Research Topics
Genomes and GenesSpecies | WILLIAM GAUDERMANSummaryAffiliation: University of Southern California Country: USA Publications
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Publications
Childhood asthma and exposure to traffic and nitrogen dioxideW James Gauderman
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles 90089, USA
Epidemiology 16:737-43. 2005..Evidence for a causal relationship between traffic-related air pollution and asthma has not been consistent across studies, and comparisons among studies have been difficult because of the use of different indicators of exposure...
Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezingChengwei Wang
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar St, CHP 236, Los Angeles, CA 90033, USA
Pediatrics 122:e107-14. 2008....- Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurementMichael Jerrett
School of Public Health, Division of Environmental Health Science, University of California, Berkeley, California 94720 7360, USA
Environ Health Perspect 116:1433-8. 2008..The question of whether air pollution contributes to asthma onset remains unresolved... 
Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasisJoshua Millstein
National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, 7600 Sand Point Way NE, Seattle, WA 98115, USA
BMC Genet 6:S147. 2005..The strongest effect was for SNP B03T3056, which had a median p-value of 1.98 x 10(-34). No two- or three-locus effects were found in more than one replicate...- Segregation and linkage analysis for longitudinal measurements of a quantitative traitConway Gee
Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Los Angeles, California, USA
BMC Genet 4:S21. 2003..5) for specific markers on chromosomes 1, 3, 5, 9, 10, and 17. For the slopes, however, the data did not support a Mendelian model, and thus no formal linkage analyses were conducted... - Multiple imputation methods for longitudinal blood pressure measurements from the Framingham Heart StudyTerri Kang
Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
BMC Genet 4:S43. 2003..This suggests that if missingness patterns are correlated within families, then imputation methods that do not allow this correlation can yield biased results... - The effect of air pollution on lung development from 10 to 18 years of ageW James Gauderman
Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
N Engl J Med 351:1057-67. 2004..Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown... - Longitudinal data analysis in pedigree studiesW James Gauderman
Department of Preventive Medicine, University of Southern California, Los Angeles, 90089, USA
Genet Epidemiol 25:S18-28. 2003..Several areas for future research are discussed... - Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort studyW James Gauderman
Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Suite 220, Los Angeles, CA 90033, USA
Lancet 369:571-7. 2007..This study investigated the association between residential exposure to traffic and 8-year lung-function growth... - Testing association between disease and multiple SNPs in a candidate geneW James Gauderman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Genet Epidemiol 31:383-95. 2007..We observe stronger evidence of an association using the PC approach (p = 0.044) than using either a genotype-based (p = 0.13) or haplotype-based (p = 0.052) approach... - Candidate gene association analysis for a quantitative trait, using parent-offspring triosW James Gauderman
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA
Genet Epidemiol 25:327-38. 2003..Hered. 47:342-350) for testing a genetic main effect, but can be as much as twice as efficient for testing G x E interaction, and three times more efficient for testing G x G interaction... - Association between air pollution and lung function growth in southern California children: results from a second cohortW James Gauderman
Department of Preventive Medicine, University of Southern California, Los Angeles 90033, USA
Am J Respir Crit Care Med 166:76-84. 2002.... - Sample size requirements for association studies of gene-gene interactionW James Gauderman
Department of Preventive Medicine, School of Medicine, University of Southern California, 1540 Alcazar Street, Suite 220, Los Angeles, CA 90089, USA
Am J Epidemiol 155:478-84. 2002..A software program that computes sample size for studies of G x G interaction and for studies of gene-environment (G x E) interaction is freely available (http://hydra.usc.edu/gxe)... - Efficient genome-wide association testing of gene-environment interaction in case-parent triosW James Gauderman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
Am J Epidemiol 172:116-22. 2010..This 2-step scan for G x E interaction is independent of any prior scan that may have been conducted for genetic main effects, and thus has the potential to uncover new genes in a GWAS that have not been previously identified... - Gene-environment interaction and affected sib pair linkage analysisW J Gauderman
Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Los Angeles, CA 90089, USA
Hum Hered 52:34-46. 2001..We propose a simple extension of the commonly used mean test and evaluate its power for several forms of GxE interaction... - Ozone, oxidant defense genes, and risk of asthma during adolescenceTalat Islam
M D Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 177:388-95. 2008.... 
