Margaret Gatz

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Lifestyle risk and delaying factors
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Alzheimer Dis Assoc Disord 20:S84-8. 2006
  2. ncbi Commentary on evidence-based psychological treatments for older adults
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA
    Psychol Aging 22:52-5. 2007
  3. ncbi Cognitive capacities of older adults who are asked to consent to medical treatment or to clinical research
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles, CA 90089 1061, USA
    Behav Sci Law 24:465-8. 2006
  4. ncbi Sex differences in genetic risk for dementia
    Margaret Gatz
    University of Southern California, Los Angeles, California, USA Karolinska Institutet, Stockholm, Sweden
    Behav Genet 33:95-105. 2003
  5. ncbi In memory of George Albee
    Margaret Gatz
    University of Southern California, Department of Psychology, Los Angeles, CA 90089-1061, USA
    J Prim Prev 28:19-20. 2007
  6. ncbi Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Neurobiol Aging 26:439-47. 2005
  7. ncbi Dementia in Swedish twins: predicting incident cases
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles, CA 90089 1061, USA
    Behav Genet 40:768-75. 2010
  8. ncbi Performance on neurocognitive tests by co-twins to dementia cases compared to normal control twins
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    J Geriatr Psychiatry Neurol 18:202-7. 2005
  9. ncbi Telephone screening to identify potential dementia cases in a population-based sample of older adults
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles, California 90089 1061, USA
    Int Psychogeriatr 14:273-89. 2002
  10. ncbi Role of genes and environments for explaining Alzheimer disease
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    Arch Gen Psychiatry 63:168-74. 2006

Research Grants

  1. A Twin Study of Cognitive Outcomes in Older Adult Cancer
    Margaret Gatz; Fiscal Year: 2006
  2. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 2002
  3. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 1993
  4. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 1991

Detail Information

Publications94

  1. ncbi Lifestyle risk and delaying factors
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Alzheimer Dis Assoc Disord 20:S84-8. 2006
    ..Such findings point to the importance of taking a life-course perspective to designing interventions to delay or to prevent dementia...
  2. ncbi Commentary on evidence-based psychological treatments for older adults
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA
    Psychol Aging 22:52-5. 2007
    ..The challenge for access is to ensure that older adults with treatable mental disorders will get connected to psychologists trained in these evidence-based therapies...
  3. ncbi Cognitive capacities of older adults who are asked to consent to medical treatment or to clinical research
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles, CA 90089 1061, USA
    Behav Sci Law 24:465-8. 2006
    ..It should neither be assumed that most adults over a certain age are too demented to consent nor that decision-making is approached the same way by younger and older adults...
  4. ncbi Sex differences in genetic risk for dementia
    Margaret Gatz
    University of Southern California, Los Angeles, California, USA Karolinska Institutet, Stockholm, Sweden
    Behav Genet 33:95-105. 2003
    ..We conclude that women are not at higher risk of developing dementia, but there is a hint that different genetic processes may be involved for women than for men...
  5. ncbi In memory of George Albee
    Margaret Gatz
    University of Southern California, Department of Psychology, Los Angeles, CA 90089-1061, USA
    J Prim Prev 28:19-20. 2007
  6. ncbi Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Neurobiol Aging 26:439-47. 2005
    ..Among monozygotic twins where both twins had Alzheimer's disease, the within pair difference in age of onset ranged from both becoming demented in the same year to 7 years difference in onset...
  7. ncbi Dementia in Swedish twins: predicting incident cases
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles, CA 90089 1061, USA
    Behav Genet 40:768-75. 2010
    ..Given the long preclinical period that characterizes Alzheimer's disease, these findings may suggest late life risk factors for dementia, or may reflect changes that are part of preclinical disease...
  8. ncbi Performance on neurocognitive tests by co-twins to dementia cases compared to normal control twins
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    J Geriatr Psychiatry Neurol 18:202-7. 2005
    ..These findings show that being at greater genetic risk for dementia is reflected in cognitive performance even in the absence of a diagnosis of dementia...
