Robert A Gatenby

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. doi Inducing catastrophe in malignant growth
    Robert A Gatenby
    Department of Radiology, Arizona Health Sciences Center, Tucson, AZ 85726, USA
    Math Med Biol 25:267-83. 2008
  2. ncbi Information theory in living systems, methods, applications, and challenges
    Robert A Gatenby
    Department of Radiology, University Medical Center, University of Arizona, 1501 North Campbell Avenue, Tucson, Arizona 85724, USA
    Bull Math Biol 69:635-57. 2007
  3. pmc Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
    R A Gatenby
    Department of Radiology, University of Arizona, Tucson, AR 85724, USA
    Br J Cancer 97:646-53. 2007
  4. ncbi Information dynamics in carcinogenesis and tumor growth
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, AZ 85724, USA
    Mutat Res 568:259-73. 2004
  5. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004
  6. ncbi Acid-mediated tumor invasion: a multidisciplinary study
    Robert A Gatenby
    Departments of Radiology, Applied Mathematics, and Optical Sciences, University of Arizona, Tucson, Arizona 85718, USA
    Cancer Res 66:5216-23. 2006
  7. ncbi An evolutionary model of carcinogenesis
    Robert A Gatenby
    Departments of Radiology, University of Arizona, Tucson, AZ 85724, USA
    Cancer Res 63:6212-20. 2003
  8. ncbi Application of quantitative models from population biology and evolutionary game theory to tumor therapeutic strategies
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, AZ 85724, USA
    Mol Cancer Ther 2:919-27. 2003
  9. ncbi The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models
    Robert A Gatenby
    Department of Radiology, The University of Arizona, Tucson, Arizona 85724 5067, USA
    Cancer Res 63:3847-54. 2003
  10. ncbi The role of non-genomic information in maintaining thermodynamic stability in living systems
    Robert A Gatenby
    Applied Mathematics, Optical Sciences, and Radiology, University of Arizona
    Math Biosci Eng 2:43-51. 2005

Detail Information

Publications37

  1. doi Inducing catastrophe in malignant growth
    Robert A Gatenby
    Department of Radiology, Arizona Health Sciences Center, Tucson, AZ 85726, USA
    Math Med Biol 25:267-83. 2008
    ..382}. These predicted growth effects have a biological basis in the known presence of multiple alleles during cancer growth...
  2. ncbi Information theory in living systems, methods, applications, and challenges
    Robert A Gatenby
    Department of Radiology, University Medical Center, University of Arizona, 1501 North Campbell Avenue, Tucson, Arizona 85724, USA
    Bull Math Biol 69:635-57. 2007
    ..Many fascinating challenges remain, including defining the intercellular information dynamics of multicellular organisms and the role of disordered information storage and flow in disease...
  3. pmc Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
    R A Gatenby
    Department of Radiology, University of Arizona, Tucson, AR 85724, USA
    Br J Cancer 97:646-53. 2007
    ..Upregulated GLUT-1 and NHE-1 were observed in microinvasive foci and adjacent intraductal cells. Adaptation to hypoxia and acidosis may represent key events in transition from in situ to invasive cancer...
  4. ncbi Information dynamics in carcinogenesis and tumor growth
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, AZ 85724, USA
    Mutat Res 568:259-73. 2004
    ....
  5. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004
    ..Subsequent cell populations with upregulated glycolysis and acid resistance have a powerful growth advantage, which promotes unconstrained proliferation and invasion...
  6. ncbi Acid-mediated tumor invasion: a multidisciplinary study
    Robert A Gatenby
    Departments of Radiology, Applied Mathematics, and Optical Sciences, University of Arizona, Tucson, Arizona 85718, USA
    Cancer Res 66:5216-23. 2006
    ..The acid-mediated tumor invasion model provides a simple mechanism linking altered glucose metabolism with the ability of tumor cells to form invasive cancers...
  7. ncbi An evolutionary model of carcinogenesis
    Robert A Gatenby
    Departments of Radiology, University of Arizona, Tucson, AZ 85724, USA
    Cancer Res 63:6212-20. 2003
    ..These previously unknown substrate dynamics in the later stages of carcinogenesis provide a mechanism for evolution of cellular properties typically found in invasive cancers including the angiogenic and glycolytic phenotypes...
  8. ncbi Application of quantitative models from population biology and evolutionary game theory to tumor therapeutic strategies
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, AZ 85724, USA
    Mol Cancer Ther 2:919-27. 2003
    ..Furthermore, the models demonstrate that administration of cytotoxic therapies will, by reducing the tumor population density, create system dynamics more conducive to perturbations by biological modifiers...
