A F Gazdar

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Application of a methylation gene panel by quantitative PCR for lung cancers
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cancer Lett 247:56-71. 2007
  2. ncbi request reprint Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation
    Amit K Das
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, NC 7 208, Mail Code 9187, Dallas, TX 75390, USA
    Cancer Res 66:9601-8. 2006
  3. pmc Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 68:7448-56. 2008
  4. pmc The relationship between aberrant methylation and survival in non-small-cell lung cancers
    S Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Br J Cancer 91:771-4. 2004
  5. pmc Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells
    Junichi Soh
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e7464. 2009
  6. pmc MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs
    Liqin Du
    Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA
    J Exp Clin Cancer Res 29:75. 2010
  7. pmc Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study
    Masaharu Nomura
    Dept, of Surgery I, Tokyo Medical University, Tokyo, Japan
    J Clin Bioinforma 1:23. 2011
  8. pmc A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT
    Norimasa Miura
    Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683 8503, Japan
    BMC Mol Biol 10:5. 2009
  9. pmc Inhibition of EGFR signaling: all mutations are not created equal
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and in the Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Med 2:e377. 2005
  10. ncbi request reprint Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?
    Adi F Gazdar
    Hamon Centre for Therapeutic Oncology Research, University of Texas Southwestern Medical Centre, Dallas, TX 75390, USA
    Trends Mol Med 10:481-6. 2004

Research Grants

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. pmc Application of a methylation gene panel by quantitative PCR for lung cancers
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cancer Lett 247:56-71. 2007
    ..Our preliminary data on the analysis of sputum DNA specimens from cancer patients further support these observations...
  2. ncbi request reprint Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation
    Amit K Das
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, NC 7 208, Mail Code 9187, Dallas, TX 75390, USA
    Cancer Res 66:9601-8. 2006
    ....
  3. pmc Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 68:7448-56. 2008
    ..Our data constitute the first direct functional evidence for CYGB, the newest member of the globin family, as a tumor suppressor gene...
  4. pmc The relationship between aberrant methylation and survival in non-small-cell lung cancers
    S Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Br J Cancer 91:771-4. 2004
    ..While there was no relationship between the other genes and survival, p16(INK4a) methylation was significantly related to unfavourable prognosis in lung adenocarcinomas...
  5. pmc Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells
    Junichi Soh
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e7464. 2009
    ..However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of oncogenes...
  6. pmc MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs
    Liqin Du
    Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA
    J Exp Clin Cancer Res 29:75. 2010
    ..However, the role of miRNAs in the pathogenesis and diagnosis of small cell carcinoma (SCLC), the majority of which represent the most aggressive lung tumors, has not been investigated...
  7. pmc Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study
    Masaharu Nomura
    Dept, of Surgery I, Tokyo Medical University, Tokyo, Japan
    J Clin Bioinforma 1:23. 2011
    ..abstract:..
  8. pmc A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT
    Norimasa Miura
    Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683 8503, Japan
    BMC Mol Biol 10:5. 2009
    ....
  9. pmc Inhibition of EGFR signaling: all mutations are not created equal
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and in the Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Med 2:e377. 2005
  10. ncbi request reprint Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?
    Adi F Gazdar
    Hamon Centre for Therapeutic Oncology Research, University of Texas Southwestern Medical Centre, Dallas, TX 75390, USA
    Trends Mol Med 10:481-6. 2004
    ..Cancer cells with mutant EGFR genes might become physiologically dependent on the continued activity of the gene for the maintenance of their malignant phenotype; however, this might also be a target for therapy...
  11. ncbi request reprint Molecular targets for cancer therapy and prevention
    Adi F Gazdar
    University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Chest 125:97S-101S. 2004
    ..These studies demonstrate that multiple, often overlapping, mechanisms of disruption are present in lung cancer cells, presenting a plethora of molecular targets...
  12. ncbi request reprint Rapid screening for EGFR mutations: pros and cons
    Adi F Gazdar
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Cancer J 12:17-8. 2006
  13. ncbi request reprint Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Clin Lung Cancer 5:177-81. 2003
    ..The molecular changes caused by each of these major etiologic factors and their interrelationships are the focus of this review...
  14. pmc Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors
    A F Gazdar
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Oncogene 28:S24-31. 2009
    ..Various second-generation EGFR TKIs are currently being evaluated and may have the potential to overcome T790M-mediated resistance by virtue of their irreversible inhibition of the receptor TK domain...