In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildrenMade Wenten
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Pediatrics 123:1344-51. 2009....- Associations of tumor necrosis factor G-308A with childhood asthma and wheezingYu Fen Li
Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 173:970-6. 2006.... - Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthmaMuhammad T Salam
Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 176:1192-9. 2007..Tobacco smoke and traffic emissions induce airway inflammation and modulate TGF-beta1 gene expression. We hypothesized that the effects of functional TGF-beta1 variants on asthma occurrence vary by these exposures... - Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children's Health StudyJoshua Millstein
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
Arch Environ Health 59:505-14. 2004..07 [95%CI = 1.61-5.86]; OR = 1.31 [95%CI = 0.47-2.71]; respectively). The authors concluded that monthly variations in some ambient air pollutants were associated with monthly respiratory morbidity among school children... - Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysisYu Fen Li
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Environ Health Perspect 116:409-15. 2008..Glutathione S-transferase P1 (GSTP1) plays a role in a spectrum of respiratory diseases; however, the effects of sequence variation across the entire locus in asthma pathogenesis have yet to be determined... - Roles of arginase variants, atopy, and ozone in childhood asthmaMuhammad T Salam
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, Calif 90033, USA
J Allergy Clin Immunol 123:596-602, 602.e1-8. 2009..Arginases (encoded by ARG1 and ARG2 genes) might play an important role in asthma pathogenesis through effects on nitrosative stress. Arginase expression is upregulated in asthma and varies with T(H)2 cytokine levels and oxidative stress... - Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthmaMuhammad T Salam
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
Thorax 62:1050-7. 2007..A study was undertaken to investigate associations of variants in EPHX1, GSTM1, GSTP1 and GSTT1 with asthma and the relationships between asthma, EPHX1 metabolic phenotypes and exposure to sources of PAHs... - Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactionsMade Wenten
Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90033, USA
Am J Epidemiol 170:1494-501. 2009..03). The association of respiratory-illness absences with functional variants in CAT and MPO that differ by air pollution levels illustrates the need to consider genetic epistasis in assessing gene-environment interactions... - Health effects of the 2003 Southern California wildfires on childrenNino Kunzli
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, School of Public Health, University of California, Los Angeles, CA, USA
Am J Respir Crit Care Med 174:1221-8. 2006..In late October 2003, Southern California wildfires burned more than 3,000 km2. The wildfires produced heavy smoke that affected several communities participating in the University of Southern California Children's Health Study (CHS)... - Does mammographic density reflect ethnic differences in breast cancer incidence rates?Zhengjia Chen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Am J Epidemiol 159:140-7. 2004..This study suggests that absolute but not percent mammographic density reflects the lower breast cancer incidence rates of Asian Americans in relation to those of African Americans and Whites... - Intercellular adhesion molecule-1 and childhood asthmaYu Fen Li
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CHP 236, Los Angeles, CA 90033, USA
Hum Genet 117:476-84. 2005..3, 95% CI 0.1-0.8), as compared with two copies of the AGA haplotype. Consistent with information on variant function, the 241A and 469G variants may indicate haplotypes that are associated with reduced risk for asthma... - Discovery of complex pathways from observational dataJames W Baurley
Department of Preventive Medicine, University of Southern California, Los Angeles, USA
Stat Med 29:1998-2011. 2010..Our method can correctly identify the risk factors and interactions involved in the simulated pathway. We apply our framework to an asthma case-control data set with polymorphisms in 12 genes... - TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absencesMade Wenten
Division of Environmental Health, Department of Preventive Medicine, Keck School of Medicine of USC, 1540 Alcazar Street, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 172:1563-8. 2005..The role of genetic susceptibility in risk for adverse effects from SHS has not been extensively investigated in children... - Indoor risk factors for asthma in a prospective study of adolescentsRob McConnell
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