  9. ncbi Telephone screening to identify potential dementia cases in a population-based sample of older adults
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles, California 90089 1061, USA
    Int Psychogeriatr 14:273-89. 2002
    ..One recommendation based on our experience is that longitudinal studies should include a telephone interview component for anyone who drops out of the study, to enable characterizing the cognitive status of dropouts...
  10. ncbi Role of genes and environments for explaining Alzheimer disease
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    Arch Gen Psychiatry 63:168-74. 2006
    ..Twin studies using selected samples have shown high heritability for Alzheimer disease (AD)...
  11. ncbi Educating the brain to avoid dementia: can mental exercise prevent Alzheimer disease?
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles, California, USA
    PLoS Med 2:e7. 2005
  12. ncbi Sequence variation in SORL1 and dementia risk in Swedes
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, Riverside, CA 92521, USA
    Neurogenetics 11:139-42. 2010
    ....
  13. ncbi Heritability of an age-dependent categorical phenotype: cognitive dysfunction
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, 92521, USA
    Twin Res Hum Genet 9:17-23. 2006
    ..The findings emphasize the extent to which research is needed to uncover nonfamilial environmental influences on cognitive dysfunction in later life...
  14. ncbi Personality and risk of cognitive impairment 25 years later
    Michael Crowe
    Department of Psychology, University of Alabama, 35294 2100, USA
    Psychol Aging 21:573-80. 2006
    ..Findings are discussed in the context of theories related to personality, psychological distress, arousal, and cognitive function...
  15. ncbi Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins
    Jessica A Brommelhoff
    Department of Psychology, University of Southern California, Los Angeles, CA 90089 1061, USA
    Psychol Aging 24:373-84. 2009
    ..These findings suggest that after partially controlling for genetic influences, late-life depression for many individuals may be a prodrome rather than a risk factor for dementia...
  16. ncbi The role of occupational complexity in trajectories of cognitive aging before and after retirement
    Deborah Finkel
    Department of Psychology, Indiana University Southeast, New Albany, IN 47150, USA
    Psychol Aging 24:563-73. 2009
    ....
  17. ncbi Accuracy and sensitivity of Parkinsonian disorder diagnoses in two Swedish national health registers
    Adina L Feldman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neuroepidemiology 38:186-93. 2012
    ..Swedish population-based national health registers are widely used data sources in epidemiological research. Register-based diagnoses of Parkinson's disease have not been validated against clinical information...
  18. ncbi A survey of ABCA1 sequence variation confirms association with dementia
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, Riverside, California, USA
    Hum Mutat 30:1348-54. 2009
    ..Results further implicate ABCA1 in dementia, reinforcing the putative involvement of lipid transport in neurodegenerative disease...
  19. ncbi Genotype-environment interactions: cognitive aging and social factors
    Chandra A Reynolds
    University of California Riverside, Department of Psychology, Riverside, CA 92521, USA
    Twin Res Hum Genet 10:241-54. 2007
    ..Further work ought to consider larger sample sizes as well as consider additional social and contextual factors...
  20. ncbi Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, Riverside, CA 92521, USA
    Hum Mol Genet 19:2068-78. 2010
    ..Several markers in strong LD (r(2) > 0.7) with rs3183702 were found to be significantly associated with AD risk in recent genome-wide association studies with similar effect sizes, providing independent support of the current findings...
  21. ncbi Nonstroke cardiovascular disease and risk of Alzheimer disease and dementia
    Ulrika K Eriksson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Alzheimer Dis Assoc Disord 24:213-9. 2010
    ....
  22. ncbi Both odor identification and ApoE-ε4 contribute to normative cognitive aging
    Deborah Finkel
    Department of Psychology, Indiana University Southeast, New Albany, IN 47150, USA
    Psychol Aging 26:872-83. 2011
    ....
  23. ncbi Cognitive engagement and cognitive aging: is openness protective?
    Emily Schoenhofen Sharp
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Psychol Aging 25:60-73. 2010
    ..Openness, however, was not predictive of differences in the trajectories of cognitive performance over age...
