Alfredo Garzino-Demo

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Chemokines and defensins as HIV suppressive factors: an evolving story
    Alfredo Garzino-Demo
    Laboratory of Virus Host Interactions, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Curr Pharm Des 13:163-72. 2007
  2. pmc Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection
    Lingling Sun
    Division of Basic Science, Institute of Human Virology, University of Maryland Biotechnology Institute, Room S613, 725 West Lombard Street, Baltimore, MD 21201, USA
    J Virol 79:14318-29. 2005
  3. ncbi request reprint Coping as a multisystem construct associated with pathways mediating HIV-relevant immune function and disease progression
    Lydia R Temoshok
    Department of Medicine, University of Maryland School of Medicine, and The Institute of Human Virology, 725 West Lombard Street, Baltimore, MD 21201, USA
    Psychosom Med 70:555-61. 2008
  4. pmc Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of β chemokines and RNases
    Fiorenza Cocchi
    Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 109:5411-6. 2012
  5. ncbi request reprint Type C coping, alexithymia, and heart rate reactivity are associated independently and differentially with specific immune mechanisms linked to HIV progression
    Lydia R Temoshok
    Institute of Human Virology, Department of Medicine, University of Maryland School of Medicine, 725 West Lombard Street, N 146, Baltimore, MD 21201, USA
    Brain Behav Immun 22:781-92. 2008
  6. pmc CCR6 ligands inhibit HIV by inducing APOBEC3G
    Mark K Lafferty
    Division of Basic Science, Institute of Human Virology, Department of Microbiology and Immunology, University of Maryland School of Medicine, 725 Lombard Street, Baltimore, MD 21201, USA
    Blood 115:1564-71. 2010
  7. pmc Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats
    Mark K Lafferty
    Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA
    Pathog Dis 71:81-9. 2014
  8. ncbi request reprint Recall antigen activation induces prompt release of CCR5 ligands from PBMC: implication in memory responses and immunization
    Lingling Sun
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Room S613, Baltimore, MD 21201 1192, USA
    Int Immunol 16:1623-31. 2004
  9. pmc B cell lymphoma in HIV transgenic mice
    Sabrina Curreli
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Retrovirology 10:92. 2013
  10. ncbi request reprint Differential polarization of immune responses by co-administration of antigens with chemokines
    Achim Frauenschuh
    Division of Basic Science, Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, MD 21201, USA
    Vaccine 23:546-54. 2004

