Marc A Gavin

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo
    Marc A Gavin
    Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 3:33-41. 2002
  2. pmc Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
    Marc A Gavin
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:6659-64. 2006
  3. ncbi request reprint Control of immune homeostasis by naturally arising regulatory CD4+ T cells
    Marc Gavin
    Department of Immunology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Curr Opin Immunol 15:690-6. 2003
  4. ncbi request reprint A function for interleukin 2 in Foxp3-expressing regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1142-51. 2005
  5. ncbi request reprint Foxp3-dependent programme of regulatory T-cell differentiation
    Marc A Gavin
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 445:771-5. 2007
  6. ncbi request reprint Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    Ye Zheng
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 445:936-40. 2007
  7. ncbi request reprint Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells
    Ryan M Swanson
    Inflammation Research, Amgen Washington, Seattle, WA 98119, USA
    J Immunol 190:2027-35. 2013
  8. pmc G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells
    Li Fan Lu
    Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
    Mol Cell Biol 27:8065-72. 2007
  9. ncbi request reprint FOXP3 and NFAT: partners in tolerance
    Alexander Y Rudensky
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Cell 126:253-6. 2006
  10. ncbi request reprint Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 4:330-6. 2003

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo
    Marc A Gavin
    Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 3:33-41. 2002
    ..DNA array analyses identified genes that may inhibit responsiveness at a number of levels in multiple signaling cascades in T(S) cells, as well as several anti-apoptotic genes that may mediate their survival...
  2. pmc Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
    Marc A Gavin
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:6659-64. 2006
    ..This observation raises the possibility that the severe autoimmunity in FOXP3 deficiency can be attributed, in part, to aggressive T helper cells that have developed from T(R) precursors...
  3. ncbi request reprint Control of immune homeostasis by naturally arising regulatory CD4+ T cells
    Marc Gavin
    Department of Immunology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Curr Opin Immunol 15:690-6. 2003
    ..T(R) cells are capable of robust antigen-driven proliferation in vivo, and may participate in clonal expansion in response to infection, similar to all other adaptive immune lineages...
  4. ncbi request reprint A function for interleukin 2 in Foxp3-expressing regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1142-51. 2005
    ..Thus, IL-2 signaling seems to be critically required for maintaining the homeostasis and competitive fitness of T(reg) cells in vivo...
  5. ncbi request reprint Foxp3-dependent programme of regulatory T-cell differentiation
    Marc A Gavin
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 445:771-5. 2007
    ..This adaptation includes Foxp3-dependent repression of cyclic nucleotide phosphodiesterase 3B, affecting genes responsible for Tr cell homeostasis...
  6. ncbi request reprint Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    Ye Zheng
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 445:936-40. 2007
    ..Together, our studies suggest that distinct transcriptional sub-programmes implemented by Foxp3 establish T(R) lineage during differentiation and its proliferative and functional competence in the periphery...
  7. ncbi request reprint Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells
    Ryan M Swanson
    Inflammation Research, Amgen Washington, Seattle, WA 98119, USA
    J Immunol 190:2027-35. 2013
    ..These findings describe a mechanism by which environmental Ag-specific Tregs may be induced by APC expressing specific modulators of costimulatory signals...
  8. pmc G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells
    Li Fan Lu
    Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
    Mol Cell Biol 27:8065-72. 2007
    ..Collectively, our results demonstrate that GPR83 is dispensable for Treg-cell development and function...
  9. ncbi request reprint FOXP3 and NFAT: partners in tolerance
    Alexander Y Rudensky
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Cell 126:253-6. 2006
    ....
  10. ncbi request reprint Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 4:330-6. 2003
    ..Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4+CD25- T cells. Thus, Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function...
  11. pmc TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    Julien C Marie
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Exp Med 201:1061-7. 2005
    ..Thus, our results establish an essential link between TGF-beta1 signaling in peripheral T reg cells and T reg cell maintenance in vivo...
  12. ncbi request reprint Dual TCR T cells: gaining entry into the periphery
    Marc A Gavin
    Nat Immunol 3:109-10. 2002