  24. ncbi Genetic association of sequence variants near AGER/NOTCH4 and dementia
    Anna M Bennet
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 24:475-84. 2011
    ....
  25. ncbi How heritable is Alzheimer's disease late in life? Findings from Swedish twins
    Nancy L Pedersen
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Ann Neurol 55:180-5. 2004
    ..Although these genetic estimates for incident disease are lower than those for prevalent disease, the importance of genetic factors for liability to Alzheimer's disease is considerable even late in life...
  26. ncbi Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study
    Weili Xu
    Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Diabetes 58:71-7. 2009
    ..We aimed to verify the association between diabetes and the risk of dementia, Alzheimer's disease, and vascular dementia in twins and to explore whether genetic and early-life environmental factors could contribute to this association...
  27. ncbi Longitudinal change in memory performance associated with HTR2A polymorphism
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, 1344 Olmsted Hall, Riverside, CA 92521 0426, USA
    Neurobiol Aging 27:150-4. 2006
    ..These findings imply a role for the 5-HT2A serotonin receptor on the formation of episodic memories in older adults...
  28. ncbi Serum lipid levels and cognitive change in late life
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, Riverside, California 92521, USA
    J Am Geriatr Soc 58:501-9. 2010
    ..To assess the effect of lipids and lipoproteins on longitudinal cognitive performance and cognitive health in late life and to consider moderating factors such as age and sex that may clarify conflicting prior evidence...
  29. ncbi Associations of gene sequence variation and serum levels of C-reactive protein and interleukin-6 with Alzheimer's disease and dementia
    Ulrika K Eriksson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 23:361-9. 2011
    ..However, neither variation in the CRP and IL6 genes nor circulating levels of their respective protein products were associated with an increased risk of developing late-life dementias...
  30. ncbi Heritability of Parkinson disease in Swedish twins: a longitudinal study
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 32:1923.e1-8. 2011
    ..Concordance rates for PD or parkinsonism were somewhat higher but the heritability estimate was nonsignificant. Our longitudinal analyses demonstrate that PD and parkinsonism are modestly heritable...
  31. ncbi Sensitivity and specificity of dementia coding in two Swedish disease registries
    Ya-Ping Jin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Neurology 63:739-41. 2004
    ..Specificity was 98% for the Inpatient Discharge Registry and 100% for the Cause of Death Registry...
  32. ncbi No evidence for heritability of Parkinson disease in Swedish twins
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurology 63:305-11. 2004
    ..The preponderance of discordant twin pairs provides an ideal material for studying environmental risk factors and potential genotype-by-environment interaction...
  33. ncbi Quantitative genetic analysis of latent growth curve models of cognitive abilities in adulthood
    Chandra A Reynolds
    Department of Psychology, University of California, 1344 Olmstead Hall, Riverside, CA 92521, USA
    Dev Psychol 41:3-16. 2005
    ..The present findings provide support for theories of the increasing influence of the environment with age on cognitive abilities...
  34. ncbi Evidence that the gene encoding insulin degrading enzyme influences human lifespan
    Mun Gwan Hong
    Department of Medical Epidemiology and Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Hum Mol Genet 17:2370-8. 2008
    ....
  35. ncbi Depression in older adults
    Amy Fiske
    Department of Psychology, West Virginia University, Morgantown, WV 26506, USA
    Annu Rev Clin Psychol 5:363-89. 2009
    ..Preventive interventions including education for individuals with chronic illness, behavioral activation, cognitive restructuring, problem-solving skills training, group support, and life review have also received support...
  36. ncbi Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism
    Hagit Katzov
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Hum Mutat 23:358-67. 2004
    ..Results indicate that variants of ABCA1 may affect the risk of AD, providing further support for a genetic link between AD and cholesterol metabolism...
  37. ncbi Cancer as a risk factor for long-term cognitive deficits and dementia
    Lara H Heflin
    Department of Psychology, University of Southern California, Los Angeles, CA 90089-1061, USA
    J Natl Cancer Inst 97:854-6. 2005
    ....