  15. ncbi request reprint Environmental tobacco smoke, carcinogenesis, and angiogenesis: a double whammy?
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Cancer Cell 4:159-60. 2003
    ..While a weak carcinogen, nicotine promotes carcinogenesis by a number of different mechanisms. The authors' findings provide further evidence of the harmful effects of ETS and indicate the desirability of reducing exposure to it...
  16. pmc Lung cancer cell lines: Useless artifacts or invaluable tools for medical science?
    Adi F Gazdar
    UT Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Lung Cancer 68:309-18. 2010
    ..Finally the issue of cell line contamination must be addressed and safeguarded against. A full understanding of the advantages and shortcomings of cell lines is required for the investigator to derive the maximum benefit from their use...
  17. pmc Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX, 75390 8593, USA
    Cancer Metastasis Rev 29:37-48. 2010
    ....
  18. pmc Lung cancer cell lines as tools for biomedical discovery and research
    Adi F Gazdar
    University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 8593, USA
    J Natl Cancer Inst 102:1310-21. 2010
    ..However, major problems including misidentification or cell line contamination remain. Ongoing studies and new approaches are expected to reveal the full potential of the lung cancer cell line panel...
  19. doi request reprint Should we continue to use the term non-small-cell lung cancer?
    A F Gazdar
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Ann Oncol 21:vii225-9. 2010
    ..For the patient to obtain maximum benefit from the recent developments in therapeutics, a multidisciplinary approach is required with co-operation between oncologists, surgeons, radiologists and pathologists...
  20. ncbi request reprint Apoptosis and lung cancer: a review
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    J Cell Biochem 88:885-98. 2003
    ..The role of apoptosis regulation in lung cancer with major focus on the differential sensitivities of the major subtypes is reviewed...
  21. pmc Preneoplasia of lung cancer
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical School, Dallas, TX, USA
    Cancer Biomark 9:385-96. 2010
    ..A study of preinvasive lung cancer has yielded much valuable biologic information that impacts on clinical management...
  22. ncbi request reprint Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas
    K O Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cancer Res 61:4556-60. 2001
    ..Our results demonstrate frequent aberrant methylation of CDH13 in breast and lung cancers accompanied by loss of gene expression, although expression may occasionally be lost by other mechanisms...
  23. ncbi request reprint Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas
    A K Virmani
    Hamon Center for Therapeutic Oncology Research, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593, USA
    Clin Cancer Res 7:1998-2004. 2001
    ..Our findings may be of biological and clinical importance...
  24. ncbi request reprint 5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer
    S Zochbauer-Muller
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 61:3581-5. 2001
    ..Methylation of FHIT commences during lung cancer pathogenesis and may represent a marker for risk assessment...
  25. ncbi request reprint Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma
    S Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cancer Res 61:5727-30. 2001
    ..Our results demonstrate a relationship between SV40 and aberrant methylation in MMs...
  26. ncbi request reprint Aberrant promoter methylation of multiple genes in non-small cell lung cancers
    S Zochbauer-Muller
    Hamon Center for Therapeutic Oncology Research, The University of Texas, Southwestern Medical Center at Dallas, 75390 8593, USA
    Cancer Res 61:249-55. 2001
    ....
  27. pmc DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers
    M Suzuki
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Bld NB, Room 8206, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Br J Cancer 93:1029-37. 2005
    ..Our results provide strong evidence that these TGFbeta-related genes are frequently deregulated through aberrant methylation in many human malignancies...
  28. ncbi request reprint DNA methylation profiles of lung tumors
    S Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390-8563, USA
    Mol Cancer Ther 1:61-7. 2001
    ..We conclude that SCLC, carcinoids, squamous cell carcinomas, and adenocarcinomas of the lung have unique profiles of aberrant methylation. Our findings should help us understand differences in the pathogenetic mechanisms of lung cancers...
  29. ncbi request reprint Aberrant methylation during cervical carcinogenesis
    A K Virmani
    Hamon Center for Therapeutic Oncology Research, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas 85930, USA
    Clin Cancer Res 7:584-9. 2001
    ....
  30. ncbi request reprint Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type
    C Y Muller
    Department of Obstetrics and Gynecology, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    J Natl Cancer Inst 90:433-9. 1998
    ..We examined abnormalities in FHIT and its RNA transcripts in cervical cancer cell lines and tumors. We also investigated the relationship between loss of heterozygosity (LOH) in FHIT/FRA3B and the presence of oncogenic HPV types...