  9. ncbi The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models
    Robert A Gatenby
    Department of Radiology, The University of Arizona, Tucson, Arizona 85724 5067, USA
    Cancer Res 63:3847-54. 2003
    ..The consequent unrestrained proliferation allows the glycolytic phenotype to emerge simultaneous with the transition from a premalignant lesion to an invasive cancer...
  10. ncbi The role of non-genomic information in maintaining thermodynamic stability in living systems
    Robert A Gatenby
    Applied Mathematics, Optical Sciences, and Radiology, University of Arizona
    Math Biosci Eng 2:43-51. 2005
    ....
  11. ncbi A microenvironmental model of carcinogenesis
    Robert A Gatenby
    Department of Radiology, University of Arizona, 1501 N Campbell Avenue, Tucson, Arizona 85724, USA
    Nat Rev Cancer 8:56-61. 2008
    ..This model provides a theoretical framework in which the diverse cancer genotypes and phenotypes can be understood according to their roles as adaptive strategies to overcome specific microenvironmental growth constraints...
  12. ncbi The possible role of postoperative azotemia in enhanced survival of patients with metastatic renal cancer after cytoreductive nephrectomy
    Robert A Gatenby
    Departments of Radiology and Applied Mathematics, University of Arizona, Tucson, AZ 85721, USA
    Cancer Res 62:5218-22. 2002
    ..0007). This is generally consistent with the predictions of the mathematical models. If confirmed, these results suggest novel and broadly applicable tumor therapies...
  13. ncbi Application of information theory and extreme physical information to carcinogenesis
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Res 62:3675-84. 2002
    ..Rather, sporadic clinical cancers are emergent structures produced by multiple, fundamentally nondeterministic genetic pathways...
  14. ncbi Glycolysis in cancer: a potential target for therapy
    Robert A Gatenby
    Department of Radiology, University of Arizona, University Medical Center, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
    Int J Biochem Cell Biol 39:1358-66. 2007
    ....
  15. doi Causes and consequences of increased glucose metabolism of cancers
    Robert J Gillies
    University of Arizona, Tucson, Arizona, USA
    J Nucl Med 49:24S-42S. 2008
    ..Specifically we propose that glycolysis is elevated because it produces acid, which provides an evolutionary advantage to cancer cells vis-à-vis normal parenchyma into which they invade...
  16. pmc Regulation of the Warburg effect in early-passage breast cancer cells
    Ian F Robey
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Neoplasia 10:745-56. 2008
    ..Glycolysis was affected by pharmacological regulation of c-Myc and HIF-1alpha. These findings suggest that c-Myc and/or HIF-1alpha activities are both involved in the regulation of glycolysis in breast cancers...
  17. pmc Bicarbonate increases tumor pH and inhibits spontaneous metastases
    Ian F Robey
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Cancer Res 69:2260-8. 2009
    ..Although the mechanism of this therapy is not known with certainty, low pH was shown to increase the release of active cathepsin B, an important matrix remodeling protease...
  18. ncbi Hypoxia and adaptive landscapes in the evolution of carcinogenesis
    Robert J Gillies
    Department of Radiology, Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Cancer Metastasis Rev 26:311-7. 2007
    ....
  19. pmc Systemic buffers inhibit carcinogenesis in TRAMP mice
    Arig Ibrahim-Hashim
    Department of Radiology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Urol 188:624-31. 2012
    ..We hypothesized that decreased acidosis in intraductal tumors would alter environmental selection pressures for acid adapted phenotypes and delay or prevent evolution to invasive cancer...
  20. doi Acid treatment of melanoma cells selects for invasive phenotypes
    Raymond E Moellering
    Arizona Cancer Center, Arizona Health Sciences Center, Tucson, AZ, USA
    Clin Exp Metastasis 25:411-25. 2008
    ..These results reinforce the hypothesis that acidosis promotes selection of stable, more invasive phenotypes, rather than inductive changes, which would be reversible...
  21. ncbi Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?
    Robert J Gillies
    Department of Radiology, Arizona Cancer Center, University of Arizona Health Sciences Center, 1515 N Campbell Ave, Tucson, AZ 85724 5024, USA
    J Bioenerg Biomembr 39:251-7. 2007
    ..Alternative hypotheses, wherein the glucose is used for generation of reducing equivalents (NADPH) or anabolic precursors (ribose) are also discussed...
