Adam Gazzaley

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Differential coupling of visual cortex with default or frontal-parietal network based on goals
    James Z Chadick
    Department of Neurology, Physiology and Psychiatry, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, USA
    Nat Neurosci 14:830-2. 2011
  2. pmc Top-down modulation: bridging selective attention and working memory
    Adam Gazzaley
    Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA
    Trends Cogn Sci 16:129-35. 2012
  3. ncbi Age-related deficits in component processes of working memory
    Adam Gazzaley
    Department of Neurology, University of California, CA 94143 2522, USA
    Neuropsychology 21:532-9. 2007
  4. pmc Age-related top-down suppression deficit in the early stages of cortical visual memory processing
    Adam Gazzaley
    Department of Neurology and Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:13122-6. 2008
  5. ncbi Functional interactions between prefrontal and visual association cortex contribute to top-down modulation of visual processing
    Adam Gazzaley
    Department of Neurology and Physiology, Keck Center of Integrative Neuroscience, University of California, San Francisco, CA 94143 2522, USA
    Cereb Cortex 17:i125-35. 2007
  6. ncbi Top-down modulation and normal aging
    Adam Gazzaley
    Department of Neurology and Physiology, Keck Center of Integrative Neuroscience, University of California, San Francisco, California 94143 2522, USA
    Ann N Y Acad Sci 1097:67-83. 2007
  7. pmc Early top-down control of visual processing predicts working memory performance
    Aaron M Rutman
    University of California, San Francisco, CA 94158, USA
    J Cogn Neurosci 22:1224-34. 2010
  8. pmc Delays in neural processing during working memory encoding in normal aging
    Theodore P Zanto
    Department of Neurology, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA
    Neuropsychologia 48:13-25. 2010
  9. pmc Mechanisms of working memory disruption by external interference
    Wesley C Clapp
    Department of Neurology and Physiology, Keck Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Cereb Cortex 20:859-72. 2010
  10. ncbi Top-down enhancement and suppression of the magnitude and speed of neural activity
    Adam Gazzaley
    University of California, Berkeley, CA, USA
    J Cogn Neurosci 17:507-17. 2005

Research Grants

  1. Neural mechanisms of memory function in normal aging
    Adam Gazzaley; Fiscal Year: 2004
  2. Top-Down Modulation & Neural Networks in Cognitive Aging
    Adam Gazzaley; Fiscal Year: 2007
  3. Neural Mechanisms Underlying Cognitive Aging
    Adam Gazzaley; Fiscal Year: 2009
  4. Neural Mechanisms Underlying Cognitive Aging
    Adam Gazzaley; Fiscal Year: 2010
  5. Neural Mechanisms Underlying Cognitive Aging
    Adam Gazzaley; Fiscal Year: 2009

Detail Information

Publications54

  1. pmc Differential coupling of visual cortex with default or frontal-parietal network based on goals
    James Z Chadick
    Department of Neurology, Physiology and Psychiatry, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, USA
    Nat Neurosci 14:830-2. 2011
    ..This indicates that sensory cortical regions are differentially and dynamically coupled with distinct networks on the basis of task goals...
  2. pmc Top-down modulation: bridging selective attention and working memory
    Adam Gazzaley
    Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA
    Trends Cogn Sci 16:129-35. 2012
    ....
  3. ncbi Age-related deficits in component processes of working memory
    Adam Gazzaley
    Department of Neurology, University of California, CA 94143 2522, USA
    Neuropsychology 21:532-9. 2007
    ..These results suggest that when working memory maintenance systems are taxed, faulty recognition processes may underlie cognitive aging deficits in healthy older individuals...
  4. pmc Age-related top-down suppression deficit in the early stages of cortical visual memory processing
    Adam Gazzaley
    Department of Neurology and Physiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:13122-6. 2008
    ..Thus, these data reconcile two cognitive aging hypotheses by revealing that an interaction of deficits in inhibition and processing speed contributes to age-related cognitive impairment...
  5. ncbi Functional interactions between prefrontal and visual association cortex contribute to top-down modulation of visual processing
    Adam Gazzaley
    Department of Neurology and Physiology, Keck Center of Integrative Neuroscience, University of California, San Francisco, CA 94143 2522, USA
    Cereb Cortex 17:i125-35. 2007
    ..Although our correlation analyses do not permit assessment of directionality, these findings suggest that PFC biases activity levels in VAC by adjusting the strength of functional coupling in accordance with stimulus relevance...
