Qing Ge

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. pmc Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs
    Qing Ge
    SomaGenics, Inc, Santa Cruz, California 95060, USA
    RNA 16:118-30. 2010
  2. pmc Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity
    Qing Ge
    SomaGenics, Inc, Santa Cruz, California 95060, USA
    RNA 16:106-17. 2010
  3. pmc Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
    Anne Dallas
    SomaGenics, Inc, 2161 Delaware Avenue, Santa Cruz, CA 95060, USA
    Nucleic Acids Res 40:9255-71. 2012

Collaborators

Detail Information

Publications3

  1. pmc Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs
    Qing Ge
    SomaGenics, Inc, Santa Cruz, California 95060, USA
    RNA 16:118-30. 2010
    ..However, 2'-OMe substitution of sshRNAs abrogated the innate immune response and improved the serum stability of the hairpins...
  2. pmc Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity
    Qing Ge
    SomaGenics, Inc, Santa Cruz, California 95060, USA
    RNA 16:106-17. 2010
    ..Our findings have implications for the mechanism of action of sshRNAs, and the ability to design highly potent shRNAs with minimal length is encouraging for the prospects of the therapeutic use of direct-delivered shRNAs...
  3. pmc Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing
    Anne Dallas
    SomaGenics, Inc, 2161 Delaware Avenue, Santa Cruz, CA 95060, USA
    Nucleic Acids Res 40:9255-71. 2012
    ..We conclude that active L-sshRNAs depend on slicing of the passenger arm to facilitate opening of the duplex, whereas R-sshRNAs primarily act via loop cleavage to generate a 5'-phosphate at the 5'-end of the guide strand...

Research Grants1