  38. ncbi A twin study of lifetime Generalized Anxiety Disorder (GAD) in older adults: genetic and environmental influences shared by neuroticism and GAD
    Margaret Anne Mackintosh
    Department of Psychology, University of Southern California, Los Angeles, California 90089 1061, USA
    Twin Res Hum Genet 9:30-7. 2006
    ..Analyses of sex effects suggested that men and women differed in the frequency of lifetime GAD and level of neuroticism; however, no sex differences for genetic and environmental influences for either trait were identified...
  39. ncbi A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity
    Hagit Katzov
    Center for Genomics and Bioinformatics, Karolinska Institute, Berzelius väg 35 171 77, Stockholm, Sweden
    Hum Mol Genet 13:2647-57. 2004
    ....
  40. ncbi Differential distribution of subjective and objective cognitive impairment in the population: a nation-wide twin-study
    Barbara Caracciolo
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
    J Alzheimers Dis 29:393-403. 2012
    ..Shared environmental influences rather than genetic background play a role in the occurrence of SCI and CIND...
  41. ncbi Pleiotropy in the presence of allelic heterogeneity: alternative genetic models for the influence of APOE on serum LDL, CSF amyloid-β42, and dementia
    Anna M Bennet
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Alzheimers Dis 22:129-34. 2010
    ....
  42. ncbi Complete ascertainment of Parkinson disease in the Swedish Twin Registry
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Neurobiol Aging 29:1765-73. 2008
    ..Overall prevalence rate for PD was 496 per 100,000 individuals. Among the 132 PD cases identified, there were only three concordant twin pairs. In total 7.2% of PD cases reported a first degree relative with PD...
  43. ncbi Does participation in leisure activities lead to reduced risk of Alzheimer's disease? A prospective study of Swedish twins
    Michael Crowe
    Department of Psychology Leonard Davis School of Gerontology, University of Southern California, Los Angeles 90089 1061, USA
    J Gerontol B Psychol Sci Soc Sci 58:P249-55. 2003
    ..Greater participation in intellectual-cultural activities was associated with lower risk of Alzheimer's disease for women, although not for men...
  44. ncbi Asthma, eczema, rhinitis and the risk for dementia
    Ulrika K Eriksson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 25:148-56. 2008
    ..Inflammation is associated with Alzheimer's disease (AD) and dementia. In light of the chronic inflammatory properties of the atopic disorders asthma, eczema and rhinitis, we hypothesized an association with dementia...
  45. ncbi Sources of influence on rate of cognitive change over time in Swedish twins: an application of latent growth models
    Chandra A Reynolds
    Department of Psychology, University of California Riverside, Riverside, California 92521, USA
    Exp Aging Res 28:407-33. 2002
    ..These same forces may overlap with those that influence higher or lower educational attainment or those leading to better or worse pulmonary functioning...
  46. ncbi Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes
    Chandra A Reynolds
    Department of Psychology, University of California Riverside, 92521, USA
    Behav Genet 36:185-94. 2006
    ..There were no significant findings for LRP. Dominance, often untested in previous studies, was important in the current study's findings...
  47. ncbi The Apartment Test: validity of a memory measure
    Amy Fiske
    Department of Psychology, University of Southern California, Los Angeles, California, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14:441-61. 2007
    ..We conclude that the Apartment Test is a valid measure of verbal memory with evidence of ecological and concurrent validity...
  48. ncbi Longitudinal verbal fluency in normal aging, preclinical, and prevalent Alzheimer's disease
    Linda J Clark
    Alzheimer Disease Research Center, and Department of Neurology, University of Southern California, Los Angeles, California 90033, USA
    Am J Alzheimers Dis Other Demen 24:461-8. 2009
    ..Few longitudinal studies evaluate differences in patterns of change of category compared to letter fluency across the spectrum of cognitive impairment...
