GEORGE GATES

..Innovar is a safe, cost-effective second-line therapy for patients with Meniere's disease who have failed conventional first-line medical therapy...

..Compare the rates of change with age in tests of hearing function that measure the peripheral and central segments of the auditory system...

..Central presbycusis is an emerging area for basic and clinical research in auditory neurotology, particularly in the relation of cognitive dysfunction to impaired auditory processing...

..Where hearing aids no longer provide benefit, cochlear implantation is the treatment of choice with excellent results even in octogenarians...

..To validate a disease-specific, health-related quality-of-life instrument for people with active, unilateral, cochleovestibular Ménière's disease (MD)...

..Although hearing loss is not improved, Meniett device usage does not adversely affect balance, as do most forms of surgical therapy. Use of the device does not preclude later surgical therapy...

..Given that the vertigo induced by MD, in general, is self-limited, the long-term outlook for balance function is good. The same cannot be said for the hearing dysfunction of MD...

..To delineate 2-year efficacy of Meniett device therapy in people with classic, unilateral, Ménière's disease unresponsive to traditional medical treatment...

..To assess the effect of memory impairment on central auditory function...

..To determine the relation of age-related auditory processing dysfunction and executive functioning...

..To confirm that central auditory dysfunction (CAD) may be a precursor to the onset of Alzheimer dementia (AD)...

..To evaluate the efficacy of a portable low-intensity alternating pressure generator, the Meniett device, in controlling the symptoms of Ménière's disease...

..Elderly listeners whose WRS fall below the Thornton-Raffin 95 percent critical difference based on AI should be considered for further testing for age-related auditory neuropathy...

..To determine the inheritance of age-related hearing loss...

..This effect supports the hypothesis that strial dysfunction is a substantive factor in cochlear aging. The etiology and mechanisms for this dysfunction are conjectural at present...

..To document the prognostic significance of a central auditory speech-processing deficit for the subsequent onset of probable Alzheimer's disease...

..Treatment with the Meniett device, which applies intermittent micropressure pulses to the inner ear through a tympanostomy tube, is effective in controlling vertigo in people with intractable Ménière's disease...

..To compare 2 screening methods for unrecognized handicapping hearing loss in the elderly...

..SIGNIFICANCE: The use of DPOE measures for screening and monitoring cochlear status of adult women should take into account the age, pure-tone thresholds, and noise exposure status of the subjects...

..To attain these objectives, measurements of particular otoacoustic emission responses were made in a reference group of young adults having excellent hearing...

..Because most patients' scores increased with SPEAK use, it is hypothesized that they accommodated to the shift in frequency of incoming sound to a higher pitch percept with the implant than would normally be perceived acoustically...

..To identify chromosomal regions that show evidence of linkage to age-associated hearing impairment (presbycusis) in humans...

..Evaluate the sensitivity of quality of life (QoL) instruments over time in patients with Ménière's disease using general, symptom-specific, and disease-specific QoL instruments...

..No significant differences in genotypes between good hearing and hearing impaired individuals could be detected in either study design. We conclude that there exists no strong association between DFNA5 and ARHI...

..e., hair cell regeneration vs. development of a vestibular prosthesis. Younger scientists will have the opportunity to present their own work in either the platform or poster session. ..

..Attendees will be physicians and clinicians in communication disorders, such as audiologists and speech/language pathologists. Fellowships will be available for attendees. ..

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..Attendees will be physicians and clinicians in communication disorders, such as audiologists and speech/language pathologists. Fellowships will be available for attendees. ..

..Fellowships will be available for attendees with a demonstrated commitment to clinical research as evidenced by a preliminary research project and letters of support in their applications. ..

..Identification of families with inherited presbycusis will facilitate future molecular genetic studies to identify genes for inherited defects. ..

..Knowing whether cardiovascular disease or its precursors are co-factors in the pathogenesis of certain types of presbycusis will allow a rational approach to prevention and possible treatment...