Epidemiology 13:288-95. 2002..However, there has been little investigation of the effect of the indoor environment on incident asthma in adolescents... - Use of an electrostatic dust cloth for self-administered home allergen collectionWendy Cozen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9175, United States of America
Twin Res Hum Genet 11:150-5. 2008.... - Gene-environment interaction in genome-wide association studiesCassandra E Murcray
Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089 9010, USA
Am J Epidemiol 169:219-26. 2009..The procedure complements screening for marginal genetic effects and thus has the potential to uncover new genetic signals that have not been identified previously... - Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung functionCarrie V Breton
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033 USA
Am J Respir Crit Care Med 179:601-7. 2009..The glutathione S-transferases (GSTs) are important detoxification enzymes... - Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9175, USA
Blood 111:3377-82. 2008..8-fold (P=.03) increase in YAHL risk. Thus, both case-twins and their unaffected cotwins had a decreased ability to produce IL-12, which may contribute to YAHL susceptibility... - Asthma in exercising children exposed to ozone: a cohort studyRob McConnell
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, CA 90089 9011, USA
Lancet 359:386-91. 2002..We investigated the relation between newly-diagnosed asthma and team sports in a cohort of children exposed to different concentrations and mixtures of air pollutants... - Sample size requirements to detect gene-environment interactions in genome-wide association studiesCassandra E Murcray
Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089 9010, USA
Genet Epidemiol 35:201-10. 2011..15, and a binary exposure with prevalence 0.3, the Murcray, Kooperberg and hybrid methods are 1.90, 1.27, and 1.87 times as efficient, respectively, as the traditional case-control analysis to detect an interaction effect size of 2.0... - Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescenceTalat Islam
Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
Thorax 65:139-45. 2010..Because nitrosative stress affects respiratory health, it was hypothesised that variants in NOS2A are associated with asthma incidence and lung function growth during adolescence... - Sample size requirements for matched case-control studies of gene-environment interactionW James Gauderman
Department of Preventive Medicine, University of Southern California, CA, USA
Stat Med 21:35-50. 2002..A software program that implements the method is freely available, and may be downloaded from the website http://hydra.usc.edu/gxe... - Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growthCarrie V Breton
Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 183:243-8. 2011..Glutathione plays an important role in antioxidant and inflammatory processes in the lung. Alterations in glutathione metabolism are a central feature of several chronic lung diseases... - Impact of respiratory illness on expiratory flow rates in normal, asthmatic, and allergic childrenEdward B Rappaport
Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
Pediatr Pulmonol 34:112-21. 2002..We conclude that RI in children who are well enough to attend school may reduce expiratory flow rates. These effects are greater for children with active asthma or hay fever than in those without, and may be inversely related to age... - Obesity and the risk of newly diagnosed asthma in school-age childrenFrank D Gilliland
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Epidemiol 158:406-15. 2003..77, 95% CI: 1.26, 2.49) than in allergic children (RR = 1.16, 95% CI: 0.63, 2.15). The authors conclude that being overweight is associated with an increased risk of new-onset asthma in boys and in nonallergic children... - Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intakeFrank D Gilliland
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Epidemiol 158:576-84. 2003..In summary, lung function levels were lower in children with inadequate dietary antioxidant vitamin intake... - SNPs, haplotypes, and model selection in a candidate gene region: the SIMPle analysis for multilocus dataDavid V Conti
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Genet Epidemiol 27:429-41. 2004..Using simulations, we demonstrate the utility of the SIMPle model to identify crucial SNPs and underlying haplotype structures across a variety of causal models and genetic architectures... - Prospective study of air pollution and bronchitic symptoms in children with asthmaRob McConnell
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 168:790-7. 2003.... - Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in childrenFrank D Gilliland
Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 166:457-63. 2002..Among children with GSTM1 (+) genotype, in utero exposure was not associated with asthma or wheezing. Our findings indicate that there are important long-term effects of in utero exposure in a genetically susceptible group of children... - Regular smoking and asthma incidence in adolescentsFrank D Gilliland
