B D Gaylinn

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Growth hormone releasing hormone receptor
    Bruce D Gaylinn
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Box 801411, Charlottesville, VA 801411, USA
    Receptors Channels 8:155-62. 2002
  2. ncbi Molecular and cell biology of the growth hormone-releasing hormone receptor
    B D Gaylinn
    Division of Endocrinology, University of Virginia, Charlottesville 22908, USA
    Growth Horm IGF Res 9:37-44. 1999
  3. ncbi The mutant growth hormone-releasing hormone (GHRH) receptor of the little mouse does not bind GHRH
    B D Gaylinn
    Department of Medicine, University of Virginia, Charlottesville 22908, USA
    Endocrinology 140:5066-74. 1999
  4. ncbi Molecular cloning of ovine and bovine growth hormone-releasing hormone receptors: the ovine receptor is C-terminally truncated
    R Horikawa
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocrinology 142:2660-8. 2001
  5. ncbi Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone
    B D Gaylinn
    Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908
    Mol Endocrinol 7:77-84. 1993
  6. ncbi Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization
    B D Gaylinn
    Department of Internal Medicine, University of Virginia, Charlottesville 22908
    Genomics 19:193-5. 1994
  7. ncbi Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system
    D L Rosin
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Comp Neurol 372:135-65. 1996
  8. ncbi Cloning of the chicken pituitary receptor for growth hormone-releasing hormone
    Andrew A Toogood
    Division of Endocrinology, University of Virginia Health System, Charlottesville, 22903, USA
    Endocrinology 147:1838-46. 2006
  9. ncbi GH in the dwarf dopaminergic D2 receptor knockout mouse: somatotrope population, GH release, and responsiveness to GH-releasing factors and somatostatin
    Isabel Garcia-Tornadú
    Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas CONICET and University of Buenos Aires, V Obligado 2490, 1428 Buenos Aires, Argentina
    J Endocrinol 190:611-9. 2006
  10. ncbi Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance
    Juan Pablo Del Rincon
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Diabetes 56:1638-46. 2007

Research Grants

  1. GROWTH HORMONE RELEASING FACTOR RECEPTOR
    Bruce Gaylinn; Fiscal Year: 2001

Collaborators

Detail Information

Publications12

  1. ncbi Growth hormone releasing hormone receptor
    Bruce D Gaylinn
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Box 801411, Charlottesville, VA 801411, USA
    Receptors Channels 8:155-62. 2002
    ..Homology among GHRH-Rs from different species is shown and a map of receptor mutations reported to effect function is presented...
  2. ncbi Molecular and cell biology of the growth hormone-releasing hormone receptor
    B D Gaylinn
    Division of Endocrinology, University of Virginia, Charlottesville 22908, USA
    Growth Horm IGF Res 9:37-44. 1999
    ..A better understanding of the GHRH receptor may lead to new therapies for the treatment of GH disorders...
  3. ncbi The mutant growth hormone-releasing hormone (GHRH) receptor of the little mouse does not bind GHRH
    B D Gaylinn
    Department of Medicine, University of Virginia, Charlottesville 22908, USA
    Endocrinology 140:5066-74. 1999
    ....
  4. ncbi Molecular cloning of ovine and bovine growth hormone-releasing hormone receptors: the ovine receptor is C-terminally truncated
    R Horikawa
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocrinology 142:2660-8. 2001
    ..This suggests that this C-terminal domain acts to inhibit cAMP signaling possibly through a role in receptor down regulation...
  5. ncbi Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone
    B D Gaylinn
    Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908
    Mol Endocrinol 7:77-84. 1993
    ..A specific GHRH antagonist blocked both binding and second messenger response. Northern analysis indicated that GHRH-R mRNA was most abundant in extracts of pituitary and was not detected in other tissues...
  6. ncbi Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization
    B D Gaylinn
    Department of Internal Medicine, University of Virginia, Charlottesville 22908
    Genomics 19:193-5. 1994
  7. ncbi Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system
    D L Rosin
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Comp Neurol 372:135-65. 1996
    ..In general, the pattern of alpha 2C-LI throughout the neuraxis is consistent with previously published reports of the distribution of receptor mRNA detected by hybridization histochemistry...
  8. ncbi Cloning of the chicken pituitary receptor for growth hormone-releasing hormone
    Andrew A Toogood
    Division of Endocrinology, University of Virginia Health System, Charlottesville, 22903, USA
    Endocrinology 147:1838-46. 2006
    ..The chicken GHRH receptor cloned in this study can serve as a tool to identify its ligand and to clarify the evolutionary development of the regulation of GH...
  9. ncbi GH in the dwarf dopaminergic D2 receptor knockout mouse: somatotrope population, GH release, and responsiveness to GH-releasing factors and somatostatin
    Isabel Garcia-Tornadú
    Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas CONICET and University of Buenos Aires, V Obligado 2490, 1428 Buenos Aires, Argentina
    J Endocrinol 190:611-9. 2006
    ..Our data also reveal that somatotrope cell number is much more sensitive to changes in neonatal GHRH input than their capacity to develop properly regulated GH-secretory function...
  10. ncbi Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance
    Juan Pablo Del Rincon
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Diabetes 56:1638-46. 2007
    ....
  11. ncbi Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates
    Karen E Foster-Schubert
    University of Washington School of Medicine, Seattle, WA 98195, USA
    J Clin Endocrinol Metab 93:1971-9. 2008
    ..Its circulating levels increase before meals and are suppressed after food ingestion. Understanding the effects of specific types of ingested macronutrients on ghrelin regulation could facilitate the design of weight-reducing diets...
  12. ncbi Regulation of ghrelin structure and membrane binding by phosphorylation
    Eva Dehlin
    Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, United States
    Peptides 29:904-11. 2008
    ..These results are consistent with binding of ghrelin and desacylghrelin to acidic lipids via the basic face of an amphipathic helix with Ser-18 phosphorylation disrupting both helical character and membrane binding...

Research Grants4

  1. GROWTH HORMONE RELEASING FACTOR RECEPTOR
    Bruce Gaylinn; Fiscal Year: 2001
    ..This suppression will be challenged by either elevating endogenous GHRH with intracerebroventricular injection of GH antagonist or by iv infusion of exogenous GHRH. ..