  49. ncbi Physical health 25 years later: the predictive ability of neuroticism
    Susan Turk Charles
    Department of Psychology, University of California, Irvine, CA 92697 7085, USA
    Health Psychol 27:369-78. 2008
    ..The objective of the current study was to examine neuroticism assessed in 1973 and the likelihood of reporting physical conditions 25 years later...
  50. ncbi Personality characteristics and motor skills attributed to occupations in Parkinson disease
    Nicole M Gatto
    Department of Epidemiology, University of California, Los Angeles, CA, USA
    Cogn Behav Neurol 24:18-25. 2011
    ..Only 1 previous study has assessed personality before PD onset, and other data collected retrospectively do not exclude reverse causation...
  51. ncbi The influence of mortality on twin models of change: addressing missingness through multiple imputation
    Nancy L Pedersen
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Behav Genet 33:161-9. 2003
    ..Results indicated that twin similarity for slopes decreases when mortality is accounted for, but that considerable age-related covariation remains...
  52. ncbi Anxiety, cognitive performance, and cognitive decline in normal aging
    Julie Loebach Wetherell
    Department of Psychology, University of Southern California, Los Angeles 92161, USA
    J Gerontol B Psychol Sci Soc Sci 57:P246-55. 2002
    ..These results provide some support for Eysenck's processing efficiency theory but none for neuroticism as a risk factor for cognitive decline in normal aging...
  53. ncbi Long-term cognitive impairment in older adult twins discordant for gynecologic cancer treatment
    Keiko Kurita
    Department of Psychology, University of Southern California, Los Angeles, CA 90089 1061, USA
    J Gerontol A Biol Sci Med Sci 66:1343-9. 2011
    ..Less studied is the extent to which cancer diagnosis may be associated with cognitive impairment as a late effect for older adults...
  54. ncbi Depressive symptoms and aging: the effects of illness and non-health-related events
    Amy Fiske
    Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA
    J Gerontol B Psychol Sci Soc Sci 58:P320-8. 2003
    ..Negative life events in the previous 3 years predicted depressive symptoms. Notably, depressive symptoms also predicted future negative life events...
  55. ncbi Demographic and contextual factors related to knowledge about Alzheimer's disease
    Brian D Carpenter
    Department of Psychology, Washington University in St Louis, MO 63130, USA
    Am J Alzheimers Dis Other Demen 26:121-6. 2011
    ..Understanding where gaps in dementia knowledge exist can guide education initiatives to increase disease awareness and improve supportive services...
  56. ncbi Baseline leisure time activity and cognition more than two decades later
    Ingemar Kåreholt
    Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
    Int J Geriatr Psychiatry 26:65-74. 2011
    ..A wide range of activities was included-political, mental, socio-cultural, social, physical, and organizational activities...
  57. ncbi Diabetes mellitus is a risk factor for vascular dementia, but not for Alzheimer's disease: a population-based study of the oldest old
    Linda B Hassing
    Department of Psychology, Goteborg University, Goteborg, Sweden
    Int Psychogeriatr 14:239-48. 2002
    ..The purpose of this study was to examine if Type 2 diabetes mellitus is a risk factor for dementia in very old age, specifically for Alzheimer's disease (AD) and vascular dementia (VaD)...
  58. ncbi Assessing age of dementia onset: validity of informant reports
    Amy Fiske
    Department of Psychology, University of Southern California, Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 19:128-34. 2005
    ..These findings suggest that informant reports of age of dementia onset are reliable and reasonably valid, even when only a single question is asked within the context of a larger interview...
  59. ncbi Relationship between education and dementia: an updated systematic review
    Emily Schoenhofen Sharp
    Department of Psychology, University of Southern California, Los Angeles, 90089 1061, USA
    Alzheimer Dis Assoc Disord 25:289-304. 2011
    ..The purpose of this study was to review the relationship between education and dementia...
  60. ncbi Occupational exposure in parkinsonian disorders: a 43-year prospective cohort study in men
    Adina L Feldman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Parkinsonism Relat Disord 17:677-82. 2011
    ..Common findings are increased risk associated with pesticide exposure and no association between Parkinson's disease and welding...
  61. ncbi Children of persons with Alzheimer disease: what does the future hold?
