Jyothsna Gattineni

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi request reprint Regulation of hormone-sensitive renal phosphate transport
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA Electronic address
    Vitam Horm 98:249-306. 2015
  2. pmc Highlights for the management of a child with proteinuria and hematuria
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Int J Pediatr 2012:768142. 2012
  3. pmc Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4
    Jyothsna Gattineni
    Dept of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX
    Am J Physiol Renal Physiol 306:F351-8. 2014
  4. pmc Genetic disorders of phosphate regulation
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Pediatr Nephrol 27:1477-87. 2012
  5. pmc Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4
    Jyothsna Gattineni
    Dept of Pediatrics, U T Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 301:F371-7. 2011
  6. pmc FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 297:F282-91. 2009
  7. pmc Effect of metabolic acidosis on neonatal proximal tubule acidification
    Katherine Twombley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1360-8. 2010
  8. pmc Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice
    Michel Baum
    Dept of Pediatrics, Univ of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 303:F1495-502. 2012
  9. pmc Evidence that prenatal programming of hypertension by dietary protein deprivation is mediated by fetal glucocorticoid exposure
    Sabeen Habib
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, USA
    Am J Hypertens 24:96-101. 2011
  10. pmc Prenatal programming of rat thick ascending limb chloride transport by low-protein diet and dexamethasone
    Amit Dagan
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 297:R93-9. 2009