  31. ncbi request reprint Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression
    D G Burbee
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, TX 75390 8593, USA
    J Natl Cancer Inst 93:691-9. 2001
    ..3 that frequently undergoes allele loss in lung and breast cancers. We explored the hypothesis that RASSF1 encodes a tumor suppressor gene for lung and breast cancers...
  32. pmc Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patients
    A L Smith
    Simmons Cancer Center, University of Texas, Dallas, USA
    Br J Cancer 73:203-9. 1996
    ..Aneuploidy was not found in preinvasive lesions accompanying the five metastatic cases. Our findings provide strong support for the concept of field cancerisation...
  33. pmc Aberrant methylation of SPARC in human lung cancers
    M Suzuki
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Br J Cancer 92:942-8. 2005
    ..001). Our findings are of biological interest and potentially of clinical importance in human lung cancers...
  34. pmc High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss
    A Maitra
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Pathol 159:119-30. 2001
    ....
  35. ncbi request reprint DNA analysis at p53 locus in carcinomas arising from pleomorphic adenomas of salivary glands: comparison of molecular study and p53 immunostaining
    Y Yamamoto
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
    Pathol Int 48:265-72. 1998
    ..These findings indicate that p53 gene mutation is an early event and occurs frequently at an early stage of precancerous lesions and may be responsible for most cases of malignant transformation of PA...
  36. ncbi request reprint DNA analysis at p53 locus in adenoid cystic carcinoma: comparison of molecular study and p53 immunostaining
    Y Yamamoto
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, USA
    Pathol Int 48:273-80. 1998
    ..These findings indicate that abnormalities of the p53 gene are involved in carcinogenesis and/or progression of this tumor and, furthermore, suggest that molecular analyses of ACC may provide information of prognostic importance...
  37. pmc Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B
    Y Tomizawa
    Hamon Center for Therapeutic Oncology Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 98:13954-9. 2001
    ..These results are consistent with SEMA3B functioning as a TSG, the expression of which is inactivated frequently in lung cancers by allele loss and promoter region methylation...
  38. ncbi request reprint Deletions of chromosome 4 occur early during the pathogenesis of colorectal carcinoma
    N Shivapurkar
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-8593, USA
    Hum Pathol 32:169-77. 2001
    ..Our results suggest that there may be multiple putative tumor suppressor genes located on both arms of chromosome 4 whose inactivation are important early events in the pathogenesis of colorectal carcinoma...
  39. pmc Development of a sensitive, specific reverse transcriptase polymerase chain reaction-based assay for epithelial tumour cells in effusions
    M Sakaguchi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas 75235 8593, USA
    Br J Cancer 79:416-22. 1999
    ..Our method appears to be highly specific and increases the sensitivity of detection of malignant cells; it may be a useful adjunct to routine cytopathological examination...
  40. ncbi request reprint Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer
    Arvind Virmani
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Int J Cancer 106:198-204. 2003
    ..Our results suggest that methylation of TMS1 may play a role in the pathogenesis of small cell and non small lung and breast cancers...
  41. ncbi request reprint A translational view of the molecular pathogenesis of lung cancer
    Mitsuo Sato
    Hamon Center for Therapeutic Oncology Research Simmons Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Thorac Oncol 2:327-43. 2007
    ..These advances highlight the translation of molecular discoveries on lung cancer pathogenesis from the laboratory to the clinic...
  42. ncbi request reprint Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
    Mitsuo Sato
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas 75390 8593, USA
    Cancer Res 66:2116-28. 2006
    ....
  43. ncbi request reprint Primary mammary small-cell carcinoma: a molecular analysis of 2 cases
    M P Hoang
    Division of Anatomic Pathology and Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Hum Pathol 32:753-7. 2001
    ..Second, mammary small-cell carcinoma is clonally related to ductal carcinoma in situ and might represent an example of divergent differentiation occurring in a multipotential neoplastic stem cell...
  44. ncbi request reprint Epigenetic down-regulation of death-associated protein kinase in lung cancers
    Shinichi Toyooka
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Clin Cancer Res 9:3034-41. 2003
    ..Treatment with 5-aza-2'-deoxycytidine restored DAPK expression in heavily methylated cell lines tested, and histone deacetylase inhibitor trichostatin A alone restored DAPK expression in some methylated cell lines as well...