    Lissy Jarvik
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 22:6-20. 2008
    ..We examine the state of knowledge with respect to risk and protective factors for AD and recommend a research agenda with special emphasis on AD offspring...
  62. ncbi Genetic and environmental mediation of the associations between self-rated health and cognitive abilities
    Pia Svedberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Exp Aging Res 35:178-201. 2009
    ..In the oldest age group (>or=67 years), associations between self-rated health and spatial reasoning, perceptual speed, and visual memory were entirely due to genetic factors...
  63. ncbi Genetic variation in a haplotype block spanning IDE influences Alzheimer disease
    Jonathan A Prince
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Hum Mutat 22:363-71. 2003
    ..These results provide substantial evidence that genetic variation within or extremely close to IDE impacts both disease risk and traits related to the severity of AD...
  64. ncbi Baseline leisure time activity and cognition more than two decades later
    Ingemar Kåreholt
    Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
    Int J Geriatr Psychiatry 26:65-74. 2011
    ..A wide range of activities was included-political, mental, socio-cultural, social, physical, and organizational activities...
  65. ncbi Individual variation for cognitive decline: quantitative methods for describing patterns of change
    Chandra A Reynolds
    Department of Psychology, University of Southern California, Riverside 92532, USA
    Psychol Aging 17:271-87. 2002
    ..Predicted slopes from the RER model also showed the strongest interrelationships within and across cognitive domains as indicated by factor analysis results and stronger associations with demographic, health, and psychosocial predictors...
  66. ncbi Performance on the CERAD Word List Memory task: a comparison of university-based and community-based groups
    Ross Andel
    Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA
    Int J Geriatr Psychiatry 18:733-9. 2003
    ..CONCLUSIONS: Accurate neuropsychological assessment of Alzheimer's disease may require consideration of potentially subtle differences between older adults tested at university centers and those tested in the community...
  67. ncbi Cultural diversity in Alzheimer disease: the interface between biology, belief, and behavior
    Helena C Chui
    Department of Neurology, University of Southern California Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 19:250-5. 2005
  68. ncbi Pathways to care for Alzheimer's disease among Korean Americans
    Kecia F Watari
    Department of Psychology, University of Southern California, Los Angeles, CA, USA
    Cultur Divers Ethnic Minor Psychol 10:23-38. 2004
    ..Those more familiar with dementia symptoms indicated they would seek help, supporting the value of public education...
  69. ncbi Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease
    Jessica A Brommelhoff
    Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA
    J Aging Res 2011:187219. 2011
    ..These findings suggest that late-onset depression may be a process that is distinct from the neurodegenerative changes caused by Alzheimer's disease...
  70. ncbi The Alzheimer's Disease Knowledge Scale: development and psychometric properties
    Brian D Carpenter
    Department of Psychology, Washington University in St Louis, St Louis, MO 63130, USA
    Gerontologist 49:236-47. 2009
    ..This study provides preliminary evidence for the acceptability, reliability, and validity of the new Alzheimer's Disease Knowledge Scale (ADKS), a content and psychometric update to the Alzheimer's Disease Knowledge Test...
  71. ncbi Sex differences after all those years? Heritability of cognitive abilities in old age
    Sanna Read
    Institute of Gerontology, School of Health Sciences, PO Box 1026, 551 11 Jönköping, Sweden
    J Gerontol B Psychol Sci Soc Sci 61:P137-43. 2006
    ..We found no sex-specific genetic influences. In other words, the same genetic effects were operating for men and women. Furthermore, the magnitude of genetic effect was similar for men and women...
  72. ncbi Age at onset of generalized anxiety disorder in older adults
    Hillary Le Roux
    Dept. of Psychiatry, Univ. of Nevada, Reno, USA
    Am J Geriatr Psychiatry 13:23-30. 2005
    ..Older adults with an early onset of GAD appear to have a more severe course, characterized by pathological worry, than those with a later onset. Role disability may be a risk factor for onset of GAD in late life...
