Robert W Gear

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Rostral ventral medulla cholinergic mechanism in pain-induced analgesia
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, United States
    Neurosci Lett 464:170-2. 2009
  2. pmc A subanalgesic dose of morphine eliminates nalbuphine anti-analgesia in postoperative pain
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
    J Pain 9:337-41. 2008
  3. ncbi request reprint Dose ratio is important in maximizing naloxone enhancement of nalbuphine analgesia in humans
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neurosci Lett 351:5-8. 2003
  4. ncbi request reprint Neuroleptics antagonize nalbuphine antianalgesia
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California 94143 0440, USA
    J Pain 7:187-91. 2006
  5. pmc Centralization of noxious stimulus-induced analgesia (NSIA) is related to activity at inhibitory synapses in the spinal cord
    Claudia H Tambeli
    Department of Oral and Maxillofacial Surgery, NIH Pain Center, University of California at San Francisco, Rm C 522, Box 0440, San Francisco, CA 94143 0440, USA
    Pain 143:228-32. 2009
  6. ncbi request reprint Gonadal hormones do not account for sexual dimorphism in vagal modulation of nociception in the rat
    Sachia G Khasar
    Department of Oral and Maxillofacial Surgery, and UCSF NIH Pain Center, University of California at San Francisco, San Francisco, California 94143, USA
    J Pain 4:190-6. 2003
  7. ncbi request reprint Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation
    Claudia H Tambeli
    Department of Oral and Maxillofacial Surgery, UCSF School of Dentistry, University of California, P O Box 0440, 707 Parnassuss Ave, San Francisco, CA 94143 0440, USA
    Pain 106:173-9. 2003
  8. ncbi request reprint Adaptations in nucleus accumbens circuitry during opioid withdrawal associated with persistence of noxious stimulus-induced antinociception in the rat
    Brian L Schmidt
    Graduate Program in Oral Biology, University of California, San Francisco, CA, USA
    J Pain 4:141-7. 2003
  9. ncbi request reprint Absence of nalbuphine anti-analgesia in the rat
    Sachia G Khasar
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neurosci Lett 345:165-8. 2003
  10. pmc Nucleus accumbens facilitates nociception
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143 0440, USA
    Exp Neurol 229:502-6. 2011