  45. ncbi request reprint Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features
    R Maruyama
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Cancer Res 61:8659-63. 2001
    ..CDH1 methylation positive status was independently associated with poor survival in multivariate analyses. Our results suggest that the methylation profile may be a potential new biomarker of risk prediction in bladder cancer...
  46. ncbi request reprint Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer
    A F Gazdar
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235 8593, USA
    Int J Cancer 78:766-74. 1998
    ..Our panel of paired tumor and non-malignant cell lines should provide important new reagents for breast cancer research...
  47. ncbi request reprint Expression of the RNA component of human telemorase (hTR) in ThinPrep preparations from bladder washings
    A Maitra
    Department of Pathology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer 93:73-9. 2001
    ..CONCLUSIONS: The use of in situ hybridization technique bypasses the need for stringent specimen processing and allows identification of the specific cell type that expresses telomerase. Cancer (Cancer Cytopathol)..
  48. ncbi request reprint Lung cancer in never smokers--a different disease
    Sophie Sun
    Division of Haematology and Oncology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Rev Cancer 7:778-90. 2007
    ..This Review summarizes our current knowledge of this unique and poorly understood disease...
  49. ncbi request reprint RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells
    Makoto Suzuki
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Cancer Res 64:3137-43. 2004
    ..These results provide direct evidence that loss of DNMT1 expression abrogates tumor-associated promoter methylation and the resultant silencing of multiple genes implicated in the pathogenesis of human lung and breast cancer...
  50. ncbi request reprint Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Int J Cancer 109:786-92. 2004
    ..Our results demonstrate that DcR1 and DcR2 genes are frequently methylated in various tumor types, and that the role of decoy receptors in tumor pathogenesis needs to be re-evaluated...
  51. ncbi request reprint Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines
    Kenichi Harada
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, TX 75390, USA
    Oncogene 21:4345-9. 2002
    ..In five of six cell lines, restoration of RASSF1A mRNA was confirmed by RT-PCR. Our findings indicate that aberrant promoter methylation of RASSF1A may contribute to the pathogenesis of many different forms of pediatric tumors...
  52. ncbi request reprint Differential inactivation of caspase-8 in lung cancers
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, Departments of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 8593, USA
    Cancer Biol Ther 1:65-9. 2002
    ..CASP8 may function as a tumor suppressor gene in neuroendocrine lung tumors...
  53. ncbi request reprint Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer
    Shinichi Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas TX 75390 8593, USA
    Int J Cancer 103:153-60. 2003
    ..Our findings demonstrate important smoke exposure, histologic type and geography-related differences in the methylation profiles of NSCLC tumors...
  54. ncbi request reprint Microdissection and the study of cancer pathways
    A Maitra
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, USA
    Curr Mol Med 1:153-62. 2001
    ..Importantly, it is now possible to analyze many of the genetic changes that precede cancer, thereby identifying populations "at risk" for developing malignancies in the future...
  55. ncbi request reprint Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier
    G E Tomlinson
    Department of Pediatrics, and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas 75235 8593, USA
    Cancer Res 58:3237-42. 1998
    ..This breast tumor-derived cell line may provide a useful model system for the study of familial breast cancer pathogenesis and for elucidating BRCA1 function and localization...
  56. ncbi request reprint Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures
    Shinichi Toyooka
    Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Clin Cancer Res 8:2292-7. 2002
    ..Because loss of heterozygosity at 8p21-22 is a frequent event in lung cancers, we studied FEZ1 alteration in short-term cultures of resected lung cancer tumors and cell lines...
  57. ncbi request reprint Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection
    Makoto Suzuki
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Oncogene 24:1302-8. 2005
    ..Our results demonstrate a relationship between SV40 and methylation of multiple genes in MM, indicating that the virus plays a role in the pathogenesis of MM...
  58. ncbi request reprint Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer
    Noriaki Sunaga
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Cancer Res 64:4277-85. 2004
    ..These results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth...
  59. ncbi request reprint Hierarchical clustering of lung cancer cell lines using DNA methylation markers
    Arvind K Virmani
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9593, USA
    Cancer Epidemiol Biomarkers Prev 11:291-7. 2002
    ..Our results show that DNA methylation patterns differ between NSCLC and SCLC cell lines and suggest that these patterns could be developed into a powerful molecular marker to achieve accurate diagnosis of lung cancer...
