Research Topics
| Michael B GatchSummaryAffiliation: University of North Texas Country: USA Publications
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Publications
The effects of adenosine ligands R-PIA and CPT on ethanol withdrawalM B Gatch
Department of Pharmacology, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
Alcohol 19:9-14. 1999..These results suggest that adenosine antagonists, at least at some doses, may be useful for ameliorating the anxiogenic effects produced by ethanol withdrawal, although it does not appear useful for reducing consumption...- Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxietyMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Life Sci 73:1347-67. 2003.... - Effects of ethanol on cocaine discrimination in ratsMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
Pharmacol Biochem Behav 75:837-44. 2003..These findings suggest that ethanol can modulate the discriminative stimulus effects of cocaine, and that these effects may not be mediated by the actions of ethanol at the GABA(A) receptor... - GABAergic modulation of the discriminative stimulus effects of methamphetamineM B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, 76107, USA
Behav Pharmacol 16:261-6. 2005..In conclusion, GABA(A) antagonists and positive modulators likely do not produce methamphetamine-like stimulus effects. However, activation of GABA(A) receptors can interfere with the discriminative stimulus effects of methamphetamine... - Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazineMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Brain Res 1062:161-5. 2005..The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol... - Effects of monoamine oxidase inhibitors on cocaine discrimination in ratsMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
Behav Pharmacol 17:151-9. 2006..These findings suggest that monoamine oxidase inhibitors can modulate the discriminative stimulus effects of cocaine for at least 24 h, and may be useful for treatment of cocaine abuse... - Tolerance to the antinociceptive effects of ethanol during ethanol withdrawalMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, United States
Prog Neuropsychopharmacol Biol Psychiatry 30:946-52. 2006..These findings indicate that L-type calcium channels and adenosine receptors play important, but differing roles in the development of hyperalgesia during withdrawal, and to tolerance to the antinociceptive effects of ethanol... 
Nicotine and methamphetamine share discriminative stimulus effectsMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
Drug Alcohol Depend 93:63-71. 2008..Because there are known interactions between central nicotinic acetylcholine receptors and dopamine receptors, it is of interest to characterize the nature of the interaction of these two compounds in vivo...- Comparison of the discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in ratsMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107 2699, USA
Psychopharmacology (Berl) 204:715-24. 2009..There has been increased recreational use of dimethyltryptamine (DMT), but little is known of its discriminative stimulus effects... - Ethanol withdrawal and hyperalgesiaMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Curr Drug Abuse Rev 2:41-50. 2009..Clinical research is essential to determine the significance of the hyperalgesia to the severity of withdrawal and to relapse... - Effects of GABA(A) compounds on mCPP drug discrimination in ratsMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
Life Sci 71:2657-65. 2002..These findings provide evidence that GABA(A) antagonists modulate the discriminative stimulus effects of mCPP, but that these effects are not mediated by activity at the benzodiazepine site... - Effects of NMDA antagonists on ethanol-withdrawal induced "anxiety" in the elevated plus mazeM B Gatch
Department of Pharmacology, University of North Texas Health Science Center, Fort Worth
Alcohol 19:207-11. 1999..These results suggest that competitive NMDA antagonists may be useful for reduction of signs of anxiety during ethanol withdrawal... - Nitrendipine blocks the nociceptive effects of chronically administered ethanolMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
Alcohol Clin Exp Res 26:1181-7. 2002..Calcium channel blockers prevent the development of tolerance to ethanol and prevent seizures and other signs of ethanol withdrawal. Calcium channels may also mediate the development of tolerance to the antinociceptive effects of ethanol... - Effects of benzodiazepines on acute and chronic ethanol-induced nociception in ratsM B Gatch
Department of Pharmacology and Substance Institute of North Texas, University of North Texas Health Science Center, Fort Worth 76107 2669, USA
Alcohol Clin Exp Res 23:1736-43. 1999..Acute and chronic ethanol produces antinociception, and ethanol withdrawal induces hyperalgesia... - Effects of ritanserin on ethanol withdrawal-induced anxiety in ratsM B Gatch
Department of Pharmacology, University of North Texas Health Science Center, Fort Worth 76107, USA
