WILLIAM GAUDERMAN

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Childhood asthma and exposure to traffic and nitrogen dioxide
    W James Gauderman
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles 90089, USA
    Epidemiology 16:737-43. 2005
  2. pmc Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing
    Chengwei Wang
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar St, CHP 236, Los Angeles, CA 90033, USA
    Pediatrics 122:e107-14. 2008
  3. pmc Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement
    Michael Jerrett
    School of Public Health, Division of Environmental Health Science, University of California, Berkeley, California 94720 7360, USA
    Environ Health Perspect 116:1433-8. 2008
  4. doi request reprint Finding novel genes by testing G × E interactions in a genome-wide association study
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089, USA
    Genet Epidemiol 37:603-13. 2013
  5. pmc Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis
    Joshua Millstein
    National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, 7600 Sand Point Way NE, Seattle, WA 98115, USA
    BMC Genet 6:S147. 2005
  6. pmc Segregation and linkage analysis for longitudinal measurements of a quantitative trait
    Conway Gee
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Los Angeles, California, USA
    BMC Genet 4:S21. 2003
  7. pmc Multiple imputation methods for longitudinal blood pressure measurements from the Framingham Heart Study
    Terri Kang
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    BMC Genet 4:S43. 2003
  8. ncbi request reprint Longitudinal data analysis in pedigree studies
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles, 90089, USA
    Genet Epidemiol 25:S18-28. 2003
  9. ncbi request reprint The effect of air pollution on lung development from 10 to 18 years of age
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
    N Engl J Med 351:1057-67. 2004
  10. ncbi request reprint Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Suite 220, Los Angeles, CA 90033, USA
    Lancet 369:571-7. 2007

Detail Information

Publications59

  1. ncbi request reprint Childhood asthma and exposure to traffic and nitrogen dioxide
    W James Gauderman
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles 90089, USA
    Epidemiology 16:737-43. 2005
    ..Evidence for a causal relationship between traffic-related air pollution and asthma has not been consistent across studies, and comparisons among studies have been difficult because of the use of different indicators of exposure...
  2. pmc Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing
    Chengwei Wang
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar St, CHP 236, Los Angeles, CA 90033, USA
    Pediatrics 122:e107-14. 2008
    ....
  3. pmc Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement
    Michael Jerrett
    School of Public Health, Division of Environmental Health Science, University of California, Berkeley, California 94720 7360, USA
    Environ Health Perspect 116:1433-8. 2008
    ..The question of whether air pollution contributes to asthma onset remains unresolved...
  4. doi request reprint Finding novel genes by testing G × E interactions in a genome-wide association study
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089, USA
    Genet Epidemiol 37:603-13. 2013
    ..We distribute a new software program (G×Escan, available at http://biostats.usc.edu/software) that implements this new method as well as several other GWIS approaches. ..
  5. pmc Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis
    Joshua Millstein
    National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, 7600 Sand Point Way NE, Seattle, WA 98115, USA
    BMC Genet 6:S147. 2005
    ..The strongest effect was for SNP B03T3056, which had a median p-value of 1.98 x 10(-34). No two- or three-locus effects were found in more than one replicate...
  6. pmc Segregation and linkage analysis for longitudinal measurements of a quantitative trait
    Conway Gee
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Los Angeles, California, USA
    BMC Genet 4:S21. 2003
    ..5) for specific markers on chromosomes 1, 3, 5, 9, 10, and 17. For the slopes, however, the data did not support a Mendelian model, and thus no formal linkage analyses were conducted...
  7. pmc Multiple imputation methods for longitudinal blood pressure measurements from the Framingham Heart Study
    Terri Kang
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    BMC Genet 4:S43. 2003
    ..This suggests that if missingness patterns are correlated within families, then imputation methods that do not allow this correlation can yield biased results...
