Research Topics
| Bradley N GaynesSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Does the presence of accompanying symptom clusters differentiate the comparative effectiveness of second-line medication strategies for treating depression?Bradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7160, USA
Depress Anxiety 28:989-98. 2011..We explored whether clinical outcomes differ by treatment strategy following initial antidepressant treatment failure among patients with and without clinically relevant symptom clusters...
What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depressionBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Psychiatr Serv 60:1439-45. 2009..STAR*D demonstrated that inclusion of more real-world patients in clinical trials is both feasible and informative. Policy implications of the findings, as well as the study's limitations, are discussed...
The STAR*D study: treating depression in the real worldBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599, USA
Cleve Clin J Med 75:57-66. 2008..Although the study found no clear-cut "winner", it does provide guidance on how to start therapy and how to proceed if initial treatment fails...- Feasibility and diagnostic validity of the M-3 checklist: a brief, self-rated screen for depressive, bipolar, anxiety, and post-traumatic stress disorders in primary careBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7160, USA
Ann Fam Med 8:160-9. 2010..We wanted to assess the feasibility and diagnostic validity of the My Mood Monitor (M-3) checklist, a new, 1-page, patient-rated, 27-item tool developed to screen for multiple psychiatric disorders in primary care... - Major depression symptoms in primary care and psychiatric care settings: a cross-sectional analysisBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Ann Fam Med 5:126-34. 2007.... - Treating depression after initial treatment failure: directly comparing switch and augmenting strategies in STAR*DBradley N Gaynes
Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Clin Psychopharmacol 32:114-9. 2012.... - Primary versus specialty care outcomes for depressed outpatients managed with measurement-based care: results from STAR*DBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
J Gen Intern Med 23:551-60. 2008..Whether the acute outcomes of major depressive disorder (MDD) treated in primary (PC) or specialty care (SC) settings are different is unknown... - Prevalence and comorbidity of psychiatric diagnoses based on reference standard in an HIV+ patient populationBradley N Gaynes
Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
Psychosom Med 70:505-11. 2008..Among those persons with psychiatric illness, psychiatric comorbidity (multiple simultaneous diagnoses) is associated with increased psychiatric severity and higher HIV risk behaviors... - Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal riskMadhukar H Trivedi
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
J Clin Psychiatry 72:757-64. 2011..This report evaluates the psychometric properties of a brief self- and clinician-rated measure of factors related to the risk of suicide attempt or completion... - Health-related quality of life in depression: a STAR*D reportElla J Daly
Department of Psychiatry, University of Texas Southwestern Medical School at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
Ann Clin Psychiatry 22:43-55. 2010..This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial... - Effects of race and ethnicity on depression treatment outcomes: the CO-MED trialIra M Lesser
Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA, USA
Psychiatr Serv 62:1167-79. 2011.... - Insomnia in patients with depression: a STAR*D reportPrabha Sunderajan
Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9119, USA
CNS Spectr 15:394-404. 2010..However, little is known about the prevalence and associated features of insomnia symptoms in representative treatment-seeking patients with depression... - Concise Associated Symptoms Tracking scale: a brief self-report and clinician rating of symptoms associated with suicidalityMadhukar H Trivedi
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
J Clin Psychiatry 72:765-74. 2011.... - Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*DWilliam R Yates
Department of Psychiatry, University of Oklahoma College of Medicine, Tulsa, OK 74135, USA
Gen Hosp Psychiatry 26:421-9. 2004..A significant percentage of patients with major depressive disorder (MDD) suffer from concurrent general medical conditions (GMCs)... - Maximizing the adequacy of medication treatment in controlled trials and clinical practice: STAR(*)D measurement-based careMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Neuropsychopharmacology 32:2479-89. 2007..This approach signals a paradigm shift toward the use of measurement-based clinical decisions, both at the point of care and following each visit, to deliver optimal pharmacotherapy for depression... - Ethnicity/race and outcome in the treatment of depression: results from STAR*DIra M Lesser
Department of Psychiatry, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, 1000 W Carson Street, Torrance, CA 90509, USA
