Research Topics
| Robert W GearSummaryAffiliation: University of California Country: USA Publications
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Publications
Rostral ventral medulla cholinergic mechanism in pain-induced analgesiaRobert W Gear
Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, United States
Neurosci Lett 464:170-2. 2009..A circuit connecting nucleus accumbens to the RVM is proposed as a novel striato-RVM pathway...- A subanalgesic dose of morphine eliminates nalbuphine anti-analgesia in postoperative painRobert W Gear
Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
J Pain 9:337-41. 2008..Here we show that morphine, given in a subanalgesic dose, reverses nalbuphine-induced anti-analgesia in males, perhaps by a similar mechanism... 
Dose ratio is important in maximizing naloxone enhancement of nalbuphine analgesia in humansRobert W Gear
Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
Neurosci Lett 351:5-8. 2003..5 mg dose and that the dose ratio of nalbuphine to naloxone is an important determinant of the analgesic efficacy of this combination...- Neuroleptics antagonize nalbuphine antianalgesiaRobert W Gear
Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California 94143-0440, USA
J Pain 7:187-91. 2006..PERSPECTIVE: This study demonstrates that neuroleptics can block the antianalgesic effect of agonist-antagonist kappa opioids. These findings could help inform the development of novel analgesics... - Centralization of noxious stimulus-induced analgesia (NSIA) is related to activity at inhibitory synapses in the spinal cordClaudia H Tambeli
Department of Oral and Maxillofacial Surgery, NIH Pain Center, University of California at San Francisco, Rm C 522, Box 0440, San Francisco, CA 94143 0440, USA
Pain 143:228-32. 2009..CTAP also blocked baclofen antinociception when administered in the spinal cord. We conclude that analgesia induced by noxious stimulation is maintained by activity in spinal inhibitory receptors... - Gonadal hormones do not account for sexual dimorphism in vagal modulation of nociception in the ratSachia G Khasar
Department of Oral and Maxillofacial Surgery, and UCSF/NIH Pain Center, University of California at San Francisco, San Francisco, California 94143, USA
J Pain 4:190-6. 2003..We conclude that although gonadal hormones and other gonadal-dependent mechanisms influence nociception, they do not account for sexual dimorphism in vagal modulation of mechanical nociceptive threshold or bradykinin hyperalgesia... - Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulationClaudia H Tambeli
Department of Oral and Maxillofacial Surgery, UCSF School of Dentistry, University of California, P.O. Box 0440, 707 Parnassuss Ave, San Francisco, CA 94143-0440, USA
Pain 106:173-9. 2003..Although substance P is also known to be released by similar stimuli, NK1 receptors do not appear to play a role in NSIA. The implications of these findings in the context of a proposed spinal circuit that mediates NSIA are discussed... - Adaptations in nucleus accumbens circuitry during opioid withdrawal associated with persistence of noxious stimulus-induced antinociception in the ratBrian L Schmidt
Graduate Program in Oral Biology, University of California, San Francisco, CA, USA
J Pain 4:141-7. 2003..These changes may result from different degrees of tolerance, with delta-receptors being the most sensitive; however, it is not known how these changes occur without affecting the magnitude of the resultant antinociception... - Absence of nalbuphine anti-analgesia in the ratSachia G Khasar
Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
Neurosci Lett 345:165-8. 2003.... - Nucleus accumbens facilitates nociceptionRobert W Gear
Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143 0440, USA
Exp Neurol 229:502-6. 2011..Thus, it is possible to modulate activity in NAc to bidirectionally attenuate or enhance nociception, suggesting a potential role for NAc in setting nociceptive sensitivity... - Mitochondrial dependence of nerve growth factor-induced mechanical hyperalgesiaCarissa Chu
Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
Pain 152:1832-7. 2011..Our results suggest a contribution of mitochondrial localization and function to NGF-dependent pain syndromes... - Response of neuropathic trigeminal pain to the combination of low-dose nalbuphine plus naloxone in humansBrian L Schmidt
Department of Oral and Maxillofacial Surgery, C-522 (Box 0440, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143-0440, USA
Neurosci Lett 343:144-6. 2003..All three patients reported marked decrease in pain following administration of the nalbuphine and naloxone combination. These findings suggest a novel approach to the management for neuropathic pain... - Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the ratLuiz F Ferrari
Department of Oral and Maxillofacial Surgery, Division of Neuroscience, University of California at San Francisco, San Francisco, California 94143 0440, USA
J Neurosci 30:13699-706. 2010..These results support the suggestion that pain syndromes can modulate activity in endogenous pain control circuits and that this effect is sympathoadrenal dependent... - Inhibition of tonic spinal glutamatergic activity induces antinociception in the ratClaudia H Tambeli
Department of Oral and Maxillofacial Surgery, University of California, San Francisco 94143 CA, USA
Eur J Neurosci 16:1547-53. 2002..As this antinociception occurred in the absence of interventions that would produce a facilitated nociceptive state, this tonic glutamatergic activity is important in setting nociceptive threshold... - Further validation of a model of fibromyalgia syndrome in the ratPaul G Green
Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California 94143 0440, USA
J Pain 12:811-8. 2011..Thus, this model may be used to test hypotheses about the underlying mechanisms and response to therapy in patients with fibromyalgia... - Altered nucleus accumbens circuitry mediates pain-induced antinociception in morphine-tolerant ratsBrian L Schmidt
Graduate Program in Oral Biology, University of California, San Francisco, California 94143-0440, USA
J Neurosci 22:6773-80. 2002..Thus, intra-accumbens dopamine release paralleled antinociceptive responses in naive and morphine pretreated rats... - Vagal modulation of bradykinin-induced mechanical hyperalgesia in the female ratSachia G Khasar
Department of Oral and Maxillofacial Surgery and UCSF/NIH Pain Center, University of California, San Francisco, California 94143, USA
J Pain 4:278-83. 2003..These findings demonstrate sexual dimorphism in the modulation of both mechanical nociceptive threshold and bradykinin-induced hyperalgesia by activity in subdiaphragmatic vagal afferents as well as the adrenal medulla... - Chronic constriction injury of the infraorbital nerve in the rat using modified syringe needleMelanie Kernisant
Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, United States
J Neurosci Methods 172:43-7. 2008..Pain behavior testing together with immunostaining for markers of nerve injury in the spinal trigeminal nucleus show the suitability of this procedure as a model of orofacial pain... - Sexual dimorphism in very low dose nalbuphine postoperative analgesiaRobert W Gear
Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
Neurosci Lett 339:1-4. 2003..In addition, the mild analgesia in women produced by this lower dose of nalbuphine is antagonized by naloxone...