  8. ncbi request reprint Longitudinal data analysis in pedigree studies
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles, 90089, USA
    Genet Epidemiol 25:S18-28. 2003
    ..Several areas for future research are discussed...
  9. ncbi request reprint The effect of air pollution on lung development from 10 to 18 years of age
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
    N Engl J Med 351:1057-67. 2004
    ..Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown...
  10. ncbi request reprint Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Suite 220, Los Angeles, CA 90033, USA
    Lancet 369:571-7. 2007
    ..This study investigated the association between residential exposure to traffic and 8-year lung-function growth...
  11. ncbi request reprint Gene-environment interaction and affected sib pair linkage analysis
    W J Gauderman
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Los Angeles, CA 90089, USA
    Hum Hered 52:34-46. 2001
    ..We propose a simple extension of the commonly used mean test and evaluate its power for several forms of GxE interaction...
  12. ncbi request reprint Candidate gene association analysis for a quantitative trait, using parent-offspring trios
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Genet Epidemiol 25:327-38. 2003
    ..Hered. 47:342-350) for testing a genetic main effect, but can be as much as twice as efficient for testing G x E interaction, and three times more efficient for testing G x G interaction...
  13. ncbi request reprint Testing association between disease and multiple SNPs in a candidate gene
    W James Gauderman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Genet Epidemiol 31:383-95. 2007
    ..We observe stronger evidence of an association using the PC approach (p = 0.044) than using either a genotype-based (p = 0.13) or haplotype-based (p = 0.052) approach...
  14. ncbi request reprint Association between air pollution and lung function growth in southern California children: results from a second cohort
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles 90033, USA
    Am J Respir Crit Care Med 166:76-84. 2002
    ....
  15. ncbi request reprint Sample size requirements for association studies of gene-gene interaction
    W James Gauderman
    Department of Preventive Medicine, School of Medicine, University of Southern California, 1540 Alcazar Street, Suite 220, Los Angeles, CA 90089, USA
    Am J Epidemiol 155:478-84. 2002
    ..A software program that computes sample size for studies of G x G interaction and for studies of gene-environment (G x E) interaction is freely available (http://hydra.usc.edu/gxe)...
  16. pmc Efficient genome-wide association testing of gene-environment interaction in case-parent trios
    W James Gauderman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Am J Epidemiol 172:116-22. 2010
    ..This 2-step scan for G x E interaction is independent of any prior scan that may have been conducted for genetic main effects, and thus has the potential to uncover new genes in a GWAS that have not been previously identified...
  17. pmc Ozone, oxidant defense genes, and risk of asthma during adolescence
    Talat Islam
    M D Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 177:388-95. 2008
    ....
  18. doi request reprint In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildren
    Made Wenten
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Pediatrics 123:1344-51. 2009
    ....
  19. pmc Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma
    Muhammad T Salam
    Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 176:1192-9. 2007
    ..Tobacco smoke and traffic emissions induce airway inflammation and modulate TGF-beta1 gene expression. We hypothesized that the effects of functional TGF-beta1 variants on asthma occurrence vary by these exposures...
  20. pmc Associations of tumor necrosis factor G-308A with childhood asthma and wheezing
    Yu Fen Li
    Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 173:970-6. 2006
    ....
  21. pmc Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma
    Muhammad T Salam
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Thorax 62:1050-7. 2007
    ..A study was undertaken to investigate associations of variants in EPHX1, GSTM1, GSTP1 and GSTT1 with asthma and the relationships between asthma, EPHX1 metabolic phenotypes and exposure to sources of PAHs...
  22. pmc Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis
    Yu Fen Li
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Environ Health Perspect 116:409-15. 2008
    ..Glutathione S-transferase P1 (GSTP1) plays a role in a spectrum of respiratory diseases; however, the effects of sequence variation across the entire locus in asthma pathogenesis have yet to be determined...