  6. ncbi Top-down modulation and normal aging
    Adam Gazzaley
    Department of Neurology and Physiology, Keck Center of Integrative Neuroscience, University of California, San Francisco, California 94143 2522, USA
    Ann N Y Acad Sci 1097:67-83. 2007
    ..We are now further characterizing the basis of these age-related alterations in top-down modulation and investigating interventions to remedy them...
  7. pmc Early top-down control of visual processing predicts working memory performance
    Aaron M Rutman
    University of California, San Francisco, CA 94158, USA
    J Cogn Neurosci 22:1224-34. 2010
    ..These results contribute to our evolving understanding of the mechanistic overlap between attention and memory...
  8. pmc Delays in neural processing during working memory encoding in normal aging
    Theodore P Zanto
    Department of Neurology, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA
    Neuropsychologia 48:13-25. 2010
    ..These results suggest that the presence of both generalized feature-based and feature-specific deficits in the speed of selective encoding of information contributes to WM performance deficits in older adults...
  9. pmc Mechanisms of working memory disruption by external interference
    Wesley C Clapp
    Department of Neurology and Physiology, Keck Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Cereb Cortex 20:859-72. 2010
    ..These results elucidate the mechanisms of external interference on WM performance and highlight similarities and differences of distraction and multitasking...
  10. ncbi Top-down enhancement and suppression of the magnitude and speed of neural activity
    Adam Gazzaley
    University of California, Berkeley, CA, USA
    J Cogn Neurosci 17:507-17. 2005
    ..We further document capacity limitations in top-down enhancement corresponding with working memory performance deficits...
  11. pmc Top-down modulation of visual feature processing: the role of the inferior frontal junction
    Theodore P Zanto
    Departments of Neurology and Physiology, University of California San Francisco, San Fransisco, CA, USA
    Neuroimage 53:736-45. 2010
    ..Furthermore, long-distance alpha (8-12Hz) phase coherence between the IFJ and visual cortices may serve as a mechanism underlying anticipatory, top-down modulation of color feature processing...
  12. pmc Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory
    Theodore P Zanto
    Department of Neurology, University of California, San Francisco, San Francisco, California, USA
    Nat Neurosci 14:656-61. 2011
    ..These results suggest that top-down modulation mediated by the prefrontal cortex is a causal link between early attentional processes and subsequent memory performance...
  13. pmc Diminished top-down control underlies a visual imagery deficit in normal aging
    Jonathan Kalkstein
    WM Keck Center For Integrative Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, California 94158 2240, USA
    J Neurosci 31:15768-74. 2011
    ..These results reveal that aging disrupts neural networks that subserve mental imagery and offers evidence of this as a factor in age-related memory decline...
  14. pmc Dissociation of motor and sensory inhibition processes in normal aging
    Joaquin A Anguera
    Departments of Neurology, Physiology and Psychiatry, WM Keck Center For Integrative Neurosciences, University of California, San Francisco, CA 94158 2330, USA
    Clin Neurophysiol 123:730-40. 2012
    ..In the present study, we hypothesized neural markers reflecting each type of inhibition may reveal a relationship across inhibitory domains in older adults...
  15. pmc Age-related changes in orienting attention in time
    Theodore P Zanto
    Departments of Neurology and Physiology, University of California San Francisco, San Francisco, California 94158, USA
    J Neurosci 31:12461-70. 2011
    ..Overall, these results provide novel evidence that older adults do not use temporal cues to orient attention in time and support an expectation deficit in normal aging...
  16. pmc Comparable mechanisms of working memory interference by auditory and visual motion in youth and aging
    Jyoti Mishra
    Department of Neurology, Physiology and Psychiatry, Sandler Neurosciences Center, University of California, San Francisco Mission Bay, San Francisco, CA 94158, USA
    Neuropsychologia 51:1896-906. 2013
    ..These results suggest that age-related sensitivity of WM to interference may be limited to complex object stimuli, at least at low WM loads. ..
  17. ncbi Measuring functional connectivity during distinct stages of a cognitive task
    Jesse Rissman
    Henry H Wheeler Jr Brain Imaging Center, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuroimage 23:752-63. 2004
    ..Distinct functional connectivity maps were generated during the component stages of this task, illustrating how important and novel observations of neural networks within the isolated stages of a cognitive task can be obtained...
  18. pmc Expectation-driven changes in cortical functional connectivity influence working memory and long-term memory performance
    Jacob Bollinger
    W M Keck Center for Integrative Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:14399-410. 2010
    ..g., FFA) can be dynamically linked or disconnected from different brain regions depending on prestimulus expectations, and the strength of distinct connections is associated with WM or LTM benefits...
