Research Topics
Genomes and Genes | Alfredo Garzino-DemoSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Publications
Chemokines and defensins as HIV suppressive factors: an evolving storyAlfredo Garzino-Demo
Laboratory of Virus Host Interactions, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
Curr Pharm Des 13:163-72. 2007..Here, we review the evidence that argues for their importance in AIDS pathogenesis and in preventive and therapeutic approaches to combat HIV infection...
Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protectionLingling Sun
Division of Basic Science, Institute of Human Virology, University of Maryland Biotechnology Institute, Room S613, 725 West Lombard Street, Baltimore, MD 21201, USA
J Virol 79:14318-29. 2005..This may predispose HIV-positive subjects to increased incidence of oral complications associated with HIV infection...
Coping as a multisystem construct associated with pathways mediating HIV-relevant immune function and disease progressionLydia R Temoshok
Department of Medicine, University of Maryland School of Medicine, and The Institute of Human Virology, 725 West Lombard Street, Baltimore, MD 21201, USA
Psychosom Med 70:555-61. 2008..Based on empirical evidence, the model suggests plausible mechanisms by which coping may be connected to HIV progression/antiprogression factors and immunopathogenesis to affect HIV clinical progression...- Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of β chemokines and RNasesFiorenza Cocchi
Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 109:5411-6. 2012..The antiviral mechanisms of these HIV X4-suppressive factors differ from those of the previously described HIV R5-suppressive β chemokines... - CCR6 ligands inhibit HIV by inducing APOBEC3GMark K Lafferty
Division of Basic Science, Institute of Human Virology, Department of Microbiology and Immunology, University of Maryland School of Medicine, 725 Lombard Street, Baltimore, MD 21201, USA
Blood 115:1564-71. 2010..This novel CCR6-mediated mechanism of inhibition allows the identification of pathways that induce intrinsic immunity to HIV, which could be useful in devising novel therapeutics that selectively target CCR6(+) cells... - Type C coping, alexithymia, and heart rate reactivity are associated independently and differentially with specific immune mechanisms linked to HIV progressionLydia R Temoshok
Institute of Human Virology, Department of Medicine, University of Maryland School of Medicine, 725 West Lombard Street, N 146, Baltimore, MD 21201, USA
Brain Behav Immun 22:781-92. 2008.... - Recall antigen activation induces prompt release of CCR5 ligands from PBMC: implication in memory responses and immunizationLingling Sun
Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Room S613, Baltimore, MD 21201-1192, USA
Int Immunol 16:1623-31. 2004..Taken together, these observations suggest that CCR5 ligands, and in particular MIP-1alpha and MIP-1beta, released in the course of memory responses may play a role in protecting CD4(+) memory T cells from infection... - Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patientsClara Lehmann
Institute of Human Virology, University of Maryland, Baltimore, Maryland, United States of America
PLoS ONE 5:e11110. 2010.... - Differential polarization of immune responses by co-administration of antigens with chemokinesAchim Frauenschuh
Division of Basic Science, Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, MD 21201, USA
Vaccine 23:546-54. 2004..These results are relevant towards the engineering of novel vaccine and immune-based therapies, and point to chemokines as candidate adjuvant and immunomodulatory molecules... - Salivary histatin-5 and oral fungal colonisation in HIV+ individualsSandra R Torres
Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, MD 21201, USA
Mycoses 52:11-5. 2009.... - HIV receptors on lymphocytesAlfredo Garzino-Demo
Institute of Human Virology, University of Maryland Biotechnology Institute Baltimore, Maryland 21201, USA
Curr Opin Hematol 10:279-83. 2003..This article reviews the most exciting aspects of these novel findings and discusses their practical application in the fight against HIV infection... - Molecular mapping of epitopes for interaction of HIV-1 as well as natural ligands with the chemokine receptors, CCR5 and CXCR4Liselotte Antonsson
Division of Molecular Neurobiology, Wallenberg Neuroscience Center, Lund University, Sweden
AIDS 17:2571-9. 2003..The results provide a basis for tailoring drugs that block viral entry through the two major coreceptors without interfering with their physiological function... - Antigen stimulation induces HIV envelope gp120-specific CD4(+) T cells to secrete CCR5 ligands and suppress HIV infectionGurvinder Kaur
Department of Veterans Affairs New York Harbor Healthcare System and Department of Pathology, New York University School of Medicine, New York, NY, USA
Virology 369:214-25. 2007..Such responses would protect virus-specific CD4(+) T cells from HIV infection and preserve their critical functions in mounting and maintaining long-lasting immunity against the virus...
Research Grants
- HIV suppression by Beta-defensinsAlfredo Garzino Demo; Fiscal Year: 2004..Finally, these studies will constitute a contribution towards the understanding of the role of innate immunity in the oral cavity. ..