  23. ncbi request reprint Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children's Health Study
    Joshua Millstein
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Arch Environ Health 59:505-14. 2004
    ..07 [95%CI = 1.61-5.86]; OR = 1.31 [95%CI = 0.47-2.71]; respectively). The authors concluded that monthly variations in some ambient air pollutants were associated with monthly respiratory morbidity among school children...
  24. pmc Roles of arginase variants, atopy, and ozone in childhood asthma
    Muhammad T Salam
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, Calif 90033, USA
    J Allergy Clin Immunol 123:596-602, 602.e1-8. 2009
    ..Arginases (encoded by ARG1 and ARG2 genes) might play an important role in asthma pathogenesis through effects on nitrosative stress. Arginase expression is upregulated in asthma and varies with T(H)2 cytokine levels and oxidative stress...
  25. pmc Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions
    Made Wenten
    Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90033, USA
    Am J Epidemiol 170:1494-501. 2009
    ..03). The association of respiratory-illness absences with functional variants in CAT and MPO that differ by air pollution levels illustrates the need to consider genetic epistasis in assessing gene-environment interactions...
  26. ncbi request reprint Intercellular adhesion molecule-1 and childhood asthma
    Yu Fen Li
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CHP 236, Los Angeles, CA 90033, USA
    Hum Genet 117:476-84. 2005
    ..3, 95% CI 0.1-0.8), as compared with two copies of the AGA haplotype. Consistent with information on variant function, the 241A and 469G variants may indicate haplotypes that are associated with reduced risk for asthma...
  27. pmc Discovery of complex pathways from observational data
    James W Baurley
    Department of Preventive Medicine, University of Southern California, Los Angeles, USA
    Stat Med 29:1998-2011. 2010
    ..Our method can correctly identify the risk factors and interactions involved in the simulated pathway. We apply our framework to an asthma case-control data set with polymorphisms in 12 genes...
  28. ncbi request reprint Does mammographic density reflect ethnic differences in breast cancer incidence rates?
    Zhengjia Chen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Am J Epidemiol 159:140-7. 2004
    ..This study suggests that absolute but not percent mammographic density reflects the lower breast cancer incidence rates of Asian Americans in relation to those of African Americans and Whites...
  29. pmc Health effects of the 2003 Southern California wildfires on children
    Nino Kunzli
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, School of Public Health, University of California, Los Angeles, CA, USA
    Am J Respir Crit Care Med 174:1221-8. 2006
    ..In late October 2003, Southern California wildfires burned more than 3,000 km2. The wildfires produced heavy smoke that affected several communities participating in the University of Southern California Children's Health Study (CHS)...
  30. pmc TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences
    Made Wenten
    Division of Environmental Health, Department of Preventive Medicine, Keck School of Medicine of USC, 1540 Alcazar Street, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 172:1563-8. 2005
    ..The role of genetic susceptibility in risk for adverse effects from SHS has not been extensively investigated in children...
  31. ncbi request reprint Indoor risk factors for asthma in a prospective study of adolescents
    Rob McConnell
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Epidemiology 13:288-95. 2002
    ..However, there has been little investigation of the effect of the indoor environment on incident asthma in adolescents...
  32. pmc Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9175, USA
    Blood 111:3377-82. 2008
    ..8-fold (P=.03) increase in YAHL risk. Thus, both case-twins and their unaffected cotwins had a decreased ability to produce IL-12, which may contribute to YAHL susceptibility...
  33. ncbi request reprint Asthma in exercising children exposed to ozone: a cohort study
    Rob McConnell
    Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, CA 90089 9011, USA
    Lancet 359:386-91. 2002
    ..We investigated the relation between newly-diagnosed asthma and team sports in a cohort of children exposed to different concentrations and mixtures of air pollutants...
  34. doi request reprint Use of an electrostatic dust cloth for self-administered home allergen collection
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9175, United States of America
    Twin Res Hum Genet 11:150-5. 2008
    ....