  19. pmc An expectation-based memory deficit in aging
    Jacob Bollinger
    Department of Neurology, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, CA, USA
    Neuropsychologia 49:1466-75. 2011
    ..This deficit may have broader consequences for the effective utilization of predictive cues to guide attention and engender optimal cognitive performance in older individuals...
  20. pmc Predictive knowledge of stimulus relevance does not influence top-down suppression of irrelevant information in older adults
    Theodore P Zanto
    Department of Neurology, University of California San Francisco, CA, USA
    Cortex 46:564-74. 2010
    ..These results suggest that the inability to suppress irrelevant information early in the visual processing stream by older adults is related to mechanisms specific to top-down suppression...
  21. pmc Neural mechanisms underlying the impact of visual distraction on retrieval of long-term memory
    Peter E Wais
    Department of Neurology, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, San Francisco, California 94158 2330, USA
    J Neurosci 30:8541-50. 2010
    ..We conclude that bottom-up influences from irrelevant visual information interfere with top-down selection of episodic details mediated by a capacity-limited frontal control region, resulting in impaired recollection...
  22. ncbi Reward modulation of prefrontal and visual association cortex during an incentive working memory task
    Daniel C Krawczyk
    Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, USA
    Brain Res 1141:168-77. 2007
    ....
  23. pmc The effect of non-visual working memory load on top-down modulation of visual processing
    Jesse Rissman
    Henry H Wheeler Jr Brain Imaging Center, University of California, Berkeley, 94720, USA
    Neuropsychologia 47:1637-46. 2009
    ..Cooney, J. W., Rissman, J., & D'Esposito, M. (2005). Top-down suppression deficit underlies working memory impairment in normal aging. Nature Neuroscience 8, 1298-1300], suggesting the possibility of a common underlying mechanism...
  24. pmc Practice-related improvement in working memory is modulated by changes in processing external interference
    Anne S Berry
    Department of Neurology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, 600 16th St, Genentech Hall, MC2240 Rm N472J, San Francisco, CA 94158, USA
    J Neurophysiol 102:1779-89. 2009
    ....
  25. pmc Neural suppression of irrelevant information underlies optimal working memory performance
    Theodore P Zanto
    Department of Neurology and Physiology, Keck Center for Integrative Neuroscience, University of California, San Francisco, California, 94158, USA
    J Neurosci 29:3059-66. 2009
    ....
  26. pmc The influence of perceptual training on working memory in older adults
    Anne S Berry
    Departments of Neurology and Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 5:e11537. 2010
    ..These findings demonstrate the strength of the perceptual discrimination training approach by offering clear psychophysical evidence of transfer-of-benefit and a neural mechanism underlying cognitive improvement...
  27. pmc Cholinergic enhancement of functional networks in older adults with mild cognitive impairment
    Judy Pa
    Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
    Ann Neurol 73:762-73. 2013
    ..We hypothesized that older adults with mild memory deficits would show behavioral and functional network enhancements with an acetylcholinesterase inhibitor treatment (donepezil) when compared to a placebo control group...
  28. ncbi Functional connectivity during working memory maintenance
    Adam Gazzaley
    University of California, Berkeley, California 94720, USA
    Cogn Affect Behav Neurosci 4:580-99. 2004
    ..These findings support the notion that the coordinated functional interaction between nodes of a widely distributed network underlies the active maintenance of a perceptual representation...
  29. pmc Attention distributed across sensory modalities enhances perceptual performance
    Jyoti Mishra
    Department of Neurology, Physiology and Psychiatry, Keck Center for Integrative Neurosciences, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 32:12294-302. 2012
    ..These results highlight a novel neural mechanism for top-down driven performance benefits via enhanced efficacy of sensory neural processing during distributed audiovisual attention relative to focused visual attention...
  30. pmc Age-related changes in expectation-based modulation of motion detectability
    Theodore P Zanto
    Department of Neurology, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 8:e69766. 2013
    ..Our results suggest that expectation-based detection ability varies with age and, for older adults, also with axis of motion. ..
  31. ncbi Reducing vascular variability of fMRI data across aging populations using a breathholding task
    Daniel A Handwerker
    Henry H Wheeler Jr Brain Imaging Center, Helen Wills Neuroscience Institute, University of California, Berkeley, USA
    Hum Brain Mapp 28:846-59. 2007
    ....
  32. pmc The impact of visual distraction on episodic retrieval in older adults
    Peter E Wais
    Departments of Neurology, Physiology and Psychiatry, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, USA
    Brain Res 1430:78-85. 2012
    ..More generally, these findings explicate a mechanistic basis for selective impairment of recollection in normal aging...