  60. ncbi request reprint Aberrant promoter methylation and silencing of laminin-5-encoding genes in breast carcinoma
    Ubaradka G Sathyanarayana
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Clin Cancer Res 9:6389-94. 2003
    ..In this study, we investigated the loss of expression of three LN5-encoding genes in breast cancer cell lines and elucidated the mechanism of silencing of the genes in breast cancer cell lines and tumors...
  61. ncbi request reprint Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers
    Sabine Zochbauer-Muller
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Int J Cancer 107:612-6. 2003
    ..Our findings suggest that detection of methylation should be investigated as an intermediate marker for lung cancer risk assessment and response to chemopreventive regimens...
  62. ncbi request reprint Epigenetic inactivation of laminin-5-encoding genes in lung cancers
    Ubaradka G Sathyanarayana
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Clin Cancer Res 9:2665-72. 2003
    ..We further studied the methylation patterns of primary non-small cell lung cancer [NSCLC (n = 36)], small cell lung cancer [SCLC (n = 26)], and carcinoids (n = 24) tumors...
  63. pmc Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation
    Di Cai
    Division of Translational Research, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 70:6477-85. 2010
    ..Taken together, these data suggest that SRC-3 may be an important oncogene and therapeutic target for lung cancer...
  64. pmc DNA methylation based biomarkers in non-invasive cancer screening
    N Shivapurkar
    Hamon Center for Therapeutic Oncology Research, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
    Curr Mol Med 10:123-32. 2010
    ..Thus, we review recent findings on DNA methylation based cancer biomarkers with particular focus on these applicable to the clinical specimens obtained non-invasively from cancer patients...
  65. ncbi request reprint Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers
    X L Xu
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 61:7943-9. 2001
    ..Our results suggest that epigenetic or mutational inactivation of hSRBC may contribute to the pathogenesis of several types of human cancers, marking hSRBC as a candidate tumor suppressor gene...
  66. pmc hTR repressor-related gene on human chromosome 10p15.1
    N Miura
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Br J Cancer 85:1510-4. 2001
    ..Our findings strongly suggest that 10p15.1 harbours a gene involved in repression of telomerase RNA component in human somatic cells and each putative repressor (on 3p and 10p) may act independently...
  67. pmc A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies
    David S Shames
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Med 3:e486. 2006
    ....
  68. ncbi request reprint Aberrant methylation of Reprimo in human malignancies
    Takao Takahashi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Int J Cancer 115:503-10. 2005
    ..Aberrant methylation of Reprimo with loss of expression is a common event and may contribute to the pathogenesis of some types of human malignancy...
  69. ncbi request reprint Promoter hypermethylation profile of ovarian epithelial neoplasms
    Prakash B Makarla
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Clin Cancer Res 11:5365-9. 2005
    ..The aim of this study was to compare the promoter hypermethylation profiles of ovarian epithelial neoplasms to better understand the role of epigenetic silencing in carcinogenesis...
  70. ncbi request reprint Aberrant methylation of Reprimo in lung cancer
    Makoto Suzuki
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Lung Cancer 47:309-14. 2005
    ..These data indicate that Reprimo methylation is frequent in lung cancers and occurs independently of p53 status. Methylation of Reprimo may play a role in the pathogenesis of lung cancers...
  71. ncbi request reprint The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer
    Ikuo Sekine
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 8593, USA
    Oncogene 24:2735-8. 2005
    ..We conclude that abnormalities of BAF180 are not frequently involved in the pathogenesis of lung cancer...
  72. ncbi request reprint Molecular pathogenesis of lung cancer and potential translational applications
    John D Minna
    Hamon Center for Therapeutic Oncology Research, Department of Internal Medicine, Unversity of Texas, Dallas 75390 8593, USA
    Cancer J 8:S41-6. 2002
    ..Finally, correcting even single genetic abnormalities can reverse the malignant phenotype...
  73. ncbi request reprint Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells
    Shinichi Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, TX 75390, USA
    Oncogene 21:4340-4. 2002
    ..These data, together with our previous findings, support a causal relationship between SV40 infection, progressive RASSF1A methylation and its silencing, and the pathogenesis of mesothelioma...
