergoing elective and emergent gastrointestinal surgery. ..
  5. De Stefano F, Chacón E, Turcios L, Marti F, Gedaly R. Novel biomarkers in hepatocellular carcinoma. Dig Liver Dis. 2018;50:1115-1123 pubmed publisher
    ..Many new findings have shown promising results both in diagnosing and treating HCC. In this review, we summarized the most recent and relevant biomarkers in HCC. ..
  6. Gedaly R, Angulo P, Chen C, Creasy K, Spear B, Hundley J, et al. The role of PI3K/mTOR inhibition in combination with sorafenib in hepatocellular carcinoma treatment. Anticancer Res. 2012;32:2531-6 pubmed
    ..032). The combination of PI-103 and sorafenib has the advantage over mono-drug therapy on inhibition of HCC cell proliferation and tumorigenesis by inhibiting both PI3K/AKT/mTOR and RAS/RAF/MAPK signaling pathways. ..
  7. Kril L, Vilchez V, Jiang J, Turcios L, Chen C, Sviripa V, et al. N-Aryl benzenesulfonamide inhibitors of [3H]-thymidine incorporation and β-catenin signaling in human hepatocyte-derived Huh-7 carcinoma cells. Bioorg Med Chem Lett. 2015;25:3897-9 pubmed publisher
    ..The absence of a clear SAR pattern in activity suggested a multiplicity of target effectors for N-aryl benzenesulfonamides. ..
  8. Lui S, Garcia C, Mei X, Gedaly R. Re-transplantation for Hepatic Artery Thrombosis: A National Perspective. World J Surg. 2018;42:3357-3363 pubmed publisher
    ..Those re-transplanted late after HAT (>30 days) were associated with worse outcomes when compared to early re-transplantation. ..
  9. Gedaly R, Angulo P, Hundley J, Daily M, Chen C, Evers B. PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation. J Surg Res. 2012;176:542-8 pubmed publisher
    ..The combination of PKI-587 and sorafenib has the advantage over monodrug therapy on inhibition of HCC cell proliferation by blocking both PI3K/AKT/mTOR and Ras/Raf/MAPK signaling pathways. ..

More Information


  1. Gedaly R, Daily M, Davenport D, McHugh P, Koch A, Angulo P, et al. Liver transplantation for the treatment of liver metastases from neuroendocrine tumors: an analysis of the UNOS database. Arch Surg. 2011;146:953-8 pubmed publisher
    ..Waiting for disease to stabilize before considering patients with liver metastases from NETs for transplantation may be appropriate. Excellent results can be obtained in highly selected patients. ..
  2. Vilchez V, Turcios L, Zaytseva Y, Stewart R, Lee E, Maynard E, et al. Cancer stem cell marker expression alone and in combination with microvascular invasion predicts poor prognosis in patients undergoing transplantation for hepatocellular carcinoma. Am J Surg. 2016;212:238-45 pubmed publisher
    ..05; P = .001, odds ratio = 9.5, survival P = .001, HR = 3.7; P = .004, HR = 3.2 respectively). CD44 or CD133 alone and in combination with MVI are independent predictors of poor prognosis in patients undergoing transplantation for HCC. ..
  3. Turcios L, Vilchez V, Acosta L, Poyil P, Butterfield D, Mitov M, et al. Sorafenib and FH535 in combination act synergistically on hepatocellular carcinoma by targeting cell bioenergetics and mitochondrial function. Dig Liver Dis. 2017;49:697-704 pubmed publisher
    ..These findings support the therapeutic potential of combinatory FH535-Sorafenib treatment of the HCC heterogeneity by the simultaneous targeting of different molecular pathways. ..
  4. Vilchez V, Gedaly R. Liver transplantation for the treatment of neuroendocrine liver metastases. Best Pract Res Clin Endocrinol Metab. 2016;30:141-7 pubmed publisher
    ..The aim of this study is to review the existing literature emphasizing on the role of transplantation to treat patients with liver metastases from NET. ..
  5. Gedaly R, Galuppo R, Musgrave Y, Angulo P, Hundley J, Shah M, et al. PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation. J Surg Res. 2013;185:225-30 pubmed publisher
    ..Cells CD133+, CD44+, CD24+, which demonstrated at least moderate resistance to therapy in vitro. The combination of PKI-587 and sorafenib was better than either drug alone at inhibiting of LCSC and on HCC cell proliferation. ..
  6. Jackson N, Dugan A, Davenport D, Daily M, Shah M, Berger J, et al. Risk factors for increased resource utilization and critical care complications in patients undergoing hepaticojejunostomy for biliary injuries. HPB (Oxford). 2016;18:712-7 pubmed publisher
    ..Age and ASA class are the strongest predictors of CCC in these patients. ..
  7. Kanthawar P, Mei X, Daily M, Chandarana J, Shah M, Berger J, et al. Kidney Transplant Outcomes in the Super Obese: A National Study From the UNOS Dataset. World J Surg. 2016;40:2808-2815 pubmed
    ..In a subgroup analysis, super-obese patients who underwent kidney transplantation had significantly worse graft and patient survival compared to underweight, normal weight, and obesity class I, II, and III (BMI 40-50) patients. ..
  8. Acosta L, Garcia C, Dugan A, Marti F, Davenport D, Gedaly R. Impact of super obesity on perioperative outcomes after hepatectomy: The weight of the risk. Surgery. 2017;162:1026-1031 pubmed publisher
    ..Future studies should be conducted using weight loss strategies in extreme obese patients to reduce their risk of life-threatening complications after hepatectomy. ..
  9. Alvarez J, Mei X, Daily M, Shah M, Grigorian A, Berger J, et al. Tipping the Scales: Liver Transplant Outcomes of the Super Obese. J Gastrointest Surg. 2016;20:1628-35 pubmed publisher
    ..Overall, our data shows that BMI ?50 is an independent predictor of perioperative mortality and graft and overall patient survival. Further studies are necessary to better understand predictors of outcomes in super obese patients. ..
  10. Galuppo R, Maynard E, Shah M, Daily M, Chen C, Spear B, et al. Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/?-catenin pathways. Anticancer Res. 2014;34:1709-13 pubmed
    ..FH535 and sorafenib combination produced synergistic effect on inhibition of HCC and LCSC. Our study demonstrated that FH535 can induce apoptosis in these two different hepatocellular carcinoma (HCC) cell lines. ..
  11. Gedaly R, Jeon H, Johnston T, McHugh P, Rowland R, Ranjan D. Surgical treatment of a rare primary renal carcinoid tumor with liver metastasis. World J Surg Oncol. 2008;6:41 pubmed publisher
    ..We report a case of a carcinoid of renal origin with synchronous single liver metastases on radiological studies...