  33. pmc Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment
    Judy Pa
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Ann Neurol 65:414-23. 2009
    ..The goal of the study was to compare clinical and neuroimaging characteristics of two single-domain MCI subgroups: amnestic MCI and dysexecutive MCI...
  34. ncbi Response bias and aging on a recognition memory task
    Terri J Huh
    Department of Psychiatry, Memory and Aging Center, University of California San Francisco, California 94143, USA
    J Int Neuropsychol Soc 12:1-7. 2006
    ..This suggests that frontal lobe changes may mediate response bias in older adults. Consistent with this frontal aging hypothesis, we predicted that response bias would become more liberal with age...
  35. pmc Prolonged disengagement from attentional capture in normal aging
    Nathan Cashdollar
    Department of Neurology, University of California, San Francisco, MC 0444, 675 Nelson Rising Lane, Room 511C, San Francisco, CA 94158, USA
    Psychol Aging 28:77-86. 2013
    ..These results suggest that the larger impact by distraction on perceptual abilities in normal aging is not the result of a greater susceptibility to attentional capture by distraction, but rather the prolonged processing of distractors...
  36. pmc Distinct mechanisms for the impact of distraction and interruption on working memory in aging
    Wesley C Clapp
    Departments of Neurology and Physiology, WM Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, United States
    Neurobiol Aging 33:134-48. 2012
    ..These results suggest that distinct underlying mechanisms mediate the impact of different types of external interference on WM in normal aging...
  37. pmc Influence of early attentional modulation on working memory
    Adam Gazzaley
    Department of Neurology, Physiology and Psychiatry, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, USA
    Neuropsychologia 49:1410-24. 2011
    ..Factors that affect attentional control at this stage include cognitive load, task practice, perceptual training, and aging. These developments highlight the complex and dynamic relationships among perception, attention, and memory...
  38. pmc Fronto-parietal network: flexible hub of cognitive control
    Theodore P Zanto
    Department of Neurology, University of California San Francisco, San Francisco, CA, USA Electronic address
    Trends Cogn Sci 17:602-3. 2013
    ..Moreover, FPN patterns of connectivity not only reflect engagement of specific tasks, but also serve as a code that can be transferred to facilitate learning novel tasks. ..
  39. pmc Rapid functional reorganization in human cortex following neural perturbation
    Theodore P Zanto
    Department of Neurology, University of California San Francisco, San Francisco, California 94158, and Departments of Physiology and Psychiatry, University of California San Francisco, San Francisco, California 94158
    J Neurosci 33:16268-74. 2013
    ..Thus, functional reorganization of cortical activity can occur within minutes of neural disruption to maintain cognitive abilities. ..
  40. pmc Distractibility during episodic retrieval is exacerbated by perturbation of left ventrolateral prefrontal cortex
    Peter E Wais
    Department of Neurology, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, CA 94158, USA
    Cereb Cortex 22:717-24. 2012
    ....
  41. doi The impact of auditory distraction on retrieval of visual memories
    Peter E Wais
    Department of Neurology, W M Keck Center for Integrative Neurosciences, University of California, San Francisco, CA 94158 2330, USA
    Psychon Bull Rev 18:1090-7. 2011
    ....
  42. pmc Subjective aspects of cognitive control at different stages of processing
    Ezequiel Morsella
    Department of Psychology, San Francisco State University, 1600 Holloway Avenue, EP 301, San Francisco, CA 94132 4168, USA
    Atten Percept Psychophys 71:1807-24. 2009
    ..In addition, these data have implications for the study of response interference in affect and self-control, and they begin to address theories regarding the function of consciousness...
  43. pmc Deficit in switching between functional brain networks underlies the impact of multitasking on working memory in older adults
    Wesley C Clapp
    Department of Neurology, The W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:7212-7. 2011
    ....
  44. pmc Structural and functional differences in medial prefrontal cortex underlie distractibility and suppression deficits in ageing
    James Z Chadick
    Department of Neurology, Physiology and Psychiatry, Center for Integrative Neuroscience, University of California, San Francisco, California 94158, USA
    Nat Commun 5:4223. 2014
    ....
  45. pmc The functional oculomotor network and saccadic cognitive control in healthy elders
    Judy Pa
    Memory and Aging Center, Department of Neurology, Sandler Neurosciences Center, University of California, San Francisco, CA 94158, USA Electronic address
    Neuroimage 95:61-8. 2014
    ..We conclude that alterations in AS task functional connectivity, quantified as hub and network efficiency, may be clinically-relevant biomarkers of cognitive decline in executive functioning. ..