Department of Preventive Medicine, Keck School of Medicine of USC, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
Am J Respir Crit Care Med 174:1094-100. 2006.... - Dog ownership enhances symptomatic responses to air pollution in children with asthmaRob McConnell
Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
Environ Health Perspect 114:1910-5. 2006..Experimental data suggest that asthma exacerbation by ambient air pollutants is enhanced by exposure to endotoxin and allergens; however, there is little supporting epidemiologic evidence... - IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Blood 103:3216-21. 2004..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma... - Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growthFrank D Gilliland
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
Am J Respir Crit Care Med 166:710-6. 2002..We conclude that GSTM1 and GSTP1 genotypes are associated with lung function growth in school children... - Relationship between air pollution, lung function and asthma in adolescentsTalat Islam
Department of Preventive Medicine, Keck School of Medicine, Los Angeles, California 90033, USA
Thorax 62:957-63. 2007..A study was undertaken to determine whether lung function is associated with new onset asthma and whether this relationship varies by exposure to ambient air pollutants... - Differential twin concordance for multiple sclerosis by latitude of birthplaceTalat Islam
Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, 90089, USA
Ann Neurol 60:56-64. 2006..INTERPRETATION: Multiple sclerosis is similarly heritable by sex, and the apparent variation in MZ concordance by latitude is influenced by environmental and genetic factors... - Childhood sun exposure influences risk of multiple sclerosis in monozygotic twinsTalat Islam
Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
Neurology 69:381-8. 2007.... - Polymorphism in the androgen receptor and mammographic density in women taking and not taking estrogen and progestin therapyElizabeth Osth Lillie
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
Cancer Res 64:1237-41. 2004..4%) than carriers of the more active AR-CAG (25.7%; P = 0.04). Our results raise the question of whether the number of AR-CAG repeats predicts breast cancer risk in estrogen progestin therapy users... - Testing association and linkage using affected-sib-parent study designsJoshua Millstein
National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, Seattle, Washington 98115, USA
Genet Epidemiol 29:225-33. 2005..8% by FBAT, and 82.5% by our joint test of linkage and association. Our model can also be used to obtain tests of linkage conditional on association and association conditional on linkage, which can be helpful in fine mapping... - A testing framework for identifying susceptibility genes in the presence of epistasisJoshua Millstein
National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, Seattle, WA 98115, USA
Am J Hum Genet 78:15-27. 2006..In an independent data set consisting primarily of African American and Asian American children, these three genes also showed a significant association with asthma status (P = .0008)... - Air pollution and children--an unhealthy mixW James Gauderman
N Engl J Med 355:78-9. 2006 - Exploiting gene-environment interaction to detect genetic associationsPeter Kraft
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Hum Hered 63:111-9. 2007..This makes the joint test an attractive tool for large-scale association scans where the true gene-environment interaction model is unknown... - Regression models for linkage: issues of traits, covariates, heterogeneity, and interactionDaniel J Schaid
Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic Foundation, Rochester, Minn 55905, USA
Hum Hered 55:86-96. 2003..The purposes of this paper are to review some recent developments in the linkage regression framework, to emphasize strengths and weaknesses of various proposed methods, and to highlight some important assumptions and caveats...
Research Grants
- STATISTICAL APPROACHES TO THE STUDY OF GXE INTERACTIONSW Gauderman; Fiscal Year: 2002..Successful completion of these aims will improve our understanding of how GxE interaction influences disease risk, and how we can optimally design studies and analyze data to find and characterize such genes. ..
- A Genome-wide Association Study of Childhood Respiratory OutcomesWILLIAM GAUDERMAN; Fiscal Year: 2007..Our novel use of air-pollution and existing candidate-gene data in the scan has the potential to identify new genes that act synergistically with important, established determinants of children's respiratory health. (End of Abstract) ..
- A Genome-wide Association Study of Childhood Respiratory OutcomesWILLIAM GAUDERMAN; Fiscal Year: 2009..End of Abstract) ..