  22. pmc Information dynamics in living systems: prokaryotes, eukaryotes, and cancer
    B Roy Frieden
    College of Optical Science, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 6:e22085. 2011
    ..Living systems use information and energy to maintain stable entropy while far from thermodynamic equilibrium. The underlying first principles have not been established...
  23. pmc Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression
    Jennifer S Fang
    Department of Physiology, University of Arizona, Tucson, AZ, USA
    Semin Cancer Biol 18:330-7. 2008
    ..We propose this phenotype is critical for subsequent malignant growth of primary and metastatic cancers...
  24. ncbi pH imaging. A review of pH measurement methods and applications in cancers
    Robert J Gillies
    Department of Biochemistry, Arizona Cancer Center, Tucson 85724 5024, USA
    IEEE Eng Med Biol Mag 23:57-64. 2004
    ..A number of approaches have been proposed to solve this problem and, once it is solved, pH imaging methods will be applicable to human clinical pathologies...
  25. ncbi An evolutionary model for initiation, promotion, and progression in carcinogenesis
    T L Vincent
    Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ 85721 0119, USA
    Int J Oncol 32:729-37. 2008
    ..The simulations provide insight into the underlying cellular and microenvironmental dynamics that govern these empirical observations and suggest novel prevention strategies that may be tested experimentally...
  26. ncbi Carcinogenesis and the plasma membrane
    R G Stern
    Department of Veterans Affairs Medical Center, and University of Arizona College of Medicine, Tucson, 85723, USA
    Med Hypotheses 52:367-72. 1999
    ..The abnormal microenvironment results in the selective survival and proliferation of malignant cells at the expense of contiguous normal cell populations...
  27. ncbi Order in a multidimensional system
    B Roy Frieden
    College of Optics, University of Arizona, Tucson, Arizona 85721, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 84:011128. 2011
    ..Finally, an application to cell growth during enforced distortion shows that a single hydrocarbon chain can be distorted into a membrane having equal order or complexity. Such membranes are prime constituents of living cells...
  28. ncbi Power laws of complex systems from extreme physical information
    B Roy Frieden
    College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 72:036101. 2005
    ..These sources are conjectured to be cellular DNA and cellular transmembrane ion gradients...
  29. ncbi Commentary: carcinogenesis as Darwinian evolution? Do the math!
    Robert A Gatenby
    Department of Radiology, University of Arizona, AZ, USA
    Int J Epidemiol 35:1165-7. 2006
  30. ncbi Conditions for correspondence between Hartree scattering and biological growth
    B Roy Frieden
    College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 78:041902. 2008
    ..Examples are given of Hartree systems that obey the population dynamics of required predator-prey systems...
  31. ncbi Cell development obeys maximum Fisher information
    B Roy Frieden
    College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Front Biosci (Elite Ed) 5:1017-32. 2013
    ..In a smoothness limit H(KL) --> I(DNA)/2, so that the total CM-NPC-DNA channel obeys maximum Fisher I. It is also shown that such maximum information --> a cell state far from thermodynamic equilibrium, one condition for life...
  32. ncbi Mathematical oncology: cancer summed up
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85724 5067, USA
    Nature 421:321. 2003
  33. ncbi Mathematical models of tumour invasion mediated by transformation-induced alteration of microenvironmental pH
    R A Gatenby
    Department of Radiology, The University of Arizona, Tucson, USA
    Novartis Found Symp 240:85-96; discussion 96-9. 2001
    ..An acellular gap at the tumour host interface is also predicted and can be demonstrated in pathologic specimens. Novel treatment approaches based on this model are discussed...
  34. ncbi Microenvironmental and cellular consequences of altered blood flow in tumours
    N Raghunand
    Department of Biochemistry and Molecular Biophysics, University of Arizona Health Sciences Center, Tucson, AZ 85724 5024, USA
    Br J Radiol 76:S11-22. 2003
    ..Empirical evidence supporting this "acid-mediated tumour invasion" model is discussed...
  35. ncbi The role of acidity in solid tumour growth and invasion
    Kieran Smallbone
    Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24 29 St Giles, Oxford, OX1 3LB, UK
    J Theor Biol 235:476-84. 2005
    ..Analysis of the model allows us to assess novel therapies directed towards changing the level of acidity within the tumour...
  36. ncbi Modelling a new angle on understanding cancer
    Robert A Gatenby
    Nature 420:462. 2002
  37. ncbi Metabolic changes during carcinogenesis: potential impact on invasiveness
    Kieran Smallbone
    Centre for Mathematical Biology, Mathematical Institute, 24 29 St Giles, Oxford, OX1 3LB, UK
    J Theor Biol 244:703-13. 2007
    ....