  46. ncbi Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging
    MARK D'ESPOSITO
    Henry H Wheeler Jr Brain Imaging Center, Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, 3210 Tolman Hall, Berkeley, California 94720 1650, USA
    Nat Rev Neurosci 4:863-72. 2003
  47. pmc A cognitive framework for understanding and improving interference resolution in the brain
    Jyoti Mishra
    Departments of Neurology, Physiology and Psychiatry, University of California, San Francisco, CA, USA Electronic address
    Prog Brain Res 207:351-77. 2013
    ..This research showcases how an in-depth understanding of neural mechanisms can then inform the development of effective deficit-targeted interventions, which can in turn benefit both healthy and cognitively impaired populations. ..
  48. pmc Anticipatory alpha phase influences visual working memory performance
    Theodore P Zanto
    Department of Neurology, University of California San Francisco, San Francisco, CA, USA Electronic address
    Neuroimage 85:794-802. 2014
    ..These results suggest that posterior alpha phase indexes a critical time period for motion processing in the context of WM encoding goals, which occurs in anticipation of stimulus onset. ..
  49. pmc Reliability measures of functional magnetic resonance imaging in a longitudinal evaluation of mild cognitive impairment
    Theodore P Zanto
    Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA Electronic address
    Neuroimage 84:443-52. 2014
    ..In conclusion, the fMRI BOLD signal is reliable across scanning sessions in this population and thus a useful tool for tracking longitudinal change in observational and interventional studies in aMCI. ..
  50. pmc Preserved discrimination performance and neural processing during crossmodal attention in aging
    Jyoti Mishra
    Department of Neurology, Physiology and Psychiatry, University of California, San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e81894. 2013
    ..Thus, there was insufficient evidence to support an age-related deficit in crossmodal attention. ..
  51. ncbi Top-down suppression deficit underlies working memory impairment in normal aging
    Adam Gazzaley
    Henry H Wheeler, Jr Brain Imaging Center, Helen Wills Neuroscience Institute and Department of Psychology, University of California Berkeley, Berkeley, California 94720, USA
    Nat Neurosci 8:1298-300. 2005
    ..Moreover, this suppression-specific attention deficit correlated with impaired working memory performance...
  52. pmc Dynamic adjustments in prefrontal, hippocampal, and inferior temporal interactions with increasing visual working memory load
    Jesse Rissman
    Henry H Wheeler, Jr Brain Imaging Center, Department of Psychology, University of California Berkeley, Berkeley, CA 94720, USA
    Cereb Cortex 18:1618-29. 2008
    ....
  53. ncbi The contribution of functional brain imaging to our understanding of cognitive aging
    Adam Gazzaley
    Henry H Wheeler, Jr Brain Imaging Center at the Helen Wills Neuroscience Institute and the Department of Psychology at the University of California, Berkeley, CA 94720, USA
    Sci Aging Knowledge Environ 2003:PE2. 2003
    ..New methods in functional brain imaging are beginning to provide possible answers to questions regarding age-related cognitive decline...
  54. ncbi Is the prefrontal cortex necessary for delay task performance? Evidence from lesion and FMRI data
    MARK D'ESPOSITO
    Helen Wills Neuroscience Institute, University of California Berkeley, 132 Barker Hall, Berkeley, CA 94720 3190, USA
    J Int Neuropsychol Soc 12:248-60. 2006
    ....

Research Grants7

  1. Neural mechanisms of memory function in normal aging
    Adam Gazzaley; Fiscal Year: 2004
    ..abstract_text> ..
  2. Top-Down Modulation & Neural Networks in Cognitive Aging
    Adam Gazzaley; Fiscal Year: 2007
    ..This training will also serve to support the candidate in his long-term goals of becoming a bridge between large-scale neural network and reductionist approaches to cognitive neuroscience. ..
  3. Neural Mechanisms Underlying Cognitive Aging
    Adam Gazzaley; Fiscal Year: 2009
    ..The identification of underlying changes in the aging brain is necessary to establish a framework for the development of therapeutic interventions to alleviate cognitive impairments. ..
  4. Neural Mechanisms Underlying Cognitive Aging
    Adam Gazzaley; Fiscal Year: 2010
    ..The identification of underlying changes in the aging brain is necessary to establish a framework for the development of therapeutic interventions to alleviate cognitive impairments. ..
  5. Neural Mechanisms Underlying Cognitive Aging
    Adam Gazzaley; Fiscal Year: 2009
    ..The identification of underlying changes in the aging brain is necessary to establish a framework for the development of therapeutic interventions to alleviate cognitive impairments. ..