  74. pmc Differential methylation of a short CpG-rich sequence within exon 1 of TCF21 gene: a promising cancer biomarker assay
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cancer Epidemiol Biomarkers Prev 17:995-1000. 2008
    ..We further showed similar applications with multiple other malignancies. Our assay might have important implications in early detection and surveillance of multiple malignancies...
  75. pmc Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized
    David Padron
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Cancer Res 67:7695-702. 2007
    ..Thus, the mutations that altered signaling also decreased the interaction of EGFRs with the mechanisms responsible for endosomal sorting...
  76. ncbi request reprint Loss of heterozygosity in benign breast epithelium in relation to breast cancer risk
    David M Euhus
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 75390 9155, USA
    J Natl Cancer Inst 94:858-60. 2002
    ..Accurate individualized breast cancer risk assessment may be possible based on molecular analysis of breast epithelial cells obtained by random FNA...
  77. ncbi request reprint Methods for detecting DNA methylation in tumors: from bench to bedside
    David S Shames
    The Hamon Center of Therapeutic Oncology Research and the Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX, USA
    Cancer Lett 251:187-98. 2007
    ..In this article, we review genome-wide and quantitative, high- resolution methods for methylation analysis that are used in the laboratory and clinic, and discuss their potential for use in a clinical setting...
  78. pmc Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines
    Wei Zhang
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    J Thorac Oncol 4:161-6. 2009
    ..In this study, we examined the effects of the histone deacetylase inhibitor, romidepsin, in combination with erlotinib, in NSCLC cell lines and xenografts...
  79. ncbi request reprint Aberrant promoter methylation of laminin-5-encoding genes in prostate cancers and its relationship to clinicopathological features
    Ubaradka G Sathyanarayana
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Clin Cancer Res 9:6395-400. 2003
    ..In this study, we investigated the aberrant promoter methylation of LN5 genes in prostate cancers and correlated the data with clinicopathological features...
  80. pmc Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines
    Jeet Gandhi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 4:e4576. 2009
    ..Mutations of EGFR (mEGFR) and copy number gains (CNGs) of EGFR (gEGFR) and HER2 (gHER2) have been reported to predict for TKI response. Mutations in KRAS (mKRAS) are associated with primary resistance to TKIs...
  81. ncbi request reprint Alterations in the mitochondrial displacement loop in lung cancers
    Makoto Suzuki
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas Texas 75390, USA
    Clin Cancer Res 9:5636-41. 2003
    ..We determined the frequency of D-loop alterations in lung cancer cell lines and tumors, and related them to clinicopathologic features...
  82. ncbi request reprint Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis
    Hittu Matta
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas Texas 75390 8593, USA
    Cancer Biol Ther 1:652-60. 2002
    ....
  83. ncbi request reprint Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines
    Hong Chen
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    J Biol Chem 278:3121-30. 2003
    ..We therefore conclude that epigenetic regulation plays a potential role in regulating hDAB2IP expression in PCa and that these results also provide a new therapeutic strategy for PCa patients...
  84. ncbi request reprint Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines
    Kenichi Harada
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Cancer Res 62:5897-901. 2002
    ..Our results suggest that deregulation of the death receptor pathway to apoptosis is frequent in many types of pediatric tumors and their cell lines...
  85. pmc Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers
    Masaharu Nomura
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Med 4:e125. 2007
    ..The objective of this study was to examine distributions of these three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers...
  86. ncbi request reprint Sun exposure related methylation in malignant and non-malignant skin lesions
    Ubaradka G Sathyanarayana
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 8593, USA
    Cancer Lett 245:112-20. 2007
    ..These differences were highly significant (P<0.0001). These findings suggest that methylation commences in UV exposed skin at a relatively early age and occurs in skin prior to the onset of recognizable preneoplastic changes...
  87. ncbi request reprint Cancer. A bull's eye for targeted lung cancer therapy
    John D Minna
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 304:1458-61. 2004
  88. ncbi request reprint Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    Hisayuki Shigematsu
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    J Natl Cancer Inst 97:339-46. 2005
    ..However, the role of such mutations in the pathogenesis of lung cancers is unclear...
  89. ncbi request reprint Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
    Hisayuki Shigematsu
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Int J Cancer 118:257-62. 2006
    ..In addition, for optimal therapeutic approach a comprehensive understanding of the genes related to EGFR signaling pathway, including RAS/RAF/MAPK and PI3K-AKT pathways, are required...