Collaborators

Detail Information

Publications19

  1. pmc Rostral ventral medulla cholinergic mechanism in pain-induced analgesia
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, United States
    Neurosci Lett 464:170-2. 2009
    ..A circuit connecting nucleus accumbens to the RVM is proposed as a novel striato-RVM pathway...
  2. pmc A subanalgesic dose of morphine eliminates nalbuphine anti-analgesia in postoperative pain
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
    J Pain 9:337-41. 2008
    ..Here we show that morphine, given in a subanalgesic dose, reverses nalbuphine-induced anti-analgesia in males, perhaps by a similar mechanism...
  3. ncbi request reprint Dose ratio is important in maximizing naloxone enhancement of nalbuphine analgesia in humans
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neurosci Lett 351:5-8. 2003
    ..5 mg dose and that the dose ratio of nalbuphine to naloxone is an important determinant of the analgesic efficacy of this combination...
  4. ncbi request reprint Neuroleptics antagonize nalbuphine antianalgesia
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California 94143 0440, USA
    J Pain 7:187-91. 2006
    ..Because chlorpromazine and haloperidol enhanced nalbuphine analgesia and eliminated sexual dimorphism, the receptor at which neuroleptics act to antagonize the "antianalgesia" might be a common site of action to both drugs...
  5. pmc Centralization of noxious stimulus-induced analgesia (NSIA) is related to activity at inhibitory synapses in the spinal cord
    Claudia H Tambeli
    Department of Oral and Maxillofacial Surgery, NIH Pain Center, University of California at San Francisco, Rm C 522, Box 0440, San Francisco, CA 94143 0440, USA
    Pain 143:228-32. 2009
    ..CTAP also blocked baclofen antinociception when administered in the spinal cord. We conclude that analgesia induced by noxious stimulation is maintained by activity in spinal inhibitory receptors...
  6. ncbi request reprint Gonadal hormones do not account for sexual dimorphism in vagal modulation of nociception in the rat
    Sachia G Khasar
    Department of Oral and Maxillofacial Surgery, and UCSF NIH Pain Center, University of California at San Francisco, San Francisco, California 94143, USA
    J Pain 4:190-6. 2003
    ..We conclude that although gonadal hormones and other gonadal-dependent mechanisms influence nociception, they do not account for sexual dimorphism in vagal modulation of mechanical nociceptive threshold or bradykinin hyperalgesia...
  7. ncbi request reprint Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation
    Claudia H Tambeli
    Department of Oral and Maxillofacial Surgery, UCSF School of Dentistry, University of California, P O Box 0440, 707 Parnassuss Ave, San Francisco, CA 94143 0440, USA
    Pain 106:173-9. 2003
    ..Although substance P is also known to be released by similar stimuli, NK1 receptors do not appear to play a role in NSIA. The implications of these findings in the context of a proposed spinal circuit that mediates NSIA are discussed...
  8. ncbi request reprint Adaptations in nucleus accumbens circuitry during opioid withdrawal associated with persistence of noxious stimulus-induced antinociception in the rat
    Brian L Schmidt
    Graduate Program in Oral Biology, University of California, San Francisco, CA, USA
    J Pain 4:141-7. 2003
    ..These changes may result from different degrees of tolerance, with delta-receptors being the most sensitive; however, it is not known how these changes occur without affecting the magnitude of the resultant antinociception...
  9. ncbi request reprint Absence of nalbuphine anti-analgesia in the rat
    Sachia G Khasar
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neurosci Lett 345:165-8. 2003
    ....
  10. pmc Nucleus accumbens facilitates nociception
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143 0440, USA
    Exp Neurol 229:502-6. 2011
    ..Thus, it is possible to modulate activity in NAc to bidirectionally attenuate or enhance nociception, suggesting a potential role for NAc in setting nociceptive sensitivity...
  11. pmc Mitochondrial dependence of nerve growth factor-induced mechanical hyperalgesia
    Carissa Chu
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Pain 152:1832-7. 2011
    ..Our results suggest a contribution of mitochondrial localization and function to NGF-dependent pain syndromes...
  12. ncbi request reprint Response of neuropathic trigeminal pain to the combination of low-dose nalbuphine plus naloxone in humans
    Brian L Schmidt
    Department of Oral and Maxillofacial Surgery, C 522 Box 0440, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0440, USA
    Neurosci Lett 343:144-6. 2003
    ..All three patients reported marked decrease in pain following administration of the nalbuphine and naloxone combination. These findings suggest a novel approach to the management for neuropathic pain...
  13. pmc Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat
    Luiz F Ferrari
    Department of Oral and Maxillofacial Surgery, Division of Neuroscience, University of California at San Francisco, San Francisco, California 94143 0440, USA
    J Neurosci 30:13699-706. 2010
    ..These results support the suggestion that pain syndromes can modulate activity in endogenous pain control circuits and that this effect is sympathoadrenal dependent...
  14. ncbi request reprint Inhibition of tonic spinal glutamatergic activity induces antinociception in the rat
    Claudia H Tambeli
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco 94143 CA, USA
    Eur J Neurosci 16:1547-53. 2002
    ..As this antinociception occurred in the absence of interventions that would produce a facilitated nociceptive state, this tonic glutamatergic activity is important in setting nociceptive threshold...
  15. pmc Further validation of a model of fibromyalgia syndrome in the rat
    Paul G Green
    Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, California 94143 0440, USA
    J Pain 12:811-8. 2011
    ....
  16. ncbi request reprint Altered nucleus accumbens circuitry mediates pain-induced antinociception in morphine-tolerant rats
    Brian L Schmidt
    Graduate Program in Oral Biology, University of California, San Francisco, California 94143 0440, USA
    J Neurosci 22:6773-80. 2002
    ..Thus, intra-accumbens dopamine release paralleled antinociceptive responses in naive and morphine pretreated rats...
  17. ncbi request reprint Vagal modulation of bradykinin-induced mechanical hyperalgesia in the female rat
    Sachia G Khasar
    Department of Oral and Maxillofacial Surgery and UCSF NIH Pain Center, University of California, San Francisco, California 94143, USA
    J Pain 4:278-83. 2003
    ..These findings demonstrate sexual dimorphism in the modulation of both mechanical nociceptive threshold and bradykinin-induced hyperalgesia by activity in subdiaphragmatic vagal afferents as well as the adrenal medulla...
  18. pmc Chronic constriction injury of the infraorbital nerve in the rat using modified syringe needle
    Melanie Kernisant
    Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, United States
    J Neurosci Methods 172:43-7. 2008
    ..Pain behavior testing together with immunostaining for markers of nerve injury in the spinal trigeminal nucleus show the suitability of this procedure as a model of orofacial pain...
  19. ncbi request reprint Sexual dimorphism in very low dose nalbuphine postoperative analgesia
    Robert W Gear
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neurosci Lett 339:1-4. 2003
    ..In addition, the mild analgesia in women produced by this lower dose of nalbuphine is antagonized by naloxone...