  35. pmc Sample size requirements to detect gene-environment interactions in genome-wide association studies
    Cassandra E Murcray
    Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089 9010, USA
    Genet Epidemiol 35:201-10. 2011
    ..15, and a binary exposure with prevalence 0.3, the Murcray, Kooperberg and hybrid methods are 1.90, 1.27, and 1.87 times as efficient, respectively, as the traditional case-control analysis to detect an interaction effect size of 2.0...
  36. pmc Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth
    Carrie V Breton
    Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 183:243-8. 2011
    ..Glutathione plays an important role in antioxidant and inflammatory processes in the lung. Alterations in glutathione metabolism are a central feature of several chronic lung diseases...
  37. pmc Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function
    Carrie V Breton
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033 USA
    Am J Respir Crit Care Med 179:601-7. 2009
    ..The glutathione S-transferases (GSTs) are important detoxification enzymes...
  38. ncbi request reprint Sample size requirements for matched case-control studies of gene-environment interaction
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, CA, USA
    Stat Med 21:35-50. 2002
    ..A software program that implements the method is freely available, and may be downloaded from the website http://hydra.usc.edu/gxe...
  39. pmc Gene-environment interaction in genome-wide association studies
    Cassandra E Murcray
    Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089 9010, USA
    Am J Epidemiol 169:219-26. 2009
    ..The procedure complements screening for marginal genetic effects and thus has the potential to uncover new genetic signals that have not been identified previously...
  40. pmc Relationship between air pollution, lung function and asthma in adolescents
    Talat Islam
    Department of Preventive Medicine, Keck School of Medicine, Los Angeles, California 90033, USA
    Thorax 62:957-63. 2007
    ..A study was undertaken to determine whether lung function is associated with new onset asthma and whether this relationship varies by exposure to ambient air pollutants...
  41. ncbi request reprint SNPs, haplotypes, and model selection in a candidate gene region: the SIMPle analysis for multilocus data
    David V Conti
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Genet Epidemiol 27:429-41. 2004
    ..Using simulations, we demonstrate the utility of the SIMPle model to identify crucial SNPs and underlying haplotype structures across a variety of causal models and genetic architectures...
  42. doi request reprint Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence
    Talat Islam
    Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Thorax 65:139-45. 2010
    ..Because nitrosative stress affects respiratory health, it was hypothesised that variants in NOS2A are associated with asthma incidence and lung function growth during adolescence...
  43. ncbi request reprint Prospective study of air pollution and bronchitic symptoms in children with asthma
    Rob McConnell
    Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 168:790-7. 2003
    ....
  44. ncbi request reprint Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake
    Frank D Gilliland
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Epidemiol 158:576-84. 2003
    ..In summary, lung function levels were lower in children with inadequate dietary antioxidant vitamin intake...
  45. ncbi request reprint Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth
    Frank D Gilliland
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Respir Crit Care Med 166:710-6. 2002
    ..We conclude that GSTM1 and GSTP1 genotypes are associated with lung function growth in school children...
  46. ncbi request reprint Obesity and the risk of newly diagnosed asthma in school-age children
    Frank D Gilliland
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Epidemiol 158:406-15. 2003
    ..77, 95% CI: 1.26, 2.49) than in allergic children (RR = 1.16, 95% CI: 0.63, 2.15). The authors conclude that being overweight is associated with an increased risk of new-onset asthma in boys and in nonallergic children...
  47. ncbi request reprint IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Blood 103:3216-21. 2004
    ..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma...
  48. pmc Regular smoking and asthma incidence in adolescents
    Frank D Gilliland
    Department of Preventive Medicine, Keck School of Medicine of USC, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 174:1094-100. 2006
    ....
  49. pmc Dog ownership enhances symptomatic responses to air pollution in children with asthma
    Rob McConnell
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    Environ Health Perspect 114:1910-5. 2006
    ..Experimental data suggest that asthma exacerbation by ambient air pollutants is enhanced by exposure to endotoxin and allergens; however, there is little supporting epidemiologic evidence...