Alcohol 21:11-7. 2000..p.) increased the motor incoordination induced by ethanol. In conclusion, coadministration of ritanserin with ethanol prevented the development of EW-induced anxiety as measured by the EPM, but not in the PTZ drug discrimination... - Effects of calcium channel blockers on pentylenetetrazol drug discrimination in ratsM B Gatch
Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Alcohol 23:141-7. 2001..Although calcium channel blockers reduce signs of ethanol withdrawal, they also markedly reduce rates of behavior and produce no clear effects on anxiety-like behaviors induced by ethanol withdrawal... - The discriminative stimulus effects of pentylenetetrazol as a model of anxiety: recent developmentsMarianna E Jung
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
Neurosci Biobehav Rev 26:429-39. 2002..Further work with the PTZ drug discrimination is warranted for characterization of anxiety during withdrawal, and the hormonal mechanisms of anxiety... - Carisoprodol tolerance and precipitated withdrawalMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
Drug Alcohol Depend 123:29-34. 2012..The purpose of the current study was to determine if repeated administration of carisoprodol produces tolerance and withdrawal signs in a mouse model... - Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studiesLorie A Gonzalez
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
J Pharmacol Exp Ther 329:827-37. 2009..Furthermore, the functional traits we have identified probably contribute to the abuse potential of carisoprodol... - Behavioral and toxicological effects of propofolMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Behav Pharmacol 22:718-22. 2011..As propofol has discriminative-stimulus effects similar to known drugs of abuse, and occasions a high-mortality rate, its potential for continued abuse is of particular concern... - Theophylline blocks ethanol withdrawal-induced hyperalgesiaMichael B Gatch
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA
Alcohol Alcohol 37:313-7. 2002.... 
The effects of chronic cocaine exposure on impulsivity in ratsKristina L Dandy
Department of Psychology, Texas Christian University, Fort Worth, Texas, USA
Behav Pharmacol 20:400-5. 2009....- Abuse liability profile of three substituted tryptaminesMichael B Gatch
Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
J Pharmacol Exp Ther 338:280-9. 2011..DIPT and 5-MeO-DET may have abuse liability similar to known hallucinogens and may be hazardous because high doses produced activity and lethality... - Sex differences in the pentylenetetrazol-like stimulus induced by ethanol withdrawalM E Jung
Department of Pharmacology and Substance Abuse Institute of North Texas, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA
J Pharmacol Exp Ther 291:576-82. 1999.... - Sex differences in the discriminative stimulus effects of m-chlorophenylpiperazine and ethanol withdrawalM E Jung
Department of Pharmacology and Substance Abuse Institute of North Texas, University of North Texas Health Science Center at Fort Worth, 76107 2699, USA
Psychopharmacology (Berl) 149:170-5. 2000..The serotonergic system plays a role in regulation of anxiety and ethanol withdrawal (EW). Nevertheless, few studies have assessed sex differences in serotonergic effects on EW... - Sex differences in nicotine substitution to a pentylenetetrazol discriminative stimulus during ethanol withdrawal in ratsM E Jung
Department of Pharmacology, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
Psychopharmacology (Berl) 149:235-40. 2000..Nicotine and ethanol are frequently co-abused in men and women, but few studies compare common stimulus effects produced by these substances between males and females... - Abecarnil and alprazolam reverse anxiety-like behaviors induced by ethanol withdrawalM E Jung
Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699
Alcohol 21:161-8. 2000..These results suggest that abecarnil and alprazolam may have therapeutic potential for treatment of ethanol withdrawal-induced anxiety-like symptoms... - Estrogen neuroprotection against the neurotoxic effects of ethanol withdrawal: potential mechanismsM E Jung
Department of Pharmacology and Neuroscience, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Exp Biol Med (Maywood) 230:8-22. 2005..These studies serve as a guide for continuing research into the mechanisms of the neuroprotective effects of estrogen during EW and for the development of potential estrogen-based treatments for male and female alcoholics... - Discriminative stimulus effects of N,N-diisopropyltryptamineTheresa M Carbonaro
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
Psychopharmacology (Berl) 226:241-6. 2013.... - Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamineS Stevens Negus
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02178, USA
Drug Alcohol Depend 70:17-27. 2003..The in vivo apparent efficacy of heroin at mu receptors was similar to or only slightly greater than that of morphine...