Research Grants

  1. HIV suppression by Beta-defensins
    Alfredo Garzino Demo; Fiscal Year: 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Chemokines and defensins as HIV suppressive factors: an evolving story
    Alfredo Garzino-Demo
    Laboratory of Virus Host Interactions, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Curr Pharm Des 13:163-72. 2007
    ..Here, we review the evidence that argues for their importance in AIDS pathogenesis and in preventive and therapeutic approaches to combat HIV infection...
  2. pmc Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection
    Lingling Sun
    Division of Basic Science, Institute of Human Virology, University of Maryland Biotechnology Institute, Room S613, 725 West Lombard Street, Baltimore, MD 21201, USA
    J Virol 79:14318-29. 2005
    ..This may predispose HIV-positive subjects to increased incidence of oral complications associated with HIV infection...
  3. ncbi request reprint Coping as a multisystem construct associated with pathways mediating HIV-relevant immune function and disease progression
    Lydia R Temoshok
    Department of Medicine, University of Maryland School of Medicine, and The Institute of Human Virology, 725 West Lombard Street, Baltimore, MD 21201, USA
    Psychosom Med 70:555-61. 2008
    ..Based on empirical evidence, the model suggests plausible mechanisms by which coping may be connected to HIV progression/antiprogression factors and immunopathogenesis to affect HIV clinical progression...
  4. pmc Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of β chemokines and RNases
    Fiorenza Cocchi
    Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 109:5411-6. 2012
    ..The antiviral mechanisms of these HIV X4-suppressive factors differ from those of the previously described HIV R5-suppressive β chemokines...
  5. ncbi request reprint Type C coping, alexithymia, and heart rate reactivity are associated independently and differentially with specific immune mechanisms linked to HIV progression
    Lydia R Temoshok
    Institute of Human Virology, Department of Medicine, University of Maryland School of Medicine, 725 West Lombard Street, N 146, Baltimore, MD 21201, USA
    Brain Behav Immun 22:781-92. 2008
    ....
  6. pmc CCR6 ligands inhibit HIV by inducing APOBEC3G
    Mark K Lafferty
    Division of Basic Science, Institute of Human Virology, Department of Microbiology and Immunology, University of Maryland School of Medicine, 725 Lombard Street, Baltimore, MD 21201, USA
    Blood 115:1564-71. 2010
    ..This novel CCR6-mediated mechanism of inhibition allows the identification of pathways that induce intrinsic immunity to HIV, which could be useful in devising novel therapeutics that selectively target CCR6(+) cells...
  7. pmc Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats
    Mark K Lafferty
    Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA
    Pathog Dis 71:81-9. 2014
    ..Understanding the molecular mechanisms of HIV-associated BMD changes has the potential to detect and treat bone metabolism disturbances early and improve the quality of life in patients. ..
  8. ncbi request reprint Recall antigen activation induces prompt release of CCR5 ligands from PBMC: implication in memory responses and immunization
    Lingling Sun
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Room S613, Baltimore, MD 21201 1192, USA
    Int Immunol 16:1623-31. 2004
    ..Taken together, these observations suggest that CCR5 ligands, and in particular MIP-1alpha and MIP-1beta, released in the course of memory responses may play a role in protecting CD4(+) memory T cells from infection...
  9. pmc B cell lymphoma in HIV transgenic mice
    Sabrina Curreli
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Retrovirology 10:92. 2013
    ..Here we describe the phenotypic and molecular characteristics of the B cell leukemia/lymphoma in the Tg mice...
  10. ncbi request reprint Differential polarization of immune responses by co-administration of antigens with chemokines
    Achim Frauenschuh
    Division of Basic Science, Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, MD 21201, USA
    Vaccine 23:546-54. 2004
    ..These results are relevant towards the engineering of novel vaccine and immune-based therapies, and point to chemokines as candidate adjuvant and immunomodulatory molecules...
  11. pmc Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients
    Clara Lehmann
    Institute of Human Virology, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e11110. 2010
    ....
  12. doi request reprint Salivary histatin-5 and oral fungal colonisation in HIV+ individuals
    Sandra R Torres
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Mycoses 52:11-5. 2009
    ....
  13. ncbi request reprint HIV receptors on lymphocytes
    Alfredo Garzino-Demo
    Institute of Human Virology, University of Maryland Biotechnology Institute Baltimore, Maryland 21201, USA
    Curr Opin Hematol 10:279-83. 2003
    ..This article reviews the most exciting aspects of these novel findings and discusses their practical application in the fight against HIV infection...
  14. pmc Antigen stimulation induces HIV envelope gp120-specific CD4(+) T cells to secrete CCR5 ligands and suppress HIV infection
    Gurvinder Kaur
    Department of Veterans Affairs New York Harbor Healthcare System and Department of Pathology, New York University School of Medicine, New York, NY, USA
    Virology 369:214-25. 2007
    ..Such responses would protect virus-specific CD4(+) T cells from HIV infection and preserve their critical functions in mounting and maintaining long-lasting immunity against the virus...
  15. ncbi request reprint Molecular mapping of epitopes for interaction of HIV-1 as well as natural ligands with the chemokine receptors, CCR5 and CXCR4
    Liselotte Antonsson
    Division of Molecular Neurobiology, Wallenberg Neuroscience Center, Lund University, Sweden
    AIDS 17:2571-9. 2003
    ..Mapping coreceptor epitopes used by the prototypic R5 and X4 strains, HIV-1BaL and HIV-1IIIB, in comparison with epitopes involved in the activation and signaling induced by the natural ligands, RANTES and SDF-1beta...

Research Grants1

  1. HIV suppression by Beta-defensins
    Alfredo Garzino Demo; Fiscal Year: 2004
    ..Finally, these studies will constitute a contribution towards the understanding of the role of innate immunity in the oral cavity. ..