  50. ncbi request reprint Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children
    Frank D Gilliland
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 166:457-63. 2002
    ..Among children with GSTM1 (+) genotype, in utero exposure was not associated with asthma or wheezing. Our findings indicate that there are important long-term effects of in utero exposure in a genetically susceptible group of children...
  51. ncbi request reprint Impact of respiratory illness on expiratory flow rates in normal, asthmatic, and allergic children
    Edward B Rappaport
    Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
    Pediatr Pulmonol 34:112-21. 2002
    ..We conclude that RI in children who are well enough to attend school may reduce expiratory flow rates. These effects are greater for children with active asthma or hay fever than in those without, and may be inversely related to age...
  52. ncbi request reprint Differential twin concordance for multiple sclerosis by latitude of birthplace
    Talat Islam
    Department of Preventive Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, 90089, USA
    Ann Neurol 60:56-64. 2006
    ..To address the inconsistency in the reported concordance of multiple sclerosis (MS) among twins by zygosity, sex, and latitude...
  53. ncbi request reprint Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins
    Talat Islam
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    Neurology 69:381-8. 2007
    ....
  54. ncbi request reprint Polymorphism in the androgen receptor and mammographic density in women taking and not taking estrogen and progestin therapy
    Elizabeth Osth Lillie
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Cancer Res 64:1237-41. 2004
    ..4%) than carriers of the more active AR-CAG (25.7%; P = 0.04). Our results raise the question of whether the number of AR-CAG repeats predicts breast cancer risk in estrogen progestin therapy users...
  55. ncbi request reprint Testing association and linkage using affected-sib-parent study designs
    Joshua Millstein
    National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, Seattle, Washington 98115, USA
    Genet Epidemiol 29:225-33. 2005
    ..8% by FBAT, and 82.5% by our joint test of linkage and association. Our model can also be used to obtain tests of linkage conditional on association and association conditional on linkage, which can be helpful in fine mapping...
  56. ncbi request reprint Air pollution and children--an unhealthy mix
    W James Gauderman
    N Engl J Med 355:78-9. 2006
  57. ncbi request reprint Exploiting gene-environment interaction to detect genetic associations
    Peter Kraft
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Hered 63:111-9. 2007
    ..This makes the joint test an attractive tool for large-scale association scans where the true gene-environment interaction model is unknown...
  58. pmc A testing framework for identifying susceptibility genes in the presence of epistasis
    Joshua Millstein
    National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, Seattle, WA 98115, USA
    Am J Hum Genet 78:15-27. 2006
    ..In an independent data set consisting primarily of African American and Asian American children, these three genes also showed a significant association with asthma status (P = .0008)...
  59. ncbi request reprint Regression models for linkage: issues of traits, covariates, heterogeneity, and interaction
    Daniel J Schaid
    Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic Foundation, Rochester, Minn 55905, USA
    Hum Hered 55:86-96. 2003
    ..The purposes of this paper are to review some recent developments in the linkage regression framework, to emphasize strengths and weaknesses of various proposed methods, and to highlight some important assumptions and caveats...

Research Grants7

  1. STATISTICAL APPROACHES TO THE STUDY OF GXE INTERACTIONS
    W Gauderman; Fiscal Year: 2002
    ..Successful completion of these aims will improve our understanding of how GxE interaction influences disease risk, and how we can optimally design studies and analyze data to find and characterize such genes. ..
  2. A Genome-wide Association Study of Childhood Respiratory Outcomes
    WILLIAM GAUDERMAN; Fiscal Year: 2007
    ..Our novel use of air-pollution and existing candidate-gene data in the scan has the potential to identify new genes that act synergistically with important, established determinants of children's respiratory health. (End of Abstract) ..
  3. A Genome-wide Association Study of Childhood Respiratory Outcomes
    WILLIAM GAUDERMAN; Fiscal Year: 2009
    ..End of Abstract) ..