  90. ncbi request reprint Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 64:9027-34. 2004
    ..These HBEC lines are a valuable new tool for studying of the pathogenesis of lung cancer...
  91. pmc Evaluation of candidate methylation markers to detect cervical neoplasia
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75930, USA
    Gynecol Oncol 107:549-53. 2007
    ..We used quantitative PCR assays to evaluate methylation in five candidate genes (TNFRSF10C, DAPK1, SOCS3, HS3ST2 and CDH1) previously demonstrated as methylated in cervical cancer...
  92. ncbi request reprint Molecular detection of noninvasive and invasive bladder tumor tissues and exfoliated cells by aberrant promoter methylation of laminin-5 encoding genes
    Ubaradka G Sathyanarayana
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Cancer Res 64:1425-30. 2004
    ..Of particular interest, methylation frequencies of LAMA3 helped to distinguish invasive (72%) from noninvasive (12%) tumors. These results suggest that methylation of LN5 genes has potential clinical applications in bladder cancers...
  93. ncbi request reprint DNA methylation profiles of lymphoid and hematopoietic malignancies
    Takao Takahashi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Clin Cancer Res 10:2928-35. 2004
    ....
  94. ncbi request reprint Molecular pathogenesis of lung cancer
    Sabine Zochbauer-Muller
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8593, USA
    Annu Rev Physiol 64:681-708. 2002
    ..All these strategies should aid in reducing the number of newly diagnosed lung cancer cases and in increasing the survival and quality of life of patients with lung cancer...
  95. ncbi request reprint Tumor suppressor genes in lung cancer
    Arvind K Virmani
    Hamon Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 222:97-115. 2003
  96. ncbi request reprint Hypermethylation of FHIT as a prognostic marker in nonsmall cell lung carcinoma
    Riichiroh Maruyama
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer 100:1472-7. 2004
    ..The purpose of the current study was to determine the correlation between the aberrant promoter methylation of multiple genes and survival in patients with nonsmall cell lung carcinoma (NSCLC)...
  97. ncbi request reprint Mutation analysis of the PTEN/MMAC1 gene in lung cancer
    E Forgacs
    Hamon Center for Therapeutic Oncology Research, University of Texas, Southwestern Medical Center, Dallas 75235, USA
    Oncogene 17:1557-65. 1998
    ..5% nt identity to PTEN/MMAC1, that needs to be accounted for in cDNA mutation analysis. Our findings suggest that genetic abnormalities of the PTEN/MMAC1 gene are only involved in a relatively small subset of lung cancers...
  98. ncbi request reprint Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients
    Federico Cappuzzo
    University of Colorado Cancer Center, Department of Medicine and Pathology, Aurora, CO 80010, USA
    J Clin Oncol 23:5007-18. 2005
    ..Preclinical data indicate that HER2, a member of the EGFR family, could enhance TKI sensitivity...
  99. ncbi request reprint Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers
    Shinichi Toyooka
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Cancer Res 66:1371-5. 2006
    ..Our results indicate the differences in the evolvement of epigenetic alterations between the EGFR- and K-RAS-mediated tumorigenesis and suggest the specific interaction of genetic and epigenetic changes in tumorigenesis of lung cancer...
  100. ncbi request reprint Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
    Samir E Witta
    Department of Medicine Medical Oncology, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Campus Box 8117, PO Box 6511, Aurora, CO 80045, USA
    Cancer Res 66:944-50. 2006
    ..Thus, combined HDAC inhibitor and gefitinib treatment represents a novel pharmacologic strategy for overcoming resistance to EGFR inhibitors in patients with lung cancer...
  101. ncbi request reprint The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers
    Masaki Tokumo
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Cancer Res 11:1167-73. 2005
    ..Here, we investigated the relationship between EGFR mutation and clinicopathologic features...

Research Grants3

  1. Novel Reagents and New Biomarkers for Lung Cancer
    Adi Gazdar; Fiscal Year: 2007
    ..Our proposal will generate unique reagents useful for many studies, identify the sequential molecular changes during multistage pathogenesis and validate markers for early detection and risk assessment. ..
  2. UNIQUE TISSUE AND TUMOR PROCESSING FACILITY
    Adi Gazdar; Fiscal Year: 2003
    ..A charge back fee system will recover some of the costs and will be used for future expansion of the Facility, which is anticipated to become self sustaining after five years. ..