Collaborators

Detail Information

Publications22

  1. doi request reprint Regulation of hormone-sensitive renal phosphate transport
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA Electronic address
    Vitam Horm 98:249-306. 2015
    ..This chapter highlights recent findings and insights regarding the hormonal regulation of renal phosphate transport along with imbalances of phosphate balance due to acquired or inherited diseases states. ..
  2. pmc Highlights for the management of a child with proteinuria and hematuria
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Int J Pediatr 2012:768142. 2012
    ....
  3. pmc Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4
    Jyothsna Gattineni
    Dept of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX
    Am J Physiol Renal Physiol 306:F351-8. 2014
    ..These data are consistent with FGFR1 and FGFR4 being the critical receptors for the phosphaturic actions of FGF23...
  4. pmc Genetic disorders of phosphate regulation
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9063, USA
    Pediatr Nephrol 27:1477-87. 2012
    ..The main focus of this educational review article is to discuss the genetic and clinical features of phosphate regulation disorders and provide understanding and treatment options...
  5. pmc Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4
    Jyothsna Gattineni
    Dept of Pediatrics, U T Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 301:F371-7. 2011
    ..In addition, when 1,25(OH)(2)Vitamin D(3) levels are not affected by FGF23, as in FGFR3(-/-)FGFR4(-/-) mice, a reduction in PTH can override the effects of FGF23 on renal phosphate transport...
  6. pmc FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 297:F282-91. 2009
    ..6 +/- 0.3 vs. 5.2 +/- 0.5 mg/dl) or BBM NaPi-2a and NaPi-2c expression. These data show that FGFR1 is the predominant receptor for the hypophosphatemic action of FGF23 in vivo, with FGFR4 likely playing a minor role...
  7. pmc Effect of metabolic acidosis on neonatal proximal tubule acidification
    Katherine Twombley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1360-8. 2010
    ..A comparable increase in NHE3 and NHE8 was found in neonatal rats with acidosis. In conclusion, the neonatal proximal tubule can adapt to metabolic acidosis with an increase in Na(+)/H(+) exchanger activity...
  8. pmc Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice
    Michel Baum
    Dept of Pediatrics, Univ of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 303:F1495-502. 2012
    ..In conclusion, NHE3 is the predominant Na(+)/H(+) exchanger in adult mice. NHE8 may play a compensatory role in renal acidification and blood pressure regulation in NHE3(-/-) mice...
  9. pmc Evidence that prenatal programming of hypertension by dietary protein deprivation is mediated by fetal glucocorticoid exposure
    Sabeen Habib
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, USA
    Am J Hypertens 24:96-101. 2011
    ..Prenatal programming by maternal dietary protein deprivation and prenatal dexamethasone result in a reduction in nephron number and hypertension when the offspring are studied as adults...
  10. pmc Prenatal programming of rat thick ascending limb chloride transport by low-protein diet and dexamethasone
    Amit Dagan
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 297:R93-9. 2009
    ..This study demonstrates that insults administered to the fetus can program altered sodium transport. Increased tubular sodium transport is a likely cause for the hypertension by prenatal programming...
  11. pmc Regulation of phosphate transport by fibroblast growth factor 23 (FGF23): implications for disorders of phosphate metabolism
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Pediatr Nephrol 25:591-601. 2010
    ..Here, we also discuss new potentially clinically important data pointing to the receptor(s) that mediate the binding and action of FGF23 and Klotho...
  12. pmc Effect of thyroid hormone on the postnatal renal expression of NHE8
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75235 9063, USA
    Am J Physiol Renal Physiol 294:F198-204. 2008
    ..In conclusion, thyroid hormone plays a potential role in the developmental isoform change from NHE8 to NHE3 and decreases NHE8 activity...
  13. pmc Effect of prenatal dexamethasone on postnatal serum and urinary angiotensin II levels
    Amit Dagan
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, TX, USA
    Am J Hypertens 23:420-4. 2010
    ..Prenatal programming of hypertension has been described in humans and in animal models that receive a prenatal insult, but the mechanism for the increase in blood pressure remains elusive...
  14. pmc Acid increases NHE8 surface expression and activity in NRK cells
    Catherine Joseph
    Dept of Pediatrics, U T Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 302:F495-503. 2012
    ..In conclusion, NHE8 surface expression and activity are regulated by acid media by increasing the rate of trafficking to the apical membrane...
  15. pmc Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea
    Michel Baum
    Department of Pediatrics, Mattel Children s Hospital, David Geffen School of Medicine at the University of California, Los Angeles, USA
    J Pediatr Gastroenterol Nutr 53:474-7. 2011
    ..Although brush border membrane Na/H exchange activity may be decreased, exonic mutations in NHE8 cannot account for this disorder in these subjects...
  16. pmc Renal NHE expression and activity in neonatal NHE3- and NHE8-null mice
    Kwanchai Pirojsakul
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas and
    Am J Physiol Renal Physiol 308:F31-8. 2015
    ..Likewise, NHE3-null mice had an increase in NHE8 brush-border membrane protein abundance and NHE activity in response to metabolic acidosis. In conclusion, both NHE3 and NHE8 likely play a role in neonatal acidification. ..
  17. doi request reprint Effect of prenatal programming and postnatal rearing on glomerular filtration rate in adult rats
    German Lozano
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas and
    Am J Physiol Renal Physiol 308:F411-9. 2015
    ..Thus, a prenatal low-protein diet causes hypertension and a reduction in GFR in mature adult offspring, which can be modified by postnatal rearing. ..
  18. pmc Accidental and iatrogenic causes of acute kidney injury
    Katherine Twombley
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Curr Opin Pediatr 23:208-14. 2011
    ..Ingestions and iatrogenic administration of drugs are all too common causes of acute kidney injury. This review will discuss these preventable causes of acute kidney injury...
  19. pmc Effect of postnatal maternal protein intake on prenatal programming of hypertension
    Khurrum Siddique
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Reprod Sci 21:1499-507. 2014
    ..Combined prenatal and postnatal maternal dietary protein deprivation and maternal dietary protein deprivation while nursing alone (20%-6%) results in hypertension, but the mechanism for the hypertension in these groups is different. ..
  20. ncbi request reprint Mercury intoxication: lack of correlation between symptoms and levels
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9063, USA
    Clin Pediatr (Phila) 46:844-6. 2007
    ..This case highlights the fact that urinary mercury levels do not necessarily correlate with the severity of clinical signs and symptoms of mercury intoxication...
  21. pmc Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone
    Amit Dagan
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1230-5. 2007
    ..The increase in proximal tubule transport may be a factor mediating the hypertension by prenatal programming with dexamethasone...
  22. pmc Complement disorders and hemolytic uremic syndrome
    Catherine Joseph
    Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Curr Opin Pediatr 25:209-15. 2013
    ..Complement mediated hemolytic uremic syndrome (aHUS) accounts for a significant proportion of non-shiga toxin HUS. The purpose of this review is to outline the pathophysiology, clinical features and therapeutic options for aHUS...