Med Care 45:1043-51. 2007.... - A direct comparison of presenting characteristics of depressed outpatients from primary vs. specialty care settings: preliminary findings from the STAR*D clinical trialBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Gen Hosp Psychiatry 27:87-96. 2005..The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study (http://www.star-d.org) provides a unique opportunity to provide this comparison for patients with a major depressive disorder (MDD) requiring treatment... - Efficacy and safety of second-generation antidepressants in the treatment of major depressive disorderRichard A Hansen
Division of Pharmaceutical Policy and Evaluative Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Ann Intern Med 143:415-26. 2005.... - Predictors of attrition during initial (citalopram) treatment for depression: a STAR*D reportDiane Warden
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9086, USA
Am J Psychiatry 164:1189-97. 2007..The purpose of this study was to identify the pretreatment predictors of attrition during acute treatment with citalopram in a large, "real world" clinical trial... - The adverse effects of comorbid pain on depression outcomes in primary care patients: results from the ARTIST trialAngela M DeVeaugh-Geiss
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, USA
Pain Med 11:732-41. 2010..To explore the effect of pain symptoms and improvements in pain on depression outcomes... - Clinical and sociodemographic characteristics associated with suicidal ideation in depressed outpatientsMadhukar H Trivedi
Professor of Psychiatry, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
Can J Psychiatry 58:113-22. 2013..Clinical Trial Registration Number: Sequenced Treatment Alternatives to Relieve Depression, NCT00021528... - Discontinuation rates for selective serotonin reuptake inhibitors and other second-generation antidepressants in outpatients with major depressive disorder: a systematic review and meta-analysisGerald Gartlehner
Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599, USA
Int Clin Psychopharmacol 20:59-69. 2005.... - Distressing adverse events after antidepressant switch in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial: influence of adverse events during initial treatment with citalopram on development of subsequent adverse events with an aAaron J Katz
Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Pharmacotherapy 32:234-43. 2012..To determine whether distressing adverse events (DAEs) experienced during initial antidepressant treatment are associated with subsequent DAEs after switching to a second antidepressant... - Depression and comorbid panic in primary care patientsAngela M DeVeaugh-Geiss
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
J Affect Disord 123:283-90. 2010..Comorbid panic symptoms may complicate depression treatment. However, most research focuses on specialty care, and the evidence in primary care is mixed... - Clinical features of depression in outpatients with and without co-occurring general medical conditions in STAR*D: confirmatory analysisWilliam R Yates
Department of Psychiatry, University of Oklahoma College of Medicine, Tulsa, OK, USA
Prim Care Companion J Clin Psychiatry 9:7-15. 2007..This association has implications for diagnosis and clinical care... - The association between antidepressant dosage titration and medication adherence among patients with depressionChung Hsuen Wu
Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7573, USA
Depress Anxiety 29:506-14. 2012..To evaluate the association between upward dose titration of antidepressants and medication adherence during the first 6 months of a newly initiated antidepressant treatment for patients with major depressive disorder (MDD)... - Identifying difficult-to-treat depression: differential diagnosis, subtypes, and comorbiditiesBradley N Gaynes
Department of Psychiatry and UNC Regional Center for STAR D, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA
J Clin Psychiatry 70:10-5. 2009.... - Efficacy and tolerability of second-generation antidepressants in social anxiety disorderRichard A Hansen
Division of Pharmaceutical Outcomes and Policy, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
Int Clin Psychopharmacol 23:170-9. 2008..Overall, a fair amount of evidence supports the efficacy of escitalopram, fluvoxamine, paroxetine, sertraline, and venlafaxine in social anxiety disorder. The drugs do not differ in efficacy, although their adverse event profiles do... - Diagnostic accuracy of Spanish language depression-screening instrumentsDaniel S Reuland
Department of Medicine, Division of General Medicine and Clinical Epidemiology, and the Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina 27599 7110, USA
Ann Fam Med 7:455-62. 2009..We aimed to review systematically the evidence regarding diagnostic accuracy of depression-screening instruments in Spanish-speaking primary care populations... - Deployment and the use of mental health services among U.S. Army wivesAlyssa J Mansfield
Department of Epidemiology, University of North Carolina, Chapel Hill, USA
N Engl J Med 362:101-9. 2010..Military operations in Iraq and Afghanistan have involved the frequent and extended deployment of military personnel, many of whom are married. The effect of deployment on mental health in military spouses is largely unstudied... - Investigating differences in treatment effect estimates between propensity score matching and weighting: a demonstration using STAR*D trial dataAlan R Ellis
Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, NC 27599, USA
Pharmacoepidemiol Drug Saf 22:138-44. 2013..Using effectiveness data, we describe lessons learned from sensitivity analyses with matched and weighted estimates... - Prescription refill records as a screening tool to identify antidepressant non-adherenceRichard A Hansen
Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Pharmacoepidemiol Drug Saf 19:33-7. 2010..Accordingly, our purpose was to determine the shortest gap in medication supply that is predictive of discontinuation, while minimizing false positive results... - Controlling for drug dose in systematic review and meta-analysis: a case study of the effect of antidepressant doseRichard A Hansen
School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Med Decis Making 29:91-103. 2009..Second-generation antidepressants are used as an example to illustrate this method and to determine whether dose influences conclusions on comparative effectiveness... - Screening for suicide risk in adults: a summary of the evidence for the U.S. Preventive Services Task ForceBradley N Gaynes
University of North Carolina at Chapel Hill, Chapel Hill 27599, USA
Ann Intern Med 140:822-35. 2004..CONCLUSION: Because of the complexity of studying the risk for suicide and the paucity of well-designed research studies, only limited evidence guides the primary care clinician's assessment and management of suicide risk... - Generalist care managers for the treatment of depressed medicaid patients in North Carolina: a pilot studySuzanne E Landis
Department of Family Medicine, Mountain Area Health Education Center and University of North Carolina, Chapel Hill, NC, USA
BMC Fam Pract 8:7. 2007..We designed a pilot program to demonstrate the feasibility of training/deploying GCMs into primary care settings... - Predicting fatigue and depression in HIV-positive gay menJulie Barroso
School of Nursing, Department of Biostatistics, Carrington Hall, University of North Carolina at Chapel Hill, NC 27599 7460, USA
Psychosomatics 43:317-25. 2002..5 years were used to develop logistic regression models for predicting fatigue and depression. Fatigue was predicted by both physiologic and psychological risk factors, whereas depression was predicted by only psychological risk factors... - Depression, sexually transmitted infection, and sexual risk behavior among young adults in the United StatesMaria R Khan
Department of Epidemiology, School of Public Health, The University of North Carolina at Chapel Hill, NC, USA
Arch Pediatr Adolesc Med 163:644-52. 2009..To measure associations among depression, sexual risk behaviors, and sexually transmitted infection (STI) among white and black youth in the United States... - Physical activity and depressive symptoms among pregnant women: the PIN3 studyZewditu Demissie
Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, 27599 7435, USA
Arch Womens Ment Health 14:145-57. 2011..63, 95% CI = 0.99, 2.70) when compared to women with no MVPA. While overall MVPA may play a role in reducing the odds of developing elevated depressive symptoms, adult and child care and indoor household activities may increase it... - Associations between physical activity and postpartum depressive symptomsZewditu Demissie
Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
J Womens Health (Larchmt) 20:1025-34. 2011..The objective of this investigation was to examine the associations between total and domain-specific moderate to vigorous physical activity (MVPA) and depressive symptoms postpartum... - Depression affects adherence measurement but not the effectiveness of an adherence intervention in heart failure patientsRichard A Hansen
Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
J Am Pharm Assoc (2003) 49:760-8. 2009.... - Relationship of pharmaceutical promotion to antidepressant switching and adherence: a retrospective cohort studyRichard A Hansen
Division of Pharmaceutical Outcomes and Policy, University of North Carolina, Chapel Hill, NC, USA
Psychiatr Serv 61:1232-8. 2010..The objectives of this study were to explore whether promotional spending is related to early antidepressant switching, acute-phase adherence, and continuation-phase adherence... - Physician reported communication about depression and psychosocial issues during postpartum visitsBetsy Lynn Sleath
School of Pharmacy and a research associate at the Cecil G Sheps Center for Health Services Research at the University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7590, USA
N C Med J 68:151-5. 2007.... - The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidenceRobert N Golden
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
Am J Psychiatry 162:656-62. 2005..The purpose of this study was to assess the evidence base for the efficacy of light therapy in treating mood disorders... - Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysisGerald Gartlehner
Danube University, Krems, Austria
Ann Intern Med 155:772-85. 2011..Second-generation antidepressants dominate the management of major depressive disorder (MDD), but evidence on the comparative benefits and harms of these agents is contradictory... - Evaluation of the Menopause-Specific Quality of Life Questionnaire: a factor-analytic approachKristen B Van Dole