  73. ncbi The effect of education and occupational complexity on rate of cognitive decline in Alzheimer's patients
    Ross Andel
    School of Aging Studies, University of South Florida, Tampa, Florida 33620, USA
    J Int Neuropsychol Soc 12:147-52. 2006
    ..These results provide support for the concept of cognitive reserve according to which greater reserve may postpone clinical onset of AD but also accelerate cognitive decline after the onset...
  74. ncbi A Swedish national twin study of lifetime major depression
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:109-14. 2006
    ..It is not known whether genetic effects on major depression are constant across historical cohorts...
  75. ncbi Endogenous and exogenous hormone exposure and risk of cognitive impairment in Swedish twins: a preliminary study
    Natalie L Rasgon
    Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, 401 Quarry Road, Room 2360, Palo Alto, CA 94305 5723, USA
    Psychoneuroendocrinology 30:558-67. 2005
    ..To analyze the risk of cognitive impairment among female Swedish Twins with regard to endogenous and exogenous hormone exposure...
  76. ncbi Comparative rating measures of health and environmental exposures: how well do twins agree?
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, Riverside, California 92521, United States of America
    Twin Res Hum Genet 8:113-9. 2005
    ..Comparative ratings appear most accurate for smoking and alcohol use, and less consistent for mental health symptoms and self-rated health...
  77. ncbi Self-rated health in a longitudinal perspective: a 9-year follow-up twin study
    Pia Svedberg
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
    J Gerontol B Psychol Sci Soc Sci 60:S331-S340. 2005
    ..This study first considers age and cohort explanations for age-related changes in mean values and variance in self-rated health. Second, it evaluates the contributions of genes and environments to self-rated health measured longitudinally...
  78. ncbi Re: Cancer as a risk factor for dementia: a house built on shifting sand
    Lara H Heflin
    J Natl Cancer Inst 97:1550-1; author reply 1551-2. 2005
  79. ncbi Age at onset and familial risk for major depression in a Swedish national twin sample
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 35:1573-9. 2005
    ..In many biomedical disorders, early age at onset (AAO) is an index of high liability to illness which is manifest by an increased risk of illness in relatives. Most but not all prior studies report such a pattern for major depression (MD)...
  80. ncbi Risk and protective factors for Parkinson's disease: a study in Swedish twins
    Karin Wirdefeldt
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-181 77 Stockholm, Sweden
    Ann Neurol 57:27-33. 2005
    ..We confirm the protective effect of smoking on Parkinson's disease and establish that the association is only partially explained by genetic and familial environmental factors...
  81. ncbi Complexity of work and risk of Alzheimer's disease: a population-based study of Swedish twins
    Ross Andel
    School of Aging Studies MHC 1321, University of South Florida, 4202 E Fowler Avenue, Tampa, FL 33620, USA
    J Gerontol B Psychol Sci Soc Sci 60:P251-8. 2005
    ..Greater complexity of work with people and data was protective in twin pairs discordant for AD. Findings suggest that greater complexity of work, and particularly complex work with people, may reduce the risk of AD...
  82. ncbi Three-state frailty model for age at onset of dementia and death in Swedish twins
    Samuli Ripatti
    Rolf Nevanlinna Institute, University of Helsinki, Länsisatamankatu 14 B 26, 00180 Helsinki, Finland
    Genet Epidemiol 24:139-49. 2003
    ..More data, however, are needed to gain precision in these estimates...
  83. ncbi Complexity of primary lifetime occupation and cognition in advanced old age
    Ross Andel
    School of Aging Studies, MHC 1321, University of South Florida, 4202 E Fowler Ave, Tampa, FL 33620, USA
    J Aging Health 19:397-415. 2007
    ..The authors explored the association between complexity of primary lifetime occupation and cognition in older adulthood...
  84. ncbi Physical exercise at midlife and risk of dementia three decades later: a population-based study of Swedish twins
    Ross Andel
    School of Aging Studies, University of South Florida, Tampa, Florida 33620, USA
    J Gerontol A Biol Sci Med Sci 63:62-6. 2008
    ..We explored the association between physical exercise at midlife and subsequent risk of dementia among members of the HARMONY study...