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Menopause 19:211-5. 2012..Despite being used in multiple studies, the Menopause-Specific Quality of Life Questionnaire (MENQOL) has not been assessed with factor analysis, a common method of item reduction in quality of life tools... - Depression and health-related quality of lifeBradley N Gaynes
Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, Chapel Hill, North Carolina 27599-7160, USA
J Nerv Ment Dis 190:799-806. 2002..The data also support the merit of adopting a multidimensional approach to HRQOL rather than treating it unidimensionally... - Validation of a brief screening instrument for substance abuse and mental illness in HIV-positive patientsBrian Wells Pence
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7160, USA
J Acquir Immune Defic Syndr 40:434-44. 2005..It missed few cases and was easily incorporated into a busy clinical setting. Persons screening positive require a more rigorous confirmatory psychiatric evaluation... - Screening for depression in adults: a summary of the evidence for the U.S. Preventive Services Task ForceMichael P Pignone
University of North Carolina Hospitals, Chapel Hill, USA
Ann Intern Med 136:765-76. 2002..CONCLUSION: Compared with usual care, screening for depression can improve outcomes, particularly when screening is coupled with system changes that help ensure adequate treatment and follow-up... - Can shelter-based interventions improve treatment engagement in homeless individuals with psychiatric and/or substance misuse disorders?: a randomized controlled trialDaniel W Bradford
Robert Wood Johnson Clinical Scholars Program, Chapel Hill, North Carolina, USA
Med Care 43:763-8. 2005..Few of these individuals engage in consistent treatment, although they are likely to benefit from it. Shelter-based interventions to help this population engage in treatment have not been studied in a rigorous manner... - Prevalence of DSM-IV-defined mood, anxiety, and substance use disorders in an HIV clinic in the Southeastern United StatesBrian Wells Pence
Center for Health Policy, Duke University, Durham, NC 27708, USA
J Acquir Immune Defic Syndr 42:298-306. 2006..Appropriate policy and program planning require accurate prevalence estimates. Yet most estimates are based on screening instruments, which are likely to overstate true prevalence... - Psychiatric illness and virologic response in patients initiating highly active antiretroviral therapyBrian Wells Pence
Center for Health Policy, Duke University, Durham, NC 27708 0253, USA
J Acquir Immune Defic Syndr 44:159-66. 2007..MI/SA consistently predict poorer antiretroviral adherence, suggesting that affected patients should be at higher risk of poor virologic and immunologic response to highly active antiretroviral therapy (HAART)... - Family history of completed suicide and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) studyAndrew A Nierenberg
Depression Clinical and Research Program, Massachusetts General Hospital Harvard Medical School, Boston, MA 01224, USA
J Affect Disord 108:129-34. 2008..It is unknown, however, whether patients with a family member who committed suicide differ from those without such a history... - Are depressed outpatients with and without a family history of substance use disorder different? A baseline analysis of the STAR*D cohortLori L Davis
Department of Veterans Affairs VA Medical Center, Tuscaloosa, Ala 35404, USA
J Clin Psychiatry 68:1931-8. 2007.... - Relationship of clinical depression to periodontal treatment outcomeJohn R Elter
Department of Dental Ecology, School of Dentistry, UNC Chapel Hill, USA
J Periodontol 73:441-9. 2002..CONCLUSION: Clinical depression may have a negative effect on periodontal treatment outcome in this group model HMO population... - A comparison of baseline sociodemographic and clinical characteristics between major depressive disorder patients with and without diabetes: a STAR*D reportCharlene J Bryan
School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Affect Disord 108:113-20. 2008.... - Depressive symptoms among working women in rural North Carolina: a comparison of women in poultry processing and other low-wage jobsHester J Lipscomb
Division of Occupational and Environmental Medicine, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
Int J Law Psychiatry 30:284-98. 2007..The concentration of this low-wage industry in economically depressed rural areas illuminates how class exploitation and racial discrimination may influence disparities in health among working women... - Treating the physical symptoms of depression with second-generation antidepressants: a systematic review and metaanalysisErin E Krebs
Center on Implementing Evidence Based Practice, Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
Psychosomatics 49:191-8. 2008..Approximately two-thirds of patients with depression experience physical pain symptoms. Coexisting pain complicates the treatment of depression and is associated with worse depression outcomes... - Recognizing and dealing with depression with psychosisBradley N Gaynes
Essent Psychopharmacol 6:173-83. 2005 - Perinatal depression: a systematic review of prevalence and incidenceNorma I Gavin
RTI International, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
Obstet Gynecol 106:1071-83. 2005..We systematically review evidence on the prevalence and incidence of perinatal depression and compare these rates with those of depression in women at non-childbearing times...