  85. ncbi Do work-related stress and reactivity to stress predict dementia more than 30 years later?
    Michael Crowe
    Division of Gerontology and Geriatric Medicine, University of Alabama, Birmingham, Birmingham, AL 35294 2041, USA
    Alzheimer Dis Assoc Disord 21:205-9. 2007
    ..Overall, indicators of stress due to environment (ie, work) were not associated with dementia, whereas the individual characteristic of reactivity to stress predicted dementia risk...
  86. ncbi Accounting for the relationship between low education and dementia: a twin study
    Margaret Gatz
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    Physiol Behav 92:232-7. 2007
    ..Low education is confirmed as a risk factor for dementia. Findings from three different analytic approaches showed that genetic influences did not explain this association...
  87. ncbi Life review therapy using autobiographical retrieval practice for older adults with depressive symptomatology
    Juan Pedro Serrano
    Department of Psychology, Universidad de Castilla La Mancha, Albacete, Spain
    Psychol Aging 19:270-7. 2004
    ..The findings suggest that practice in autobiographical memory for specific events may be among the components of life review that account for its effectiveness and could be a useful tool in psychotherapy with older adults...
  88. ncbi The Swedish Twin Registry in the third millennium: an update
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Twin Res Hum Genet 9:875-82. 2006
    ..In particular, we describe recent efforts to screen all twins born between 1959 and 1985, and young twin pairs when they turn 9 and 12 years of age. For these studies, we present initial frequencies of common conditions and exposures...
  89. ncbi Latent growth curve analyses of accelerating decline in cognitive abilities in late adulthood
    Deborah Finkel
    School of Social Sciences, Indiana University Southeast, New Albany 47150 6405, USA
    Dev Psychol 39:535-50. 2003
    ..Gender differences were found only in mean level, not in rate of decline...
  90. ncbi The sources of co-morbidity between major depression and generalized anxiety disorder in a Swedish national twin sample
    Kenneth S Kendler
    Department of Psychiatry Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Psychol Med 37:453-62. 2007
    ..The personality trait of neuroticism (N) is substantially correlated with risk for MD and GAD...
  91. ncbi Personality and major depression: a Swedish longitudinal, population-based twin study
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 63:1113-20. 2006
    ..Prior studies suggest that the personality traits of neuroticism and extroversion may be related to the liability to major depression (MD)...
  92. ncbi Quality of life in geriatric generalized anxiety disorder: a preliminary investigation
    Julie Loebach Wetherell
    Department of Psychiatry, University of California, San Diego and Veterans Affairs San Diego Healthcase System, 9500 Gilman Drive, Dept 0603V, La Jolla, CA 92093 0603, USA
    J Psychiatr Res 38:305-12. 2004
    ..To examine the impact of late-life generalized anxiety disorder (GAD) on health-related quality of life...
  93. ncbi DSM-IV criteria for generalized anxiety disorder in older adults: distinguishing the worried from the well
    Julie Loebach Wetherell
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0603, USA
    Psychol Aging 18:622-7. 2003
    ....
  94. ncbi Treatment of generalized anxiety disorder in older adults
    Julie Loebach Wetherell
    Department of Psychiatry, University of California, San Diego and VA San Diego Healthcare System 92161, USA
    J Consult Clin Psychol 71:31-40. 2003
    ....

Research Grants17

  1. A Twin Study of Cognitive Outcomes in Older Adult Cancer
    Margaret Gatz; Fiscal Year: 2006
    ..Through abstracting data from cancer treatment records and linking them to existing datasets, we will be able to examine possible longer term effects, along with likely covariates, with optimal comparison groups. ..
  2. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 2002
    ..Different diagnostic criteria will be compared. Quantitative indices will be derived from neuropsychological scores and from neuroimaging data subjected to quantitative mapping. ..
  3. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 1993
    ..The Swedish sample provides a special research opportunity to achieve these purposes...
  4. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 1991
    ....